FN ISI Export Format VR 1.0 PT J AU Espinosa-Mansilla, A de la Pena, AM Canada-Canada, F de Llanos, AM AF Espinosa-Mansilla, A. Munoz de la Pena, A. Canada-Canada, F. Mancha de Llanos, A. TI LC determination of biopterin-reduced forms by UV-photogeneration of biopterin and fluorimetric detection SO TALANTA LA English DT Article DE LC; Fluorimetric detection; Photoirradiation; Tetrahydrobiopterin (BH4); Biopterin (BIO); Serum; Hyperphenylalaninemia ID TETRAHYDROBIOPTERIN; REGRESSION; PLASMA AB An off-line photoirradiation LC fluorimetric method to determine tetrahydrobiopterin (BH4), by photo-generation of biopterin (BIO). is described, as an alternative way to the chemical oxidation procedure. To minimize the uncontrolled BH4 oxidation, due to environmental oxygen, an antioxidant, dithiothreitol (DTT), was used. The acidity of the medium, as well as the presence of hydrogen peroxide, affects the rate of the photoreaction and the nature of the obtained fluorescent photoproducts. The best conditions were achieved by irradiation in hydrochloric acid (0.2 M) medium, in presence of 100 mM hydrogen peroxide, and using an irradiation time of 20 min. The method was tested in the analysis of serum samples containing BH4, and recoveries between 89 and 105% were found. Also, the proposed method allows the resolution of BH4 and BIO, in the same sample, by injection of non-irradiated and irradiated sample aliquots in the chromatographic system. (C) 2008 Elsevier B.V. All rights reserved. C1 [Espinosa-Mansilla, A.; Munoz de la Pena, A.; Canada-Canada, F.; Mancha de Llanos, A.] Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. RP Canada-Canada, F, Univ Extremadura, Dept Analyt Chem, Avda Elvas, E-06071 Badajoz, Spain. EM floricanada@gmail.com FU DGI-MCI of Spain [CTQ 2008-00468/BQU]; Consejeria de EdUcacion, Ciencia y Tecnologia de la Junta de Extremadura for a fellowship [DOE 29/06/2006] FX Financial Support was provided by DGI-MCI of Spain (Project CTQ 2008-00468/BQU). Alicia Mancha de Llanos is grateful to the Consejeria de EdUcacion, Ciencia y Tecnologia de la Junta de Extremadura for a fellowship (DOE 29/06/2006). CR BJLAKOVIC G, 2004, MED BIOL, V11, P49 BLAU N, 2001, METABOLIC MOL BASES, P1725 CLAYTON CA, 1987, ANAL CHEM, V59, P2506 DELRIO FJ, 2001, ANAL CHIM ACTA, V446, P49 DHONDT LJ, 1989, PATHOL BIOL, V37, P283 ESPINOSAMANSILL.A, 2001, CHROMATOGRAPHIA, V53, P510 FEKKES D, 2007, CLIN BIOCHEM, V40, P411, DOI 10.1016/j.clinbiochem.2006.12.001 FIEGE B, 2004, MOL GENET METAB, V81, P45, DOI 10.1016/j.ymgme.2003.09.014 FUKUSHIMA T, 1980, ANAL BIOCHEM, V102, P176 GIRON AJ, 2008, ANAL BIOANAL CHEM, V391, P827, DOI 10.1007/s00216-008-1840-3 MASSART DL, 1997, HDB CHEMOMETRICS Q A RIU J, 1997, TRAC-TREND ANAL CHEM, V16, P211 SCRIVER RC, 1995, METABOLIC MOL BASES, P1015 SHIMIZU S, 2005, INT J BIOCHEM CELL B, V37, P864, DOI 10.1016/j.biocel.2004.11.003 TELEGINA TA, 2005, APPL BIOCHEM MICROB, V41, P275 NR 15 TC 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD DEC 15 PY 2008 VL 77 IS 2 BP 844 EP 851 DI 10.1016/j.talanta.2008.07.046 PG 8 SC Chemistry, Analytical GA 379SM UT ISI:000261416500063 ER PT J AU Piccirilli, GN Escandar, GM Canada, FC Meras, ID de la Pena, AM AF Piccirilli, Gisela N. Escandar, Graciela M. Canada Canada, Florentina Duran Meras, Isabel Munoz de la Pena, Arsenio TI Flow-through photochemically induced fluorescence optosensor for the determination of linuron SO TALANTA LA English DT Article DE Pesticides; Linuron; Photochemically induced fluorescence; Flow-through sensor; Environmental waters ID PERFORMANCE LIQUID-CHROMATOGRAPHY; PHENYLUREA HERBICIDES; PHARMACEUTICAL PREPARATIONS; INJECTION ANALYSIS; UREA HERBICIDES/; WATER; SAMPLES; RESIDUES; SPECTROFLUOROMETRY; CHLORBROMURON AB This manuscript presents the development of a new photochemically induced fluorescence flow-injection system, combined with solid-surface adsorption, for the determination of the benzoylurea pesticide linuron. The determination is carried Out by measuring the fluorescence intensity of a photoproduct, formed by on-line irradiation with ultraviolet light, and retention on a solid matrix filling the flow-cell. The procedure is developed in the presence of two surfactants: sodium dodecyl sulphate and hexadecyltrimethylammonium chloride, which are critical for the detection of the fluorescence emission in the solid Surface. The possible interactions between the linuron photoproduct, the micellar medium employed and the solid Support (C-18 silica gel) are discussed. Parameters related to the analytical signal and to the FIA manifold are optimized. Finally, the feasibility of the developed method was tested by the determination of linuron in both environmental and drinking water samples. Determinations at mu g L-1 level were accomplished after a solid-phase pre-concentration procedure. (C) 2008 Elsevier B.V. All rights reserved. C1 [Piccirilli, Gisela N.; Escandar, Graciela M.] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Dept Quim Analit,Inst Quim Rosario, RA-2000 Rosario, Santa Fe, Argentina. [Canada Canada, Florentina; Duran Meras, Isabel; Munoz de la Pena, Arsenio] Univ Extremadura, Fac Ciencias, Dept Quim Analit, E-06071 Badajoz, Spain. RP Escandar, GM, Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Dept Quim Analit,Inst Quim Rosario, Suipacha 531,S2002LRK, RA-2000 Rosario, Santa Fe, Argentina. EM arsenio@unex.es FU Ministerio de Educacion y Ciencia of Spain, [CTQ2008-06657/BQU]; Agencia Espanola de Cooperacion Internacional [A/6576/06]; Universidad Nacional de Rosario ; Agencia Nacional de Promocion Cientifica y Tecnologica [PAE 22204]; Consejo Nacional de Investigaciones Cientificas y Tecnicas FX The authors gratefully acknowledge the Ministerio de Educacion y Ciencia of Spain, Project CTQ2008-06657/BQU, Agencia Espanola de Cooperacion Internacional (AECI), Project A/6576/06, Universidad Nacional de Rosario. Agencia Nacional de Promocion Cientifica y Tecnologica (Project PAE 22204) and Consejo Nacional de Investigaciones Cientificas y Tecnicas, for financially Supporting this work. 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However, much less is known regarding the contribution of culture media to the oxidative stress of gametes during assisted reproductive techniques. This study measured the generation of ROS by culture media during IVF procedures and its effects oil human oocytes. Commercially supplied culture media generated ROS at various rates, depending on the composition, whereas follicular fluid generated ROS at a Much lower level. The incubation Of cumulus-oocyte complexes (COC) ill Culture media induced marked lipid peroxidation compared with levels found in freshly retrieved COC. This plasma membrane damage. measured with the quenching of cis-parinaric acid fluorescence assay, was attenuated by supplementation of the medium With alpha-tocopherol or catalase. Moreover, there was air association between ROS production by Culture medium and thiolic content consumption within the oocytes. suggesting that the intracellular reduced glutathione pool was partially depleted during in-vitro manipulation. The results show that culture medium could damage oocytes (and consequently embryo development) depending on their composition, and it is proposed that current IVF protocols could be revised in order to decrease ROS generation. C1 [Santiago Alvarez, Ignacio] Univ Extremadura, Fac Ciencias, Reprod & Dev Grp ReDes, E-06071 Badajoz, Spain. [Javier Martin-Romero, Francisco] Univ Extremadura, Dept Bioquim & Biol Mol, E-06071 Badajoz, Spain. [Maria Miguel-Lasobras, Eva; Santiago Alvarez, Ignacio] Univ Extremadura, Dept Biol Celular, E-06071 Badajoz, Spain. [Antonio Dominguez-Arroyo, Jose; Gonzalez-Carrera, Ernesto; Santiago Alvarez, Ignacio] IERA, Badajoz 06004, Spain. RP Alvarez, IS, Univ Extremadura, Fac Ciencias, Reprod & Dev Grp ReDes, Ave Elvas S-N, E-06071 Badajoz, Spain. EM ialvarez@unex.es FU Consejeria de Sanidad y Dependencia (Junta de Extremadura) [SCSS-0676, SCSS-0715]; Consejeria de Economia, Comercio e Innovacion (Junta de Extremadura) [PRIB06B300] FX The authors are grateful to Dr Carlos Gutierrez-Merino for the use of the Nikon-Diaphot epifluorescence inverted microscope and the Perkin-Elmer 650-40 spectrofluorometer. Eva M Miguel-Lasobras was the recipient of a predoctoral fellowship from Serono, Inc. Laboratorios Leti S.L. (Spain), provided free of charge the media used in this study. This work was supported by Grants SCSS-0676 and SCSS-0715 from the Consejeria de Sanidad y Dependencia (Junta de Extremadura), and PRIB06B300 from the Consejeria de Economia, Comercio e Innovacion (Junta de Extremadura). 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Biomed. Online PD NOV PY 2008 VL 17 IS 5 BP 652 EP 661 PG 10 SC Obstetrics & Gynecology; Reproductive Biology GA 374VW UT ISI:000261072800008 ER PT J AU Aven, T Castro, IT AF Aven, Terje Castro, I. T. TI A delay-time model with safety constraint SO RELIABILITY ENGINEERING & SYSTEM SAFETY LA English DT Article DE Delay time; Safety constraint; Replacement; Discounted costs; Optimal inspection time ID MAINTENANCE; REPLACEMENT; INSPECTION; FAILURE AB We consider the basic delay-time model in which a system has three states, the perfect functioning state, a defective state and the failure state. The system is deteriorating and to reduce the number of failures, preventive replacements are carried Out when the system is in the defective state. The time in the defective state is referred to as the delay time. Inspections are required to check whether the system is in the defective state. System failures are safety critical and to control the risk, management considers two types of safety constraints: (i) the probability of at least one failure in the interval [0,A] should not exceed a fixed probability omega(1) and (ii) the fraction of time the system is in the defective state should not exceed a fixed limit omega(2) . The problem is to determine optimal inspection intervals T, minimizing the expected discounted costs under the safety constraints. Conditions are established for when the safety constraints affect the optimal inspection time and causes increased costs. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Aven, Terje] Univ Stavanger, N-4036 Stavanger, Norway. [Castro, I. T.] Univ Extremadura, Escuela Politecn, Dept Matemat, Caceres 10071, Spain. RP Aven, T, Univ Stavanger, N-4036 Stavanger, Norway. EM terje.aven@uis.no inmatorres@unex.es CR ABRAHAMSEN E, 2005, RISK DECISION POLICY, V9, P347 ASH RB, 2000, PROBABILITY MEASURE AVEN T, 1983, ADV APPL PROBAB, V15, P198 AVEN T, 1999, STOCHASTIC MODELS RE AVEN T, 2007, RISK MANAGEMENT APPL AVEN T, 2008, EUR J OPER RES, V188, P506, DOI 10.1016/j.ejor.2007.04.038 BAKER RD, 1994, EUR J OPER RES, V73, P407 CHRISTER AH, 1982, J OPL RES SOC, V33, P723 CHRISTER AH, 1992, INT J PROD ECON, V24, P227 CHRISTER AH, 1999, J OPER RES SOC, V50, P1120 NR 10 TC 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0951-8320 J9 RELIAB ENG SYST SAFETY JI Reliab. Eng. Syst. Saf. PD FEB PY 2009 VL 94 IS 2 BP 261 EP 267 DI 10.1016/j.ress.2008.03.004 PG 7 SC Engineering, Industrial; Operations Research & Management Science GA 376RO UT ISI:000261200900014 ER PT J AU Navarro, CC Canavate, AM Bleda, AM AF Navarro, Celia Chain Canavate, Antonio Munoz Bleda, Amalia Mas TI Information management in the websites of Spanish city councils SO REVISTA ESPANOLA DE DOCUMENTACION CIENTIFICA LA Spanish DT Article DE Council; municipalities; web; Internet; Spain; Information Management; Content Management; webmaster; test; electronic administration ID E-GOVERNMENT AB Spain's authorities have become more agile since the generalisation of the Internet, the use of which has significantly improved the ways in which they communicate with the country's citizens and companies. The subjects of this study were the websites produced by the Town Councils of Spain's provincial capitals as well as those of the autonomous cities Ceuta and Melilla. Their content and the personnel in charge of their creation, development, maintenance and updating were all examined. A questionnaire was designed to study the content of and the services offered by these websites; information was recorded by direct observation. The persons charged with the technical and content management of these sites were identified by a multiple choice-type questionnaire sent by e-mail and fax to those responsible for these new services. Thirty three of the 52 councils contacted responded. The results show that at the municipal level Spain is still in the phase of making information available, with some local governments moving faster than others towards an 'electronic administration'. Nonetheless, the country is still far from working by 'electronic government'. C1 [Navarro, Celia Chain; Bleda, Amalia Mas] Univ Murcia, Dept Informat & Documentat, Fac Comun & Documentat, E-30001 Murcia, Spain. [Canavate, Antonio Munoz] Univ Extremadura, Dept Informat & Comunicac, Fac Bibliotec & Documentac, E-06071 Badajoz, Spain. RP Navarro, CC, Univ Murcia, Dept Informat & Documentat, Fac Comun & Documentat, E-30001 Murcia, Spain. EM chain@um.es amunoz@alcazaba.unex.es amaliamas@um.es CR *ACCENTURE, 2003, LID ADM EL CONS PART *ACCENTURE, 2007, LID SERV CLIENT CUMP *ACCTIVIA, 2005, INF 2005 ACC WEBS AY *CIS, 2006, ENC CAL SERV PUBL *DISCAPNET, ACC WEB PORT AYUNT C ANDERSON D, 2003, CIVIC WEB ONLINE POL BANON R, 1997, NUEVA ADM PUBLICA, P17 CAMPS JL, 2002, E GOBIERNO GOBERNAR, P116 CANAVATE AM, 2004, GOVT INFORM Q, V2, P199 CANAVATE AM, 2005, 9 JORNADAS ESPANOLAS, P371 CANAVATE AM, 2007, 10 JORNADAS ESPANOLA, P373 CANAVATE M, 2004, REV BIBLIOTECOLOGIA, V36, P96 CODINA L, 2000, REVISTA ESPANOLA DOC, V23, P9 CODINA L, 2004, ACTAS 9 JORNADAS CAT, P59 DELARBE RT, 2003, DIALOGOS COMUNICACIO, V67, P29 DOMINGUEZ MM, 2007, 10 JORNADAS TECNOLOG GALINDO F, 2004, INT REV LAW COMPUTER, V18, P7 HO ATK, 2002, PUBLIC ADMIN REV, V62, P434 HUGHES OE, 1997, LECT GESTION PUBLICA, P103 LAYNE K, 2001, GOV INFORM Q, V18, P122 MATO D, 2004, POLITICAS CIUDADANIA NARVAEZ A, 2002, PUENTES TECNOLOGICOS NAVARRO CC, 2004, CIENCIAS INFORM, V35, P43 NAVARRO CC, 2005, ANALES DOCUMENTACION, V8, P37 NAVARRO CC, 2005, REV ESPANOLA DOCUMEN, V28, P309 NAVARRO CC, 2008, LIBRI IN PRESS PIANO MJ, 2001, REV ESPANOLA DOCUMEN, V24, P405 QUIRCE MML, 2006, 9 JORNADAS TECNOLOGI REDDICK CG, 2004, GOVT INFORM Q, V21, P54 RUIZ FH, 2003, ACTAS 3 JORNADAS AND, P333 WARSCHAUER M, 2003, TECHNOLOGY SOCIAL IN NR 31 TC 0 PU CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS PI MADRID PA VITRUVIO 8, 28006 MADRID, SPAIN SN 0210-0614 J9 REV ESP DOC CIENT JI Rev. Esp. Doc. Cient. PD OCT-DEC PY 2008 VL 31 IS 4 BP 612 EP 638 DI 10.3989/redc.2008.4.662 PG 27 SC Information Science & Library Science GA 378VN UT ISI:000261352700005 ER PT J AU Saavedra, JM Torres, S Caro, B Escalante, Y De la Cruz, E Duran, MJ Rodriguez, FA AF Saavedra, Jose M. Torres, Silvia Caro, Berta Escalante, Yolanda De la Cruz, Ernesto Duran, Maria J. Rodriguez, Ferran A. TI Relationship between health-related fitness and educational and income levels in Spanish women (vol 122, pg 794, 2008) SO PUBLIC HEALTH LA English DT Correction C1 [Saavedra, Jose M.; De la Cruz, Ernesto] Univ Extremadura, Fac Ciencias Deporte, AFIDES Res Grp, E-06071 Badajoz, Spain. [Torres, Silvia; Caro, Berta] Univ Extremadura, Fac Med, AFIDES Res Grp, Caceres, Spain. [Escalante, Yolanda] Univ Extremadura, Fac Formac Profesorado, AFIDES Res Grp, Caceres, Spain. [Duran, Maria J.] Univ Extremadura, Escuela Univ Enfermeri & Terapia Ocupac, AFIDES Res Grp, Caceres, Spain. [Rodriguez, Ferran A.] Univ Barcelona, Inst Nac Educ Fis Catalunya, Barcelona, Spain. RP Saavedra, JM, Univ Extremadura, Fac Ciencias Deporte, AFIDES Res Grp, E-06071 Badajoz, Spain. CR SAAVEDRA JM, 2008, PUBLIC HEALTH, V122, P794, DOI 10.1016/j.puhe.2007.07.017 NR 1 TC 0 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0033-3506 J9 PUBLIC HEALTH JI Public Health PD NOV PY 2008 VL 122 IS 11 BP 1139 EP 1139 DI 10.1016/j.puhe.2008.07.015 PG 1 SC Public, Environmental & Occupational Health GA 378CU UT ISI:000261299500002 ER PT J AU Canal, C Murillo, JM Poizat, P AF Canal, Carlos Manuel Murillo, Juan Poizat, Pascal TI Software Adaptation J. UCS Special Issue SO JOURNAL OF UNIVERSAL COMPUTER SCIENCE LA English DT Editorial Material C1 [Canal, Carlos] Univ Malaga, E-29071 Malaga, Spain. [Manuel Murillo, Juan] Univ Extremadura, E-06071 Badajoz, Spain. RP Canal, C, Univ Malaga, E-29071 Malaga, Spain. EM canal@lcc.uma.es juanmamu@unex.es pascal.poizat@inria.fr NR 0 TC 0 PU GRAZ UNIV TECHNOLGOY, INST INFORMATION SYSTEMS COMPUTER MEDIA-IICM PI GRAZ PA INFFELDGASSE 16C, GRAZ, A-8010, AUSTRIA SN 0948-695X J9 J UNIVERS COMPUT SCI JI J. Univers. Comput. Sci. PY 2008 VL 14 IS 13 BP 2107 EP 2109 PG 3 SC Computer Science, Software Engineering; Computer Science, Theory & Methods GA 381RY UT ISI:000261554800001 ER PT C AU Perez-Toledano, MA Navasa, A Murillo, JM Canal, C AF Perez-Toledano, Miguel A. Navasa, Amparo Murillo, Juan M. Canal, Carlos TI A Safe Dynamic Adaptation Framework for Aspect-Oriented Software Development SO JOURNAL OF UNIVERSAL COMPUTER SCIENCE LA English DT Proceedings Paper DE Aspect-Oriented Programming; Software Adaptation; UML; CCS; Extended State Machines; Interaction Pattern Specification ID SPECIFICATIONS; ARCHITECTURE; MODELS; LOGIC AB One focus of current software development is the re-use of components in the construction of systems. Software Adaptation facilitates the consequent need to adapt these components to the new environment by employing adaptors which are obtained automatically and hence with a certain guarantee of suitability, from formal descriptions of the interface behaviour. One appropriate technique for Software Adaptation is Aspect-Oriented Programming (AOP) which makes use of aspects to facilitate the dynamic adaptation of components transparently and non-intrusively. However, owing to the way that aspects are integrated, these can unexpectedly modify the functionality of the system, and consequently completely alter its semantics. It is hence necessary to study the final behaviour of the system to ensure its correctness after adding aspects for its adaptation. This study must go beyond just detecting problems at the protocol level, to analyze the potential semantic problems. This is the main focus of the present communication. We start from the Unified Modeling Language (UML 2.0) specification of both the initial system and the aspects. This specification is validated by generating an algebraic Calculus of Communicating Systems (CCS) description of the system. Next, extended ( finite) state machines are automatically generated to verify, simulate, and test the modeled system's behaviour. The result of that process can also be compared with the behaviour of the new running system. To facilitate this task, we propose grouping components so as to centre the study on the points actually affected by the behaviour of the aspects. C1 [Perez-Toledano, Miguel A.; Navasa, Amparo; Murillo, Juan M.] Univ Extremadura, Quercus Software Engn Grp, Caceres, Spain. [Canal, Carlos] Univ Malaga, GISUM Grp, E-29071 Malaga, Spain. RP Perez-Toledano, MA, Univ Extremadura, Quercus Software Engn Grp, Caceres, Spain. EM toledano@unex.es amparonm@unex.es juanmamu@unex.es canal@lcc.uma.es CR 2000, CONCURRENCY WORKBENC 2002, ASPECTJ 2006, ASPECTUALACME 2007, FUSEJ UNIFYING ASPEC *EEUU, 2005, P INT WORKSH SCEN ST ALDAWUD T, 2003, P 3 INT WORKSH ASP O ALEXANDER RT, 2006, SYSTEMATIC TESTING A ARAUJO J, 2004, P 12 IEEE INT REQ EN, P58 AUTILI M, 2007, P INT C SOFTW ENG MI BANIASSAD E, 2004, P WORKSH EARL ASP LA BANIASSAD E, 2005, THEME ASPECT ORIENTE BARAIS O, 2005, P 31 EUR C SOFTW ENG BECKER S, 2006, LNCS, V4379, P72 BEIZER BB, 1990, SOFTWARE TESTING TEC BLAIR L, 1999, P 3 INT C FORM METH, P401 CANAL C, 2006, OBJET, V12, P9 CHOUALI S, 2006, FACS 2006, P211 CLARKE EM, 1986, ACM T PROGR LANG SYS, V8, P244 CLIFTON C, 2002, P FDN ASP LANG DEVEREUX B, 2003, P FDN ASP LANG ELRAD T, 2005, P ASP OR SOFTW DEV FILLMAN R, 2005, P ASP OR SOFTW DEV FRANTZ S, 2004, NAT REV DRUG DISCOV, V3, P193, DOI 10.1038/nrd1358 INVERARDI P, 2002, LNCS, V2941, P184 INVERARDI P, 2003, LECT NOTES COMPUT SC, V2804, P92 JACOBSON I, 2005, ASPECT ORIENTED SOFT JONES T, 1999, P WORKSH ASP OR PROG KATARA M, 2003, P ASP OR SOFTW DEV B KATZ S, 2003, LNCS, V2772, P389 KATZ S, 2004, P FDN ASP LANG KRISHNAMURTHI S, 2004, P INT C FDN SOFTW EN MCEACHEN N, 2005, P 4 INT C ASP OR SOF, P192 NAVASA A, 2005, LECT NOTES COMPUT SC, V3527, P41 NAVASA A, 2007, LECT NOTES COMPUT SC, V4758, P330 OCCELLO A, 2006, P WORKSH COORD AD TE PEREZTOLEDANO MA, 2007, P 2 INT C SOFTW ENG SIBERTIN C, 2006, P WORKSH COORD AD TE SIMMONDS J, 2005, 20 IEEE ACM INT C AU, P431 STEIN D, 2002, P 1 INT C ASP OR SOF, P106 UCHITEL S, 2004, ACM T SOFTW ENG METH, V13, P37 VALMARI A, 1998, LECT NOTES COMPUTER, V1491, P429 VANDERSTRAETEN R, 2003, LECT NOTES COMPUT SC, V2863, P326 WHITTLE J, 2000, P 22 INT C SOFTW ENG, P314 WHITTLE J, 2004, IEE P-SOFTW, V151, P157, DOI 10.1049/ip-sen:20040921 NR 44 TC 0 PU GRAZ UNIV TECHNOLGOY, INST INFORMATION SYSTEMS COMPUTER MEDIA-IICM PI GRAZ PA INFFELDGASSE 16C, GRAZ, A-8010, AUSTRIA SN 0948-695X J9 J UNIVERS COMPUT SCI JI J. Univers. Comput. Sci. PY 2008 VL 14 IS 13 BP 2212 EP 2238 PG 27 SC Computer Science, Software Engineering; Computer Science, Theory & Methods GA 381RY UT ISI:000261554800005 ER PT C AU Preciado, JC Linaje, M Sanchez-Figueroa, F AF Carlos Preciado, Juan Linaje, Marino Sanchez-Figueroa, Fernando TI Adapting Web 1.0 User Interfaces to Web 2.0 Multidevice User Interfaces using RUX-Method SO JOURNAL OF UNIVERSAL COMPUTER SCIENCE LA English DT Proceedings Paper DE Adaptation Techniques; Web Engineering AB The development of Web applications, both functionality and Web User Interfaces (UIs), has been facilitated over the last few years using Web models and methodologies. However, new requirements that overcome traditional HTML-based Web 1.0 User Interfaces limits have arisen. Developers and tool vendors have answered these limits introducing Rich Internet Applications (RIAs). RIA technologies provide Web 2.0 UI capabilities such as high interactivity and native multimedia support among others. Currently, numerous developers are adapting many of their legacy Web 1.0 applications to Web 2.0 introducing Web 2.0 UI capacities while maintaining the business logic. Nevertheless, there is a lack of methodologies to support this adaptation process. In this paper we show how to use a model driven method called RUX-Method for the systematic adaptation of existing Web 1.0 UIs to Web 2.0 multidevice UIs. This method focuses on new UI capabilities provided by RIAs while taking advantage of functionality already provided by existing Web models. The proposal follows a common UI design for all the devices and an ad-hoc design approach for each device attending to its specific features. C1 [Carlos Preciado, Juan; Linaje, Marino; Sanchez-Figueroa, Fernando] Univ Extremadura, Escuela Politecn, Quercus Software Engn Grp, Caceres, Spain. RP Preciado, JC, Univ Extremadura, Escuela Politecn, Quercus Software Engn Grp, Caceres, Spain. EM jcpreciado@unex.es mlinaje@unex.es fernando@unex.es CR BOZZON A, 2006, INT C WEB ENG, P353 BRENT S, 2007, J INTERNET COMPUTING, V11, P67 CANAL C, 2006, OBJECT, V12 CERI S, 2002, DESIGNING DATA INTEN DANIEL F, 2007, IEEE INTERNET COMPUT, V11, P59 DESOUSA G, 2004, INT C COMP AID DES U, V1 KOCH N, 2002, IWWOST02, P105 LIMBOURG Q, 2005, LNCS, V3425, P207 LINAJE M, 2007, IEEE INTERNET COMPUT, V11, P53 MESBAH A, 2006, TUDSERG2006018 DELFT PRECIADO JC, 2005, IEEE INT S WEB SIT E, P7 PRECIADO JC, 2007, IEEE INT S WEB SIT E, P23 SUH W, 2005, WEB ENG PRINCIPLES T, P31 URBIETA M, 2007, P 5 LAT AM WEB C, P144 YAHIAOUI N, 2004, 1 WCAT WORKSH, P55 NR 15 TC 0 PU GRAZ UNIV TECHNOLGOY, INST INFORMATION SYSTEMS COMPUTER MEDIA-IICM PI GRAZ PA INFFELDGASSE 16C, GRAZ, A-8010, AUSTRIA SN 0948-695X J9 J UNIVERS COMPUT SCI JI J. Univers. Comput. Sci. PY 2008 VL 14 IS 13 BP 2239 EP 2254 PG 16 SC Computer Science, Software Engineering; Computer Science, Theory & Methods GA 381RY UT ISI:000261554800006 ER PT J AU Sanchez, B Rodriguez, M Casado, EM Martin, A Cordoba, JJ AF Sanchez, Beatriz Rodriguez, Mar Casado, Eva M. Martin, Alberto Cordoba, Juan J. TI Development of an Efficient Fungal DNA Extraction Method To Be Used in Random Amplified Polymorphic DNA-PCR Analysis To Differentiate Cyclopiazonic Acid Mold Producers SO JOURNAL OF FOOD PROTECTION LA English DT Article ID REAL-TIME PCR; GENOMIC DNA; ASPERGILLUS-FUMIGATUS; FILAMENTOUS FUNGI; STARTER CULTURES; SUBSTRATE; REAGENT; RAPD; HAM AB A variety of previously established mechanical and chemical treatments to achieve fungal cell lysis combined with a semiautomatic system operated by it vacuum pump were tested to obtain DNA extract to be directly used in randomly amplified polymorphic DNA (RAPD)-PCR to differentiate cyclopiazonic acid-producing and -nonproducing mold strains. A DNA extraction method that includes digestion with proteinase K and lyticase prior to using a mortar and pestle grinding and a semiautomatic vacuum system yielded DNA of high quality in all the fungal strains and species tested, at concentrations ranging from 17 to 89 ng/mu l in 150 mu l of the final DNA extract. Two microliters of DNA extracted with this method was directly used for RAPD-PCR using, primer (GACA)(4). Reproducible RAPD fingerprints showing high differences between producer and nonproducer strains were observed. These differences in the RAPD patterns did not differentiate all the strains tested in clusters by cyclopiazonic acid production but may be very useful to distinguish cyclopiazonic acid producer strains from nonproducer strains by a simple RAPD analysis. Thus, the DNA extracts obtained could be used directly without previous purification and quantification for RAPD analysis to differentiate cyclopiazonic acid producer from nonproducer mold strains. This combined analysis could be adaptable to other toxigenic fungal species to enable differentiation of toxigenic and nontoxigenic molds. a procedure of great interest in food safety. C1 [Sanchez, Beatriz; Rodriguez, Mar; Casado, Eva M.; Cordoba, Juan J.] Univ Extremadura, Fac Vet, Caceres 10071, Spain. [Martin, Alberto] Escuela Ingn Agr, Badajoz 06071, Spain. RP Cordoba, JJ, Univ Extremadura, Fac Vet, Avda Univ S-N, Caceres 10071, Spain. EM jcordoba@unex.es FU Spanish Ministerio de Education y Ciencia FX This work is part of project AGL2004-03291 funded by the Spanish Ministerio de Education y Ciencia. B. Sanchez was the recipient of a contract from the Technician formation program from the Spanish Ministerio de Educacion y Ciencia. 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Food Prot. PD DEC PY 2008 VL 71 IS 12 BP 2497 EP 2503 PG 7 SC Biotechnology & Applied Microbiology; Food Science & Technology GA 380NR UT ISI:000261472900018 ER PT J AU Castillo, JMF Suarez, J AF Castillo, Jesus M. F. Suarez, Jesus TI EXTENDING OPERATORS INTO LINDENSTRAUSS SPACES SO ISRAEL JOURNAL OF MATHEMATICS LA English DT Article ID BANACH-SPACES; C(K) SPACES; EXTENSION; SUBSPACES; L1; THEOREM AB We study the global and local approaches to the problem of extension of operators into Lindenstrauss spaces. C1 [Castillo, Jesus M. F.; Suarez, Jesus] Univ Extremadura, Dept Matemat, E-06071 Badajoz, Spain. RP Castillo, JMF, Univ Extremadura, Dept Matemat, Ave Elvas S-N, E-06071 Badajoz, Spain. EM castillo@unex.es jesussf@telefonica.net FU DGICYT [MTM2004-02635] FX The research of the first author has been supported in part by DGICYT project MTM2004-02635. CR BENYAMINI Y, 1972, ISR J MATH, V13, P246 BENYAMINI Y, 1973, ISR J MATH, V14, P287 BENYAMINI Y, 1977, ISR J MATH, V28, P98 BOMBAL F, 1989, LONDON MATH SOC LECT, V140, P94 BOURGAIN J, 1983, BOL SOC BRAS MAT, V14, P109 CASTILLO J, 2006, STUD MATH, V174, P213 CASTILLO JMF, 1997, LECT NOTES MATH, V1667 CASTILLO JMF, 2004, ISRAEL J MATH, V140, P253 GONZALEZ M, 1994, MATH Z, V215, P621 GURARIJ VI, 1966, SIB MAT ZH, V7, P1002 JOHNSON WB, 1973, ISRAEL J MATH, V16, P198 JOHNSON WB, 1989, P AM MATH SOC, V107, P751 JOHNSON WB, 1995, STUD MATH, V117, P43 KALTON NJ, ILLINOIS J IN PRESS KALTON NJ, 2007, NEW YORK J MATH, V13, P317 LAZAR AJ, 1971, ACTA MATH, V126, P165 LINDENSTRAUSS J, 1969, J FUNCT ANAL, V4, P332 LINDENSTRAUSS J, 1971, J FUNCT ANAL, V8, P225 LINDENSTRAUSS J, 1977, ERGEBNISSE MATH IHRE, V92 MICHAEL EA, 1966, ISR J MATH, V4, P189 MORENO Y, ISRAEL J MATH SAMUEL C, 1971, B SCI MATH, V95, P65 SANCHEZ FC, 2003, T AM MATH SOC, V355, P4523 SANCHEZ FC, 2004, N HOLAND MATH STUDIE, V197, P59 SANCHEZ FC, 2004, POSITIVITY, V8, P379 SEMADENI Z, 1968, STUD MATH, V31, P373 WOJTASZCZYK P, 1972, STUD MATH, V41, P207 ZIPPIN M, 1990, ILLINOIS J MATH, V34, P586 ZIPPIN M, 1990, LECT NOTES MATH, V1470, P78 ZIPPIN M, 1999, P AM MATH SOC, V127, P1371 ZIPPIN M, 2003, HDB GEOMETRY BANACH, V2, P1703 NR 31 TC 1 PU HEBREW UNIV MAGNES PRESS PI JERUSALEM PA PO BOX 39099, JERUSALEM 91390, ISRAEL SN 0021-2172 J9 ISR J MATH JI Isr. J. Math. PD JAN PY 2009 VL 169 IS 1 BP 1 EP 27 DI 10.1007/s11856-009-0001-5 PG 27 SC Mathematics GA 377OU UT ISI:000261261300001 ER PT J AU Moreno, Y Plichko, A AF Moreno, Yolanda Plichko, Anatolij TI ON AUTOMORPHIC BANACH SPACES SO ISRAEL JOURNAL OF MATHEMATICS LA English DT Article ID RANDOM-VARIABLES; C(K) SPACES; SUBSPACES; EXTENSION; OPERATORS; THEOREM; L(1); L1; LP AB A Banachs pace X will be called extensible if every operator E -> X from a subspace E subset of X can be extended to an operator X -> X. Denote by dens X. The smallest cardinal of a subset of X whose linear span is dense in X, the space X will be called automorphic when for every subspace E subset of X every into isomorphism T : E -> X for which dens X/E = dens X/TE can be extended to an automorphism X -> X. Lindenstrauss and Rosenthal proved that c(0) is automorphic and conjectured that c(0) and l(2) are the only separable automorphic spaces. Moreover, they ask about the extensible or automorphic character of c(0)(Gamma), for Gamma uncountable. That c(0)(Gamma) is extensible was proved by Johnson and Zippin, and we prove here that it is automorphic and that, moreover, every automorphic space is extensible while the converse fails. We then study the local structure of extensible spaces, showing in particular that an infinite dimensional extensible space cannot contain uniformly complemented copies of l(p)(n) , 1 <= p < infinity, p not equal 2. We derive that infinite dimensional spaces such as L-p(mu), p not equal 2, C(K) spaces not isomorphic to c(0) for K metric compact, subspaces of c(0) which are not isomorphic to c(0), the Gurarij space, Tsirelson spaces or the Argyros-Deliyanni HI space cannot be automorphic. C1 [Moreno, Yolanda] Univ Extremadura, Escuela Politecn, Dept Matemat, Caceres 10071, Spain. [Plichko, Anatolij] Politech Krakowska Tadeusza Kosciuszki, Inst Matemat, PL-31155 Krakow, Poland. RP Moreno, Y, Univ Extremadura, Escuela Politecn, Dept Matemat, Ave Univ S-N, Caceres 10071, Spain. EM ymoreno@unex.es aplichko@usk.pk.edu.pl FU [MTM200402635] FX The work of the first author has been supported in part by project MTM200402635 CR AMIR D, 1964, P AM MATH SOC, V15, P396 ARGYROS SA, 1997, T AM MATH SOC, V349, P973 BENNETT G, 1977, ISR J MATH, V26, P178 BOURGAIN J, 1981, COMPOS MATH, V43, P133 CASTILLO JMF, 2004, ISRAEL J MATH, V140, P253 CAZAZZA FC, 2003, STUD MATH, V155, P1 JOHNSON WB, 1989, P AM MATH SOC, V107, P751 JOHNSON WB, 1995, STUD MATH, V117, P43 LINDENSTRAUS J, 1964, MEMOIRS AM MATH SOC, V48 LINDENSTRAUSS J, 1964, B ACAD POL SCI, V12, P539 LINDENSTRAUSS J, 1968, STUD MATH, V29, P275 LINDENSTRAUSS J, 1969, ISR J MATH, V7, P227 LINDENSTRAUSS J, 1971, J FUNCT ANAL, V8, P225 LINDENSTRAUSS J, 1977, CLASSICAL BANACH SPA, V1 LUSKY W, 1976, ARCH MATH, V27, P627 MAUREY B, 1974, CR HEBD ACAD SCI, V279, P329 MAUREY B, 1976, STUD MATH, V58, P45 MILMAN VD, 1986, ISR J MATH, V54, P139 ODELL E, 2003, HDB GEOMETRY BANACH, V2, P1333 PELCZYNSKI A, 1968, DISSERTATIONEN MATH, V58 PISIER G, 1982, ANN MATH, V115, P375 ROSENTHAL HP, 1970, ISR J MATH, V8, P273 TOKAREV E, 2002, MATHFA0206013 BAN SP VEECH WA, 1971, P AM MATH SOC, V28, P627 WOJTASZCZYK P, 1972, STUD MATH, V41, P207 ZIPPIN M, 2003, HDB GEOMETRY BANACH, V2, P1703 NR 26 TC 0 PU HEBREW UNIV MAGNES PRESS PI JERUSALEM PA PO BOX 39099, JERUSALEM 91390, ISRAEL SN 0021-2172 J9 ISR J MATH JI Isr. J. Math. PD JAN PY 2009 VL 169 IS 1 BP 29 EP 45 DI 10.1007/s11856-009-0002-4 PG 17 SC Mathematics GA 377OU UT ISI:000261261300002 ER PT J AU Fuentes, AC AF Fuentes, Alejandro Curado TI Corpus linguistics and specialized discourse: different points of view SO DISCOURSE STUDIES LA English DT Book Review C1 [Fuentes, Alejandro Curado] Univ Extremadura, E-06071 Badajoz, Spain. RP Fuentes, AC, Univ Extremadura, E-06071 Badajoz, Spain. CR BIBER D, 2006, U LANGUAGE CORPUS BA PARODI G, 2007, LINGUISTICA CORPUS D NR 2 TC 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1461-4456 J9 DISCOURSE STUD JI Discourse Stud. PD DEC PY 2008 VL 10 IS 6 BP 813 EP 815 DI 10.1177/1461445608096577 PG 3 SC Communication GA 380MX UT ISI:000261470900006 ER PT J AU Casado, JG Delgado, E Patsavoudi, E Duran, E Sanchez-Correa, B Morgad, S Solana, R Tarazona, R AF Casado, Javier G. Delgado, Elena Patsavoudi, Evangelia Duran, Esther Sanchez-Correa, Beatriz Morgad, Sara Solana, Rafael Tarazona, Raquel TI Functional Implications of HNK-1 Expression on Invasive Behaviour of Melanoma Cells SO TUMOR BIOLOGY LA English DT Article DE CD57; HNK-1; Melanoma; Cell adhesion ID NK-ASSOCIATED RECEPTORS; ADHESION MOLECULE; NEURAL CREST; MONOCLONAL-ANTIBODY; CANCER CELLS; T-CELLS; METASTASIS; LINES; GLYCOSYLATION; CARCINOMA AB HNK-1 epitope, also known as CD57, is expressed on a wide range of cells and has been related to cell to cell and cell to extracellular matrix interactions. Expression of the HNK-1 epitope has been considered a prognostic factor in several tumours, as it has been associated with the risk of metastasis. HNK-1 has been found to be expressed on uveal and cutaneous melanoma and proposed as a useful marker of the risk of metastasis. We have analysed the HNK-1 expression on a large panel of melanoma cell lines, the involvement of this epitope in melanoma cell adhesion, as well as its migrative and invasive behaviour. HNK-1 was highly expressed in 12.9% of melanoma cell lines, and in vitro experiments using invasive melanoma cell lines demonstrated that an HNK-1 blockade reduces cell adhesion to extracellular matrix as well as their migrative and invasive ability. These data support the functional relevance of HNK-1 expression in metastatic melanoma. Copyright (C) 2008 S. Karger AG, Basel C1 [Casado, Javier G.; Delgado, Elena; Sanchez-Correa, Beatriz; Morgad, Sara; Tarazona, Raquel] Univ Extremadura, Fac Vet Sci, Dept Physiol, Immunol Unit, ES-10071 Caceres, Spain. [Duran, Esther] Univ Extremadura, Fac Vet Sci, Anat & Comparat Pathol Anat Unit, ES-10071 Caceres, Spain. [Solana, Rafael] Univ Cordoba, Fac Med, Dept Cellular Biol Physiol & Immunol, Cordoba, Spain. [Patsavoudi, Evangelia] Hellenic Pasteur Inst, Dept Biochem, Athens, Greece. RP Casado, JG, Univ Extremadura, Fac Vet Sci, Dept Physiol, Immunol Unit, ES-10071 Caceres, Spain. EM jgarcas@unex.es FU Spanish Ministry of Education and Science [SAF03/05184, SAF06/03687]; Spanish Ministry of Health [FIS PI06/1320]; Junta de Extremadura, Spain [03/2, 3PR05A012]; European Regional Development Fund ; OISTER [QLRT-2001-00668]; Junta de Extremadura FX This work was supported by grants SAF03/05184 and SAF06/03687 (to R. T.) from the Spanish Ministry of Education and Science, FIS PI06/1320 (to R. S.) from the Spanish Ministry of Health, 03/2 and 3PR05A012 (to R. T.) from Junta de Extremadura, Spain, and co-financed by the European Regional Development Fund. This work was also supported by a post-doctoral fellowship to J.G.C. associated to the fifth Framework Programme, contract QLRT-2001-00668 (OISTER) and by pre-doctoral fellowships (to B. S. C. and S. M.) from Junta de Extremadura. Special thanks to M.R. Gonzalez and J.J. Gordillo for their technical assistance in flow cytometry. 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PY 2008 VL 29 IS 5 BP 304 EP 310 DI 10.1159/000156707 PG 7 SC Oncology GA 375RC UT ISI:000261130000003 ER PT C AU Lima-Rodriguez, JR Garcia-Gil, FA Garcia-Garcia, JJ Rocha-Camarero, G Martin-Cancho, MF Luis-Fernandez, L Crisostomo, V Uson-Gargallo, J Carrasco-Jimenez, MS AF Lima-Rodriguez, J. R. Garcia-Gil, F. A. Garcia-Garcia, J. J. Rocha-Camarero, G. Martin-Cancho, M. F. Luis-Fernandez, L. Crisostomo, V. Uson-Gargallo, J. Carrasco-Jimenez, M. S. TI Effects of Premedication With Tiletamine/Zolazepam/Medetomidine During General Anesthesia Using Sevoflurane/Fentanyl in Swine Undergoing Pancreas Transplantation SO TRANSPLANTATION PROCEEDINGS LA English DT Proceedings Paper ID BISPECTRAL INDEX; PIGS; MEDETOMIDINE; COMBINATION; ISOFLURANE; MIDAZOLAM; XYLAZINE; TELAZOL AB Objective. To assess cardiac and hemodynamic responses and body temperature during long-term general anesthesia using sevoflurane/fentanyl after premedication with a tiletamine/zolazepam/medetomidine combination in swine undergoing experimental pancreas transplantation. Materials and methods. Twelve Landrace female pigs of means weight 46.4 +/- 5.1 kg were premedicated by intramuscular administration of tiletamine/zolazeparn (3.5 mg/kg), medetomidine (0.03 mg/kg), and atropine (0.02 mg/kg), before anesthesia with 0.75 minimum alveolar concentration sevoflurane and continuous intravenous fentanyl infusion (5.7 +/- 0.7 mu/kg/h). Assessment of heart rate, arterial blood pressure, and temperature in pigs undergoing allogenic pancreas transplant surgery were registered at the start of anesthesia (T0), as well as at 60 (T60), 120 (T120), and 180 (T180) minutes after TO, and finally at the end of anesthesia (T anesthesia end), when we switched off the sevoflurane vaporizer. Analysis of variance was used to determine differences between times with P <.05 considered significant. Results are given as mean values standard deviations. Results. Arterial blood pressure significantly decreased from T120 to the end of anesthesia, while a significantly decreased heart rate was only evident at T60. Body temperature decreased significantly from T60 to the end of anesthesia. These decreases, however, lacked clinical relevance; all parameters were within normal range. No major anesthetic complications were observed in this study. Conclusions. The administration of a tiletamine/zolazepam/medetomidine combination as premedication in swine subjected to pancreas transplantation allowed for a safe reduction of sevoflurane/fentanyl requirements during long-term general anesthesia. Despite arterial blood pressure and body temperature evidencing a decrease during anesthetic maintenance, all parameters remained within normal range values. C1 [Lima-Rodriguez, J. R.; Martin-Cancho, M. F.; Luis-Fernandez, L.; Crisostomo, V.; Uson-Gargallo, J.] Minimally Invas Surg Ctr Jesus Uson, Caceres, Spain. [Garcia-Gil, F. A.; Garcia-Garcia, J. J.] Univ Zaragoza, Lozano Blesa Hosp, Dept Surg, E-50009 Zaragoza, Spain. [Carrasco-Jimenez, M. S.] Univ Cadiz, Fac Med, Puerto Real Hosp, Dept Anesthesiol, Cadiz, Spain. [Rocha-Camarero, G.] Univ Cadiz, Fac Med, Puerto Real Hosp, Univ Extremadura, Cadiz, Spain. RP Garcia-Gil, FA, Univ Zaragoza, Dept Surg, Domingo Miral S-N, E-50009 Zaragoza, Spain. 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Proc. PD NOV PY 2008 VL 40 IS 9 BP 3001 EP 3006 DI 10.1016/j.transproceed.2008.09.042 PG 6 SC Immunology; Surgery; Transplantation GA 375QQ UT ISI:000261128800045 ER PT J AU Rodriguez-Caceres, MI Agbaria, RA Luna, UJ White, S Warner, IM AF Rodriguez-Caceres, M. I. Agbaria, R. A. Luna, U. J. White, S. Warner, I. M. TI Fluorescence of zirconium-naphthalene complexes: Effect of ortho-naphthalene substitution SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY LA English DT Article DE 1-Hydroxy-2-naphthoic acid; 3-Hydroxy-2-naphthoic acid; Zirconium; Stability constants ID 3-HYDROXY-2-NAPHTHOIC ACID; HYDROXYNAPHTHALENECARBOXYLIC ACIDS; SPECTROFLUOROMETRIC DETERMINATION; BETA-CYCLODEXTRIN; IONIZATION; DERIVATIVES AB The effect of the position of substituents on the formation of metal-naphthalene complexes has been investigated. Two positional isomers, 1-hydroxy-2-naphthoic acid (1H2NA) and 3-hydroxy-2-naphthoic acid (3H2NA), have been chosen. A comparative study of the luminescence behaviour of the two isomers in the presence of Zr(IV) has been performed. Interesting results were obtained. While 1-hydroxy-2-naphthoic acid is quenched in the presence of Zr(IV). 3-hydroxy-2-naphihoic acid produced high-fluorescence enhancement. Several pH studies were performed between pH 2.5 and 5.0 and the stoichiometries of the complexes were also established at the different pH values tested. by use of the Benesi-Hildebrand method. In addition, the formation constants have been calculated. Finally, quenching and lifetime studies were performed in an attempt to establish the type of quenching (static or dynamic) that is produced when a complex is formed between 1-hydroxy-2-naphihoic acid and zirconium metal ion. (C) 2008 Elsevier B.V. All rights reserved. C1 [Rodriguez-Caceres, M. I.] Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. [Agbaria, R. A.; Luna, U. J.; White, S.; Warner, I. M.] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA. RP Rodriguez-Caceres, MI, Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. EM maribelro@unex.es FU National Science Foundation of United States ; Ministerio de Educacion y Ciencia [CTQ2005-02389] FX Funding for this study was provided by a grant from the National Science Foundation of United States and Ministerio de Educacion y Ciencia (project CTQ2005-02389) of Spain. 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Acta Pt. A-Molec. Biomolec. Spectr. PD DEC 1 PY 2008 VL 71 IS 3 BP 907 EP 914 DI 10.1016/j.saa.2008.02.011 PG 8 SC Spectroscopy GA 375MQ UT ISI:000261118400029 ER PT J AU Baeza, A Salas, A Legarda, F AF Baeza, A. Salas, A. Legarda, F. TI Determining factors in the elimination of uranium and radium from groundwaters during a standard potabilization process SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Potabilization; Groundwater; Uranium; Radium; Elimination of radioactivity ID BACTERIOGENIC IRON-OXIDES; HEAVY-METAL IONS; REMOVING URANIUM; HYDRATED OXIDES; CACERES SPAIN; ADSORPTION; WATERS; COPRECIPITATION; SORPTION; RADIOACTIVITY AB We studied the physico-chemical and radioactive characteristics of four waters of subsurface origin. They were chosen for having the highest natural radioactivity levels of waters for human consumption in the Autonomous Community of Extremadura, Spain Their activity levels for alpha emitting radionuclides are between 120 and 19 300 mBq L-1, all exceeding the 100 mBq L-1 threshold established in the European Union above which radioactive isotopes that are present in water should be investigated to determine which corrective action, if any, is needed. These waters were used to compare the efficiency in eliminating their uranium and radium content of two potabilization processes - one the standard chlorination-only process used by their respective municipalities, and the other a procedure consisting of coagulation, flocculation, settling, filtration, and chlorination stages, specifically designed to maximize the elimination of their natural radioactive content. The results showed the uranium and radium elimination efficiencies to depend strongly on the water's hydrogencarbonate, calcium, and magnesium ion concentrations. In particular, with increasing concentrations of any of these ions, the uranium elimination efficiency fell from 90% to 60% at its optimal working pH, pH=6, while the radium elimination efficiency rose from 50% to 90% at its optimal working pH, pH = 10. (C) 2008 Elsevier B.V. All rights reserved. C1 [Baeza, A.; Salas, A.] Univ Extremadura, Fac Vet, Dept Fis, Caceres 10071, Spain. [Legarda, F.] Univ Pais Vasco, Escuela Super Ingenieros, Dept Ingn Nucl & Mecan Fluidos, Bilbao 48013, Spain. RP Baeza, A, Univ Extremadura, Fac Vet, Dept Fis, Avda Univ S-N, Caceres 10071, Spain. EM ymiralle@unex.es FU Spain's Consejo de Seguridad Nuclear ; Empresa Nacional de Residuos Radiactivos FX The present work was made possible by financing from Spain's Consejo de Seguridad Nuclear and the Empresa Nacional de Residuos Radiactivos for the project "Adecuacion de los sistemas de potabilizacion radiologica del agua". 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Total Environ. PD NOV 15 PY 2008 VL 406 IS 1-2 BP 24 EP 34 DI 10.1016/j.scitotenv.2008.07.050 PG 11 SC Environmental Sciences GA 372ZS UT ISI:000260941400002 ER PT J AU Sinicropi, A Martin, E Ryazantsev, M Helbing, J Briand, J Sharma, D Leonard, J Haackee, S Cannizzo, A Chergui, M Zanirato, V Fusi, S Santoro, F Basosi, R Ferre, N Olivucci, M AF Sinicropi, Adalgisa Martin, Elena Ryazantsev, Mikhail Helbing, Jan Briand, Julien Sharma, Divya Leonard, Jeremie Haackee, Stefan Cannizzo, Andrea Chergui, Majed Zanirato, Vinicio Fusi, Stefania Santoro, Fabrizio Basosi, Riccardo Ferre, Nicolas Olivucci, Massimo TI An artificial molecular switch that mimics the visual pigment and completes its photocycle in picoseconds SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE CASPT2//CASSCF; mid-IR; photochemical switch; time resolved spectroscopy; UV-vis ID PHOTORESPONSIVE CROWN ETHERS; EXCITED-STATE DYNAMICS; CONFORMATIONAL STATES; PERTURBATION-THEORY; CYCLIC PEPTIDE; PHOTOMODULATION; RHODOPSIN; AZOBENZENE; BACKBONE; MOTORS AB Single molecules that act as light-energy transducers (e.g., converting the energy of a photon into atomic-level mechanical motion) are examples of minimal molecular devices. Here, we focus on a molecular switch designed by merging a conformationally locked diarylidene skeleton with a retinal-like Schiff base and capable of mimicking, in solution, different aspects of the transduction of the visual pigment Rhodopsin. Complementary ab initio multiconfigurational quantum chemistry-based computations and time-resolved spectroscopy are used to follow the light-induced isomerization of the switch in methanol. The results show that, similar to rhodopsin, the isomerization occurs on a 0.3-ps time scale and is followed by <10-ps cooling and solvation. The entire (2-photon-powered) switch cycle was traced by following the evolution of its infrared spectrum. These measurements indicate that a full cycle can be completed within 20 ps. C1 [Helbing, Jan] Univ Zurich, Inst Phys Chem, CH-8057 Zurich, Switzerland. [Sinicropi, Adalgisa; Fusi, Stefania; Basosi, Riccardo; Olivucci, Massimo] Univ Siena, Dipartimento Chim, I-53100 Siena, Italy. [Ryazantsev, Mikhail; Olivucci, Massimo] Bowling Green State Univ, Dept Chem, Bowling Green, OH 43403 USA. [Martin, Elena] Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. [Briand, Julien; Sharma, Divya; Leonard, Jeremie; Haackee, Stefan] Univ Strasbourg 1, Inst Phys & Chim Mat Strasbourg, Grp Nonlinear Opt, UMR 7504,CNRS, F-67034 Strasbourg, France. [Cannizzo, Andrea; Chergui, Majed] Ecole Polytech Fed Lausanne, Lab Spect Ultrarapide, CH-1015 Lausanne, Switzerland. [Zanirato, Vinicio] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy. [Santoro, Fabrizio] CNR, Ist Proc Chim Fis, I-56124 Pisa, Italy. [Ferre, Nicolas] Univ Aix Marseille 1, Lab Chim Theor & Modelisat Mol, UMR 6517, CNRS,Fac St Jerome Case 521, F-13397 Marseille 20, France. RP Helbing, J, Univ Zurich, Inst Phys Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland. EM j.helbing@pci.uzh.ch stefan.haacke@ipcms.u-strasbg.fr olivucci@unisi.it FU Universita di Siena (Progetto di Ateneo 05/07) ; Fondazione Monte dei Paschi and Research Programmes of National Interest (PRIN) 2006 ; Conseil Scientifique de l'Universite Louis Pasteur ; Centre National de la Recherche Scientifique ; Institut de Physique et Chimie des Materiaux de Strasbourg ("program mi-lourd 2005") FX M.O. is grateful to Bowling Green State University for a start-up grant. This work was partially supported by the Universita di Siena (Progetto di Ateneo 05/07), Fondazione Monte dei Paschi and Research Programmes of National Interest (PRIN) 2006. We thank the Ohio Supercomputer Center for granted calculation time. S.H. acknowledges start-up funds from the Conseil Scientifique de l'Universite Louis Pasteur, from the Centre National de la Recherche Scientifique, and from the Institut de Physique et Chimie des Materiaux de Strasbourg ("program mi-lourd 2005"). 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Natl. Acad. Sci. U. S. A. PD NOV 18 PY 2008 VL 105 IS 46 BP 17642 EP 17647 DI 10.1073/pnas.0802376105 PG 6 SC Multidisciplinary Sciences GA 377BB UT ISI:000261225600016 ER PT J AU Reyes, FV Urbach, JS AF Vega Reyes, Francisco Urbach, Jeffrey S. TI Effect of inelasticity on the phase transitions of a thin vibrated granular layer SO PHYSICAL REVIEW E LA English DT Article ID DYNAMICS; SPHERES; MEDIA AB We describe an experimental and computational investigation of the ordered and disordered phases of a vibrating thin, dense granular layer composed of identical metal spheres. We compare the results from spheres with different amounts of inelasticity and show that inelasticity has a strong effect on the phase diagram. We also report the melting of an ordered phase to a homogeneous disordered liquid phase at high vibration amplitude or at large inelasticities. 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EM urbach@physics.georgetown.edu CR ARANSON IS, 2006, REV MOD PHYS, V78, P641, DOI 10.1103/RevModPhys.78.641 CLERC MG, 2008, NAT PHYS, V4, P249, DOI 10.1038/nphys884 FOERSTER SF, 1994, PHYS FLUIDS, V6, P1108 GOLDHIRSCH I, 2003, ANNU REV FLUID MECH, V35, P267, DOI 10.1146/annurev.fluid.35.101101.161114 LINDEMANN FA, 1910, PHYS Z, V11, P609 LORENZ A, 1997, EXP MECH, V37, P292 MELBY P, 2005, J PHYS-CONDENS MAT, V17, S2689, DOI 10.1088/0953-8984/17/24/020 NIE X, 2000, EUROPHYS LETT, V51, P679 OLAFSEN JS, 1998, PHYS REV LETT, V81, P4369 OLAFSEN JS, 2005, PHYS REV LETT, V95, ARTN 098002 PREVOST A, 2004, PHYS REV E 1, V70, ARTN 050301 REIS PM, 2006, PHYS REV LETT, V96, ARTN 258001 SCHMIDT M, 1997, PHYS REV E B, V55, P7228 URBACH JS, 2002, LECT NOTE PHYS, V546, P410 WATANABE K, 2008, PHYS REV LETT, V100, ARTN 158002 WEDEKIND J, 2006, J CHEM PHYS, V125, P14505 NR 16 TC 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD NOV PY 2008 VL 78 IS 5 PN Part 1 AR 051301 DI 10.1103/PhysRevE.78.051301 PG 5 SC Physics, Fluids & Plasmas; Physics, Mathematical GA 376WL UT ISI:000261213600036 ER PT J AU Vallejo, RBDB Iglesias, MEL Gomez-Martin, B Gomez, RS Crespo, AS AF de Bengoa Vallejo, Ricardo Becerro Losa Iglesias, Marta Elena Gomez-Martin, Beatriz Gomez, Ruben Sanchez Crespo, Antonio Saez TI Application of Cantharidin and Podophyllotoxin for the Treatment of Plantar Warts SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION LA English DT Article ID THERAPY AB Background: A variety of treatment modalities have been described for cutaneous warts. We sought to determine the safety and efficacy of a topical formulation of cantharidin, podophyllotoxin, and salicylic acid in the treatment of plantar warts. This combination treatment is widely used in Europe and elsewhere but has not been described in the podiatric medical literature. Methods: A retrospective study was conducted of 144 patients with simple or mosaic plantar warts who were treated with a topical, pharmacy-compounded solution of cantharidin, 1%; podophyllotoxin, 5%; and salicylic acid, 30%. All of the patients, aged 8 to 52 years (mean +/- SD, 20.9 +/- 11.0 years), were treated according to the authors' standard protocol. Of the 144 patients, 92 were being treated for the first time. None of the 52 previously treated patients had received more than one other type of treatment in the past. Results: After 6 months of follow-up, complete eradication of the plantar warts was noted in 138 of the 144 patients (95.8%). Of these patients, 125 (86.8%) required a single application of the solution, and 13 (9.0%) needed two or more applications. No significant adverse effects or complications were observed. Conclusion: A topical solution of cantharidin, podophyllotoxin, and salicylic acid was found to be safe and effective in the treatment of simple and mosaic plantar warts. This formulation is a promising alternative treatment modality for plantar warts. (J Am Podiatr Med Assoc 98(6): 445-450, 2008) C1 [de Bengoa Vallejo, Ricardo Becerro; Crespo, Antonio Saez] Univ Complutense Madrid, Escuela Univ Enfermeria Fisioterapia & Podologia, E-28040 Madrid, Spain. [Losa Iglesias, Marta Elena] Univ Rey Juan Carlos, Fac Ciencias Salud, Madrid, Spain. [Gomez-Martin, Beatriz] Univ Extremadura, Dept Enfermeria, Caceres, Spain. [Gomez, Ruben Sanchez] Ctr Ortoped & Quirurg, Madrid, Spain. RP Vallejo, RBDB, Univ Complutense Madrid, Escuela Univ Enfermeria Fisioterapia & Podologia, E-28040 Madrid, Spain. 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PD NOV-DEC PY 2008 VL 98 IS 6 BP 445 EP 450 PG 6 SC Orthopedics GA 375OF UT ISI:000261122500004 ER PT J AU Anton, M Serrano, A Cancillo, ML Vilaplana, JM Cachorro, VE Grobner, J AF Anton, Manuel Serrano, Antonio Cancillo, Maria L. Vilaplana, Jose M. Cachorro, Victoria E. Grobner, Julian TI Correction of Angular Response Error in Brewer UV Irradiance Measurements SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article ID SOLAR ULTRAVIOLET IRRADIANCE; QUALITY-ASSURANCE; SPECTROPHOTOMETER; SPECTRORADIOMETER; OZONE AB Ultraviolet spectral irradiance measured by spectroradiometers usually presents high deviations from the ideal angular response due to imperfections in the entrance optics. In this paper a methodology to correct the angular error in the global UV spectral measurements of a Brewer MKIII spectroradiometer under all weather conditions is presented. This methodology calculates the global correction factor as a function of three variables: the direct irradiance correction factor, the diffuse irradiance correction factor, and a factor depending on the direct-to-global irradiance ratio. This work contributes to better measuring the UV radiation by improving the parameterization of the clouds effects. Depending mainly on wavelength, solar zenith angle, and cloud optical thickness, the angular correction obtained ranges from 2% to 9%. The accuracy of this correction is limited by the uncertainties in the measured angular response and in the ratio of direct to global radiation. The original and the corrected Brewer measurements are compared with simultaneous values of the transportable Quality Assurance of Spectral Ultraviolet Measurements in Europe through the Development of a Transportable Unit (QASUME) reference spectroradiometer. A notable decrease (about a factor higher than 2) in the relative differences between the two instruments is obtained when Brewer-corrected measurements are considered. C1 [Anton, Manuel; Serrano, Antonio; Cancillo, Maria L.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. [Vilaplana, Jose M.] INTA, Estac Sondeos Atmosfer Arenosillo, Huelva, Spain. [Cachorro, Victoria E.] Univ Valladolid, Grp Opt Atmosfer, Valladolid, Spain. [Grobner, Julian] World Radiat Ctr, Phys Meteorol Observ Davos, Davos, Switzerland. RP Anton, M, Univ Extremadura, Dept Fis, Avda Elvas S-N, E-06071 Badajoz, Spain. EM mananton@unex.es FU MEC [CGL2005-05693-C03-03/CLI] FX This work has been partially supported by MEC under Project CGL2005-05693-C03-03/CLI. CR *WMO, 1997, 125 WMO GLOB ATM WAT *WMO, 2003, SCI ASS OZ DEPL 2002 BAIS AF, 1997, APPL OPTICS, V36, P5199 BAIS AF, 1998, APPL OPTICS, V37, P6339 BAIS AF, 2005, APPL OPTICS, V44, P7136 BERNHARD G, 1999, J GEOPHYS RES-ATMOS, V104, P14321 BERNHARD G, 2003, P SOC PHOTO-OPT INS, V4896, P79 BLUMTHALER M, 1996, GEOPHYS RES LETT, V23, P547 DIFFEY BL, 1991, PHYS MED BIOL, V36, P299 FEISTER U, 1997, SOL ENERGY, V60, P313 FIOLETOV VE, 2001, J GEOPHYS RES-ATMOS, V106, P23009 FIOLETOV VE, 2002, OPT ENG, V41, P3051, DOI 10.1117/1.1516818 GROBNER J, 1996, GEOPHYS RES LETT, V23, P2493 GROBNER J, 2005, APPL OPTICS, V44, P5321 GROBNER J, 2005, METROLOGIA, V42, P134, DOI 10.1088/0026-1394/42/2/008 GROBNER J, 2006, METROLOGIA, V43, S66, DOI 10.1088/0026-1394/43/2/S14 JOSEFSSON W, 1986, 53 SMHI KIMLIN MG, 2003, J ATMOS SOL-TERR PHY, V65, P1401, DOI 10.1016/j.jastp.2003.09.003 MAYER B, 2005, ATMOS CHEM PHYS DISC, V5, P1319 SECKMEYER G, 1993, P SOC PHOTO-OPT INS, V2049, P140 TOLEDANO C, 2005, THESIS U VALLADOLID VILAPLANA JM, 2004, THESIS U VALLADOLID ZENG J, 1994, J GEOPHYS RES-ATMOSP, V99, P23019 NR 23 TC 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0739-0572 J9 J ATMOS OCEAN TECHNOL JI J. Atmos. Ocean. Technol. PD NOV PY 2008 VL 25 IS 11 BP 2018 EP 2027 DI 10.1175/2008JTECHA1040.1 PG 10 SC Engineering, Ocean; Meteorology & Atmospheric Sciences GA 375IR UT ISI:000261107900009 ER PT J AU Maneta, MP Schnabel, S Wallender, WW Panday, S Jetten, V AF Maneta, M. P. Schnabel, S. Wallender, W. W. Panday, S. Jetten, V. TI Calibration of an evapotranspiration model to simulate soil water dynamics in a semiarid rangeland SO HYDROLOGICAL PROCESSES LA English DT Article DE evapotranspiration; model calibration; semiarid rangeland; root water uptake ID MOISTURE; PARAMETERS; GRASSLAND; ECOSYSTEM AB Soil is the largest reservoir of water in a catchment and evapotranspiration is the largest yearly output flux of water from the soil in semiarid environments at the catchment scale. Hydrologic stress is one of the typical characteristics of semiarid environments. The shortage of water affects all the biophysical processes and increases the nonlinearity in the rainfall-runoff relationship. A proper description of semiarid watersheds should include an accurate description of the wetting-drying cycle of the soil, which is critical to properly describe important processes Such it.,; the connection between the surface and the soil saturated zone, the production of runoff or the growth of plants. Evapotranspiration is typically modelled in comprehensive distributed hydrologic models (e.g. MIKE-SHE or MODHMS) using functions that relate evapotranspiration to soil moisture and plant biomass through a set of empirical coefficients, which typically adopt some default values regardless of the conditions of the area where the model is applied. In this work, using a global and a local search algorithm, a three-dimensional soil water flow model coupled to an evapotranspiration model is calibrated in it soil profile covered with grass in a semiarid environment. Four parameters for the water flow model and three parameters for the evapotranspiration model are calibrated. An existing trend between daily average Soil Moisture and daily maximum temperature is used as extra information during the calibration process. The results showed that the known relationship between maximum temperature and average soil moisture includes information on the seasonality of the atmospheric demand. Although total evapotranspiration is similar in all calibrations, the trade-off between evaporation and transpiration is sensitive to this extra information mainly through one model parameter. Further research is necessary to identify the value of the parameter that produces the correct trade-off. Copyright (C) 2008 John Wiley & Sons, Ltd. C1 [Maneta, M. P.; Wallender, W. W.] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA. [Panday, S.] Geomatrix Consultants Inc, Herndon, VA 20170 USA. [Jetten, V.] ITC, Dept Earth Syst Anal, NL-7500 AA Enschede, Netherlands. [Maneta, M. P.; Schnabel, S.] Univ Extremadura, Dept Geog & Ordenac Terr, Grp Invest Geoambiental, Caceres 10071, Spain. RP Maneta, MP, Univ Calif Davis, Dept Land Air & Water Resources, 1 Shields Ave, Davis, CA 95616 USA. EM mpmaneta@ucdavis.edu FU Spanish Ministry of Science and Technology [REN2001-2268-C02-02]; CANOA [CGL-2004-04919-C02-02] FX Research funded by the Spanish Ministry of Science and Technology through the projects PROHISEM (REN2001-2268-C02-02) and CANOA (CGL-2004-04919-C02-02). 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Process. PD NOV 30 PY 2008 VL 22 IS 24 BP 4655 EP 4669 DI 10.1002/hyp.7087 PG 15 SC Water Resources GA 376YM UT ISI:000261218900001 ER PT J AU Andrade, MJ Cordoba, JJ Sanchez, B Casado, EM Rodriguez, M AF Jesus Andrade, M. Jose Cordoba, Juan Sanchez, Beatriz Casado, Eva M. Rodriguez, Mar TI Evaluation and selection of yeasts isolated from dry-cured Iberian ham by their volatile compound production SO FOOD CHEMISTRY LA English DT Article DE Yeasts; Volatile compounds; Dry-cured ham ID FREE AMINO-ACIDS; SACCHAROMYCES-CEREVISIAE; DEBARYOMYCES-HANSENII; MEAT-PRODUCTS; POPULATION; HYDROLYSIS; HEADSPACE; PHASE AB One hundred and seventeen yeast strains isolated from dry-cured Iberian ham from the four different protected designations of origin of Spain were investigated for their volatile compound production. The yeast strains were grouped into the two main yeast species usually found in this product (Debaryomyces hansenii and Candida zeylanoides) and 10 different biotypes by restriction mitochondrial DNA analysis. Yeast strains were grown in a designed model culture medium under conditions representative of dry-cured ham processing. Volatile compounds were extracted from this medium using solid-phase micro-extraction and were analysed by gas chromatography/mass spectrometry. Marked differences in volatile compound production were found between D. hansenii and C. zeylanoides and between the mitochondrial DNA patterns of these species. Two of the mitochondrial DNA patterns of D. hansenii exhibited the highest production of the volatile compounds involved in the dry-cured flavour. Consequently, these patterns of D. hansenii should be proposed as starter cultures for dry-cured ham. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Jesus Andrade, M.; Jose Cordoba, Juan; Sanchez, Beatriz; Casado, Eva M.; Rodriguez, Mar] Univ Extremadura, Fac Vet, Caceres 10071, Spain. RP Rodriguez, M, Univ Extremadura, Fac Vet, Avda Univ S-N, Caceres 10071, Spain. EM marrodri@unex.es FU Spanish Comision Interministerial de Ciencia y Tecnologia [AGL2001-0804, AGL2004-3291]; Regional Government of junta de Extremadura (Consejeria de Educacion, Ciencia y Tecnologia) FX This work is part of projects AGL2001-0804 and AGL2004-3291 funded by the Spanish Comision Interministerial de Ciencia y Tecnologia. M.J. Andrade was the recipient of a Grant of the Regional Government of junta de Extremadura (Consejeria de Educacion, Ciencia y Tecnologia). 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PD MAR 15 PY 2009 VL 113 IS 2 BP 457 EP 463 DI 10.1016/j.foodchem.2008.07.080 PG 7 SC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics GA 375AJ UT ISI:000261084600013 ER PT J AU Arroyo, ST Garcia, AH Martin, JAS AF Arroyo, S. Tolosa Garcia, A. Hidalgo Martin, J. A. Sanson TI Calculation of free-energy curves for the study of hydrolysis reactions in aqueous solution from ab initio potentials and molecular dynamics simulation SO CHEMICAL PHYSICS LA English DT Article DE Molecular dynamics simulation; Reaction mechanism; Solute-solvent ab initio potential; Chemical reactivity in solution ID GAUSSIAN-TYPE BASIS; ORGANIC-MOLECULES; ORBITAL METHODS; FORCE-FIELD; AMIDE HYDROLYSIS; FORMAMIDE; WATER; MECHANISM; APPROXIMATION; DECOMPOSITION AB In the present work a theoretical study of chemistry react ions by means of molecular dynamics simulation, with solute-solvent interaction potentials derived from ab initio quantum calculations, is carried out. We apply the procedure proposed to the case of the neutral formamide hydrolysis: HCONH2 + H2O -> HCOOH + NH3 in aqueous solution via a concerted mechanism. We used the solvent as reaction coordinate and the free-energy curves for the calculation of the properties related with the reaction mechanisms, with especial interest in the structures of the species participating in the reaction, and in the reaction and activation energies. (C) 2008 Elsevier B.V. All rights reserved. C1 [Arroyo, S. Tolosa; Garcia, A. Hidalgo; Martin, J. A. Sanson] Univ Extremadura, Dept Quim Fis, E-06071 Badajoz, Spain. RP Arroyo, ST, Univ Extremadura, Dept Quim Fis, Avda Elvas, E-06071 Badajoz, Spain. EM santi@unex.es FU Consejeria de Infraestructuras y Desarrollo Tecnologico de la junta de Extremadura [GRU07013, GRU08008] FX This research was sponsored by the Consejeria de Infraestructuras y Desarrollo Tecnologico de la junta de Extremadura (Projects GRU07013 and GRU08008). 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Phys. PD NOV 3 PY 2008 VL 353 IS 1-3 BP 73 EP 78 DI 10.1016/j.chemphys.2008.07.023 PG 6 SC Chemistry, Physical; Physics, Atomic, Molecular & Chemical GA 375SX UT ISI:000261134700010 ER PT J AU Sanchez-Bajo, F Ortiz, AL Cumbrera, FL AF Sanchez-Bajo, F. Ortiz, A. L. Cumbrera, F. L. TI An analytical model for the determination of crystallite size and crystal lattice microstrain distributions in nanocrystalline materials from the variance of the X-ray diffraction peaks SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article DE 81; 07; Bc; 61; 72; Mm; 61; 72; Dd; 61; 72; Bd; 61; 05; cp ID LINE-BROADENING ANALYSIS; POWDER DIFFRACTOMETRY; DEBYE-SCHERRER; VOIGT-FUNCTION; PARTICLE-SIZE AB An analytical model for the determination of crystallite size and crystal lattice microstrain distributions in nanocrystalline (nc) materials by X-ray diffractometry (XRD) is presented. It entails generalizing the variance method to establish analytically the connection between the variance coefficients of the physically broadened XRD peaks and the characteristic parameters of explicit distributions of crystallite sizes and crystal lattice microstrains, which results in a more detailed characterization of the nc-materials. The proposed model is generic in nature and has the potential to be used under the assumption of different mathematical functions for the two distributions, which suggests that it may have an important role to play in the characterization of nc-materials. Nevertheless, the specialization to the case of nc-materials with log-normal crystallite size distribution and three typical types of lattice microstrains is used as an illustration and to formulate explicit analytical expressions of interest. Finally, the usefulness of the proposed model is demonstrated on standard XRD profiles. C1 [Ortiz, A. L.] Univ Extremadura, Dept Ingn Mecan Energet & Mat, E-06071 Badajoz, Spain. [Sanchez-Bajo, F.] Univ Extremadura, Dept Fis Aplicada, E-06071 Badajoz, Spain. [Cumbrera, F. L.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Ortiz, AL, Univ Extremadura, Dept Ingn Mecan Energet & Mat, E-06071 Badajoz, Spain. 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Phys. A-Mater. Sci. Process. PD JAN PY 2009 VL 94 IS 1 BP 189 EP 194 DI 10.1007/s00339-008-4732-7 PG 6 SC Materials Science, Multidisciplinary; Physics, Applied GA 372YH UT ISI:000260937700027 ER PT J AU Miranda, P Pajares, A Guiberteau, F AF Miranda, Pedro Pajares, Antonia Guiberteau, Fernando TI Finite element modeling as a tool for predicting the fracture behavior of robocast scaffolds SO ACTA BIOMATERIALIA LA English DT Article DE Finite element analysis; Robocasting; Scaffolds; Strength; Fracture modes ID BRITTLE-COATING STRUCTURES; PHOSPHATE SCAFFOLDS; TRILAYERS AB The use of finite element modeling to calculate the stress fields in complex scaffold structures and thus predict their mechanical behavior during service (e.g., as load-bearing bone implants) is evaluated. The method is applied to identifying the fracture modes and estimating the strength of robocast hydroxyapatite and beta-tricalcium phosphate scaffolds, consisting of a three-dimensional lattice of interpenetrating rods. The calculations are performed for three testing configurations: compression, tension and shear. Different testing orientations relative to the calcium phosphate rods are considered for each configuration. The predictions for the compressive configurations are compared to experimental data from uniaxial compression tests. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Miranda, Pedro; Pajares, Antonia; Guiberteau, Fernando] Univ Extremadura, Dept Ingn Mecan Energet & Mat, E-06071 Badajoz, Spain. RP Miranda, P, Univ Extremadura, Dept Ingn Mecan Energet & Mat, Avda Elvas S-N, E-06071 Badajoz, Spain. EM pmiranda@unex.es FU Ministerio de Educacion y Ciencia (Spanish Government) ; Fondo Social Europeo [MAT2006-08720] FX This work was supported by the Ministerio de Educacion y Ciencia (Spanish Government) and the Fondo Social Europeo (MAT2006-08720). 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PD NOV PY 2008 VL 4 IS 6 BP 1715 EP 1724 DI 10.1016/j.actbio.2008.05.020 PG 10 SC Engineering, Biomedical; Materials Science, Biomaterials GA 377LT UT ISI:000261253400015 ER PT J AU Moreira, XQ Sampedro, L Zas, R Solla, A AF Moreira, Xoaquin Sampedro, Luis Zas, Rafael Solla, Alejandro TI Alterations of the resin canal system of Pinus pinaster seedlings after fertilization of a healthy and of a Hylobius abietis attacked stand SO TREES-STRUCTURE AND FUNCTION LA English DT Article DE Herbivory; Constitutive defence; Induced defence; Phloem; Xylem; Large pine weevil ID NORWAY SPRUCE; WHITE SPRUCE; BARK BEETLES; RESOURCE AVAILABILITY; BALANCE HYPOTHESIS; PISSODES-STROBI; AIT. SEEDLINGS; DEFENSE; WEEVIL; DAMAGE AB Changes in resource availability and biotic and abiotic stress may alter the defensive mechanisms of pine trees. The effect of fertilisation on the resin canal structure of Pinus pinaster seedlings established in two trials in NW Spain, one attacked by Hylobius abietis and the other non-attacked, was studied. The leaders of 50 plants were destructively sampled and the resin canal density, the canal area and its relative conductive area in the phloem and xylem were assessed. Experimentally increased nutrient availability significantly decreased resin canal density in the phloem of the seedlings in the two analysed trials, where unfertilised seedlings presented up to 30% more resin canal density than the fertilised seedlings (mean value +/- SEM = 0.32 +/- 0.02 resin canals mm-2 in the fertilised plants versus 0.45 +/- 0.04 resin canals mm-2in the control plants). Fertilisation had no effect on the resin canal system in the xylem, but significantly increased tracheid size. Significant differences of resin canals among sites were observed mainly in the xylem; the resin canal density was 1.7-fold greater in the attacked site than in the non-attacked site. The similar structure of phloem resin canals in both sites supports that phloem resin canals are constitutive mechanisms of defence in P. pinaster, whereas xylem resin canals would be constitutive mechanisms but also inducible mechanisms of resistance following the attack of pine weevils or bark beetles. C1 [Moreira, Xoaquin; Sampedro, Luis; Zas, Rafael] Ctr Invest Ambiental Lourizan, Pontevedra 36080, Spain. [Solla, Alejandro] Univ Extremadura, Plasencia 10600, Spain. RP Sampedro, L, Ctr Invest Ambiental Lourizan, Apdo 127, Pontevedra 36080, Spain. EM lsampe@uvigo.es FU INIA [RTA05-173] FX Research was supported by the INIA RTA05-173 grant. We thank one anonymous referee for improving previous version of this manuscript; Miguel Angel Ramos for his help with image processing; Francisco Fernandez de Ana Magan and Josefa Fernandez Lopez for the microtome and lab facilities; and Benito Santos and Emily Weissman for helpful assistance with language. 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Funct. PD DEC PY 2008 VL 22 IS 6 BP 771 EP 777 DI 10.1007/s00468-008-0237-4 PG 7 SC Forestry GA 371ON UT ISI:000260840700003 ER PT J AU del Barco, BL Perez, CL AF Leon del Barco, Benito Latas Perez, Carlos TI The formation in techniques of cooperative learning of the university professor in the context of the European convergence SO REVISTA DE PSICODIDACTICA LA Spanish DT Article DE Cooperative learning; attitudes; education; educational; university AB The necessity of formation in techniques of cooperative learning has been an excellent fact in the formation of the university teaching staff and no only for decades but, also, at the present time. The new European Space of Superior Education supposes a displacement of an education centered in education towards an education centered in the learning, simultaneously that demands to the students new interpersonal competitions that facilitate the social interaction and the cooperation. The smaller doubt does not fit to us of than the cooperative learning, within this new context, goes to be an innovating methodology that all university professor must know and apply in the university classrooms. C1 [Latas Perez, Carlos] Univ Extremadura, Fac Formac Profesorado, Dpto Ciencias Educac, Caceres 10700, Spain. [Latas Perez, Carlos] Univ Extremadura, Fac Formac Profesorado, Dpto Ciencias Educac & Vicedecano Pract, Caceres 10700, Spain. [Leon del Barco, Benito] Univ Extremadura, Fac Formac Profesorado, Dpto Psicol & Sociol Educac, Caceres 10700, Spain. RP del Barco, BL, Univ Extremadura, Fac Formac Profesorado, Dpto Psicol & Sociol Educac, Avda Univ S-N, Caceres 10700, Spain. EM bleon@unex.es latas@unex.es CR *MAG AN, 2004, AD TIT MAESTR ESP EU *TUN ED STRUCT EUR, 2003, INF FIN PROYECT PIL APARICIO F, 1991, C INT CAL ED U CAD BLAZQUEZ F, 1999, REV INTERUNIVERSITAR, V34, P171 BRICALL J, 2000, INFORM U 2000 BROWN GY, 1988, EFFECTIVE TEACHING H CHICKERING A, 1991, 47 G MAS U COLAS P, 1993, REV ENSENANZA INTERU, V5, P83 COLL C, 1990, DESARROLLO PSICOLOGI, V2, P335 DELORS J, 1996, EDUCACION ENCIERRA T DEUTSCH M, 1949, HUM RELAT, V2, P129 ECHEITA G, 1995, INTERACCION SOCIAL C, P175 GAGE NL, 1988, ED PSYCHOL IMBERNON F, 1999, REV INTERUNIVERSITAR, V34, P123 JOHNSON DW, 1981, PSYCHOL BULL, V89, P47 JOHNSON DW, 1987, LEARNING TOGETHER AL JOHNSON DW, 1989, COOPERATION COMPETIT KELLEY HH, 1969, HDB SOCIAL PSYCHOL, P41 KRISHNAMURTI, 1997, ARTE VIVIR OVEJERO A, 1994, 5 SEM COMP PSIC FORM REGO MAS, 1990, REV ESP PEDAGOG, V185, P53 SHULMAN LS, 1986, EDUC RES, V15, P4 SLAVIN RE, 1990, COOPERATIVE LEARNING VALCARCEL M, 2003, PREPARACION PROFESOR WEBB NM, 1989, INT J ED RES, V13, P5 NR 25 TC 0 PU ESCUELA UNIV MAGISTERIO PI BILBAO PA RAMON Y CAJAL 72, BILBAO, 48014, SPAIN SN 1136-1034 J9 REV PSICODIDACT JI Rev. Psicodidact. PY 2007 VL 12 IS 2 BP 269 EP 277 PG 9 SC Psychology, Educational GA 374JW UT ISI:000261040600007 ER PT J AU Rangel, C Corchado, JC Espinosa-Garcia, J AF Rangel, Cipriano Corchado, Jose C. Espinosa-Garcia, Joaquin TI Quasi-classical trajectory calculations in asymmetrically substituted polyatomic systems of the type A + CX3Y -> products: the H + CH3Cl hydrogen abstraction reaction channel SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID ZERO-POINT-ENERGY; HYDROGEN ABSTRACTION REACTION; QUANTUM RELAXATION DYNAMICS; STRETCH MODE EXCITATION; H-ATOMS; SIMPLEST REACTION; CARBON-ATOM; PHASE-SPACE; KINETICS; SURFACE AB A state-to-state dynamics study was performed for the first time for asymmetrically substituted reactions of the type H + CX3Y -> products, and was applied to the H + CH3Cl gas-phase hydrogen abstraction reaction, analyzing the influence of CH3Cl reactant vibrational stretching and bending excitations. Quasi-classical trajectory calculations were performed on an analytical potential energy surface constructed previously by our group. The strong coupling between different vibrational modes in the entry channel makes the reaction non-adiabatic and the reactant vibrational excitation increases the reactivity of the vibrational ground-state by factors of approximate to 2-3 depending on the excited mode. While the H-2 and CH2Cl products appear with similar moderate amounts of internal energy, about 25% of the total available energy, most of this energy appears as translational energy, and the reactant vibrational excitation has little influence. The two products appear vibrationally cold, and in the case of the H-2 product, also rotationally cold. The product angular distribution is predominantly sideways-backward, the sideways component increasing with the vibrational excitation of the H-2 product. The reactant vibrational excitations have little effect on this behaviour. Finally, comparison with theoretical results for the analogue H + CH4 reaction shows that the dynamic behaviour of the two reactions is similar, with the chlorine substituent effect being small or negligible. C1 [Rangel, Cipriano; Corchado, Jose C.; Espinosa-Garcia, Joaquin] Univ Extremadura, Dept Quim Fis, E-06071 Badajoz, Spain. RP Espinosa-Garcia, J, Univ Extremadura, Dept Quim Fis, E-06071 Badajoz, Spain. EM joaquin@unex.es FU Junta de Extremadura, Spain [PRI07A009] FX This work was partially supported by the Junta de Extremadura, Spain (Project No. PRI07A009). 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Chem. Chem. Phys. PY 2008 VL 10 IS 45 BP 6776 EP 6786 DI 10.1039/b809999e PG 11 SC Chemistry, Physical; Physics, Atomic, Molecular & Chemical GA 373WU UT ISI:000261005000005 ER PT J AU Pittman, AM Webb, E Carvajal-Carmona, L Howarth, K Di Bernardo, MC Broderick, P Spain, S Walther, A Price, A Sullivan, K Twiss, P Fielding, S Rowan, A Jaeger, E Vijayakrishnan, J Chandler, I Penegar, S Qureshi, M Lubbe, S Domingo, E Kemp, Z Barclay, E Wood, W Martin, L Gorman, M Thomas, H Peto, J Bishop, T Gray, R Maher, ER Lucassen, A Kerr, D Evans, GR van Wezel, T Morreau, H Wijnen, JT Hopper, JL Southey, MC Giles, GG Severi, G Castellvi-Bel, S Ruiz-Ponte, C Carracedo, A Castells, A Forsti, A Hemminki, K Vodicka, P Naccarati, A Lipton, L Ho, JWC Cheng, KK Sham, PC Luk, J Agundez, JAG Ladero, JM de la Hoya, M Caldes, T Niitymaki, I Tuupanen, S Karhu, A Aaltonen, LA Cazier, JB Tomlinson, IPM Houlston, RS AF Pittman, Alan M. Webb, Emily Carvajal-Carmona, Luis Howarth, Kimberley Di Bernardo, Maria Chiara Broderick, Peter Spain, Sarah Walther, Axel Price, Amy Sullivan, Kate Twiss, Philip Fielding, Sarah Rowan, Andrew Jaeger, Emma Vijayakrishnan, Jayaram Chandler, Ian Penegar, Steven Qureshi, Mobshra Lubbe, Steven Domingo, Enric Kemp, Zoe Barclay, Ella Wood, Wendy Martin, Lynn Gorman, Maggie Thomas, Huw Peto, Julian Bishop, Timothy Gray, Richard Maher, Eamonn R. Lucassen, Anneke Kerr, David Evans, Gareth R. van Wezel, Tom Morreau, Hans Wijnen, Juul T. Hopper, John L. Southey, Melissa C. Giles, Graham G. Severi, Gianluca Castellvi-Bel, Sergi Ruiz-Ponte, Clara Carracedo, Angel Castells, Antoni Foersti, Asta Hemminki, Kari Vodicka, Pavel Naccarati, Alessio Lipton, Lara Ho, Judy W. C. Cheng, K. K. Sham, Pak C. Luk, J. Agundez, Jose A. G. Ladero, Jose M. de la Hoya, Miguel Caldes, Trinidad Niitymaki, Iina Tuupanen, Sari Karhu, Auli Aaltonen, Lauri A. Cazier, Jean-Baptiste Tomlinson, Ian P. M. Houlston, Richard S. CA CORGI Consortium; EPICOLON Consortium TI Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer SO HUMAN MOLECULAR GENETICS LA English DT Article ID GENOME-WIDE ASSOCIATION; GENE-EXPRESSION; METAANALYSIS; VARIANT; LOCUS; SCAN AB The common single-nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To examine this association in detail we genotyped rs3802842 in eight independent case-control series comprising a total of 10 638 cases and 10 457 healthy individuals. A significant association between the C allele of rs3802842 and CRC risk was found (per allele OR = 1.17; 95% confidence interval [CI]: 1.12-1.22; P = 1.08 x 10(-12)) with the risk allele more frequent in rectal than colonic disease (P = 0.02). In combination with 8q21, 8q24, 10p14, 11q, 15q13.3 and 18q21 variants, the risk of CRC increases with an increasing numbers of variant alleles for the six loci (ORper allele = 1.19; 95% CI: 1.15-1.23; P-trend = 7.4 x 10(-24)). Using the data from our genome-wide association study of CRC, LD mapping and imputation, we were able to refine the location of the causal locus to a 60 kb region and screened for coding changes. The absence of exonic mutations in any of the transcripts (FLJ45803, LOC120376, C11orf53 and POU2AF1) mapping to this region makes the association likely to be a consequence of non-coding effects on gene expression. C1 [Pittman, Alan M.; Webb, Emily; Di Bernardo, Maria Chiara; Broderick, Peter; Price, Amy; Sullivan, Kate; Twiss, Philip; Fielding, Sarah; Vijayakrishnan, Jayaram; Chandler, Ian; Penegar, Steven; Qureshi, Mobshra; Lubbe, Steven; Wood, Wendy; Gorman, Maggie; Houlston, Richard S.] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England. [Carvajal-Carmona, Luis; Howarth, Kimberley; Spain, Sarah; Walther, Axel; Rowan, Andrew; Jaeger, Emma; Domingo, Enric; Kemp, Zoe; Barclay, Ella; Martin, Lynn; Tomlinson, Ian P. M.] London Res Inst, Mol & Populat Genet Lab, London WC2A 3PX, England. [Thomas, Huw] St Marks Hosp, Family Canc Clin, Harrow HA1 3UJ, Middx, England. [Peto, Julian] Univ London London Sch Hyg & Trop Med, Noncommunicable Dis Epidemiol Unit, London WC1E 7HT, England. [Peto, Julian] Inst Canc Res, Canc Res UK Epidemiol & Genet Unit, Surrey, England. [Bishop, Timothy] Univ Leeds, Leeds Inst Mol Med, Epidemiol & Biostat Sect, Leeds, W Yorkshire, England. [Gray, Richard] Univ Birmingham, Birmingham Clin Trials Unit, Birmingham, W Midlands, England. [Martin, Lynn; Maher, Eamonn R.] Univ Birmingham, Sch Med, Dept Med & Mol Genet, Birmingham B15 2TT, W Midlands, England. [Martin, Lynn; Maher, Eamonn R.] Birmingham Womens Hosp, W Midlands Reg Genet Serv, Birmingham, W Midlands, England. [Martin, Lynn; Lucassen, Anneke] Princess Anne Hosp, Wessex Clin Genet Serv, Southampton SO16 5YA, Hants, England. [Martin, Lynn; Lucassen, Anneke] Univ Southampton, Southampton SO16 5YA, Hants, England. [Kerr, David] Univ Oxford, Radcliffe Infirm, Dept Clin Pharmacol, Oxford OX2 6HA, England. [Martin, Lynn; Evans, Gareth R.] St Marys Hosp, Dept Med Genet, Manchester M13 0JH, Lancs, England. [van Wezel, Tom; Morreau, Hans; Wijnen, Juul T.] Leiden Univ, Med Ctr, Dept Pathol, NL-2333 ZA Leiden, Netherlands. [Morreau, Hans; Wijnen, Juul T.] Leiden Univ, Med Ctr, Ctr Human & Clin Genet, NL-2333 ZA Leiden, Netherlands. [Hopper, John L.; Giles, Graham G.] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Carlton, Vic 3053, Australia. [Southey, Melissa C.] Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3052, Australia. [Giles, Graham G.; Severi, Gianluca] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic 3053, Australia. [Castellvi-Bel, Sergi; Castells, Antoni] IDIBAPS, CIBER EHD, Hosp Clin, Inst Malalties Digest & Metab,Dept Gastroenterol, Barcelona, Catalonia, Spain. [Ruiz-Ponte, Clara; Carracedo, Angel] Univ Santiago Compostela, Hosp Clin, Spanish Natl Genotyping Ctr CeGen, FPGMX,Genom Med Grp,CIBERER, Santiago De Compostela, Galicia, Spain. [Foersti, Asta; Hemminki, Kari] German Canc Res Ctr, DKFZ, Div Mol Genet Epidemiol, D-69120 Heidelberg, Germany. [Foersti, Asta; Hemminki, Kari] Karolinska Inst, Ctr Family & Community Med, S-14183 Huddinge, Sweden. [Vodicka, Pavel; Naccarati, Alessio] Acad Sci Czech Republic, Inst Expt Med, Prague 14200, Czech Republic. [Lipton, Lara] Western Hosp, Dept Med Oncol & Clin Haematol, Footscray, Vic 3011, Australia. [Ho, Judy W. C.; Cheng, K. K.; Sham, Pak C.; Luk, J.] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China. [Agundez, Jose A. G.] Univ Extremadura, Sch Med, Dept Pharmacol, Badajoz, Spain. [Ladero, Jose M.] San Carlos Univ Hosp, Serv Gastroenterol, Madrid, Spain. [de la Hoya, Miguel; Caldes, Trinidad] Hosp San Carlos, Oncol Mol Lab, Madrid 28040, Spain. [Niitymaki, Iina; Tuupanen, Sari; Karhu, Auli; Aaltonen, Lauri A.] Univ Helsinki, Dept Med Genet, Biomedicum, Genome Scale Biol Res Program, Helsinki, Finland. [Cazier, Jean-Baptiste] London Res Inst, London WC2A 3PX, England. RP Houlston, RS, Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England. EM richard.houlston@icr.ac.uk FU Cancer Research UK ; Institute of Cancer Research ; European Union [LSHC-CT-2004-503465]; Bobby Moore Fund ; CORE ; Thomas Falknor Fund ; St. George's Hospital Medical School ; Fondo de Investigacion Sanitaria [03/0070, 05/0071, 05/2031]; Ministerio de Educacion y Ciencia [SAF 04-07190, 07-64873]; Asociacion Espanola contra el Cancer ; Merck, Co ; Xunta de Galicia [PGI-DIT07PXIB9101209PR]; Fundacion Olga Torres ; Fundacion de Investigacion Medica Mutua Madrilena ; Instituto de Salud Carlos III ; Ministerio de Sanidad ; FIS [051056, RD07/0064/0016]; Instituto de Salud Carlos III, Madrid, Spain ; Academy of Finland ; Finnish Cancer Society ; Sigrid Juselius Foundation ; European Commission [9LSHG-CT2004-512142]; Deutsche Krebshilfe ; German Ministry of Education and Research [01GS0426, 01GR0468]; Medical Faculty, Kiel ; Federal Ministry of Education and Research [ZZ9603]; Ministry of Cultural Affairs ; Social Ministry of the Federal State of Mecklenburg-West Pomerania. Leiden ; Dutch Cancer Society [UL2005-3247]; Medical Ethical Committee [P01.019]; Dutch Federation of Medical Sciences, Madrid ; Fondo Investigacion Sanitaria [PI070316, RD06/0020/0021]; National Health and Medical Research Council (NHMRC) [209057, 251533, 396414]; Cancer Council Victoria ; NHMRC Australia ; [GACR310/07/1430] FX Cancer Research UK provided principal funding for this study. Institute of Cancer Research: Additional funding was provided by the European Union (CPRB LSHC-CT-2004-503465), the Bobby Moore Fund, CORE and the Thomas Falknor Fund. I. C. was in receipt of a clinical training fellowship from St. George's Hospital Medical School. London Institute: Additional funding was provided by CORE and the Bobby Moore Fund. Barcelona: We are sincerely grateful to all patients participating in this study that were recruited in 25 Spanish hospitals as part of the EPI-COLON project. This work was supported by grants from the Fondo de Investigacion Sanitaria (03/0070, 05/0071 and 05/2031), from the Ministerio de Educacion y Ciencia (SAF 04-07190 and 07-64873), the Asociacion Espanola contra el Cancer, from Merck, Co, from the Xunta de Galicia (PGI-DIT07PXIB9101209PR), from Fundacion Olga Torres (S. C.- B.), and from Fundacion de Investigacion Medica Mutua Madrilena (C. R.- P.). CIBEREHD and CIBERER are funded by the Instituto de Salud Carlos III. S. C.- B. is supported by a contract from the Fondo de Investigacion Sanitaria ( CP 03-0070, Ministerio de Sanidad). Extremadura: Work was supported by grants FIS 051056 and RD07/0064/0016 from Instituto de Salud Carlos III, Madrid, Spain. Finland: This work was supported by grants from Academy of Finland ( Finnish Centre of Excellence Program 2006 - 2011), the Finnish Cancer Society, the Sigrid Juselius Foundation and the European Commission 9LSHG-CT2004-512142). Heidelberg: Supported by Deutsche Krebshilfe and the Swedish Cancer Society. Kiel: This study was supported by the German Ministry of Education and Research through the National Genome Research Network through the POPGEN biobank project ( 01GS0426, 01GR0468) and the Medical Faculty, Kiel. The SHIP recuitment project is funded by the Federal Ministry of Education and Research ( ZZ9603), the Ministry of Cultural Affairs as well as the Social Ministry of the Federal State of Mecklenburg-West Pomerania. Leiden: DFCCS was supported by Dutch Cancer Society grant UL2005-3247 and approved by the local Medical Ethical Committee ( protocol P01.019); samples were handled according to Code Proper Secondary Use of Human Tissue by the Dutch Federation of Medical Sciences (www.federa.org). Madrid: Work was supported by the Fondo Investigacion Sanitaria (PI070316 and RD06/0020/0021). Melbourne: The Melbourne Collaborative Cohort Study is supported by National Health and Medical Research Council (NHMRC) grants 209057, 251533 and 396414 and receives core funding and infrastructure support from the The Cancer Council Victoria. J. L. H. is a NHMRC Australia Fellow and M. C. S. is a NHMRC Senior Research Fellow. We would like to acknowledge Mr Fabrice Odefrey for performing the genotyping. Prague: Supported by the grant GACR310/07/1430. 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Mol. Genet. PD DEC 1 PY 2008 VL 17 IS 23 BP 3720 EP 3727 DI 10.1093/hmg/ddn267 PG 8 SC Biochemistry & Molecular Biology; Genetics & Heredity GA 373OG UT ISI:000260980800010 ER PT J AU Olivares-Marin, M Del Prete, V Garcia-Moruno, E Fernandez-Gonzalez, C Macias-Garcia, A Gomez-Serrano, V AF Olivares-Marin, M. Del Prete, V. Garcia-Moruno, E. Fernandez-Gonzalez, C. Macias-Garcia, A. Gomez-Serrano, V. TI The development of an activated carbon from cherry stones and its use in the removal of ochratoxin A from red wine SO FOOD CONTROL LA English DT Article DE Cherry stones; Activated carbon; Red wines; Ochratoxin A adsorption ID IMMUNOAFFINITY COLUMN CLEANUP; CHEMICAL ACTIVATION; ADSORPTION; SPECTROSCOPY; CHEMISTRY AB The ability of activated carbon (AC) prepared from cherry stones (CS) by activation with H3PO4, ZnCl2 or KOH to remove ochratoxin A (OTA) from two Italian red wines has been studied. AC was characterized in terms of texture and surface chemistry. OTA was analyzed by reversed-phase high-performance liquid chromatrography, using a fluorescence detector. The content of OTA in the starting wines is 7.38 and 2.36 mu g/L. The adsorption of OTA is high only for one AC, which was prepared by KOH activation at 900 degrees C, using the 3:1 KOH:CS impregnation ratio. It possesses a large apparent surface area (S-BET = 1620 m(2)/g) and a high volume of large size macropores (1.84 cm(3)/g). It also contains narrow mesopores and intermediate size and wide micropores. Its content of acidic oxygen surface groups is low, whereas the content of basic groups is high (2.62 meq/g). The treatment of the wines with such an AC results in a decrease of the initial OTA content of more than 50%. However, the changes produced in the total polyphenolic index, color intensity, and hue are small (i.e. similar to 8%, similar to 5.5% and similar to 1.2%, respectively). (C) 2008 Elsevier Ltd. All rights reserved. C1 [Olivares-Marin, M.; Fernandez-Gonzalez, C.; Gomez-Serrano, V.] Univ Extremadura, Fac Ciencias, Dept Quim Organ & Inorgan, E-06071 Badajoz, Spain. [Del Prete, V.; Garcia-Moruno, E.] Ist Sperimentale Enol, CRA, I-14100 Asti, Italy. [Macias-Garcia, A.] Univ Extremadura, Escuela Ingn Ind, Area Ciencia Mat, E-06071 Badajoz, Spain. RP Gomez-Serrano, V, Univ Extremadura, Fac Ciencias, Dept Quim Organ & Inorgan, Avd Elvas S-N, E-06071 Badajoz, Spain. EM vgomez@unex.es FU Ministerio de Educacion y Ciencia (MEC) de Espafia FX Financial support from "Ministerio de Educacion y Ciencia (MEC) de Espafia" is gratefully acknowledged by the authors. We also thank the "CRA-Istituto Sperimentale per I'Enologia (Asti, Italia)" for valuable assistance in laboratory tasks. 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M. Ferrera, C. Shevtsova, V. M. TI Experimental study of the free surface deformation due to thermal convection in liquid bridges SO EXPERIMENTS IN FLUIDS LA English DT Article ID FLOATING HALF ZONE; THERMOCAPILLARY CONVECTION; MARANGONI INSTABILITIES; INTERFACIAL-TENSION; MICROGRAVITY; STABILITY; CONTAINERS; VOLUME; ONSET; FLOWS AB Optical imaging was used to measure the free surface deformation due to thermal (Marangoni-buoyant) convection in liquid bridges of 5-cSt silicone oil. We obtained the free surface position averaged over time in both the steady and oscillatory regimes. The deviation of the free surface contour from the corresponding equilibrium shape was determined with an uncertainty of about 2 mu m. This deviation grew linearly with the applied temperature difference with a proportionality coefficient depending on the liquid bridge volume at equilibrium. Shrinkage at the upper part of the liquid bridge was slightly greater than bulging at the lower with the sum of the maximum deviations at both parts being about 30 mu m near the onset of oscillations. This sum, normalized with the radius of the supporting disks, was of the same order of magnitude as the Capillary number. We observed the influence of thermal expansion, surface tension variation over the free surface, and fluid motion separately. The local mean curvature was also calculated and compared with its value at equilibrium, showing that the hydrodynamic effects were important. C1 [Montanero, J. M.; Ferrera, C.; Shevtsova, V. M.] Univ Libre Bruxelles, Micrograv Res Ctr, B-1050 Brussels, Belgium. RP Montanero, JM, Univ Extremadura, Dept Mech Energet & Mat Engn, Avda Elvas S-N, E-06071 Badajoz, Spain. EM jmm@unex.es FU Ministerio de Educacion y Ciencia (Spain) [PR2007-0510] FX We are indebted to Prof. J.C. Legros for helpful discussions and creating the academic environment that made this research possible. J.M.M. acknowledges partial support from the Ministerio de Educacion y Ciencia (Spain) through Grant No. PR2007-0510. 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Fluids PD DEC PY 2008 VL 45 IS 6 BP 1087 EP 1101 DI 10.1007/s00348-008-0529-x PG 15 SC Engineering, Mechanical; Mechanics GA 371NG UT ISI:000260837400010 ER PT J AU Ibanez, SJ Sampaio, J Feu, S Lorenzo, A Gomez, MA Ortega, E AF Ibanez, Sergio J. Sampaio, Jaime Feu, Sebastian Lorenzo, Alberto Gomez, Miguel A. Ortega, Enrique TI Basketball game-related statistics that discriminate between teams' season-long success SO EUROPEAN JOURNAL OF SPORT SCIENCE LA English DT Article DE Basketball; discriminant analysis; professional league; game-related statistics ID EMPIRICAL VERIFICATION; PLAYERS; CHAMPIONSHIP; PERFORMANCE; POSITION; CENTERS; SYSTEM; LEVEL AB The aim of the present study was to identify the game-related statistics that discriminate between season-long successful and unsuccessful basketball teams participating in the Spanish Basketball League (LEB1). The sample included all 145 average records per season from the 870 games played between the 2000-2001 and the 2005-2006 regular seasons. The following game-related statistics were gathered from the official box scores of the Spanish Basketball Federation: 2- and 3-point field-goal attempts (both successful and unsuccessful), free-throws (both successful and unsuccessful), defensive and offensive rebounds, assists, steals, turnovers, blocks (both made and received), and fouls (both committed and received). To control for season variability, all results were normalized to minutes played each season and then converted to z-scores. The results allowed discrimination between best and worst teams' performances through the following game-related statistics: assists (SC=0.47), steals (SC=0.34), and blocks (SC=0.30). The function obtained correctly classified 82.4% of the cases. In conclusion, season-long performance may be supported by players' and teams' passing skills and defensive preparation. C1 [Ibanez, Sergio J.; Feu, Sebastian] Univ Extremadura, Fac Sport Sci, E-06071 Badajoz, Spain. [Sampaio, Jaime] Univ Tras os Montes & Alto Douro, Sport Sci Dept, Vila Real, Spain. [Lorenzo, Alberto; Gomez, Miguel A.] Univ Politecn Madrid, Fac Phys Act & Sport Sci, Madrid, Spain. [Ortega, Enrique] Catholic Univ St Anthony Murcia, Fac Hlth Phys Act & Sport Sci, Murcia, Spain. RP Sampaio, J, Univ Tras os Montes & Alto Douro, Dept Desporto, Ap 202,Via Real, Vila Real 5000911, Spain. EM ajaime@utad.pt CR AKERS M, 1991, J BUSINESS EC STUDIE, V1, P57 CARTER JEL, 2005, J SPORT SCI, V23, P1057, DOI 10.1080/02640410400023233 DEZMAN B, 2001, COLLEGIUM ANTROPOL, V25, P141 GOMEZ MA, 2006, INT J PERFORMANCE AN, V6, P98 HEUZE JP, 2006, J SPORT SCI, V24, P59, DOI 10.1080/02640410500127736 IBANEZ SJ, 2003, J HUM MOVEMENT STUD, V45, P1 ITTENBACH RF, 1995, J SPORT BEHAV, V18, P216 KARIPIDIS A, 2001, J HUM MOVEMENT STUD, V41, P385 KOZAR B, 1994, PERCEPT MOTOR SKILL, V78, P243 KUBATKO J, 2007, J QUANTITATIVE ANAL, V3, P1 MELNICK MJ, 2001, PERCEPT MOTOR SKILL, V92, P595 MILLER S, 1996, J SPORT SCI, V14, P243 NORUSIS MJ, 2004, SPSS 13 00 ADV STAT NTOUMANIS N, 2001, STEP BY STEP GUIDE S OLIVER D, 2004, BASKETBALL PAPER RUL OTTO K, 1998, SCHOLASTIC COACH ATH, V67, P24 PAPADIMITRIOU K, 1999, J HUM MOVEMENT STUD, V37, P87 SAMPAIO J, 2003, INT J PERFORMANCE AN, V3, P40 SAMPAIO J, 2004, PERCEPT MOTOR SKIL 2, V99, P1231 SAMPAIO J, 2006, EUR J SPORT SCI, V6, P173, DOI 10.1080/17461390600676200 SPORIS G, 2006, INT J PERFORM ANAL S, V6, P120 TABACHNICK B, 2007, USING MULTIVARIATE S TAXILDARIS K, 2001, J HUM MOVEMENT STUD, V40, P405 TRNINIC S, 2000, COLLEGIUM ANTROPOL, V24, P443 TRNINIC S, 2002, COLLEGIUM ANTROPOL, V26, P521 NR 25 TC 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1746-1391 J9 EUR J SPORT SCI JI Eur. J. Sport Sci. PY 2008 VL 8 IS 6 BP 369 EP 372 DI 10.1080/17461390802261470 PG 4 SC Sport Sciences GA 374AM UT ISI:000261014600011 ER PT J AU Fernandez, AJC AF Campesino Fernandez, Antonio-J TI Zafra, dynamic urban development (1940-1995) SO BOLETIN DE LA ASOCIACION DE GEOGRAFOS ESPANOLES LA Spanish DT Book Review C1 [Campesino Fernandez, Antonio-J] Univ Extremadura, E-06071 Badajoz, Spain. RP Fernandez, AJC, Univ Extremadura, E-06071 Badajoz, Spain. CR FERNANDEZ T, 2007, ZAFRA DINAMICA URBAN NR 1 TC 0 PU ASOCIACION GEOGRAFOS ESPANOLES PI MADRID PA PINAR 25, MADRID, 28006, SPAIN SN 0212-9426 J9 BOL ASOC GEOGR ESP JI Bol. Asoc. Geogr. Esp. PY 2008 IS 47 BP 433 EP 435 PG 3 SC Geography GA 370KB UT ISI:000260760000031 ER PT J AU Aviles, A Moreno, Y AF Aviles, Antonio Moreno, Yolanda TI Automorphisms in spaces of continuous functions on Valdivia compacta SO TOPOLOGY AND ITS APPLICATIONS LA English DT Article DE Automorphism; Automorphic space; Eberlein compact; Valdivia compact; Space of continuous functions ID BANACH-SPACES AB We show that there are no automorphic Banach spaces of the form C(K) with K continuous image of Valdivia compact except the spaces c(0)(Gamma). Nevertheless, when K is an Eberlein compact of finite height such that C(K) is not isomorphic to c(0)(Gamma), all isomorphism between subspaces of C(K) of size less than aleph(omega) extend to automorphisms of C(K). (C) 2008 Elsevier B.V. All rights reserved. C1 [Aviles, Antonio] Univ Paris 07, Equipe Log Math, UFR Math, F-75251 Paris, France. [Moreno, Yolanda] Univ Extremadura, Escuela Politecn, Dept Matemat, Caceres 10071, Spain. RP Aviles, A, Univ Paris 07, Equipe Log Math, UFR Math, 2 Pl Jussieu, F-75251 Paris, France. EM avileslo@um.es ymoreno@unex.es FU Marie Curie Intra-European Felloship [MCEIF-CT2006-038768]; Seneca (Spain) [00690/PI/04]; [MTM2005-08379]; [MTM2004-02635] FX The author was supported by a Marie Curie Intra-European Felloship MCEIF-CT2006-038768 (E.U.) and research projects MTM2005-08379 and Seneca 00690/PI/04 (Spain). The author was partially supported by project MTM2004-02635. CR ALSTER K, 1979, FUND MATH, V104, P43 ARGYROS SA, 2002, P LOND MATH SOC 3, V85, P742, DOI 10.1112/S0024611502013618 BELL M, 2007, ISR J MATH, V158, P217, DOI 10.1007/s11856-007-0011-0 FABIAN M, 1997, CANADIAN MATH SOC SE GODEFROY G, 2000, GEOM FUNCT ANAL, V10, P798 KALENDA O, 2000, EXTRACTA MATH, V15, P1 LINDENSTRAUSS J, 1969, ISR J MATH, V7, P227 MARCISZEWSKI W, 2003, STUD MATH, V156, P295 MORENO Y, ISRAEL J MA IN PRESS PELCZYNSKI A, 1968, DISSERTATIONES MATH, V58 NR 10 TC 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-8641 J9 TOPOL APPL JI Topology Appl. PD OCT 15 PY 2008 VL 155 IS 17-18 BP 2027 EP 2030 DI 10.1016/j.topol.2007.07.007 PG 4 SC Mathematics, Applied; Mathematics GA 365MT UT ISI:000260411400018 ER PT J AU Calvo, TG Castuera, RJ Ruano, FJSR Vaillo, RR Gimeno, EC AF Garcia Calvo, Tomas Jimenez Castuera, Ruth Santos-Rosa Ruano, Francisco Javier Reina Vaillo, Raul Cervello Gimeno, Eduardo TI Psychometric Properties of the Spanish Version of the Flow State Scale SO SPANISH JOURNAL OF PSYCHOLOGY LA English DT Article DE Flow State Scale; psychometric properties; motivation ID MOTIVATIONAL CLIMATE; OPTIMAL EXPERIENCE; SPORT PERFORMANCE; GOAL ORIENTATIONS; TASK INVOLVEMENT; QUESTIONNAIRE; ANXIETY; VALIDATION; VALIDITY AB The purpose of this research was to examine the psychometric properties of a Spanish translation of the Flow State Scale (FSS-, Jackson & Marsh, 1996). This instrument is used to assess the Flow State in participants of physical activity, although it can be adapted to other contexts (such as work, educational contexts, etc.). This construct can be considered the optimal psychological state to carry out all activity. being closely related to motivation and personal enjoyment (Csikszentmihalyi. 1997). A sample of 2036 athletes was recruited from diverse sports activities. The results revealed satisfactory validity and internal consistency of the instrument. obtaining a factor model made up of a main factor and nine subscales. The correlations between motivational orientations and the now state are highlighted. The Spanish translation of this instrument is found to be acceptable, with similar psychometric properties as the original scale, although future research in other contexts is needed to support these outcomes. C1 [Garcia Calvo, Tomas] Univ Extremadura, Fac Ciencias Deporte, Caceres 10071, Spain. [Santos-Rosa Ruano, Francisco Javier] Univ Seville, Seville, Spain. [Reina Vaillo, Raul; Cervello Gimeno, Eduardo] Univ Miguel Hernandez, Alicante, Spain. RP Calvo, TG, Univ Extremadura, Fac Ciencias Deporte, Avda Univ S-N, Caceres 10071, Spain. 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J. Psychol. PD NOV PY 2008 VL 11 IS 2 BP 660 EP 669 PG 10 SC Psychology, Multidisciplinary GA 367JV UT ISI:000260549200030 ER PT J AU Jimenez, A Hernandez, A Urena, J Perez, MC Alvarez, FJ De Marziani, C Garcia, JJ Villadangos, JM AF Jimenez, Ana Hernandez, Alvaro Urena, Jesus Perez, Ma Carmen Alvarez, Fernando J. De Marziani, Carlos Garcia, Juan Jesus Villadangos, J. Manuel TI EMFi-based ultrasonic transducer for robotics applications SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE Ultrasonic transducer; Encoded ultrasonic emission; Electromechanical film; Broad bandwidth ID PIEZOELECTRIC POLYMERS; CELLULAR POLYMERS; SONAR; ELECTRET; SENSOR; LOCALIZATION; CLASSIFICATION; FERROELECTRETS; SYSTEM; FILM AB A prototype of an ultrasonic transducer based on electromechanical film (EMFi) is presented, as well as its electronic driving and receiving blocks. The electromechanical film provides a wide bandwidth response, showing enough of a level of sensitivity to allow echo-pulse measurement in the most frequency ranges for robotics applications. Emission patterns are obtained, verifying the correspondence between experimental data and the theoretical piston model. Experimental results show that the EMFi-based transducer can be used as a broadband ultrasonic transducer, allowing transmission from 20 to 200 kHz. The wide bandwidth provided by the transducer is a remarkable advantage for sensor systems using encoded ultrasonic signals with wideband modulation schemes, which require considerably more bandwidth than what conventional transducers allow. In this way, main lobes can be discriminated more easily from sidelobes and crosstalk interference can be reduced. (c) 2008 Elsevier B.V. All rights reserved. C1 [Jimenez, Ana; Hernandez, Alvaro; Urena, Jesus; Perez, Ma Carmen; Garcia, Juan Jesus; Villadangos, J. Manuel] Univ Alcala de Henares, Dept Elect, E-28806 Alcala De Henares, Spain. [Alvarez, Fernando J.] Univ Extremadura, Dept Elect Engn Elect & Automat, E-06071 Badajoz, Spain. [De Marziani, Carlos] Natl Univ Patagonia San Juan Bosco, Dept Elect, RA-9005 Comodoro Rivadavia, Argentina. RP Jimenez, A, Univ Alcala de Henares, Dept Elect, E-28806 Alcala De Henares, Spain. EM ajimenez@depeca.uah.es FU Ministerio de Educacion y Ciencia from Spain [TIN2006-14896-CO2-01]; Comunidad de Madrid ; University of Alcald [CCG06-UAH/DPI-0725]; Ministerio de Trabajo y Asuntos Sociales from Spain [81/06] FX This work was supported by the Ministerio de Educacion y Ciencia from Spain (RESELAI project, ref. TIN2006-14896-CO2-01), by the Comunidad de Madrid and by the University of Alcald (INCUBUS project, ref. CCG06-UAH/DPI-0725), and by the Ministerio de Trabajo y Asuntos Sociales from Spain (DEDALO project, ref. 81/06). 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Actuator A-Phys. PD NOV 4 PY 2008 VL 148 IS 1 BP 342 EP 349 DI 10.1016/j.sna.2008.07.024 PG 8 SC Engineering, Electrical & Electronic; Instruments & Instrumentation GA 371AP UT ISI:000260804500047 ER PT J AU Valera, E Sanchez-Martin, FJ Ferrer-Montiel, AV Messeguer, A Merino, JM AF Valera, Elvira Sanchez-Martin, Francisco J. Ferrer-Montiel, Antonio V. Messeguer, Angel Merino, Jaime M. TI NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway SO NEUROCHEMISTRY INTERNATIONAL LA English DT Article DE Glutamate; Excitotoxicity; N-Methyl-D-aspartate; CREB; Neuroprotection ID METHYL-D-ASPARTATE; CEREBELLAR GRANULE CELLS; FAMILY TRANSCRIPTION FACTOR; NERVOUS-SYSTEM; IN-VIVO; GLUTAMATE NEUROTOXICITY; MOLECULAR DIVERSITY; CHANNEL BLOCKER; RAT-BRAIN; RECEPTORS AB N-Methyl-D-aspartate (NMDA) receptors play a critical role in the brain stimulating synaptic plasticity and mediating neurodegeneration; a neuroprotective role has also been described, but its molecular mechanisms in hippocampus are under study. Here, we report that in primary cultures of rat hippocampal neurons exposure to low micromolar NMDA concentrations are neuroprotective against excitotoxic insults, while high micromolar NMDA concentrations provoke neuronal death. Molecular analysis reveals that a toxic concentration of NMDA induced a transient phosphorylation of cAMP-response element-binding protein (pCREB) in 2 min that rapidly decreased below basal levels. In contrast, a nontoxic NMDA concentration gave up to longer (20 min) rise of pCREB, suggesting that neuroprotection could be associated to a relatively prolonged presence of pCREB in the neurons. In support of this tenet, rolipram, an inhibitor of phosphodiesterase IV that increases the levels of cAMP and pCREB, protected against NMDA-induced neuronal death. Similar results were obtained with clibutyrate-cAMP (a cAMP analogue with membrane permeability) that also abrogated NMDA excitotoxicity. Conversely, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamicle (H89), an inhibitor of protein kinase A (PKA), that prevents the formation of pCREB induced by nontoxic NMDA concentrations, reverted the neuroprotection achieved by preincubation of low micromolar NMDA concentrations. These results substantiate the notion that induction of pCREB via PKA plays an important role in NMDA-mediated neuroprotection. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Valera, Elvira; Sanchez-Martin, Francisco J.; Merino, Jaime M.] Univ Extremadura, Fac Ciencias, Dept Bioquim & Biol Mol, E-06071 Badajoz, Spain. [Ferrer-Montiel, Antonio V.] Univ Miguel Hernandez, Inst Biol Mol & Celular, Elche, Spain. [Messeguer, Angel] IIQAB CSIC, Dept Quim Organ Biol, Barcelona, Spain. RP Merino, JM, Univ Extremadura, Fac Ciencias, Dept Bioquim & Biol Mol, E-06071 Badajoz, Spain. EM jmmerino@unex.es FU Junta de Extremadura, Spain [2PR04A061]; Ministerio de Educacion y Ciencia (Spain) FX This work was supported by a Grant from the Junta de Extremadura, Spain (2PR04A061). Elvira Valera was the recipient of a predoctoral fellowship from the Ministerio de Educacion y Ciencia (Spain). Francisco J. Sanchez-Martin is the recipient of a predoctoral fellowship from the Junta de Extremadura (Spain). We thank Dr. P. Macias and Dr. P. Fernandez-Salguero for comments, suggestions and critical reading of the manuscript. 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Int. PD NOV PY 2008 VL 53 IS 5 BP 148 EP 154 DI 10.1016/j.neuint.2008.07.007 PG 7 SC Biochemistry & Molecular Biology; Neurosciences GA 367JN UT ISI:000260548400007 ER PT J AU Gonzalez, M Martinez, R Mota, M AF Gonzalez, M. Martinez, R. Mota, M. TI Bisexual branching processes in a genetic context: Rates of growth for Y-linked genes SO MATHEMATICAL BIOSCIENCES LA English DT Article DE Sex-linked inheritance; Bidimensional bisexual stochastic model; Perfect fidelity mating; Rates of growth AB A multitype bisexual branching process is considered to model the behaviour of a Y-linked gene with two genotypes in a two-sex population. It is assumed perfect fidelity mating with preference of females for the males carrying certain allele of the gene. Under these assumptions, we study the rate of growth of each genotype on the event of non-extinction. The rate of growth of a genotype may depend on whether the other survives or becomes extinct and, in general, both genotype frequencies grow at different rates. We also investigate conditions for the simultaneous explosion of both genotypes to have positive or zero probability. (C) 2008 Elsevier Inc. All rights reserved. C1 [Gonzalez, M.; Martinez, R.; Mota, M.] Univ Extremadura, Dept Math, E-06071 Badajoz, Spain. RP Martinez, R, Univ Extremadura, Dept Math, E-06071 Badajoz, Spain. EM mvelasco@unex.es rmartinez@unex.es mota@unex.es CR ASMUSSEN S, 1983, BRANCHING PROCESSES BAGLEY JH, 1986, J APPL PROBAB, V23, P820 BERNARDO A, 2001, P NATL ACAD SCI USA, V98, P13225 CHARLESWORTH D, 2005, HEREDITY, V95, P118, DOI 10.1038/sj.hdy.6800697 DALEY DJ, 1968, Z WAHRSCHEINLICHKEIT, V9, P315 GONZALEZ M, 2006, BERNOULLI, V12, P931 GONZALEZ M, 2006, MATH BIOSCI, V202, P227, DOI 10.1016/j.mbs.2006.03.010 HACCOU P, 2005, BRANCHING PROCESSES HUGHES JF, 2005, NATURE, V437, P100 JAGERS P, 1975, BRANCHING PROCESSES KIMMEL M, 2002, BRANCHING PROCESSES MAKRINOU E, 2001, GENOME RES, V11, P935 QUINTANAMURCI L, 2001, J BIOMED BIOTECHNOL, V1, P18 STROMBERG K, 1981, INTRO REAL ANAL YAMADA D, 2004, CHROMOSOME RES, V12, P741 NR 15 TC 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0025-5564 J9 MATH BIOSCI JI Math. Biosci. PD OCT PY 2008 VL 215 IS 2 BP 167 EP 176 DI 10.1016/j.mbs.2008.07.009 PG 10 SC Biology; Mathematical & Computational Biology GA 368HI UT ISI:000260611800006 ER PT J AU Alexandru, N Jardin, I Popov, D Simionescu, M Garcia-Estan, J Salido, GM Rosado, JA AF Alexandru, N. Jardin, I. Popov, D. Simionescu, M. Garcia-Estan, J. Salido, G. M. Rosado, J. A. TI Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE LA English DT Article DE thrombin; homocysteine; aggregation; platelets; calcium signalling; ROS production ID OPERATED CA2+ ENTRY; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; NITRIC-OXIDE; ACTIN CYTOSKELETON; PLASMA-MEMBRANE; TYROSINE PHOSPHORYLATION; AMYLASE SECRETION; ENDOTHELIAL-CELLS; INVOLVEMENT AB Type 2 diabetes mellitus induces a characteristic platelet hyperactivity that might be due to several factors including oxidativ stress and abnormal intracellular Ca2+ homeostasis. Hyperhomocysteinaemia is considered a risk factor in the development of thrombosis although its effect on platelet function and the mechanisms involved are still poorly understood. Here we show tha homocysteine induce a concentration-dependent increase in endogenous production of reactive oxygen species (ROS), which was significantly greater in platelets from diabetic patients than in controls. Platelet treatment with homocysteine resulted in Ca2+ release from the dense tubular system and the acidic stores. Ca2+ mobilization-induced by homocysteine consisted in two components, an initial slow increase in intracellular free Ca (+) concentration ([Ca2+]i) and a rapid and marked increase in [Ca2+]i, th second leading to the activation of platelet aggregation. As well as ROS generation, Ca2+ mobilization and platelet aggregation were significantly greater in platelets from diabetic donors than in controls, which indicate that platelets from diabetic donors are more sensitive to homocysteine. These findings, together with the hyperhomocysteinaemia reported in diabetic patients, strongly suggest that homocysteine might be considered a risk factor in the development of cardiovascular complications associated to type 2 diabetes mellitus. C1 [Jardin, I.; Salido, G. M.; Rosado, J. A.] Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Caceres 10071, Spain. [Alexandru, N.; Popov, D.; Simionescu, M.] Inst Cellular Biol & Pathol N Simionescu, Bucharest, Romania. [Garcia-Estan, J.] Univ Murcia, Fac Med, Dept Physiol, Murcia, Spain. RP Rosado, JA, Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Av Univ S-N, Caceres 10071, Spain. EM jarosado@unex.es FU M.E.C.-FEDER [BFU2007-60104/BFI]; Junta de Extremadura-Consejeria de Educacion, Ciencia y Tecnologia FEDER [2PR04A009]; Consejeria de Sanidad y Consumo ; FP6 European Community SSA-SERA [016873] FX This work was supported by M.E.C.-FEDER (BFU2007-60104/BFI), Junta de Extremadura-Consejeria de Educacion, Ciencia y Tecnologia & FEDER (2PR04A009) and Consejeria de Sanidad y Consumo. N. Alexandru was the recipient of 3 month training at University Extremadura, Spain financially supported by a grant from the FP6 European Community SSA-SERA Project 016873. We thank Dr. Hernandez-Cruz for providing blood samples and Mercedes Gomez Blazquez for her technical assistance. 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Cell. Mol. Med. PD OCT PY 2008 VL 12 IS 5B BP 2015 EP 2026 DI 10.1111/j.1582-4934.2007.00200.x PG 12 SC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental GA 367FQ UT ISI:000260538300019 ER PT J AU Camacho, LM Gomez, JR Navarro, RM AF Camacho, L. M. Gomez, J. R. Navarro, R. M. TI Heisenberg superalgebras SO INTERNATIONAL JOURNAL OF COMPUTER MATHEMATICS LA English DT Article DE Heisenberg algebras; lie algebras; lie superalgebras ID NILPOTENT LIE-SUPERALGEBRAS; ALGEBRAS AB Heisenberg algebras are the only Lie algebras (, [,]) which verify [, ]=Z( ) and dim (Z( ))=1, where Z denotes the center of the algebra. We classify nilpotent Lie superalgebras that verify the same algebraic conditions in arbitrary finite dimension. We study the geometrical properties with the aid of the software Mathematica. C1 [Navarro, R. M.] Univ Extremadura, Dept Matemat, Caceres, Spain. [Camacho, L. M.; Gomez, J. R.] Univ Seville, Dept Matemat Aplicada 1, Seville, Spain. RP Navarro, RM, Univ Extremadura, Dept Matemat, Caceres, Spain. EM lcamacho@us.es FU PAICYT ; Junta de Andalucia (Spain) ; Ministerio de Ciencia y Tecnologia (Spain) [BFM 2000-1047]; Junta de Extremadura-Consejer a de Infraestructuras y Desarrollo Tecnologico [3PR05A074] FX The authors want to thank the reviewers who provided extra references and some technical comments for our paper. The paper is Partially supported by the PAICYT, FQM143 of the Junta de Andalucia (Spain), by the Ministerio de Ciencia y Tecnologia (Spain), Ref. BFM 2000-1047, and by the Junta de Extremadura-Consejer a de Infraestructuras y Desarrollo Tecnologico (N. 3PR05A074). 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PY 2009 VL 86 IS 1 BP 67 EP 78 DI 10.1080/00207160701868278 PG 12 SC Mathematics, Applied GA 370OP UT ISI:000260771800005 ER PT J AU Escrig, PD Meco, AG Polo, AP AF de Frutos Escrig, Pilar Garriga Meco, Alvaro Padilla Polo, Ana TI Improved Procedure for Hydrogen Peroxide Production by Oxidation of Secondary Alcohols and Oxygenated Cosolvents SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID COMPETITIVE DES HYDROCARBURES; ANTHRAQUINONE PROCESS; CONSTANTES AB An improved procedure for the production of hydrogen peroxide via oxidation, with molecular oxygen, of secondary alcohols admixed with Oxygenated co-solvents as primary alcohols and/or ether has been studied. The selectivity, conversion, and rates have been increased, in comparison to the data obtained in the absence of co-solvents. The increase observed in the oxidation rate of 1-phenylethanol in the presence of co-solvents has been interpreted using the chain co-oxidation reaction theory. 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Eng. Chem. Res. PD NOV 5 PY 2008 VL 47 IS 21 BP 8025 EP 8031 DI 10.1021/ie800159u PG 7 SC Engineering, Chemical GA 367EF UT ISI:000260534600010 ER PT J AU Ayala, L Pedraja, F Salinas-Jimenez, J AF Ayala, Luis Pedraja, Francisco Salinas-Jimenez, Javier TI Performance measurement of local welfare programmes: evidence from Madrid's regional government SO ENVIRONMENT AND PLANNING C-GOVERNMENT AND POLICY LA English DT Article ID EFFICIENCY AB Interest in how social assistance programmes are organized has recently heightened, fed by concerns about the limits on achieving greater efficiency. Most available evidence considers performance indicators that are too general, there being few studies relating the use of inputs to outcomes. We compare different performance indicators of Madrid's programme with resource endowments in a group of local agencies of social services. In addition to constructing a detailed system of input and performance indicators, an empirical analysis of efficiency for each of the social services agencies is carried out using data envelopment analysis. Results confirm that there is a wide margin for obtaining efficiency gains. The empirical analysis shows that some detected inefficiencies arise from an excessive number of staff in relation to the work to be performed. Agencies with a higher incidence of social problems present higher efficiency scores. C1 [Ayala, Luis] Univ Rey Juan Carlos, Madrid 28032, Spain. [Pedraja, Francisco] Univ Extremadura, Fac Ciencias Econ & Empresariales, Badajoz 06071, Spain. [Salinas-Jimenez, Javier] Univ Extremadura, Ist Estudios Fiscales, Madrid 28035, Spain. RP Ayala, L, Univ Rey Juan Carlos, Paseo Artilleros S-N, Madrid 28032, Spain. 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Plan. C-Gov. Policy PD OCT PY 2008 VL 26 IS 5 BP 906 EP 923 DI 10.1068/c0805r PG 18 SC Environmental Studies; Public Administration GA 369RY UT ISI:000260712800005 ER PT J AU Gonzalez-Romera, E Jaramillo-Moran, MA Carmona-Fernandez, D AF Gonzalez-Romera, E. Jaramillo-Moran, M. A. Carmona-Fernandez, D. TI Monthly electric energy demand forecasting with neural networks and Fourier series SO ENERGY CONVERSION AND MANAGEMENT LA English DT Article DE Fourier series; Load forecasting; Neural network applications; Spectral analysis; Time series ID SHORT-TERM; TIME-SERIES; LOAD; IMPLEMENTATION; METHODOLOGY; CONSUMPTION AB Medium-term electric energy demand forecasting is a useful tool for grid maintenance planning and market research of electric energy companies. Several methods, such as ARIMA, regression or artificial intelligence, have been usually used to carry out those predictions. Some approaches include weather or economic variables, which strongly influence electric energy demand. Economic variables usually influence the general series trend, while weather provides a periodic behavior because of its seasonal nature. This work investigates the periodic behavior of the Spanish monthly electric demand series, obtained by rejecting the trend from the consumption series. A novel hybrid approach is proposed: the periodic behavior is forecasted with a Fourier series while the trend is predicted with a neural network. Satisfactory results have been obtained, with a lower than 2% MAPE, which improve those reached when only neural networks or ARIMA were used for the same purpose. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Gonzalez-Romera, E.; Jaramillo-Moran, M. A.; Carmona-Fernandez, D.] Univ Extremadura, Sch Ind Engn, E-06071 Badajoz, Spain. RP Gonzalez-Romera, E, Univ Extremadura, Sch Ind Engn, Avda Elvas S-N, E-06071 Badajoz, Spain. 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Manag. PD NOV PY 2008 VL 49 IS 11 SI Sp. Iss. SI BP 3135 EP 3142 DI 10.1016/j.enconman.2008.06.004 PG 8 SC Thermodynamics; Energy & Fuels; Mechanics; Physics, Nuclear GA 372JS UT ISI:000260898500023 ER PT J AU Lopez, SR AF Ruano Lopez, Soledad TI Culture and television. A controversial relation SO COMUNICAR LA Spanish DT Article DE Television; public; private; generalist; culture; quality AB From the birth of the public television in Europe, media has been related with cultural and divulging objectives. Nevertheless, it is necessary to admit that the relation between television and culture have always been difficult or al least controversial. Until the eighties there seemed to exist a mutual respect among each other but since the loss of monopoly on the part of the public European chains the relation has been getting worse. Public television has got involved in drag by a crazy race for audience rates where programmes on or with cultural values have been progressively diminished. C1 Univ Extremadura, Area Comunicac Audiovisual Badajoz, E-06071 Badajoz, Spain. RP Lopez, SR, Univ Extremadura, Area Comunicac Audiovisual Badajoz, E-06071 Badajoz, Spain. EM solruano@unex.es CR 2005, CONTENIDOS CULTURALE *PBS, 1969, CAD PUBL PREST EEUU CEBRIAN HM, 2004, MODELOS TELEVISION G, P51 PALACIOS M, 2001, HIST TELEVISION ESPA, P171 RICHERI G, 1994, TRANSICION TELEVISIO RODRIGUEZ PF, 2003, CULTURA TELEVISION R, P62 WOLTON D, 1995, ELOGIO GRAN PUBLICO NR 7 TC 0 PU GRUPO COMUNICAR PI HUELVA PA APDO CORREOS 527, HUELVA, 21080, SPAIN SN 1134-3478 J9 COMUNICAR JI Comunicar PD MAR PY 2007 IS 28 BP 177 EP 182 PG 6 SC Communication GA 364HA UT ISI:000260325600019 ER PT J AU Cordeiro, A Sanchez-Sevilla, J Alvarez-Tinaut, M Gomez-Jimenez, M AF Cordeiro, A. I. Sanchez-Sevilla, J. F. Alvarez-Tinaut, M. C. Gomez-Jimenez, M. C. TI Genetic diversity assessment in Portugal accessions of Olea europaea by RAPD markers SO BIOLOGIA PLANTARUM LA English DT Article DE olive cultivars; UPGMA ID AMPLIFIED POLYMORPHIC DNA; SIMPLE SEQUENCE REPEATS; OLIVE CULTIVARS; SSR MARKERS; L.; VARIETIES; CAPACITY; PRIMERS; TISSUE; ISSR AB Eighty seven olive (Olea europaea ssp. sativa L.) cultivar accessions from Portugal were characterized by means of randomly amplified polymorphic DNA (RAPD) markers. Of the 11 arbitrary 10-mer primers tested a total of 92 polymorphic bands were obtained, representing 87.6 % of the total amplification products. Twenty nine different genotypes were clearly discriminated. Differences were not found among the amplification profiles from different individuals of the same cultivar. All the genotypes could be identified by the combination of three primers: OPR-1, OPK-14 and OPA-1, seven genotype-specific markers being detected. Genetic relationships were estimated by the unweighted pair-group method with arithmetic averaging (UPGMA). The genetic analysis of the results showed a gradual distance between the various cultivars, making it difficult to identify well-differentiated phylogenetic groups, although two clusters were distinguishable with 35 % similarity, in addition to three independent branches with lower similarity: Galega, Tentilheira and Redondal. The dendrogram reflect some relationships for most of the cultivars according to the use of the fruit and ecological adaptation. C1 [Alvarez-Tinaut, M. C.; Gomez-Jimenez, M. C.] Univ Extremadura, Dept Biol & Prod Vegetales, Area Fisiol Vegetal, Fac Ciencias, E-06071 Badajoz, Spain. [Cordeiro, A. I.] ENMP INIAP, Dept Olivicultura, P-7350951 Elvas, Portugal. [Sanchez-Sevilla, J. F.] IFAPA CICE Junta Andalucia, Lab Bioquim, Dept Agr Litoral, Malaga, Spain. RP Gomez-Jimenez, M, Univ Extremadura, Dept Biol & Prod Vegetales, Area Fisiol Vegetal, Fac Ciencias, Avda Elvas S-N, E-06071 Badajoz, Spain. EM mcgomez@unex.es FU Ministerio da Agricultura do Desenvolvimento Rural e das Pescas, Portugal ; Government of Portugal FX This project was partially funded by the Ministerio da Agricultura do Desenvolvimento Rural e das Pescas, Portugal. AIC was granted with a fellowship from the Government of Portugal. 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Plant. PD DEC PY 2008 VL 52 IS 4 BP 642 EP 647 DI 10.1007/s10535-008-0125-1 PG 6 SC Plant Sciences GA 370PH UT ISI:000260773600006 ER PT J AU Jensen, S AF Jensen, Soren TI Trace Fossil Analysis SO SCIENCE LA English DT Book Review C1 [Jensen, Soren] Univ Extremadura, Fac Ciencias, Area Paleontol, E-06071 Badajoz, Spain. RP Jensen, S, Univ Extremadura, Fac Ciencias, Area Paleontol, E-06071 Badajoz, Spain. EM soren@unex.es CR RASMUSSEN B, 2002, SCIENCE, V296, P1112 SEILACHER A, 1998, SCIENCE, V282, P80 SEILACHER A, 2007, TRACE FOSSIL ANAL NR 3 TC 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD NOV 14 PY 2008 VL 322 IS 5904 BP 1051 EP 1052 DI 10.1126/science.1166220 PG 2 SC Multidisciplinary Sciences GA 371YD UT ISI:000260867700018 ER PT J AU Branco, A Parejo, FM AF Branco, Amelia Parejo, Francisco M. TI INCENTIVES OR OBSTACLES? INSTITUTIONAL ASPECTS OF THE CORK BUSINESS IN THE IBERIAN PENINSULA (1930-1975) SO REVISTA DE HISTORIA ECONOMICA LA English DT Article DE Portugal; Spain; cork; cork trade; economic policy AB The quantitative and comparative analysis of Spanish and Portuguese cork exportations during the 20(th) century shows that Spain lost its leading position in the world trade of transformed cork while Portugal rose to claim first place. This article takes a step towards identifying the institutional aspects behind the different paths taken by the cork business in the two countries between 1930 and 1975. Starting with a comparative analysis of the legal framework and economic policies which had an impact on the various branches of business during the two Iberian dictatorships, it is argued that Salazar and Franco attributed different degrees of importance to the cork sector. It concludes that these institutional aspects explain a part of the loss of competitiveness of Spanish exports in comparison with Portuguese exports, insofar as they influenced the extent to which the two economies participated in international trade flows as well as production costs in the industry. C1 [Branco, Amelia] Univ Tecn Lisbon, Dept Ciencias Sociais, ISEG, P-1200781 Lisbon, Portugal. [Parejo, Francisco M.] Univ Extremadura, Fac Ciencias Econ, Area Hist & Instituc Econ, E-06071 Badajoz, Spain. RP Branco, A, Univ Tecn Lisbon, Dept Ciencias Sociais, ISEG, Rua Miguel Lupi 20 4 Andar Gab 412, P-1200781 Lisbon, Portugal. 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Hist. Econ. PD SPR PY 2008 VL 26 IS 1 BP 17 EP 43 PG 27 SC Economics; History GA 365KT UT ISI:000260406000002 ER PT J AU Ulzurrun, E Lucena, MI Martinez, C Garcia-Martin, E Borraz, Y Fernandez, MC Romero-Gomez, M Castiella, A Planas, R Costa, J Anzola, S Andrade, RJ Agundez, JA AF Ulzurrun, E. Lucena, M. I. Martinez, C. Garcia-Martin, E. Borraz, Y. Fernandez, M. C. Romero-Gomez, M. Castiella, A. Planas, R. Costa, J. Anzola, S. Andrade, R. J. Agundez, J. A. CA Spanish Grp Study Drug Induced Liv; GEHAM TI GLUTATHIONE-S-TRANSFERASE M1 AND T1 NULL GENOTYPES INCREASE SUSCEPTIBILITY TO IDIOSYNCRATIC DRUG-INDUCED LIVER INJURY SO METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY LA English DT Meeting Abstract C1 [Ulzurrun, E.; Lucena, M. I.; Borraz, Y.] Hosp Univ Virgen Victoria, Serv Farmacol Clin, Fac Med, Malaga, Spain. [Martinez, C.; Agundez, J. A.] Univ Extremadura, Fac Med, Dept Farmacol, Badajoz, Spain. [Garcia-Martin, E.] Univ Extremadura, Fac Ciencias, Dept Bioquim & Biol Mol & Genet, Badajoz, Spain. [Fernandez, M. C.] Hosp Torrecardenas, Serv Farmacol Clin & Aparato Digest, Almeria, Spain. [Romero-Gomez, M.] Serv Aparato Digest, Seville, Spain. [Castiella, A.] Serv Aparato Digest, Guipuzcoa, Spain. [Planas, R.; Costa, J.; Anzola, S.] Serv Farmacol Clin, Badalona, Spain. [Andrade, R. J.] Hosp Univ Virgen Victoria, Fac Med, Unidad Hepatol, Malaga, Spain. NR 0 TC 0 PU PROUS SCIENCE, SA PI BARCELONA PA PO BOX 540, PROVENZA 388, 08025 BARCELONA, SPAIN SN 0379-0355 J9 METH FIND EXP CLIN PHARMACOL JI Methods Find. Exp. Clin. Pharmacol. PY 2008 VL 30 SU Suppl. 2 BP 134 EP 134 PG 1 SC Pharmacology & Pharmacy GA 368NR UT ISI:000260629400121 ER PT J AU Martin-Montanez, E Lopez-Tellez, JF Acevedo, MJ Lopez-Aranda, MF Blanco, E Navarro-Lobato, I Masmudi-Martin, M Gonzalez, A Guatteo, E Koulen, P Khan, ZU AF Martin-Montanez, E. Lopez-Tellez, J. F. Acevedo, M. J. Lopez-Aranda, M. F. Blanco, E. Navarro-Lobato, I. Masmudi-Martin, M. Gonzalez, A. Guatteo, E. Koulen, P. Khan, Z. U. TI L-TYPE CALCIUM CHANNEL BLOCKAGE BY THE PROTEINS 101 AND 102 SO METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY LA English DT Meeting Abstract C1 [Martin-Montanez, E.] Univ Malaga, Dept Farmacol, E-29071 Malaga, Spain. [Gonzalez, A.] Univ Extremadura, Fac Vet, Badajoz, Spain. [Guatteo, E.] IRCCS, Fdn Santalucia, Rome, Italy. [Koulen, P.] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX USA. NR 0 TC 0 PU PROUS SCIENCE, SA PI BARCELONA PA PO BOX 540, PROVENZA 388, 08025 BARCELONA, SPAIN SN 0379-0355 J9 METH FIND EXP CLIN PHARMACOL JI Methods Find. Exp. Clin. Pharmacol. PY 2008 VL 30 SU Suppl. 2 BP 168 EP 168 PG 1 SC Pharmacology & Pharmacy GA 368NR UT ISI:000260629400177 ER PT J AU Araujo, N Banos, M Gil, MV Caceres, LE Roman, E Serrano, JA AF Araujo, Noelia Banos, Manuel Gil, Maria V. Caceres, Luis E. Roman, Emilio Serrano, Jose A. TI New C-aryl alditols from Diels-Alder adducts of sugar nitroalkenes SO ARKIVOC LA English DT Article DE Nitro compounds; C-aryl alditols; anhydro derivatives; C-nucleosides; aromatization ID DERIVATIVES; NUCLEOSIDES; DEHYDRATION; FURAN AB 2-Nitro-, 2-amino- and 2-acetamido-1-(penta-O-acetylpentitol-1'-yl) benzenes were prepared using previously reported Diels-Alder cycloadducts obtained from sugar-derived nitroalkenes with D-galacto and D-manno configurations as starting materials. Deacetylation and oxidative cleavage of the sugar side-chain of nitrobenzene pentitol peracetates yielded nitrobenzaldehydes. From 2-nitro-1-(D-galacto-pentitol-1'-yl) benzene also 1', 4'- and 2', 5'-anhydro derivatives were synthesized. C1 [Araujo, Noelia; Banos, Manuel; Gil, Maria V.; Caceres, Luis E.; Roman, Emilio; Serrano, Jose A.] Univ Extremadura, Fac Ciencias, Dept Quim Organ & Inorgan, E-06071 Badajoz, Spain. RP Roman, E, Univ Extremadura, Fac Ciencias, Dept Quim Organ & Inorgan, E-06071 Badajoz, Spain. 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J. Ortega-Olivencia, A. Rodriguez-Riano, T. TI Germination and seed bank biology in some Iberian populations of Anagyris foetida L. (Leguminosae) SO PLANT SYSTEMATICS AND EVOLUTION LA English DT Article DE Anagyris foetida; Dispersion; Dormancy; Mediterranean region; Mimicry; Predation; Sheep; Stinking bean trefoil ID DISPERSAL; SOIL; FABACEAE; PLANT; TEMPERATURE; RECRUITMENT; DORMANCY; ECOLOGY; FIRE; GENISTEAE AB In Anagyris foetida, the fruits are disseminated by fall under gravity. No dispersing agent is as yet known, so that the fruits are located near the mother plant. The species presents an important seed bank that differs between the two populations studied, probably due to their different production of seeds/individual and to the livestock pressure. The germination of control seeds was found to be null or very low, with no improvement following exposure to high temperatures, but reaching high values following scarification in all the populations studied. This indicates that the failure in germination must be attributed to the hardness of the testa, with the seeds presenting physical dormancy. Also, the browsing of sheep on ripe fruit increases germination to 48% due to mechanical scarification, with this being the only positive effect those animals have on these plants. There were differences in germination after scarification between populations and years which could have been due to intrinsic characteristics. C1 [Valtuena, F. J.; Ortega-Olivencia, A.; Rodriguez-Riano, T.] Univ Extremadura, Fac Ciencias, Area Bot, E-06071 Badajoz, Spain. RP Ortega-Olivencia, A, Univ Extremadura, Fac Ciencias, Area Bot, Avda Elvas S-N, E-06071 Badajoz, Spain. EM aortega@unex.es FU Ministry of Education and Science of Spain [BOS2002-00703, CGL2005-00783/BOS]; FEDER ; Ministry to FJV [BES-2003-2187] FX This work was financed by the Ministry of Education and Science of Spain through projects BOS2002-00703 and CGL2005-00783/BOS, both cofinanced by FEDER. A predoctoral grant of that Ministry to FJV (BES-2003-2187) is greatly appreciated. We thank Dr Miguel Gonzalez for statistical assistance and to an anonymous referee for valuable comments on the manuscript. 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Chem. Liq. PY 2008 VL 46 IS 5 BP 564 EP 573 DI 10.1080/00319100801993399 PG 10 SC Chemistry, Physical; Physics, Condensed Matter GA 365CF UT ISI:000260382800011 ER PT J AU Tejeda, JF Pena, RE Andres, AI AF Florendo Tejeda, Juan Pena, Ramon E. Andres, Ana I. TI Effect of live weight and sex on physico-chemical and sensorial characteristics of Merino lamb meat SO MEAT SCIENCE LA English DT Article DE Lamb; Slaughter weight; Sex; Meat quality ID FATTY-ACID-COMPOSITION; SLAUGHTER WEIGHT; SUCKLING LAMBS; CARCASS CHARACTERISTICS; CROSSBRED LAMBS; PRODUCTION SYSTEMS; RASA ARAGONESA; LIGHT LAMBS; QUALITY; BREED AB Forty-eight lamb carcasses were divided into four groups (n = 12) according to slaughter weight (24 and 29 kg) and sex (male and female). Colour, pH, moisture, and intramuscular fat were not affected (p > 0.05) by slaughter weight or sex. With respect to fatty acid composition, slaughter weight had significant effects on C12:0 (p < 0.01), C14:0, C16:0, and C18:1 n-9 (p < 0.05) in Longissimus lumborum (LL) muscle. The percentage of C12:0 and C14:0 decreased as slaughter weight increased, while C16:0 increased. In Semimembranosus (SM) m., only C18:3 n-3 and C20:2 n-6 were affected (p < 0.001) by slaughter weight. Total PUFA in LL m. was greater (p < 0.01) in females than in males. Although in general, sensorial quality was not significantly affected by slaughter weight or sex, meat from lighter lambs (24 kg) had greater general acceptability than meat from heavier lambs (29 kg). (C) 2008 Elsevier Ltd. All rights reserved. C1 [Florendo Tejeda, Juan; Pena, Ramon E.; Andres, Ana I.] Univ Extremadura, Escuela Ingn Agr, E-06071 Badajoz, Spain. RP Tejeda, JF, Univ Extremadura, Escuela Ingn Agr, Ctra Caceres S-N, E-06071 Badajoz, Spain. 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PD DEC PY 2008 VL 80 IS 4 BP 1061 EP 1067 DI 10.1016/j.meatsci.2008.04.026 PG 7 SC Food Science & Technology GA 363VC UT ISI:000260294000014 ER PT J AU Martin, D Antequera, T Muriel, E Perez-Palacios, T Ruiz, J AF Martin, Diana Antequera, Teresa Muriel, Elena Perez-Palacios, Trinidad Ruiz, Jorge TI Effect of dietary conjugated linoleic acid in combination with monounsaturated fatty acids on the meat composition and quality traits of dry-cured loin SO MEAT SCIENCE LA English DT Article DE Conjugated linoleic acid; Monounsaturated fatty acids; Pork; Dry-cured meat products ID SENSORY CHARACTERISTICS; LIPID OXIDATION; ALPHA-TOCOPHEROL; IBERIAN HAM; PRODUCTS; TISSUES; MUSCLE; PIGS; RNA AB Three levels (0%, 1% and 2%) of an enriched conjugated linoleic acid oil (CLA) were combined with two levels of mono unsaturated fattyacids (MUFA)(low -19% average and high -39% average) for pig feeding. Composition, weight losses, lipid oxidation (thiobarbituric acid test, TBARs), change in the fatty acid content of the lipid fractions and sensory analysis of dry-cured loin as affected by dietary CLA, MUFA and CLA x MUFA interaction were studied. CLA and CLA x MUFA did not affect moisture and intramuscular fat content of dry-cured loin, weight losses during the processing, changes in the content of most fatty acids from lipid fractions and sensory traits. CLA and MUFA supplementation led to lower TBARs values (1.3 mg MDA/kg sample for 0% CLA and 0.9 mg MDA/kg sample for 2% CLA: 1.2 mg MDA/kg sample for low MUFA diets and 0.9 mg MDA/kg sample for high MUFA diets), the highest TBARs values being detected for 0% CLA-low MUFA diets [1.5 mg MDA/kg sample]. The combination of dietary CLA with different MUFA levels in pig diets did not affect most composition and quality traits of dry-cured loin. Dietary CLA and MUFA seemed to lead to lower lipid oxidation in this product. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Martin, Diana; Antequera, Teresa; Muriel, Elena; Perez-Palacios, Trinidad; Ruiz, Jorge] Univ Extremadura, Fac Vet, Caceres 10071, Spain. RP Ruiz, J, Univ Extremadura, Fac Vet, Avda Univ S-N, Caceres 10071, Spain. EM jruiz@unex.es FU Ministerio de Educacion y Ciencia, Spain [AGL 2003-03538] FX This research was supported by the Ministerio de Educacion y Ciencia, Spain (AGL 2003-03538). CLA was generously provided by BASF. The valuable cooperation of Dr. Clemente Lopez-Bote and Dra. Elena Gonzalez as well as the collaboration of I + D Agropecuaria in designing the experimental diets, sampling and pig management are also acknowledged. Diana Martin thanks the Ministerio de Educacion y Ciencia for funding her research. 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PD DEC PY 2008 VL 80 IS 4 BP 1309 EP 1319 DI 10.1016/j.meatsci.2008.06.006 PG 11 SC Food Science & Technology GA 363VC UT ISI:000260294000050 ER PT J AU Plaza, A Chang, CI AF Plaza, Antonio Chang, Chein-I TI Special Issue on High Performance Imaging PREFACE SO INTERNATIONAL JOURNAL OF HIGH PERFORMANCE COMPUTING APPLICATIONS LA English DT Editorial Material C1 [Plaza, Antonio] Univ Extremadura, Tech Sch Caceres, Dept Technol Comp & Commun, E-10071 Caceres, Spain. [Chang, Chein-I] Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, RSSIPL, Baltimore, MD 21250 USA. RP Plaza, A, Univ Extremadura, Tech Sch Caceres, Dept Technol Comp & Commun, 1000 Hilltop Circle, E-10071 Caceres, Spain. EM aplaza@unex.es NR 0 TC 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1094-3420 J9 INT J HIGH PERFORM COMPUT APP JI Int. J. High Perform. Comput. Appl. PD NOV PY 2008 VL 22 IS 4 SI Sp. Iss. SI BP 363 EP 365 DI 10.1177/1094342007088375 PG 3 SC Computer Science, Hardware & Architecture; Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods GA 364MO UT ISI:000260340000001 ER PT J AU Plaza, A Chang, CI AF Plaza, Antonio Chang, Chein-I TI CLUSTERS VERSUS FPGA FOR PARALLEL PROCESSING OF HYPERSPECTRAL IMAGERY SO INTERNATIONAL JOURNAL OF HIGH PERFORMANCE COMPUTING APPLICATIONS LA English DT Article DE hyperspectral imaging; commodity clusters; reconfigurable computing; hyperspectral data processing chain; pixel purity index ID ALGORITHMS; PERFORMANCE AB Hyperspectral imaging is a new technique in remote sensing that generates images with hundreds of spectral bands, at different wavelength channels, for the same area on the surface of the Earth. Although in recent years several efforts have been directed toward the incorporation of parallel and distributed computing in hyperspectral image analysis, there are no standardized architectures for this purpose in remote sensing missions. To address this issue, this paper develops two highly innovative implementations of a standard hyperspectral data processing chain utilized, among others, in commercial software tools such as Kodak's Research Systems ENVI software package ( one of the most popular tools currently available for processing remotely sensed data). It should be noted that the full hyperspectral processing chain has never been implemented in parallel in the past. Analytical and experimental results are presented in the context of a real application, using hyperspectral data collected by NASA's Jet Propulsion Laboratory over the World Trade Center area in New York City, shortly after the terrorist attacks of September 11th 2001. The parallel implementations are tested in two different platforms, including Thunderhead, a massively parallel Beowulf cluster at NASA's Goddard Space Flight Center, and a Xilinx Virtex-II field programmable gate array (FPGA) device. Combined, these platforms deliver an excellent snapshot of the state-of-the-art in those areas, and offer a thoughtful perspective on the potential and emerging challenges of incorporating parallel processing systems into realistic hyperspectral imaging problems. C1 [Plaza, Antonio] Univ Extremadura, Tech Sch Caceres, Dept Technol Comp & Commun, E-10071 Caceres, Spain. [Chang, Chein-I] Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, RSSIPL, Baltimore, MD 20250 USA. RP Plaza, A, Univ Extremadura, Tech Sch Caceres, Dept Technol Comp & Commun, Avda Univ S-N, E-10071 Caceres, Spain. EM aplaza@unex.es FU European Commission [MRTN-CT-2006-035927]; Spanish Ministry of Education and Science [PR2003-0360] FX This research was supported in part by the European Commission through the Marie Curie Research Training Network project Hyperspectral Imaging Network (MRTN-CT-2006-035927). The authors would like to gratefully thank John E. Dorband, James C. Tilton and J. Anthony Gualtieri for several helpful discussions, and also for their collaboration on experimental results using the Thunderhead Beowulf cluster at NASA's Goddard Space Flight Center. The first author would also like to acknowledge support received from the Spanish Ministry of Education and Science (Fellowship PR2003-0360), which allowed him to conduct postdoctoral research at NASA's Goddard Space Flight Center and University of Maryland, Baltimore County in 2004. Last but not least, the authors gratefully acknowledge the anonymous reviewers for their fruitful suggestions and comments, which greatly helped increase the quality and presentation of the manuscript. 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SI BP 366 EP 385 DI 10.1177/1094342007088376 PG 20 SC Computer Science, Hardware & Architecture; Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods GA 364MO UT ISI:000260340000002 ER PT J AU Valencia, D Lastovetsky, A O'Flynn, M Plaza, A Plaza, J AF Valencia, David Lastovetsky, Alexey O'Flynn, Maureen Plaza, Antonio Plaza, Javier TI PARALLEL PROCESSING OF REMOTELY SENSED HYPERSPECTRAL IMAGES ON HETEROGENEOUS NETWORKS OF WORKSTATIONS USING HETEROMPI SO INTERNATIONAL JOURNAL OF HIGH PERFORMANCE COMPUTING APPLICATIONS LA English DT Article DE heterogeneous parallel computing; hyperspectral image processing; HeteroMPI; mathematical morphology; performance evaluation ID CLASSIFICATION; COMPUTERS; ALGORITHM AB The development of efficient techniques for transforming massive volumes of remotely sensed hyperspectral data into scientific understanding is critical for space-based Earth science and planetary exploration. Although most available parallel processing strategies for information extraction and mining from hyperspectral imagery assume homogeneity in the underlying computing platform, heterogeneous networks of computers (HNOCs) have become a promising cost-effective solution, expected to play a major role in many on-going and planned remote sensing missions. In this paper, we develop a new morphological parallel algorithm for hyperspectral image classification using HeteroMPI, an extension of MPI for programming high-performance computations on HNOCs. The main idea of HeteroMPI is to automate and optimize the selection of a group of processes that executes a heterogeneous algorithm faster than any other possible group in a heterogeneous environment. In order to analyze the impact of many-to-one ( gather) communication operations introduced by our proposed algorithm, we resort to a recently proposed collective communication model. The parallel algorithm is validated using two heterogeneous clusters at University College Dublin and a massively parallel Beowulf cluster at NASA's Goddard Space Flight Center. C1 [Valencia, David; Plaza, Antonio; Plaza, Javier] Univ Extremadura, Tech Sch Caceres, Dept Technol Comp & Commun, E-10071 Caceres, Spain. [Lastovetsky, Alexey; O'Flynn, Maureen] Univ Coll Dublin, Sch Comp Sci & Informat, Heterogeneous Comp Lab, Dublin 4, Ireland. RP Valencia, D, Univ Extremadura, Tech Sch Caceres, Dept Technol Comp & Commun, E-10071 Caceres, Spain. EM alexey.lastovetsky@ucd.ie CR ACHALAKUL T, 2003, J PARALLEL DISTR COM, V63, P373, DOI 10.1016/S0743-7315(03)00017-0 BRIGHTWELL R, 2000, PARALLEL COMPUT, V26, P243 CHANG CI, 2003, HYPERSPECTRAL IMAGIN DHODHI MK, 1999, J PARALLEL DISTR COM, V59, P280 DONGARRA J, 1996, MPI COMPLETE REFEREN DORBAND J, 2003, J SPACE COMMUNICATIO, V1, P23 KALLURI SNV, 2001, INT J REMOTE SENS, V22, P2171 LASTOVETSKY A, 2002, PARALLEL COMPUT, V28, P1369 LASTOVETSKY A, 2003, PARALLEL COMPUTING H LASTOVETSKY A, 2006, J PARALLEL DISTR COM, V66, P197, DOI 10.1016/j.jpdc.2005.08.002 LASTOVETSKY A, 2006, P INT C PAR DISTR SY, V2 LASTOVETSKY A, 2007, P 21 IEEE INT PAR DI LEMOIGNE J, 2002, IEEE T GEOSCI REMOTE, V40, P1849, DOI 10.1109/TGRS.2002.802501 PLAZA A, 2002, IEEE T GEOSCI REMOTE, V40, P2025, DOI 10.1109/TGRS.2002.802494 PLAZA A, 2005, IEEE T GEOSCI REMOTE, V43, P466, DOI 10.1109/TGRS.2004.841417 PLAZA A, 2006, J PARALLEL DISTR COM, V66, P345, DOI 10.1016/j.jpdc.2005.10.001 PLAZA A, 2007, HIGH PERFORMANCE COM PLAZA A, 2007, J SUPERCOMPUT, V40, P81, DOI 10.1007/s11227-006-0015-2 RICHARDS J, 2005, REMOTE SENSING DIGIT SOILLE P, 2003, MORPHOLOGICAL IMAGE TILTON JC, 2005, 09839147, US, APPL TILTON JC, 2007, HIGH PERFORMANCE COM VALENCIA D, 2006, P 5 INT S PAR DISTR, V1, P301 WANG P, 2002, PARALLEL COMPUT, V28, P53 NR 24 TC 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1094-3420 J9 INT J HIGH PERFORM COMPUT APP JI Int. J. High Perform. Comput. Appl. PD NOV PY 2008 VL 22 IS 4 SI Sp. Iss. SI BP 386 EP 407 DI 10.1177/1094342007088377 PG 22 SC Computer Science, Hardware & Architecture; Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods GA 364MO UT ISI:000260340000003 ER PT J AU Anton, M Serrano, A Cancillo, ML Garcia, JA AF Anton, M. Serrano, A. Cancillo, M. L. Garcia, J. A. TI Total ozone and solar erythemal irradiance in southwestern Spain: Day-to-day variability and extreme episodes SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID UV-B RADIATION; ULTRAVIOLET-RADIATION; TIME SCALES; FLUCTUATIONS; ATMOSPHERE; REDUCTION; LATITUDE; CLOUDS AB This paper focuses on the influence of short-term changes in total ozone column ( TOC) on the variability of ultraviolet erythemal irradiance ( UVER) at Badajoz ( southwestern Spain). The study is performed on clear sky cases when the contribution of cloudiness and aerosols can be neglected. The period of study extends from 2001 to 2005. The results show that a reduction of 5% in TOC between two consecutive days may cause an increase of about 10% in UVER. The UVER variability associated to day-to-day changes in TOC presents a clear seasonal cycle with minimum values in summer and maximum in winter. Considering the monthly mean TOC value plus/minus two standard deviation as thresholds for identifying extreme events, the number of episodes with extreme low and high ozone amount was 54 and 9, respectively. The low ozone events occurred mainly in winter, causing a maximum increase of 30% in UVER. Citation: Anton, M., A. Serrano, M. L. Cancillo, and J. A. Garcia (2008), Total ozone and solar erythemal irradiance in southwestern Spain: Day-to-day variability and extreme episodes, Geophys. Res. Lett., 35, L20804, doi: 10.1029/2008GL035290. C1 [Anton, M.; Serrano, A.; Cancillo, M. L.; Garcia, J. A.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Anton, M, Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. EM mananton@unex.es FU MEC [CGL2005-05693-C03-03]; Junta de Extremadura [GRU07126] FX This work has been partially supported by MEC under project CGL2005-05693-C03-03/CLI by the Junta de Extremadura under "Convenio para la creacion y mantenimiento de una red de medida de la radiacion solar ultravioleta en Extremadura'' and under the project GRU07126. CR *WORLD MET ORG, 2006, 50 WORLD MET ASS SCI ALADOSARBOLEDAS L, 2003, ATMOS RES, V66, P273, DOI 10.1016/S0169-8095(03)00027-9 ANTON M, 2007, GEOPHYS RES LETT, V34, P10808 ANTON M, 2008, ANN GEOPHYS-GERMANY, V26, P401 BAIS AF, 1993, J GEOPHYS RES-ATMOSP, V98, P5199 BARSBY J, 1995, J GEOPHYS RES-ATMOS, V100, P3023 BERNHARD G, 2004, J GEOPHYS RES-ATMOS, V109, ARTN D21207 BOJKOV RD, 2001, ANN GEOPHYS, V19, P797 BORKOWSKI JL, 2008, ANN GEOPHYS-GERMANY, V26, P441 CALBO J, 2005, REV GEOPHYS, V43, ARTN RG2002 CANADA J, 2000, J GEOPHYS RES, V105, P4766 CANCILLLO ML, 2005, PHOTOCHEM PHOTOBIOL, V81, P860 DENOUTER PN, 2005, J GEOPHYS RES-ATMOS, V110, ARTN D02203 DIFFEY B, 2004, PHYS MED BIOL, V49, R1 DIFFEY BL, 1991, PHYS MED BIOL, V36, P299 DOBSON GMB, 1926, P R SOC LOND A-CONTA, V110, P660 FIOLETOV VE, 2001, J GEOPHYS RES, V106, P2307 FREDERICK JE, 2001, PHOTOCHEM PHOTOBIOL, V74, P771 GALLIANI A, 1996, ANN GEOPHYS-ATM HYDR, V14, P1044 GIL M, 2004, QUADR OZ S EUR COMM GLANDORF M, 2005, THEOR APPL CLIMATOL, V81, P33, DOI 10.1007/s00704-004-0109-9 HANELT D, 2006, J PHOTOCH PHOTOBIO B, V84, P89, DOI 10.1016/j.jphotobiol.2006.01.013 KIEHL JT, 1999, J GEOPHYS RES-ATMOS, V104, P31239 KOCH G, 2005, GEOPHYS RES LETT, V32, P12810 MCKINLAY AF, 1987, CIE J, V6, P21 MCPETERS RD, 1998, TP1998206895 NASA, P1998 NEWSHAM KK, 2005, ENVIRON EXP BOT, V54, P22, DOI 10.1016/j.envexpbot.2004.05.006 NIKULIN G, 2005, ATMOS CHEM PHYS, V5, P3159 ORSOLINI YJ, 2003, Q J ROY METEROL SOC, V129, P3256 PEREZ A, 2002, J ATMOS SOL-TERR PHY, V64, P283 REX M, 2004, GEOPHYS RES LETT, V31, ARTN L04116 SALBY ML, 1993, J GEOPHYS RES-ATMOSP, V98, P2715 STICK C, 2006, ATMOS CHEM PHYS, V6, P1771 VAUGHAN G, 1991, Q J ROY METEOR SOC, V117, P1281 WOHLTMANN I, 2005, GEOPHYS RES LETT, V32, ARTN L09811 NR 35 TC 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD OCT 17 PY 2008 VL 35 IS 20 AR L20804 DI 10.1029/2008GL035290 PG 5 SC Geosciences, Multidisciplinary GA 362DA UT ISI:000260177200002 ER PT J AU Garcia-Martin, E Ayuso, P Martinez, C Agundez, JAG AF Garcia-Martin, Elena Ayuso, Pedro Martinez, Carmen Agundez, Jose A. G. TI Response to the Letter to the Editor regarding "Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals" SO CLINICAL BIOCHEMISTRY LA English DT Letter ID 3 NONSYNONYMOUS POLYMORPHISMS; CLINICAL-MANIFESTATIONS; GENETIC-VARIABILITY; ALLERGIC RHINITIS; ASTHMA; ASSAY C1 [Garcia-Martin, Elena; Ayuso, Pedro] Univ Extremadura, Dept Biochem & Mol Biol, Sch Biol Sci, E-06071 Badajoz, Spain. [Martinez, Carmen; Agundez, Jose A. G.] Univ Extremadura, Dept Pharmacol, Sch Med, E-06071 Badajoz, Spain. RP Garcia-Martin, E, Univ Extremadura, Dept Biochem & Mol Biol, Sch Biol Sci, Avda Elvas S-N, E-06071 Badajoz, Spain. EM elenag@unex.es CR AARSEN PN, 1964, NATURE, V204, P1195 AGUNDEZ JAG, 2006, BASIC CLIN PHARMA S1, V99, P52 AYUSO P, 2007, PHARMACOGENET GENOM, V17, P687 GARCIAMARTIN E, 2006, BASIC CLIN PHARM TOX, V99, P52, DOI 10.1111/j.1365-2222.2007.02769.x GARCIAMARTIN E, 2006, WORLD J GASTROENTERO, V12, P615 GARCIAMARTIN E, 2007, CLIN BIOCHEM, V40, P1339, DOI 10.1016/j.clinbiochem.2007.07.019 GARCIAMARTIN E, 2007, CLIN EXP ALLERGY, V37, P1175, DOI 10.1111/j.1365-2222.2007.02769.x HAMASE K, 2006, J CHROMATOGR A, V1106, P159, DOI 10.1016/j.chroma.2005.08.043 KAZMIERCZAK SC, 1992, ANN CLIN LAB SCI, V22, P155 KLOCKER J, 2004, VASC PHARMACOL, V40, P293, DOI 10.1016/j.vph.2004.02.002 TAKAGI K, 1994, CLIN CHIM ACTA, V226, P67 NR 11 TC 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0009-9120 J9 CLIN BIOCHEM JI Clin. Biochem. PD OCT PY 2008 VL 41 IS 14-15 BP 1260 EP 1261 DI 10.1016/j.clinbiochem.2008.07.002 PG 2 SC Medical Laboratory Technology GA 366MT UT ISI:000260486900023 ER PT J AU Gonzalez, A Pariente, JA Salido, GM AF Gonzalez, Antonio Pariente, Jose A. Salido, Gines M. TI Ethanol impairs calcium homeostasis following CCK-8 stimulation in mouse pancreatic acinar cells SO ALCOHOL LA English DT Article DE Alcohol; Calcium; Cholecystokinin; Pancreas; Imaging; Fluorescence ID MITOCHONDRIAL ACTIVITY; ALCOHOLIC PANCREATITIS; AMYLASE SECRETION; ENZYME ACTIVATION; PLASMA-MEMBRANE; ROS GENERATION; INJURY; THAPSIGARGIN; STORES; DEATH AB fAlcohol consumption has long been associated with cell damage, and it is thought that it is involved in approximately 40% of cases of acute pancreatitis. In the present study, we have investigated the early effects of acute ethanol exposure on cholecystokinin octapeptide (CCK-8)-evoked calcium (Ca2+) signals in mouse pancreatic acinar cells. Cells were loaded with fura-2 and the changes in fluorescence were monitorized using a spectrofluorimeter. Our results show that stimulation of cells with 1 nM CCK-8 led to a transient increase in [Ca2+](c), which consisted of an initial increase followed by a decrease of [Ca2+](c) toward a value close to the prestimulation level. In the presence of 50 film ethanol. CCK-8 lead to a greater Ca2+ mobilization compared to that obtained with CCK-8 alone. The peak of CCK-8-evoked Ca2+ response, the "steady-state level" reached 5 min after stimulation, the rate of decay of [Ca2+](c) toward basal values and the total Ca2+ mobilization were significantly affected by ethanol pretreatment. Thapsigargin (Tps) induced an increase in [Ca2+](c) due to its release from intracellular stores. After stimulation of cells with CCK-8 or Tps in the presence of 50 film ethanol, a greater [Ca2+](c) peak response, a slower rate of decay of [Ca2+](c), and higher values of [Ca2+](c) were observed. The effects of ethanol might result from if delayed or reduced Ca2+ extrusion from the cytosol toward the extracellular space by plasma membrane Ca2+ adenosine triphosphatase (ATPase), or into the cytosolic stores by the sarcoendoplasmic reticulum Ca2+-ATPase. Participation of mitochondria in Ca2+ handling is also demonstrated. The actions of ethanol on CCK-8 stimulation of cells create a situation potentially leading to Ca2+ overload, which is a common pathological precursor that mediates pancreatitis. (C) 2008 Elsevier Inc. All rights reserved. C1 [Gonzalez, Antonio; Pariente, Jose A.; Salido, Gines M.] Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Fac Vet Sci, E-10071 Caceres, Spain. RP Gonzalez, A, Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Fac Vet Sci, Avenida Univ S-N,POB 643, E-10071 Caceres, Spain. EM agmateos@unex.es FU Junta de Extremadura-Consejeria de Educacion ; Ciencia y Tecnologia [2PR04A009] FX This work was supported by Junta de Extremadura-Consejeria de Educacion, Ciencia y Tecnologia (2PR04A009). The authors would like to thank Mrs. Mercedes Gomez Blazquez for her excellent technical support. 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Tormo, Maria A. Campillo, Carlos Carmona, Maria I. Torres, Montana Reymundo, Mercedes Garcia, Purificacion Campillo, Jose E. TI Etiologic and Cardiovascular Risk Factors in Obese Children From Extremadura in Spain. Their Relationship With Insulin Resistance and Plasma Adipocytokine Levels SO REVISTA ESPANOLA DE CARDIOLOGIA LA Spanish DT Article DE Children; Obesity; Cardiovascular risk; Insulin resistance; Adipocytokines; Extremadura ID METABOLIC SYNDROME; CHILDHOOD OBESITY; PHYSICAL-ACTIVITY; ADOLESCENTS; ADIPONECTIN; OVERWEIGHT; POPULATION; PREVALENCE; FREQUENCY; LEPTIN AB Introduction and objectives. The aim was to investigate etiologic and cardiovascular risk factors in obese children from Extremadura, Spain, and their relationship with insulin resistance and plasma adipocytokine levels. Methods. The study included 373 children (age, 3-13 years) who were randomly selected from schools in the city and province of Badajoz and from two health centers in the Spanish autonomous community of Extremadura. Results. Some 9.5% of children were obese. Compared with normal weight children, obese children exhibited a greater weight gain in the first year of life (7.3 +/- 0.5 kg vs. 6.3 +/- 0.8 kg), were less physically active (9.6 +/- 7.2 h/week vs. 13.1 +/- 8.1 h/week), and had more screen time (18.0 +/- 12.4 h/week vs. 12.8 +/- 8.2 h/week), a lower high-density lipoprotein cholesterol level (46.0 +/- 11.4 mg/dL vs. 64.6 +/- 22.9 mg/dL), higher arterial systolic pressure (102.3 +/- 8.5 mmHg vs. 89.9 +/- 13.4 mmHg), increased insulin resistance (6.2 +/- 3.6 vs. 4.6 +/- 4.5), a higher level of leptinemia (24.8 +/- 13.8 ng/mL vs. 12.9 +/- 10.8 ng/mL) and a lower level of adiponectinemia (8.4 +/- 5.7 mu g/mL vs. 15.6 +/- 7.9 mu g/mL). Conclusions. Our findings demonstrate that there is a relationship between a sedentary lifestyle and the development of insulin resistance and altered adipocytokines levels in obese children, and that these changes are related to a number of cardiovascular risk factors. C1 [Torres, Maria D.; Tormo, Maria A.; Campillo, Carlos; Carmona, Maria I.; Campillo, Jose E.] Univ Extremadura, Fac Med, Dept Fisiol, E-06071 Badajoz, Spain. [Torres, Montana; Garcia, Purificacion] Ctr Salud San Jorge, Caceres, Spain. [Reymundo, Mercedes] Ctr Salud La Paz, Badajoz, Spain. RP Campillo, JE, Univ Extremadura, Fac Med, Dept Fisiol, Avda Elvas S-N, E-06071 Badajoz, Spain. 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Esp. Cardiol. PD SEP PY 2008 VL 61 IS 9 BP 923 EP 929 PG 7 SC Cardiac & Cardiovascular Systems GA 359RR UT ISI:000260006300005 ER PT J AU Belletti, F Cotallo, M Cruz, A Fernandez, LA Gordillo-Guerrero, A Guidetti, M Maiorano, A Mantovani, F Marinari, E Martin-Mayor, V Sudupe, AM Navarro, D Parisi, G Perez-Gaviro, S Ruiz-Lorenzo, JJ Schifano, SF Sciretti, D Tarancon, A Tripiccione, R Velasco, JL Yllanes, D AF Belletti, F. Cotallo, M. Cruz, A. Fernandez, L. A. Gordillo-Guerrero, A. Guidetti, M. Maiorano, A. Mantovani, F. Marinari, E. Martin-Mayor, V. Sudupe, A. Munoz Navarro, D. Parisi, G. Perez-Gaviro, S. Ruiz-Lorenzo, J. J. Schifano, S. F. Sciretti, D. Tarancon, A. Tripiccione, R. Velasco, J. L. Yllanes, D. TI Nonequilibrium Spin-Glass Dynamics from Picoseconds to a Tenth of a Second SO PHYSICAL REVIEW LETTERS LA English DT Article ID OFF-EQUILIBRIUM DYNAMICS; ORDERED PHASE; COMPUTER; SYSTEMS; BEHAVIOR; MODELS; IANUS; STATE AB We study numerically the nonequilibrium dynamics of the Ising spin glass, for a time spanning 11 orders of magnitude, thus approaching the experimentally relevant scale (i.e., seconds). We introduce novel analysis techniques to compute the coherence length in a model-independent way. We present strong evidence for a replicon correlator and for overlap equivalence. The emerging picture is compatible with noncoarsening behavior. C1 [Belletti, F.; Guidetti, M.; Maiorano, A.; Mantovani, F.; Schifano, S. F.; Tripiccione, R.] Univ Ferrara, Dipartmento Fis, I-44100 Ferrara, Italy. [Belletti, F.; Guidetti, M.; Maiorano, A.; Mantovani, F.; Schifano, S. F.; Tripiccione, R.] Ist Nazl Fis Nucl, Sez Ferrara, Ferrara, Italy. [Cotallo, M.; Cruz, A.; Fernandez, L. A.; Gordillo-Guerrero, A.; Maiorano, A.; Martin-Mayor, V.; Perez-Gaviro, S.; Ruiz-Lorenzo, J. J.; Sciretti, D.; Tarancon, A.; Velasco, J. L.; Yllanes, D.] Inst Biocomputac & Fis Sistemas Complejos BIFI, Zaragoza, Spain. [Cruz, A.; Tarancon, A.] Univ Zaragoza, Dept Fis Teor, E-50009 Zaragoza, Spain. [Fernandez, L. A.; Martin-Mayor, V.; Sudupe, A. Munoz; Yllanes, D.] Univ Complutense, Dept Fis Teor 1, E-28040 Madrid, Spain. [Gordillo-Guerrero, A.; Ruiz-Lorenzo, J. J.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. [Marinari, E.] Univ Roma La Sapienza, Ist Nazl Fis Nucl, I-00185 Rome, Italy. [Marinari, E.; Parisi, G.] INFM, Dipartimento Fis, I-00185 Rome, Italy. [Navarro, D.] Univ Zaragoza, D Ingn Elect & Comunicac, Zaragoza 50018, Spain. [Navarro, D.] Univ Zaragoza, I3A, Zaragoza 50018, Spain. RP Belletti, F, Univ Ferrara, Dipartmento Fis, I-44100 Ferrara, Italy. FU EU FEDER [UNZA05-33-003]; MEC (Spain) [FIS2006-08533, FIS2007-60977, FPA2004-02602, TEC2007-64188]; Microsoft FX We corresponded with M. Hasenbusch, A. Pelissetto, and E. Vicari. Janus was supported by EU FEDER funds (UNZA05-33-003, MEC-DGA, Spain), and developed in collaboration with ETHlab. We were partially supported by MEC (Spain), through Contracts No. FIS2006-08533, FIS2007-60977, FPA2004-02602, TEC2007-64188; by CAM (Spain), and by Microsoft. 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Rev. Lett. PD OCT 10 PY 2008 VL 101 IS 15 AR 157201 DI 10.1103/PhysRevLett.101.157201 PG 4 SC Physics, Multidisciplinary GA 359CY UT ISI:000259965000059 ER PT J AU Mata, A Marques, D Martinez-Burgos, MA Silveira, J Marques, J Mesquita, MF Pariente, JA Salido, GM Singh, J AF Mata, Antonio Marques, Duarte Martinez-Burgos, Maria A. Silveira, Joao Marques, Joana Mesquita, Maria F. Pariente, Jose A. Salido, Gines M. Singh, Jaipaul TI Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland SO MOLECULAR AND CELLULAR BIOCHEMISTRY LA English DT Article DE Rat; Parotid gland; Calcium; Caspase-3; Amylase; Hydrogen peroxide; Oxidative stress ID PANCREATIC ACINAR-CELLS; OXIDATIVE STRESS; SARCOPLASMIC-RETICULUM; AMYLASE SECRETION; OXYGEN RADICALS; HUMAN PLATELETS; ALPHA-AMYLASE; CA2+; GENERATION; MITOCHONDRIAL AB The parotid glands are highly active secretory systems subjected to continuous stress, which in turn, can lead to several pathophysiological conditions. Damage of the parotid glands are caused by radical oxygen species (ROS) as by-products of oxygen metabolism. This study investigated the effect of hydrogen peroxide (H2O2) on Carbachol (CCh)-evoked secretory responses and caspase-3 activity in the isolated rat parotid gland to understand the role of oxidative stress on the function of the gland. Amylase secretion, cytosolic calcium concentration ([Ca2+](i)) and caspase-3 activity in parotid gland tissue were measured using fluorimetric methods. H2O2 had little or no effect on amylase secretion compared to basal level. Combining H2O2 with CCh resulted in an attenuation of the CCh-evoked amylase secretion compared to the effect of CCh alone. CCh can evoke a large increase in ([Ca2+](i)) comprising an initial peak followed by a plateau. In a Ca2+-free medium containing 1 mM EGTA, CCh evoked only the initial peak of [Ca2+](i). H2O2 alone evoked a gradual and dose-dependent increase in [Ca2+](i). Combining H2O2 with CCh resulted in a decrease in [Ca2+](i) compared to the effect of CCh alone. In a Ca2+-free medium, H2O2 still evoked a small increase in ([Ca2+](i)), but this response was less compared to the results obtained with H2O2 in normal ([Ca2+](0)). Combining H2O2 with CCh resulted in only a small transient increase in ([Ca2+](i)). Following CCh stimulation, H2O2 application resulted in a large increase in ([Ca2+](i)) in normal ([Ca2+](0)). This effect of H2O2 was partially abolished in a nominally free Calcium medium containing EGTA. H2O2 can stimulate caspase-3 activity in parotid gland tissue. Similar response was obtained with betulinic acid and thapsigargin (TPS) on caspase-3 activity compared to basal. The results have demonstrated that like CCh, H2O2 can also mobilise Ca2+ from intracellular stores and facilitate its influx into the cell from extracellular medium. This effect of H2O2 may be due to its activity to induce apoptosis in the parotid gland, since H2O2 can stimulate the activity of caspase-3, a marker of cellular apoptosis. C1 [Singh, Jaipaul] Univ Cent Lancashire, Fac Sci & Technol, Sch Forens & Investigat Sci, Preston PR1 2HE, Lancs, England. [Mata, Antonio; Marques, Duarte; Silveira, Joao; Marques, Joana] Univ Lisbon, Fac Med Dent, UICOB Oral Sci & Biomed Res Grp, P-1649003 Lisbon, Portugal. [Martinez-Burgos, Maria A.; Pariente, Jose A.; Salido, Gines M.] Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Caceres, Spain. [Mesquita, Maria F.] Inst Super Ciencias Saude Egas Moniz, Oral Biol Res Grp, Monte De Caparica, Portugal. RP Singh, J, Univ Cent Lancashire, Fac Sci & Technol, Sch Forens & Investigat Sci, Preston PR1 2HE, Lancs, England. EM jsingh3@uclan.ac.uk FU MEC-DGI BFU [2007-60091] FX This work was supported by MEC-DGI BFU2007-60091. 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Cell. Biochem. PD DEC PY 2008 VL 319 IS 1-2 BP 23 EP 31 DI 10.1007/s11010-008-9873-7 PG 9 SC Cell Biology GA 363UQ UT ISI:000260292800004 ER PT J AU Santamaria, GE Valverde, JV Perez-Aloe, R Vinagre, BM AF Santamaria, Guillermo E. Valverde, Jose V. Perez-Aloe, Raquel Vinagre, Bias M. TI Microelectronic Implementations of Fractional-Order Integrodifferential Operators SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS LA English DT Article DE fractional order operator; field programmable gate array; field programmable analog array; switched capacitor; active filter AB For practical applications, the fractional-order integral and differential operators require to be approximated as stable, causal, minimum-phase integer-order systems, which usually leads, in both continuous and discrete domains, to high order transfer functions. Assuming that art approximation of good quality is available for the fractional operator, efficient implementations, in both cost and speed, are required. The fast development of the microelectronics gives us the opportunity of using cheap, accurate, programmable, and fast devices for implementing reconfigurable analog and digital circuits. Among these devices, field programmable gate arrays, switched capacitor circuits, and field programmable analog arrays are used in this paper for the implementation of a fractional-order integrator, previously approximated by recursive Oustaloups method. The fundamentals of the devices as well as the design procedures are given, and the implementations are compared considering their simulated frequency responses, the design efforts, and other important issues. C1 [Santamaria, Guillermo E.; Valverde, Jose V.; Perez-Aloe, Raquel; Vinagre, Bias M.] Univ Extremadura, Sch Ind Engn, E-06071 Badajoz, Spain. RP Santamaria, GE, Univ Extremadura, Sch Ind Engn, Ave Elvas S-N, E-06071 Badajoz, Spain. EM guillermo.santamariagaldon@telefonica.es valsan@unex.es raquel@unex.es bvinagre@unex.es FU Spanish Ministerio de Educacion y Ciencia [DPI2005-07980-C03-03] FX This work has been partially supported by Research Grant No. DPI2005-07980-C03-03 (Spanish Ministerio de Educacion y Ciencia). 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PD APR PY 2008 VL 3 IS 2 AR 021301 DI 10.1115/1.2833907 PG 6 SC Engineering, Mechanical; Mechanics GA 359QC UT ISI:000260002200013 ER PT J AU Perez, MC Urena, J Hernandez, A Alvarez, FJ Jimenez, A De Marziani, C AF Perez, Ma. Carmen Urena, Jesus Hernandez, Alvaro Alvarez, Fernando J. Jimenez, Ana De Marziani, Carlos TI Efficient Correlator for LS Codes Generated from Orthogonal CSS SO IEEE COMMUNICATIONS LETTERS LA English DT Article DE Code division multiaccess; correlation; pulse compression methods; sequences ID SEQUENCES AB This paper presents a novel method to correlate Loosely Synchronized (LS) codes generated from mutually orthogonal Complementary Sets of Sequences (CSS). The proposed correlator significantly reduces the total number of multiplications and additions to be performed, in comparison with straightforward correlators. This fast correlator, together with the interference free window that LS codes exhibit, make them a good choice for next generation of Wireless communications. C1 [Perez, Ma. Carmen; Urena, Jesus; Hernandez, Alvaro; Jimenez, Ana] Univ Alcala de Henares, Dept Elect, Escuela Politecn, Madrid 28805, Spain. [Alvarez, Fernando J.] Univ Extremadura, Dept Elect Engn Elect & Automat, Fac Ciencias, E-06071 Badajoz, Spain. [De Marziani, Carlos] Natl Univ Patagonia San Juan Bosco, Dept Elect Engn, San Juan, Argentina. RP Perez, MC, Univ Alcala de Henares, Dept Elect, Escuela Politecn, Campus Univ S-N, Madrid 28805, Spain. EM carmen@depeca.uah.es urena@depeca.uah.es alvaro@depeca.uah.es fafranco@unex.es ajimenez@depeca.uah.es marziani@unpata.edu.ar FU Community of Madrid (FPI) [CAM-UAH2006/016]; Spanish Ministry of Science and Technology [TIN2006-14986-CO2-01] FX This work has been possible thanks to the Community of Madrid (FPI grant, INCUBUS project: CAM-UAH2006/016), and to the Spanish Ministry of Science and Technology (RESELAI project: TIN2006-14986-CO2-01). CR LI DB, 2003, IEEE COMMUN MAG, V41, P114 MARZIANI CD, 2007, IEEE T SIGNAL PROCES, V55, P2323 PEREZ MC, 2007, P IEEE INT S IND EL, V1, P1663 STANCZAK S, 2001, P GLOBECOM 01 NOV, V1, P589 TSENG CC, 1972, IEEE T INFORM THEORY, V18, P644 ZHANG C, 2005, IEICE T COMMUN EB, V88, P3484 NR 6 TC 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1089-7798 J9 IEEE COMMUN LETT JI IEEE Commun. Lett. PD OCT PY 2008 VL 12 IS 10 BP 764 EP 766 DI 10.1109/LCOMM.2008.081000 PG 3 SC Telecommunications GA 359PI UT ISI:000260000200022 ER PT J AU Sanchez-Vega, J del Rey, FE Farinas-Seijas, H de Escobar, GM AF Sanchez-Vega, Javier Escobar del Rey, Francisco Farinas-Seijas, Humberto Morreale de Escobar, Gabriella TI Inadequate iodine nutrition of pregnant women from Extremadura (Spain) SO EUROPEAN JOURNAL OF ENDOCRINOLOGY LA English DT Article ID BRAIN-DEVELOPMENT; DEFICIENCY; HYPOTHYROIDISM; DISORDERS AB Objective: To evaluate the iodine nutrition of the pregnant women of the Spanish Autonomous Community Extremadura. There are similar to 10 000 births per year in Extremadura, which historically contains areas with endemic goiter (Las Hurdes). Design: Population study in which a representative sample of pregnant women of the general population was analyzed, along with another sample of pregnant women from traditionally goitrogenic areas. With the collaboration of selected health centers, an additional sample of blood and urine was obtained within the primary health care pregnancy-mointoring program; these samples were sent to a single central laboratory. Methods: Biochemistry; determination of iodine and creatinine in urine, and serum concentrations of thyroxine, free thyroxine, tri-iodothyronine. TSH, thyroglobulin, and two anti-thyroid antibodies. Each parameter was measured by means of a single specific RIA. Results: Changes between the first trimester and later stages of pregnancy of all biochemical variables studied corresponded with those described for other European areas with a comparable iodine nutrition. Using the urinary iodine concentration value as an indicator of iodine ingestion, it was found that in the first trimester of pregnancy six out of ten women from Extremadura ingested less than the currently recommended amount (250 mu g l/day), and approximately three out of ten of these women ingested less than half of this amount. Conclusions: It is imperative to implement in all Extremadura the generalized and controlled use of complements that contain 200-250 mu g/l throughout pregnancy and, if possible, before. C1 [Escobar del Rey, Francisco; Morreale de Escobar, Gabriella] CSIC UAM, Inst Invest Biomed Alberto Sols, Madrid 28029, Spain. [Sanchez-Vega, Javier; Farinas-Seijas, Humberto] Extremadura Univ Hosp & Med Sch, Clin Res Ctr, CICAB, Badajoz 07071, Spain. RP de Escobar, GM, CSIC UAM, Inst Invest Biomed Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain. EM gmorreale@iib.uam.es FU Consejeria de Sanidad, Junta de Extremadura FX This study was carried out with a Grant from Consejeria de Sanidad, Junta de Extremadura. CR 2007, ICCIDD NEWSLETTER, V23, P1 BENOTTI J, 1963, CLIN CHEM, V9, P408 BERBELL P, 2007, TRENDS ENDOCRIN MET, V18, P338, DOI 10.1016/j.tem.2007.08.009 BLEICHRODT N, 1987, PREVENTION CONTROL I, V1, P65 BLEICHRODT N, 1989, IODINE BRAIN, P269 BLEICHRODT N, 1994, DAMAGED BRAIN IODINE, P195 DEBENOIST B, 2007, PUBLIC HEALTH NUTR, V10, A12 DEESCOBAR GA, 2007, PUBLIC HEALTH NUTR, V10, P1554, DOI 10.1017/S1368980007360928 DEESCOBAR GM, 2003, THYROID BRAIN, V1, P33 DEESCOBAR GM, 2004, BEST PRACT RES CL EN, V18, P225, DOI 10.1016/j.beem.2004.03.012 DEESCOBAR GM, 2004, EUROPEAN J ENDOCRINO, V151, P1125 DELREY EE, 1981, Q J MED, V198, P233 FOLIN O, 1914, J BIOL CHEM, V17, P469 GLINOER D, 1991, J CLIN ENDOCR METAB, V73, P421 GLINOER D, 1994, J CLIN ENDOCR METAB, V79, P197 GLINOER D, 1995, J CLIN ENDOCR METAB, V80, P258 GLINOER D, 1997, ENDOCR REV, V18, P404 GLINOER D, 2006, J CLIN ENDOCR METAB, V91, P2500, DOI 10.1210/jc.2006-0834 GLINOER D, 2007, ENDOCRIN DEV, V10, P62 MORREALE DE, 2000, J CLIN ENDOCR METAB, V85, P3975 PIERCE EN, 2007, THYROID, V17, P823 POPPE K, 2003, HUM REPROD UPDATE, V9, P149, DOI 10.1093/humupd/dmg012 VERMIGLIO F, 2004, J CLIN ENDOCR METAB, V89, P6054, DOI 10.1210/jc.2004-0571 ZIMMERMANN MB, 2007, THYROID, V17, P829, DOI 10.1089/thy.2007.0108 NR 24 TC 0 PU BIO SCIENTIFICA LTD PI BRISTOL PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT, ENGLAND SN 0804-4643 J9 EUR J ENDOCRINOLOGY JI Eur. J. Endocrinol. PD OCT PY 2008 VL 159 IS 4 BP 439 EP 445 DI 10.1530/EJE-08-0309 PG 7 SC Endocrinology & Metabolism GA 362AF UT ISI:000260169900012 ER PT J AU Dorado, P Cavaco, I Caceres, MC Piedade, R Ribeiro, V LLerena, A AF Dorado, P. Cavaco, I. Caceres, M. C. Piedade, R. Ribeiro, V. LLerena, A. TI Relationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers SO EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article DE CYP2C8; CYP2C9; Diclofenac; Healthy volunteers; Spaniards ID GENETIC POLYMORPHISMS; CLINICAL-RELEVANCE; METABOLISM; CYTOCHROME-P450; PACLITAXEL; LINKAGE AB Purpose CYP2C8 seems to be involved in diclofenac 5-hydroxylation, while, in vitro, the 4'-hydroxylation and 3'-hydroxylation seem to be mediated mainly by CYP2C9. We have demonstrated the relevance of CYP2C9 genotypes for diclofenac 4'-hydroxylation in healthy volunteers, so that the present study was aimed at analyzing the role of both CYP2C8 and CYP2C9 genotypes on diclofenac metabolism, as well as determining the CYP2C8 allele frequencies and their relationship with CYP2C9 variants. Methods A group of 142 healthy white Spanish volunteers was studied. Previously, 102 of these subjects had been phenotyped with diclofenac and genotyped for CYP2C9. The CYP2C8 genotypes were determined by allele-specific PCR-RFLP methods. The urinary concentrations of diclofenac and its main metabolites were analysed using an HPLC-UV method after the administration of a single oral dose of diclofenac as described previously for part of the population studied here. Results The diclofenac/5-hydroxydiclofenac urinary concentration ratio was higher in individuals carrying a CYP2C8*3 or CYP2C8*4 allele than in those homozygous for wild-type allele CYP2C8*1 (P< 0.05). Moreover, approximately 93% of the subjects with a CYP2C8*3 allele also carried a CYP2C9*2, and 80% of the subjects that had CYP2C9*2 variant also carried a CYP2C8*3. In addition, the four CYP2C9*2/*2 individuals were CYP2C8*3/*3. Conclusions This is the first study showing the influence of CYP2C8 genotypes on diclofenac metabolism in vivo. The linkage disequilibrium between CYP2C8*3 and CYP2C9*2 alleles was confirmed in this Spanish population. C1 [Dorado, P.; Caceres, M. C.; LLerena, A.] Extremadura Univ Hosp, CICAB, Badajoz, Spain. [Dorado, P.; Caceres, M. C.; LLerena, A.] SES, Sch Med, Badajoz, Spain. [Cavaco, I.; Piedade, R.; Ribeiro, V.] Univ Algarve, Inst Biotechnol & Bioengn IBB LA, Ctr Mol & Struct Biomed CBME, Faro, Portugal. RP LLerena, A, Extremadura Univ Hosp, CICAB, Badajoz, Spain. EM allerena@unex.es FU Ministries of Education and Science [SAF2006/13589]; Instituto de Salud Carlos III-FIS, and European Union (FEDER) [PI06/1681, CP/06/0030] FX This study was supported by the Ministries of Education and Science (SAF2006/13589) and Health, the Instituto de Salud Carlos III-FIS, and European Union (FEDER) grants: CIBER-SAM, PI06/1681 and CP/06/0030 ( P. Dorado). The study was coordinated through the networks Red Iberoamericana de Farmacogenetica y Farmacogenomica (CYTED206RT0290). CR BAHADUR N, 2002, BIOCHEM PHARMACOL, V64, P1579 BARBOSASICARD E, 2005, BIOCHEM BIOPH RES CO, V329, P1275, DOI 10.1016/j.bbrc.2005.02.103 BORT R, 1999, BIOCHEM PHARMACOL, V58, P787 CAVACO I, 2005, EUR J CLIN PHARMACOL, V61, P15, DOI 10.1007/s00228-004-0871-8 CAVACO I, 2006, CLIN CHEM LAB MED, V44, P168, DOI 10.1515/CCLM.2006.030 DAI D, 2001, PHARMACOGENETICS, V11, P597 DAVIES NM, 1997, CLIN PHARMACOKINET, V33, P184 DORADO P, 2003, EUR J CLIN PHARMACOL, V59, P221, DOI 10.1007/s00228-003-0588-0 DORADO P, 2003, EUR J DRUG METAB PH, V28, P213 DORADO P, 2003, J CHROMATOGR B, V789, P437, DOI 10.1016/S1570-0232(03)00137-5 DORADO P, 2007, PHARMACOGENOMICS ADM, P60 FINTA C, 2000, GENOMICS, V63, P433 GIL JP, 2007, PHARMACOGENOMICS, V8, P187 PFISTER SL, 2003, ARCH BIOCHEM BIOPHYS, V420, P142, DOI 10.1016/j.abb.2003.09.026 PRITCHARD JK, 2001, AM J HUM GENET, V69, P1 SCHWARZ UI, 2003, EUR J CLIN INVEST S2, V33, P23 TOTAH RA, 2005, CLIN PHARMACOL THER, V77, P341, DOI 10.1016/j.clpt.2004.12.267 YASAR U, 2002, BIOCHEM BIOPH RES CO, V299, P25 NR 18 TC 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0031-6970 J9 EUR J CLIN PHARMACOL JI Eur. J. Clin. Pharmacol. PD OCT PY 2008 VL 64 IS 10 BP 967 EP 970 DI 10.1007/s00228-008-0508-4 PG 4 SC Pharmacology & Pharmacy GA 365RM UT ISI:000260425500004 ER PT J AU Vaz-Leal, FJ Rodriguez-Santos, L Melero, MJ Ramos, MI Monge, M Lopez-Vinuesa, B AF Vaz-Leal, F. J. Rodriguez-Santos, L. Melero, M. J. Ramos, M. I. Monge, M. Lopez-Vinuesa, B. TI Hostility and helper T-cells in patients with bulimia nervosa SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY LA English DT Article DE Eating disorders; bulimia nervosa; psychopathology; immunity; lymphocytes; lymphocyte subsets ID DEXAMETHASONE SUPPRESSION TEST; PITUITARY-ADRENAL-AXIS; DIPEPTIDYL-PEPTIDASE-IV; EATING-DISORDERS; IMMUNE-SYSTEM; ANOREXIA-NERVOSA; NUTRITIONAL-STATUS; MULTIDIMENSIONAL MODEL; SOCIAL SUPPORT; STRESS AB OBJECTIVE: The study aimed to analyze the correlation between lymphocyte counts and several psychopathological variables associated with psychological instability (depression, hostility, impulsivity, self-defeating personality traits, and borderline personality symptoms) in patients with bulimia nervosa (BN). METHOD: Sixty BN patients were assessed, using specific scales for eating pathology, general psychopathology, impulsivity, depression, and borderline personality features. Lymphocyte and lymphocyte subset counts were performed. Plasma cortisol at 8:00, before and after administration of 1mg of dexamethasone at 23:00, was determined. The influence of body weight, and the use of tobacco, alcohol, and caffeine was controlled. The relationship between each isolated variable and the number of immune cells was analyzed. In a second step, supplementary post-hoc analysis of the variables was introduced to confirm the accuracy of the psychopathological assessment. RESULTS: Hostility was negatively correlated with the number of helper T-cells (CD4(+)). Patients with high hostility had lower CD4(+) cell counts and lower CD4(+)/CDB+ ratios. In the post-hoc control study, hostility was significantly related with other "interpersonal" items. CONCLUSIONS: These results support the idea that hostility, as an expression of disturbed interpersonal relationships, could play a role as a modulator of immune activity in patients with BN. C1 [Vaz-Leal, F. J.; Rodriguez-Santos, L.; Ramos, M. I.; Lopez-Vinuesa, B.] Univ Extremadura, Dept Psychiat, Fac Med, E-06071 Badajoz, Spain. [Melero, M. J.] Univ Extremadura, Dept Immunol, Fac Med, E-06071 Badajoz, Spain. [Vaz-Leal, F. J.; Monge, M.; Lopez-Vinuesa, B.] Univ Extremadura, Eating Disorders Unit, Fac Med, Mental Hlth Unit, E-06071 Badajoz, Spain. Univ Hosp Badajoz, Extremadura Hlth Serv, Badajoz, Spain. RP Vaz-Leal, FJ, Univ Extremadura, Dept Psychiat, Fac Med, Avda Elvas S-N, E-06071 Badajoz, Spain. EM fjvaz@unex.es FU Fondo de Investigacion Sanitaria [0211464]; Instituto de Salud Carlos III ; Ministerio de Sanidad y Consumo, Spain ; European Social Found FX This study has been supported by grant 0211464 (Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I). Fondo de Investigacion Sanitaria. Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Spain, and European Social Found. CR ARMSTRONGESTHER CA, 1978, POSTGRAD MED J, V54, P395 BASURTE E, 2004, ACTAS ESP PSIQUIATRI, V32, P149 BECK AT, 1978, BECK DEPRESSION INVE BIONDI M, 1997, PSYCHOTHER PSYCHOSOM, V66, P3 BIRKETVEDT GS, 2006, APPETITE, V46, P164, DOI 10.1016/j.appet.2005.11.007 BRAMBILLA F, 1996, PSYCHIAT RES, V62, P97 BRAMBILLA F, 2001, PHYSIOL BEHAV, V73, P365 BRAMBILLA F, 2006, PSYCHONEUROENDOCRINO, V31, P131, DOI 10.1016/j.psyneuen.2005.06.003 CHANDRA RK, 1999, P NUTR SOC, V58, P681 CHANDRA RK, 2002, EUR J CLIN NUTR S3, V56, S73, DOI 10.1038/sj.ejcn.1601492 CHIAPPELLI F, 1991, PSYCHONEUROENDOCRINO, V16, P423 CHRISTENSEN AJ, 1996, PSYCHOSOM MED, V58, P150 CRUESS DG, 2001, SEMIN CLIN NEUROPSYC, V6, P241 DEJONGE PV, 2003, PSYCHOL MED, V33, P1311, DOI 10.1017/S0033291703007505 DEROGATIS LR, 1977, SYMPTOM CHECKLIST 90 DESOUZA EB, 1995, PSYCHONEUROENDOCRINO, V20, P789 ESTERLING BA, 1996, PSYCHOSOM MED, V58, P264 FICHTER MM, 1990, BIOL PSYCHIAT, V27, P1021 FUKATA S, 1988, JPN J PSYCHIAT NEUR, V42, P59 GLEAVES DH, 1993, J ABNORM PSYCHOL, V102, P173 GLEAVES DH, 1995, J CLIN PSYCHOL, V51, P181 GOODKIN K, 1996, CLIN DIAGN LAB IMMUN, V3, P109 GRANGER DA, 2000, PSYCHOSOM MED, V62, P583 HENDERSON M, 1987, BRIT J PSYCHIAT, V150, P18 HEUSER MD, 1997, CLIN GERIATR MED, V13, P697 HILDEBRANDT M, 2000, ADV EXP MED BIOL, V477, P197 HILDEBRANDT M, 2001, NUTRITION, V17, P451 HOLDEN RJ, 1996, MED HYPOTHESES, V47, P423 HUDSON JI, 1983, PSYCHIAT RES, V8, P111 IRWIN M, 1999, ADV EXP MED BIOL, V461, P1 KIECOLTGLASER JK, 2001, PSYCHOL BULL, V127, P472 LEAL FJV, 2001, ACTAS ESP PSIQUIATRI, V29, P374 LEONARD BE, 2002, INT J NEUROPSYCHOPH, V5, P345, DOI 10.1017/S1461145702003140 LESTER NA, 2003, PSYCHOL MED, V33, P51, DOI 10.1017/S0033291702006815 LINDY DC, 1985, AM J PSYCHIAT, V142, P1375 LOPEZVARELA S, 2000, INT J VITAM NUTR RES, V70, P185 MARCOS A, 1993, AM J CLIN NUTR, V57, P65 MARCOS A, 1993, EUR J CLIN NUTR, V47, P787 MARCOS A, 1997, NUTRITION, V13, P853 MARCOS A, 2000, EUR J CLIN NUTR S1, V54, S61 MCEWEN BS, 2000, BRAIN RES, V886, P172 MILLER GE, 1997, ANN BEHAV MED, V19, P139 MILLER GE, 1999, PSYCHOSOM MED, V61, P850 MILLON T, 1987, MILLON CLIN MULTIAXI MILLS PJ, 1996, J PSYCHOSOM RES, V40, P417 MITCHELL JE, 1984, J CLIN PSYCHIAT, V45, P508 MOHR DC, 2004, J PSYCHOSOM RES, V57, P155, DOI 10.1016/S0022-3999(03)00601-9 MONTELEONE P, 1999, NEUROPSYCHOBIOLOGY, V40, P115 MONTELEONE P, 2001, PSYCHOSOM MED, V63, P62 NEUDECK P, 2001, PHYSIOL BEHAV, V72, P93 NOVA E, 2002, EUR J CLIN NUTR S3, V56, S34, DOI 10.1038/sj.ejcn.1601482 OBRIEN G, 1998, BRIT J PSYCHIAT, V152, P654 ORGAZ MT, 2004, NUTR CLIN, V24, P28 PENASLLEDO E, 2002, INT J EAT DISORDER, V32, P98 ROEBOTHAN BV, 1994, AGE AGEING, V23, P49 ROSMOND R, 1998, J CLIN ENDOCR METAB, V83, P1853 SPIEGEL D, 2001, SEMIN CLIN NEUROPSYC, V6, P252 STEIGER H, 2001, ARCH GEN PSYCHIAT, V58, P837 THOMAS PD, 1985, AM J PSYCHIAT, V142, P735 UCHINO BN, 1996, PSYCHOL BULL, V119, P488 WALSH BT, 1987, ARCH GEN PSYCHIAT, V44, P797 ZANARINI MC, 2002, J PERS DISORD, V16, P270 NR 62 TC 0 PU EDITRICE KURTIS S R L PI MILAN PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY SN 1124-4909 J9 EAT WEIGHT DISORD-STUD ANOREX JI Eat. Weight Disord.-Stud. Anorex. PD JUN PY 2007 VL 12 IS 2 BP 83 EP 90 PG 8 SC Psychiatry GA 360XJ UT ISI:000260091200004 ER PT J AU Penas-Lledo, EM Loeb, KL Martin, L Fan, J AF Penas-Lledo, E. M. Loeb, K. L. Martin, L. Fan, J. TI Anterior cingulate activity in bulimia nervosa: A fMRI case study SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY LA English DT Article DE Cortex; binge eating; eating disorders; cognitive control; conflict; anticipation ID ANOREXIA-NERVOSA; CORTEX; BRAIN; ANTICIPATION; ATTENTION; CONFLICT; NETWORK AB INTRODUCTION: Eating disordered patients (EDp) who binge-eat appear to present impulse control deficits that influence treatment outcome. The present bulimia nervosa (BN) study tests the function of brain areas involved in top-down control of behavior, associated with the anterior cingulate cortex (ACC), at the individual level. METHODS: ACC activity was analyzed in two women with BN and one matched control with a reliable and simple cue imperative target paradigm for response anticipation and response conflict processing using an event-related functional magnetic resonance imaging (fMRI) design. RESULTS: Patients showed meaningful ACC patterns of activation, less recruitment for response anticipation, and abnormal for response conflict, when they had to suppress an inappropriate response. DISCUSSION: Preliminary evidence suggests a BN neurocognitive model of impaired executive control-related brain activity. Reliable fMRI paradigms may be clinically useful to determine ACC dysfunction in EDp, to inform treatment and track changes. (Eating Weight Disord. 12: e78-e82, 2007). (C) 2007, Editrice Kurtis C1 [Penas-Lledo, E. M.; Loeb, K. L.; Martin, L.; Fan, J.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Fan, J.] Mt Sinai Sch Med, Dept Neurosci, New York, NY USA. RP Penas-Lledo, EM, Univ Extremadura, Sch Med, Avda Elvas Sn, E-06071 Badajoz, Spain. EM elledo@unex.es FU General Clinical Research Center (GCRC) at Mount Sinai School of Medicine [M01-RR-00071]; Network RETICS : Red de Enfermedades Mentales [RD06-0011REM-TAP]; Junta Extremadura ; Fondo Social Europeo, Spain [MOV06A550] FX This study was supported by the General Clinical Research Center (GCRC) at Mount Sinai School of Medicine (Grant n. M01-RR-00071). This study was also supported by the Network RETICS: Red de Enfermedades Mentales (RD06-0011REM-TAP). Eva Penas-Lledo was partially funded by a grant from Junta Extremadura and Fondo Social Europeo, Spain (MOV06A550). CR BECK AT, 1979, COGNITIVE THERAPY DE BEUTEL ME, 2006, NERVENARZT, V77, P1323, DOI 10.1007/s00115-005-1951-4 BOTVINICK MM, 2004, TRENDS COGN SCI, V8, P539 CORBETTA M, 2002, NAT REV NEUROSCI, V3, P201 DEROGATIS LR, 1983, PSYCHOL MED, V13, P595 EDDY KT, 2002, INT J EAT DISORDER, V31, P191 FAIRBURN CG, 2003, BINGE EATING NATURE, P317 FAN J, 2007, J NEUROSCI, V27, P2272, DOI 10.1523/JNEUROSCI.3470-06.2007 FASSBENDER C, 2006, HUM BRAIN MAPP, V27, P819, DOI 10.1002/hbm.20223 KOJIMA S, 2005, PSYCHIAT RES-NEUROIM, V140, P251, DOI 10.1016/j.pscychresns.2005.08.002 NARUO T, 2001, BMC PSYCHIATRY, V1, P2 PAUS T, 2001, NAT REV NEUROSCI, V2, P417 PENASLLEDO E, 2002, INT J EAT DISORDER, V32, P98 PENASLLEDO E, 2005, TRENDS EATING DISORD, P45 QUINTANA J, 2004, PSYCHIAT RES-NEUROIM, V132, P117, DOI 10.1016/j.psychresns.2004.06.005 STEINGLASS J, 2006, INT J EAT DISORDER, V39, P267, DOI 10.1002/eat.20244 STROBER M, 2004, INT J EAT DISORDER, V35, P504, DOI 10.1002/eat.20029 STUNKARD AJ, 1985, J PSYCHOSOM RES, V29, P71 TAKANO A, 2001, PSYCHIAT RES-NEUROIM, V107, P45 UHER R, 2003, BIOL PSYCHIAT, V54, P934, DOI 10.1016/S0006-3223(03)00172-0 UHER R, 2004, AM J PSYCHIAT, V161, P1238 NR 21 TC 2 PU EDITRICE KURTIS S R L PI MILAN PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY SN 1124-4909 J9 EAT WEIGHT DISORD-STUD ANOREX JI Eat. Weight Disord.-Stud. Anorex. PD DEC PY 2007 VL 12 IS 4 BP E78 EP E82 PG 5 SC Psychiatry GA 360XM UT ISI:000260091500008 ER PT J AU Beltran-Heredia, J Martin, JS AF Beltran-Heredia, Jesus Martin, Jesus Sanchez TI Azo dye removal by Moringa oleifera seed extract coagulation SO COLORATION TECHNOLOGY LA English DT Article ID REACTIVE DYES; WATER-TREATMENT; SALT SOLUTION; PERFORMANCE; DECOLORIZATION; ADSORPTION; MECHANISM; POLYSACCHARIDES; FLOCCULATION; EFFLUENTS AB In this paper, the ability of Moringa oleifera seed extract-among other natural coagulants-to remove several different types of dyes has been researched. Moringa oleifera has been demonstrated to have a high removal ability for anionic dyes. This study is particularly focused on testing the removal of an azo dye such as Chicago Sky Blue 6B (CSB). It has taken out the fast kinetic of coagulant action and the high potential of this coagulant agent to treat wastewater from dyestuff. Up to 99% of CSB removal has been achieved with M. oleifera extract dosage of 150, 200 and 250 mg l(-1) for 100, 160 and 200 mg l(-1) of initial CSB concentration, respectively. Temperature does not affect the coagulant process and a pH level greater than 8 has a negative influence. Lower CSB percentage removal is achieved by increasing the initial dye concentration, but an optimum relationship between dye amount removed and M. oleifera extract amount has been established and it appears to be between 0.7 and 0.9, depending on the initial dye concentration and the bulk of the remaining dye concentration. C1 [Beltran-Heredia, Jesus; Martin, Jesus Sanchez] Univ Extremadura, Dept Chem Engn & Phys Chem, E-06071 Badajoz, Spain. RP Martin, JS, Univ Extremadura, Dept Chem Engn & Phys Chem, Avda Elvas S-N, E-06071 Badajoz, Spain. EM jsanmar@unex.es FU Programa de Iniciacion a la Investigacion ; Universidad de Extremadura ; Gespesa SA sub-programme ; Comision Interministerial de Ciencia y Tecnologia (CICYT) [CTQ 2007-60255/PPQ]; Junta de Extremadura [PRI-07A031] FX This investigation has been supported by the Programa de Iniciacion a la Investigacion, Universidad de Extremadura, oriented modality, Gespesa SA sub-programme, to Comision Interministerial de Ciencia y Tecnologia (CICYT) CTQ 2007-60255/PPQ project as well as to Junta de Extremadura under PRI-07A031 project. 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Technol. PY 2008 VL 124 IS 5 BP 310 EP 317 DI 10.1111/j.1478-4408.2008.00158.x PG 8 SC Chemistry, Applied; Engineering, Chemical; Materials Science, Textiles GA 360HX UT ISI:000260049700007 ER PT J AU Beltran, FJ Aguinaco, A Garcia-Araya, JF Oropesa, A AF Beltran, Fernando J. Aguinaco, Almudena Garcia-Araya, Juan F. Oropesa, Ana TI Ozone and photocatalytic processes to remove the antibiotic sulfamethoxazole from water SO WATER RESEARCH LA English DT Article DE titania; ozone; sulfamethoxazole; photocatalytic ozonation; ozone photolysis; photocatalytic oxidation; water ozonation ID ADVANCED OXIDATION PROCESSES; HUMAN PHARMACEUTICALS; AQUATIC ENVIRONMENT; HYDROGEN-PEROXIDE; AQUEOUS-SOLUTIONS; PULSE RADIOLYSIS; DRINKING-WATER; RATE CONSTANTS; OZONATION; TIO2 AB In this study, water containing the pharmaceutical compound sulfamethoxazole (SMT) was subjected to the various treatments of different oxidation processes involving ozonation, and photolysis and catalysis under different experimental conditions. Removal rates of SMT and total organic carbon (TOC), from experiments of simple UVA radiation, ozonation (O-3), catalytic ozonation (O-3/TiO2), ozone photolysis (O-3/UVA), photocatalytic oxidation (O-2/TiO2/UVA) and photocatalytic ozonation (O-3/UVA/TiO2), have been compared. Photocatalytic ozonation leads to the highest SMT removal rate (pH 7 in buffered systems, complete removal is achieved in less than 5 min) and total organic carbon (in unbuffered systems, with initial pH = 4, 93% TOC removal is reached). Also, lowest ozone consumption per TOC removed and toxicity was achieved with the O-3/UVA/TiO2 process. Direct ozone and free radical reactions were found to be the principal mechanisms for SMT and TOC removal, respectively. In photocatalytic ozonation, with buffered (pH 7) aqueous solutions phosphates (buffering salts) and accumulation of bicarbonate scavengers inhibit the reactions completely on the TiO2 surface. As a consequence, TOC removal diminishes. in all cases, hydrogen peroxide plays a key role in TOC mineralization. According to the results obtained in this work the use of photocatalytic ozonation is recommended to achieve a high mineralization degree of water containing SMT type compounds. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Beltran, Fernando J.; Aguinaco, Almudena; Garcia-Araya, Juan F.] Univ Extremadura, Dept Ingn Quim & Energet, E-06071 Badajoz, Spain. [Oropesa, Ana] Univ Extremadura, Dept Sanidad Anim, E-06071 Badajoz, Spain. RP Beltran, FJ, Univ Extremadura, Dept Ingn Quim & Energet, Ave Elvas S-N, E-06071 Badajoz, Spain. EM fbeltran@unex.es FU CICYT of Spain ; European Commission [PPQ2006/04745]; the Spanish Ministry of Science and Education FX This work has been supported by the CICYT of Spain and the European Region Development Funds of the European Commission (Project PPQ2006/04745). Mrs. Aguinaco also thanks the Spanish Ministry of Science and Education for an FPU grant. 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Fanjul Suarez, Jose Luis TI Determinants of OECD commercial banks' residual profitability SO REVISTA ESPANOLA DE FINANCIACION Y CONTABILIDAD-SPANISH JOURNAL OF FINANCE AND ACCOUNTING LA Spanish DT Article DE abnormal profitability; Ohlson model; contextual analysis; financial firms; valuation ID LOAN LOSS PROVISIONS; DISCLOSURES; EQUITY; INCOME; COMPETITION; VALUATION; EARNINGS; TESTS AB Using a contextual approach on a sample of commercial banks from the OECD countries, this study identifies some drivers of abnormal ROE (residual income scaled by beginning-of-period book value of equity). We select the key theoretical variables from the banking and the accounting literature and analyze the impact on the prediction of future abnormal ROEs. After regressing the following year's abnormal ROE on those variables, we verify that some of them, related to the competitiveness of banks and the accounting system, play a determinant role. 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Esp. Financ. Contab. PD JUL-SEP PY 2008 VL 37 IS 139 BP 469 EP 499 PG 31 SC Business, Finance GA 355CX UT ISI:000259687700006 ER PT J AU Gonzalez-Soltero, R Jimenez-Sanchez, A Botello, E AF Gonzalez-Soltero, Rocio Jimenez-Sanchez, Alfonso Botello, Emilia TI Functional requirements for heat induced genome amplification in Escherichia coli SO PROCESS BIOCHEMISTRY LA English DT Article DE replication heat stress; Escherichia coli; Pol I; PriA; RecA ID STALLED REPLICATION FORKS; COORDINATING DNA-REPLICATION; GENETIC-RECOMBINATION; RECA PROTEIN; HOMOLOGOUS RECOMBINATION; TEMPERATURE UPSHIFT; BACILLUS-SUBTILIS; POLYMERASE-I; HOT-SPOT; MUTANT AB A temperature shift-up induces extra rounds of fully replicated chromosomes in Escherichia coli and leads to an increase in DNA/mass ratio. In the present work we characterize the requirements for this heat-induced replication (HIR) with respect to replisome components, replication restart, and recombination functions. We found that HIR requires Klenow and 5'-3' exonuclease activities from Pol I and Pol III, but does not require translesion synthesis polymerases. We also found that replication restart is PriA-PriB pathway dependent. The dnaC809 allele suppresses the dependency on PriA, confirming the requirement for primosome assembly, in which PriA helicase function is not required. Rep helicase and the replication-associated function of RecA were found to be essential. HIR has low recombination requirements, and no DSBs are generated by heat stress. We propose that the Pol I-dependent replisome in HIR, which gives a slow replication speed, is more unstable and disassembles more frequently than normal replisome. Rep and RecA would be required to stabilize HIR replication forks. Since neither D-loops nor R-loops support HIR restart, the PriA-PriB pathway must reload the replisome by a direct restart mechanism from a 3'-end of a nascent leading strand. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Gonzalez-Soltero, Rocio; Jimenez-Sanchez, Alfonso; Botello, Emilia] Univ Extremadura, Fac Sci, Dept Biochem Mol Biol & Genet, E-06071 Badajoz, Spain. RP Botello, E, Univ Extremadura, Fac Sci, Dept Biochem Mol Biol & Genet, E-06071 Badajoz, Spain. EM ebotello@unex.es FU Spanish Ministry of Science and Technology [BMC2002-00830]; Junta de Extremadura, Spain [IPR00C035, 2PR04A036]; Spanish Ministry of Education, Culture and Sport FX We are grateful to the scientists listed in Table 1 for generous gifts of bacterial strains and plasmids, and to Encarna Ferrera for technical help. This work was supported by grants BMC2002-00830 from the Spanish Ministry of Science and Technology, and IPR00C035 and 2PR04A036 from the Junta de Extremadura, Spain. R.G-S. acknowledges an FPU fellowship from the Spanish Ministry of Education, Culture and Sport. 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PD OCT PY 2008 VL 43 IS 10 BP 1162 EP 1170 DI 10.1016/j.procbio.2008.06.016 PG 9 SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Engineering, Chemical GA 356IY UT ISI:000259773100023 ER PT J AU Molina, F Sanchez-Romero, MA Jimenez-Sanchez, A AF Molina, Felipe Antonia Sanchez-Romero, Maria Jimenez-Sanchez, Alfonso TI Dynamic organization of replication forks into factories in Escherichia coli SO PROCESS BIOCHEMISTRY LA English DT Article DE replication factory; bacterial cell cycle; Escherichia coli; replication fork; replication foci; nucleotide synthesis ID CHROMOSOME-REPLICATION; BIDIRECTIONAL MIGRATION; CELL-DIVISION; DNA; HYPERSTRUCTURE; SEGREGATION; SEQUESTRATION; CYCLE; REDUCTASE; COHESION AB In rapidly growing bacteria, replication cycles overlap and the cells contain replisomes assembled at different generations. We have compared the organization of replication forks in cultures with different cell cycles, strains and labeling techniques. The extent of fork-colocalization was found to be dependent on the replication pattern. In slowly growing cells, sister forks were found to colocalize for a fraction of the replication time, whereas cells growing with higher overlapping of replication cycles showed an extensive grouping of replication forks. These results indicate that clustering of replisomes correlates with the number of rounds of replication harbored by each chromosome. The dynamic organization of replisomes reported here, may allow ending the controversy among alternative models. Cell division, DNA-to-cell mass ratio and the integrity of the replication factories were compromised in a ribonucleotide reductase mutant. These results reinforce the idea that regulatory networks connect the synthesis of DNA precursors with the cell cycle. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Molina, Felipe; Antonia Sanchez-Romero, Maria; Jimenez-Sanchez, Alfonso] Univ Extremadura, Dept Bioquim & Biol Mol & Genet, E-06080 Badajoz, Spain. RP Molina, F, Univ Extremadura, Dept Bioquim & Biol Mol & Genet, E-06080 Badajoz, Spain. EM fmolina@unex.es FU Junta de Extremadura [2PR04A036]; MEC [BMC2002-00830] FX We are very grateful to Dr. J. Jimenez and Dr. R. Daga from Centro Andaluz de Biologia del Desarrollo (Seville, Spain) for the use of Delta Vision microscope, Dr. K. Skarstad for the gift of the anti-SeqA antibody and the Norwegian Radium Hospital for the use of flow cytometer, and Encarna Ferrera for her excellent technical help. This work was supported by grants from Junta de Extremadura 2PR04A036 and MEC BMC2002-00830. MAS-R acknowledges a studentship from J. Extremadura. CR ADACHI S, 2008, GENES CELLS, V13, P181, DOI 10.1111/j.1365-2443.2007.01157.x BACH T, 2003, EMBO J, V22, P315 BATES D, 2005, CELL, V121, P899, DOI 10.1016/j.cell.2005.04.013 BRENDLER T, 2000, EMBO J, V19, P6249 COOPER S, 1968, J MOL BIOL, V31, P519 DINGMAN CW, 1974, J THEOR BIOL, V43, P187 ESPELI O, 2003, MOL CELL, V11, P189 FOSSUM S, 2003, MOL MICROBIOL, V47, P619 FOSSUM S, 2007, EMBO J FOTI JJ, 2007, MOL MICROBIOL, V65, P569, DOI 10.1111/j.1365-2958.2007.05811.x GUZMAN EC, 2002, MOL MICROBIOL, V43, P487 HELMSTETTER CE, 1996, ESCHERICHIA COLI SAL, P1627 HERRICK J, 2007, MOL MICROBIOL, V63, P22, DOI 10.1111/j.1365-2958.2006.05493.x HIRAGA S, 1998, MOL CELL, V1, P381 HIRAGA S, 2000, GENES CELLS, V5, P327 LEMON KP, 1998, SCIENCE, V282, P1516 LEMON KP, 2001, GENE DEV, V15, P2031 LIU GW, 2001, MOL MICROBIOL, V40, P909 MOLINA F, 2004, MOL MICROBIOL, V52, P1597, DOI 10.1111/j.1365-2958.2004.04097.x NIELSEN HJ, 2007, J BACTERIOL NORRIS V, 2000, MOL MICROBIOL, V37, P696 NORRIS V, 2007, ANNU REV MICROBIOL, V61, P309, DOI 10.1146/annurev.micro.61.081606.103348 RIOLA J, 2006, CELL MOL BIOL LETT SUNAKO Y, 2001, MOL MICROBIOL, V42, P1233 VANHELVOORT JMLM, 1994, MOL MICROBIOL, V13, P577 VANHELVOORT JMLM, 1998, MICROBIOL-UK 5, V144, P1309 NR 26 TC 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-5113 J9 PROCESS BIOCHEM JI Process Biochem. PD OCT PY 2008 VL 43 IS 10 BP 1171 EP 1177 DI 10.1016/j.procbio.2008.06.017 PG 7 SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Engineering, Chemical GA 356IY UT ISI:000259773100024 ER PT J AU Garcia, JA Moreno, FJ Reina, R Menayo, R Fuentes, JP AF Garcia, J. A. Moreno, F. J. Reina, R. Menayo, R. Fuentes, J. P. TI ANALYSIS OF EFFECTS OF DISTRIBUTION OF PRACTICE IN LEARNING AND RETENTION OF A CONTINUOUS AND A DISCRETE SKILL PRESENTED ON A COMPUTER SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID ACQUISITION; PERFORMANCE; MEMORY AB This investigation examined the effects of distributed and massed practice on the learning and retention of a discrete computerized skill (Exp. 1) and a continuous computerized skill (Exp. 2). 40 men were randomly assigned to one of four groups, of which two groups took part in Exp. 1. and two groups in Exp. 2. Performance was assessed at various points during acquisition and then on 8 retention tests conducted at varying times after acquisition. Learning curves for practice were highly similar for the two conditions. Participants in the distributed-practice group performed significantly better than those in the massed-practice group at the end of practice on both the discrete and continuous skills. However, participants in the distributed-practice group performed significantly more poorly on retention during 24 hr. and after acquisition. Participants in the massed-practice condition performed significantly better on retention tests than did those who learned in the distributed-practice condition. C1 [Garcia, J. A.] Univ Extremadura, Sports Sci Fac, Caceres 10071, Spain. [Moreno, F. J.; Reina, R.] Miguel Hernandez Univ, Elche, Spain. RP Garcia, JA, Univ Extremadura, Sports Sci Fac, Avda Univ S-N, Caceres 10071, Spain. EM gherrero@unex.es CR ADAMS JA, 1954, J EXP PSYCHOL, V47, P32 AMMONS RB, 1950, J EXP PSYCHOL, V40, P777 AMMONS RB, 1988, RES Q EXERCISE SPORT, V59, P288 BADDELEY AD, 1978, ERGONOMICS, V21, P627 BOURNE LE, 1956, J EXP PSYCHOL, V51, P25 BRASHERSKRUG T, 1996, NATURE, V382, P252 DENNY MR, 1955, J EXP PSYCHOL, V49, P48 DEZAZZO J, 1995, TRENDS NEUROSCI, V18, P212 DONOVAN JJ, 1999, J APPL PSYCHOL, V84, P795 DORE LR, 1937, J PSYCHOL, V4, P245 EBBINGHAUS H, 1964, MEMORY CONTRIBUTION KIMBLE GA, 1948, J EXP PSYCHOL, V38, P239 KIMBLE GA, 1952, J EXP PSYCHOL, V44, P355 LEE TD, 1988, RES Q EXERCISE SPORT, V59, P277 LEE TD, 1989, RES Q EXERCISE SPORT, V60, P59 MAGILL RA, 1998, MOTOR LEARNING CONCE METALIS SA, 1985, PERCEPT MOTOR SKILL, V61, P457 MURPHY HH, 1916, J EDUC PSYCHOL, V7, P150 NEWELL KM, 2001, PSYCHOL REV, V108, P57 SAVIONLEMIEUX T, 2005, EXP BRAIN RES, V161, P423, DOI 10.1007/s00221-004-2085-9 SCHMIDT RA, 1988, CONTROL MOTOR LEARNI SHEA CH, 2000, HUM MOVEMENT SCI, V19, P737 WEINGARTNER H, 1984, MEMORY CONSOLIDATION NR 23 TC 0 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0031-5125 J9 PERCEPT MOT SKILLS JI Percept. Mot. Skills PD AUG PY 2008 VL 107 IS 1 BP 261 EP 272 DI 10.2466/PMS.107.1.261-272 PG 12 SC Psychology, Experimental GA 357JI UT ISI:000259841700027 ER PT J AU Castro, IT Sanjuan, EL AF Castro, I. T. Sanjuan, E. L. TI An optimal maintenance policy for repairable systems with delayed repairs SO OPERATIONS RESEARCH LETTERS LA English DT Article DE Repairable systems; Maintenance policy; Increasing failure rates; Alternating renewal processes; Renewal density ID PERIODICALLY INSPECTED SYSTEMS; PREVENTIVE MAINTENANCE; DETERIORATING SYSTEMS; AVAILABILITY; DEGRADATION; EQUIPMENT; SUBJECT; SHOCKS; MODELS AB This work considers a combined maintenance strategy in which the repair of the system failures is performed only in an interval of time of the working period. The objective of this paper is to find the optimal interval in which the repairs can be performed. (c) 2008 Elsevier B.V. All rights reserved. C1 [Castro, I. T.; Sanjuan, E. L.] Univ Extremadura, E-06071 Badajoz, Spain. RP Castro, IT, Escuela Politecn, Dept Matemat, Caceres 10071, Spain. EM inmatorres@unex.es etlopez@unex.es FU Ministerio de Educacion y Ciencia, Spain [MTM2006-01973] FX This research was supported by the Ministerio de Educacion y Ciencia, Spain, under grant MTM2006-01973. CR BARLOW RE, 1981, STAT THEORY RELIABIL CASTRO IT, 2008, EUR J OPER RES, V187, P84, DOI 10.1016/j.ejor.2007.03.027 KHAROUFEH JP, 2006, J APPL PROBAB, V43, P303 KIESSLER PC, 2002, J APPL PROBAB, V39, P700 KLUTKE GA, 2002, IEEE T RELIAB, V51, P371, DOI 10.1109/TR.2002.802591 MCCALL JJ, 1965, MANAGE SCI, V11, P493 PANAGIOTIDOU S, 2007, EUR J OPER RES, V180, P329, DOI 10.1016/j.ejor.2006.04.014 PHAM H, 1996, EUR J OPER RES, V94, P425 PIERSKALLA WP, 1976, NAV RES LOG, V23, P353 VALDEZFLORES C, 1989, NAV RES LOG, V36, P419 WANG HZ, 2002, EUR J OPER RES, V139, P469 NR 11 TC 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6377 J9 OPER RES LETT JI Oper. Res. Lett. PD SEP PY 2008 VL 36 IS 5 BP 561 EP 564 DI 10.1016/j.orl.2008.05.007 PG 4 SC Operations Research & Management Science GA 357VH UT ISI:000259874700012 ER PT J AU Martin, D Ruiz, J Kivikari, R Puolanne, E AF Martin, Diana Ruiz, Jorge Kivikari, Riitta Puolanne, Eero TI Partial replacement of pork fat by conjugated linoleic acid and/or olive oil in liver pates: Effect on physicochemical characteristics and oxidative stability SO MEAT SCIENCE LA English DT Article DE conjugated linoleic acid; olive oil; pate; oxidation; texture; stability ID LIPID OXIDATION; FERMENTED SAUSAGES; PROTEIN OXIDATION; DAIRY-PRODUCTS; COLOR; QUALITY; BACKFAT; FRANKFURTERS; NUTRITION; STORAGE AB The effect of replacing pork fat in liver pates by an enriched conjugated linoleic acid oil (CLA-pate), olive oil (OO-pdte), or the combination of both type of oils (CLA + OO-pdte) on the fatty acid profile, lipid oxidative stability, consistency and emulsion stability was studied and compared with a traditional liver pate (C-pate). Pates were analyzed at days 1, 6, 21 and 71 of refrigerated storage (4 degrees C). A enrichment in CLA was attained in CLA-pate and CLA + OO-pate. CLA-pates had the highest content in polyunsaturated fatty acids (PUFA) (p < 0.05) due to their content in CLA. A lower content in saturated fatty acids was achieved when using 00 or CLA in pates (p < 0.05). OO-pates showed the highest levels of monounsaturated fatty acids (MUFA) (p < 0.05). No changes in the fatty acid profile and in lipid oxidation (mg malondialdehyde per kg of sample) throughout the storage of the products were found. Lower consistency and emulsion stability were obtained when using CLA or 00 in the formulation. Consistency values (in N/cm(2)) tended to increase and emulsion stability to decrease throughout the storage in CLA or 00 enriched pdtes. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Martin, Diana; Ruiz, Jorge] Univ Extremadura, Fac Vet, Dept Food Sci, Caceres 10071, Spain. [Kivikari, Riitta] Univ Helsinki, Dept Appl Chem & Microbiol Food Chem, FIN-00014 Helsinki, Finland. [Puolanne, Eero] Univ Helsinki, Dept Food Technol, FIN-00014 Helsinki, Finland. RP Martin, D, Univ Extremadura, Fac Vet, Dept Food Sci, Avda Univ S-N, Caceres 10071, Spain. EM dimaga@unex.es FU Ministerio de Educacion y Ciencia FX CLA was generously provided by COGNIS. Diana Martin thanks the Ministerio de Educacion y Ciencia for funding her research and the Department of Food Technology and Department of Applied Chemistry and Microbiology/Food Chemistry of University of Helsinki for allowing the realization of these experiments. The technical assistance of lrja Korhonen, Kirsti Risunen and Olavi Torma is gratefully acknowledged. CR *AOAC, 1990, OFF METH AN ASS OFF, P935 *WHO STUD GROUP, 1990, DIET NUTR PREV CHR D BLOUKAS JG, 1993, J FOOD SCI, V58, P705 BLOUKAS JG, 1997, MEAT SCI, V45, P133 BRIGGS GM, 1990, MEAT HLTH, P1 CAVESTANY M, 1994, MEAT SCI, V38, P27 COLEMENERO FJ, 2000, TRENDS FOOD SCI TECH, V11, P56 CORINO C, 2004, MEAT SCI, V66, P97, DOI 10.1016/S0309-1740(03)00024-X CORINO C, 2006, PROD ANIM, V19, P39 ENSER M, 1999, ANIM SCI 1, V69, P143 ESTEVEZ M, 2004, MEAT SCI, V68, P551, DOI 10.1016/j.meatsci.2004.05.007 ESTEVEZ M, 2006, MEAT SCI, V74, P396, DOI 10.1016/j.meatsci.2006.04.010 FERNANDEZLOPEZ J, 2004, J FOOD SCI, V69, P85 FOLCH J, 1957, J BIOL CHEM, V226, P497 HA YL, 1989, J AGR FOOD CHEM, V37, P75 HAH KH, 2006, ASIAN AUSTRAL J ANIM, V19, P744 HARO AM, 2006, MED CLIN-BARCELONA, V127, P508 HUGHES E, 1997, MEAT SCI, V45, P273 JEUNHORNG L, 2002, MEAT SCI, V60, P161 JOO ST, 2002, J ANIM SCI, V80, P108 KNEKT P, 1996, BRIT J CANCER, V73, P687 MANNING BB, 2006, AQUACULTURE, V261, P337, DOI 10.1016/j.aquaculture.2006.07.029 MARQUEZRUIZ G, 2006, P 4 EUROFED LIP C OC MARTIN D, 2008, FOOD CHEM, V108, P86, DOI 10.1016/j.foodchem.2007.10.048 MATAIX FJ, 1988, ACEITE OLIVA BASES F MUGUERZA E, 2003, J FOOD SCI, V68, P1531 NAVARRO V, 2003, J PHYSIOL BIOCHEM, V59, P193 NAVARRO V, 2006, J PHYSIOL BIOCHEM, V62, P137 OCKERMAN H, 1989, SAUSAGE PROCESSED ME PARIZA MW, 1985, CARCINOGENESIS, V6, P591 PERLO F, 1995, MEAT SCI, V41, P325 SALASSALVADO J, 2006, CRIT REV FOOD SCI, V46, P479, DOI 10.1080/10408390600723953 SALIH AM, 1987, POULTRY SCI, V66, P1483 SERVERINI C, 2003, MEAT SCI, V64, P323 SHAHIDI F, 1992, ACS SYM SER, V500, P161 SHANTHA NC, 1995, J FOOD SCI, V60, P695 SIRRI F, 2003, POULTRY SCI, V82, P1356 SLOVER HT, 1979, J AM OIL CHEM SOC, V56, P933 VISIOLI F, 1998, J AGR FOOD CHEM, V46, P4292 NR 39 TC 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1740 J9 MEAT SCI JI Meat Sci. PD OCT PY 2008 VL 80 IS 2 BP 496 EP 504 DI 10.1016/j.meatsci.2008.01.014 PG 9 SC Food Science & Technology GA 356TD UT ISI:000259799600042 ER PT J AU Carrapiso, AI Garcia, C AF Carrapiso, Ana I. Garcia, Carmen TI Effect of the Iberian pig line on dry-cured ham characteristics SO MEAT SCIENCE LA English DT Article DE Iberian ham; pig line; acceptance; sensory analysis; colour; dry-cured meat ID REARING SYSTEM; SENSORY CHARACTERISTICS; MEAT QUALITY; ACCEPTABILITY; LOIN; PERFORMANCE; CROSSES; CARCASS; FAT; SEX AB The purpose of this study was to compare the characteristics (chemical composition, instrumental colour, sensory characteristics and acceptance) of dry-cured hams obtained form three genetic lines of Iberian pig (Censyra, Torbiscal and Entrepelado). The instrumental colour of fat was affected by the genetic line (b*, p = 0.008; and h degrees, p = 0.024), the Censyra group having the largest values. The genetic line did not affect the chemical composition of the subcutaneous fat and lean of the dry-cured hams or the instrumental colour of the lean. Data from a descriptive analysis showed that the only characteristic significantly affected was the toasted flavour (p = 0.004), and juiciness and sweetness were slightly affected (p = 0.062 and 0.061, respectively). In spite of the slight effect on the physical-chemical and sensory characteristics, acceptance was significantly different, Torbiscal hams having the highest scores. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Carrapiso, Ana I.] Univ Extremadura, Escuela Ingn Agr, E-06071 Badajoz, Spain. [Garcia, Carmen] Univ Extremadura, Fac Vet, Caceres 10071, Spain. RP Carrapiso, AI, Univ Extremadura, Escuela Ingn Agr, Ctra Caceres S-N, E-06071 Badajoz, Spain. EM acarrapi@unex.es CR *AOAC, 1984, OFF METH AN *BOE, 2004, B OF EST, V283, P38770 *CIE, 1976, PUBL CIE, V15 BLIGH EG, 1959, CAN J BIOCH PHYSL, V37, P911 CARRAPISO AI, 2000, MEAT SCI, V56, P159 CARRAPISO AI, 2003, FOOD SCI TECHNOL INT, V9, P421, DOI 10.1177/1082013203040396 CARRAPISO AI, 2003, MEAT SCI, V65, P623, DOI 10.1016/S0309-1740(02)00256-5 CARRAPISO AI, 2005, MEAT SCI, V71, P284, DOI 10.1016/j.meatsci.2005.03.024 CILLA I, 2006, MEAT SCI, V72, P252, DOI 10.1016/j.meatsci.2005.07.010 ESTEVEZ M, 2003, MEAT SCI, V64, P499 FRANCI O, 2007, MEAT SCI, V76, P597, DOI 10.1016/j.meatsci.2007.01.020 GOU P, 1995, MEAT SCI, V40, P21 HAIR JF, 1998, MULTIVARIATE DATA AN HORNSEY HC, 1956, J SCI FOOD AGR, V7, P534 JURADO A, 2003, 2 C MUND JAM 26 28 M JURADO A, 2007, MEAT SCI, V75, P585, DOI 10.1016/j.meatsci.2006.09.006 MEILGAARD M, 1999, SENSORY EVALUATION T MURIEL E, 2004, FOOD SCI TECHNOL INT, V10, P117, DOI 10.1177/1082013204043766 MURIEL E, 2004, MEAT SCI, V67, P299, DOI 10.1016/j.meatsci.2003.11.002 OLIVER MA, 1994, LIVEST PROD SCI, V40, P179 RAMIREZ MR, 2007, MEAT SCI, V76, P333, DOI 10.1016/j.meatsci.2006.11.017 RESANO H, 2007, FOOD QUAL PREFER, V18, P1064, DOI 10.1016/j.foodqual.2007.05.002 RUIZ J, 2002, MEAT SCI, V61, P347 SERRANO MP, 2008, MEAT SCI, V78, P420, DOI 10.1016/j.meatsci.2007.07.006 TEJEDA JF, 2002, 48 INT C MEAT SCI TE, V2, P734 VENTANAS S, 2007, MEAT SCI, V77, P324, DOI 10.1016/j.meatsci.2007.04.001 WYSZECKI G, 1982, COLOR SCI CONCEPTS M NR 27 TC 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1740 J9 MEAT SCI JI Meat Sci. PD OCT PY 2008 VL 80 IS 2 BP 529 EP 534 DI 10.1016/j.meatsci.2008.02.004 PG 6 SC Food Science & Technology GA 356TD UT ISI:000259799600046 ER PT J AU Benito, MJ Serradilla, MJ Ruiz-Moyano, S Martin, A Perez-Nevado, F Cordoba, MG AF Benito, Maria J. Serradilla, Manuel J. Ruiz-Moyano, Santiago Martin, Alberto Perez-Nevado, Francisco Cordoba, Maria G. TI Rapid differentiation of lactic acid bacteria from autochthonous fermentation of Iberian dry-fermented sausages SO MEAT SCIENCE LA English DT Article DE lactic acid bacteria; differentiation; SDS-PAGE; Iberian dry-fermented sausages ID SDS-PAGE; STARTER CULTURES; IDENTIFICATION; SALAMI; CHORIZO; SAFETY; FLORA AB The populations of lactic acid bacteria (LAB) in different types of Iberian dry-fermented sausages from central-west Spain were identified. A simple and rapid electrophoretic method of whole-cell protein profiles was evaluated, correlating it with 16S rRNA gene sequence analysis and biochemical identification by API 50 CHL. A total of 96 isolates were identified by SDS-PAGE showing stable profiles corresponding to 30-45 polypeptides in the range 95-8 kDa that were clearly different for the different species and were grouped with those of the 9 reference strains used in this study. The SDS-PAGE method showed that the predominant species were Pediococcus acidilactici (48%) followed by Lactobacillus plantarum (23%) and Lactobacillus brevis (18%). The identifications obtained by this approach were confirmed by sequencing the V2-V3 region of the 16S rRNA gene and by a BLAST search of the GenBank database. However, biochemical identifications by API 50 CHL showed different errors at the genus and species level. In sum, the SDS-PAGE analysis showed itself to be a rapid and accurate differentiation method for the most commonly encountered LAB isolates in dry-fermented sausages. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Benito, Maria J.; Serradilla, Manuel J.; Ruiz-Moyano, Santiago; Martin, Alberto; Perez-Nevado, Francisco; Cordoba, Maria G.] Univ Extremadura, Escuela Ingn Agr, E-06071 Badajoz, Spain. RP Benito, MJ, Univ Extremadura, Escuela Ingn Agr, Carretera Caceres S-N, E-06071 Badajoz, Spain. EM mjbenito@unex.es FU Consejeria de Educacion y Tecnologia (Junta de Extremadura) [IPR00B019, PDT05A037] FX This work is part of the Projects IPR00B019 and PDT05A037 funded by the Consejeria de Educacion y Tecnologia (Junta de Extremadura). CR AYMERICH T, 2006, J APPL MICROBIOL, V100, P40, DOI 10.1111/j.1365-2672.2005.02772.x BENITO MJ, 2007, J FOOD SCI, V72, M193, DOI 10.1111/j.1750-3841.2007.00419.x CORDOBA MG, 2003, NAHRUNG, V47, P166 DEANGELIS M, 2001, APPL ENVIRON MICROB, V67, P2011 DROSINOS EH, 2005, MEAT SCI, V69, P307, DOI 10.1016/j.meatsci.20043.07.012 ELLIOTT JA, 1991, J CLIN MICROBIOL, V29, P2731 HAMMES WP, 1990, FOOD BIOTECHNOL, V4, P383 HUGAS M, 1997, FOOD CHEM, V59, P547 HUYS G, 2006, RES MICROBIOL, V157, P803, DOI 10.1016/j.resmic.2006.06.006 KULWICHIT W, 2007, BMC INFECT DIS, V7, ARTN 69 MARTIN A, 2007, MEAT SCI, V75, P696, DOI 10.1016/j.meatsci.2006.10.001 MONTEL MC, 1998, MEAT SCI, V49, P111 MOSCHETTI G, 1997, RES MICROBIOL, V148, P501 PAPAMANOLI E, 2003, MEAT SCI, V65, P859, DOI 10.1016/S0309-1740(02)00292-9 PATARATA L, 1994, J APPL BACTERIOL, V76, P288 POT B, 1994, MODERN MICROBIOLOGIC PRAKASH VP, 2005, BMC INFECT DIS, V5, P14 SAMELIS J, 1994, INT J FOOD MICROBIOL, V23, P179 SAMELIS J, 1995, J APPL BACTERIOL, V78, P157 SAMELIS J, 1998, INT J FOOD MICROBIOL, V44, P69 SANCHEZ I, 2003, INT J FOOD MICROBIOL, V82, P181 SANTOS EM, 1998, INT J FOOD MICROBIOL, V39, P123 SCHEIRLINCK I, 2007, INT J SYST EVOL MI 2, V57, P223, DOI 10.1099/ijs.0.64607-0 SCHILLINGER U, 1987, FOOD MICROBIOL, V4, P199 WALTER J, 2000, APPL ENVIRON MICROB, V66, P297 NR 25 TC 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1740 J9 MEAT SCI JI Meat Sci. PD NOV PY 2008 VL 80 IS 3 BP 656 EP 661 DI 10.1016/j.meatsci.2008.03.002 PG 6 SC Food Science & Technology GA 357KI UT ISI:000259844300012 ER PT J AU Ruiz-Moyano, S Martin, A Benito, MJ Nevado, FP Cordoba, MD AF Ruiz-Moyano, Santiago Martin, Alberto Jose Benito, Maria Perez Nevado, Francisco de Guia Cordoba, Maria TI Screening of lactic acid bacteria and bifidobacteria for potential probiotic use in Iberian dry fermented sausages SO MEAT SCIENCE LA English DT Article DE lactic acid bacteria; probiotic; Iberian dry fermented sausages ID ESCHERICHIA-COLI O157-H7; STARTER CULTURES; LISTERIA-MONOCYTOGENES; TECHNOLOGICAL PROPERTIES; GASTROINTESTINAL-TRACT; SELECTIVE MEDIUM; BILE TOLERANCE; LACTOBACILLUS; SAFETY; IDENTIFICATION AB The purpose of this study was to select lactic acid bacteria and bifibobacteria strains as potential probiotic cultures during the processing of Iberian dry fermented sausages. A total of 1000 strains were isolated from Iberian dry fermented sausages (363), and human (337) and pig faeces (300) in different culture media. Around 30% of these strains, mainly isolated from Iberian dry fermented sausages in LAMVAB agar, were pre-selected for testing as potential probiotics by their ability to grow adequately at the pH values and NaCl concentrations of these meat products during the ripening process. Of the in vitro investigations used to predict the survival of a strain in conditions present in the gastro intestinal tract, exposure to pH 2.5 showed itself to be a highly discriminating factor with only 51 out of 312 pre-selected strains resisting adequately after 1.5 h of exposure. All acid-resistant isolates identified as lactobacilli originated from human faeces (Lactobacillus casei and Lactobacillus fermentum) and pig faeces (Lactobacillus reuteri, Lactobacillus animalis, Lactobacillus murinus, and Lactobacillus vaginalis). Pediococcus acidilactici strains were isolated from Iberian dry fermented sausages and pig faeces, whereas the greatest number of Enterococcus strains were identified as Enterococcus faecium, with this species being isolated from Iberian dry fermented sausages, and human and pig faeces. Most of these strains are promising probiotic meat culture candidates suitable for Iberian dry fermented sausages. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Ruiz-Moyano, Santiago; Martin, Alberto; Jose Benito, Maria; Perez Nevado, Francisco; de Guia Cordoba, Maria] Univ Extremadura, Escuela Ingn Agr, E-06071 Badajoz, Spain. RP Martin, A, Univ Extremadura, Escuela Ingn Agr, Carretera Caceres S-N, E-06071 Badajoz, Spain. EM amartin@unex.es FU Consejeria de Educacion y Tecnologia (junta de Extremadura) [21PR04A051]; Ministerio de Educacion y Ciencia (Spain) FX This work formed part of the project 21PR04A051 funded by the Consejeria de Educacion y Tecnologia (junta de Extremadura). S. Ruiz Moyano is the beneficiary of a pre-doctoral grant from the Ministerio de Educacion y Ciencia (Spain). The authors are grateful to M. Cabrero and C. Cebrian for technical assistance. 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PD NOV PY 2008 VL 80 IS 3 BP 715 EP 721 DI 10.1016/j.meatsci.2008.03.011 PG 7 SC Food Science & Technology GA 357KI UT ISI:000259844300022 ER PT J AU Ninoles, L Sanjuan, N Ventanas, S Benedito, J AF Ninoles, L. Sanjuan, N. Ventanas, S. Benedito, J. TI Ultrasonic and sensory characterization of dry-cured ham fat from Iberian pigs with different genetics and feeding backgrounds SO MEAT SCIENCE LA English DT Article DE ultrasound; dry-cured ham fat; Iberian pig; sensory analysis ID REARING SYSTEM; ACID-COMPOSITION; QUALITY; PROFILES; LOCATION; MUSCLE; DIET AB The textural and ultrasonic properties of the subcutaneous fat from five batches of dry-cured hams from animals with different genetics (Iberian, Iberian x Duroc) and type of feeding ("montanera", concentrate feeds with different oleic acid content) were studied and related to the sensory traits (oiliness and brightness) of their biceps femoris muscle. The different genetics and feeding backgrounds found in the batches brought about differences in their ultrasonic velocities (average velocity from 4 to 20 degrees C ranged from 1608 to 1650 m/s) and textural parameters (maximum force at 8 degrees C ranged from 11 to 21 N). On average, batches with lower textural parameters had lower velocities and higher sensory scores. Ultrasonic measurements were used to carry out a discriminant analysis which allowed 78.3% of the samples to be correctly classified in the batches considered. Therefore, ultrasonic and sensory techniques could be useful in the characterization and differentiation of dry-cured hams from Iberian pigs. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Ninoles, L.; Sanjuan, N.; Benedito, J.] Univ Politecn Valencia, Dept Tecnol Alimentos, Valencia 46022, Spain. [Ventanas, S.] Univ Extremadura, Fac Vet, Caceres 10071, Spain. RP Benedito, J, Univ Politecn Valencia, Dept Tecnol Alimentos, Cno Vera S-N, Valencia 46022, Spain. EM jjbenedi@tal.upv.es FU "Ministerio de Educacion y Ciencia" in Spain [AGL 2007-65923-C02-02] FX The authors acknowledge the financial support from the "Ministerio de Educacion y Ciencia" in Spain (Project AGL 2007-65923-C02-02) and the valuable advice of Professor Jesus Ventanas. 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PD NOV PY 2008 VL 80 IS 3 BP 896 EP 902 DI 10.1016/j.meatsci.2008.04.008 PG 7 SC Food Science & Technology GA 357KI UT ISI:000259844300049 ER PT C AU Tian, JW Dai, K Villegas, JC Shaw, L Liaw, PK Klarstrom, DL Ortiz, AL AF Tian, J. W. Dai, K. Villegas, J. C. Shaw, L. Liaw, P. K. Klarstrom, D. L. Ortiz, A. L. TI Tensile properties of a nickel-base alloy subjected to surface severe plastic deformation SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Proceedings Paper DE nanocrystalline materials; Ni alloy; severe plastic deformation; residual stresses; work hardening ID MECHANICAL ATTRITION TREATMENT; LOW-CARBON STEEL; NANOCRYSTALLINE METALS; NANOSTRUCTURED MATERIALS; RESIDUAL-STRESS; MICROSTRUCTURE; LAYER; TITANIUM; BEHAVIOR AB A surface severe plastic deformation ((SPD)-P-2) method has been applied to bulk specimens of HASTELLOY(R) C-2000 alloy, a nickel-base alloy. The mechanical properties of the processed C-2000 alloy were determined via tensile tests and Vickers hardness measurements, whereas the microstructure was characterized using scanning electron microscopy, transmission electron microscopy, and X-ray diffractometry. The improved tensile strength was related to the nanostructure at the surface region, the residual compressive stresses, and the work-hardened surface layer, all of which resulted from the (SPD)-P-2 process. To understand the contributions of these three factors, finite element modeling was performed. It was found that the improved tensile strength could be interpreted based on the contributions of nano-grains, residual stresses, and work hardening. (C) 2007 Elsevier B.V. All rights reserved. C1 [Shaw, L.] Univ Connecticut, Dept Chem Mat & Biomol Engn, Storrs, CT 06269 USA. [Tian, J. W.; Liaw, P. K.] Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37996 USA. [Dai, K.] Qual Engn & Software Technol, E Hartford, CT 06108 USA. [Villegas, J. C.] Intel Corp, Chandler, AZ 85226 USA. [Klarstrom, D. L.] Haynes Int Inc, Kokomo, IN 46901 USA. [Ortiz, A. L.] Univ Extremadura, Dept Ingn Mecan Energet & Mat, E-06071 Badajoz, Spain. RP Shaw, L, Univ Connecticut, Dept Chem Mat & Biomol Engn, Storrs, CT 06269 USA. EM leon.shaw@uconn.edu CR AGNEW SR, 2000, MAT SCI ENG A-STRUCT, V285, P391 ALHASSANI STS, 1984, P 2 INT C SHOT PEEN, P11 CAO W, 1995, MATER SCI TECH-LOND, V11, P967 DAI K, 2004, ACTA MATER, V52, P5771, DOI 10.1016/j.actamat.2004.08.031 DAI K, 2004, SCRIPTA MATER, V52, P259 DAI K, 2007, MAT SCI ENG A-STRUCT, V463, P46, DOI 10.1016/j.msea.2006.07.159 GLEITER H, 2000, ACTA MATER, V48, P1 KALPAKJIAN S, 2003, MANUFACTURING PROCES, P31 KOCH CC, 1999, MRS BULL, V24, P54 LEGROS M, 2000, PHILOS MAG A, V80, P1017 LIU G, 2001, SCRIPTA MATER, V44, P1791 MEYERS MA, 2006, PROG MATER SCI, V51, P427, DOI 10.1016/j.pmatsci.2005.08.003 ORTIZ AL, 2008, ACTA MATER, V56, P413, DOI 10.1016/j.actamat.2007.10.003 SHAW L, 2007, CRC MAT PROCESSING H SRIDHAR BR, 1992, J MATER SCI, V27, P5783 TAO NR, 1999, NANOSTRUCT MATER, V11, P433 TAO NR, 2002, ACTA MATER, V50, P4603 TIAN JW, 2007, MAT SCI ENG A-STRUCT, V468, P164 TODAKA Y, 2004, MATER TRANS, V45, P376 UMEMOTO M, 2004, MAT SCI ENG A-STRUCT, V375, P899, DOI 10.1016/j.msea.2003.10.198 VILLEGAS JC, 2005, MAT SCI ENG A-STRUCT, V410, P257, DOI 10.1016/j.msea.2005.09.087 VILLEGAS JC, 2005, PHIL MAG LETT, V85, P427, DOI 10.1080/09500830500311705 VILLEGAS JC, 2005, THESIS U CONNECTICUT WAGNER L, 1999, MAT SCI ENG A-STRUCT, V263, P210 WANG ZB, 2003, MAT SCI ENG A-STRUCT, V352, P144 WEERTMAN JR, 2002, MATER SCI FORUM, V386, P519 WOHLFAHET H, 1984, P 2 INT C SHOT PEEN, P293 WU X, 2002, ACTA MATER, V50, P2075 ZHANG HW, 2003, ACTA MATER, V51, P1871, DOI 10.1016/S1359-6454(02)00594-3 ZHU KY, 2004, ACTA MATER, V52, P4101, DOI 10.1016/j.actamat.2004.05.023 NR 30 TC 1 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MATER SCI ENG A-STRUCT MATER JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD OCT 15 PY 2008 VL 493 IS 1-2 SI Sp. Iss. SI BP 176 EP 183 DI 10.1016/j.msea.2007.07.102 PG 8 SC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary GA 357KN UT ISI:000259844800028 ER PT J AU Rivas, FJ de la Calle, RG Alvarez, P Acedo, B AF Javier Rivas, F. Garcia de la Calle, R. Alvarez, P. Acedo, B. TI Polycyclic aromatic hydrocarbons sorption on soils: Some anomalous isotherms SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Polycyclic aromatic hydrocarbons; Anomalous isotherms; Soil; Freundlich; Oswin; Peleg; Caurie ID ADSORPTION; CARBON AB The sorption of four polycyclic aromatic hydrocarbons (PAHs). namely acenaphthene (Ac). phenanthrene (Ph). anthracene (An), and fluoranthene (H), on soil has been investigated. The kinetics of the sorption is characterised by the presence of two distinct periods. A fast initial stage followed by a second slower sorption process. Various kinetic models (i.e., Elvoich. Lagergren. second order and double exponential models) have been used to tit experimental data. The sorption equilibrium of individual PAHs has been assessed in the 298-333 K temperature range. Unlike Ac. Ph at 333 K and An and Fl at any temperature showed anomalous isotherms. The reason seems to rely on the "trapping" of dissolved PAHs by soil organic matter (SOM) released to water. This abnormal trend was not experienced when the isotherms were obtained for four PAHs mixture. Apparently. the most soluble Ac was capable of binding all the released material so no effect was thereafter observed. (c) 2008 Elsevier B.V. All rights reserved. C1 [Javier Rivas, F.; Garcia de la Calle, R.; Alvarez, P.; Acedo, B.] Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. RP Rivas, FJ, Univ Extremadura, Dept Ingn Quim & Quim Fis, Ave Elvas S-N, E-06071 Badajoz, Spain. EM fjrivas@unex.es FU Junta de Extremadura [3PR05A072] FX This work has been supported by the Junta de Extremadura through Project 3PR05A072. The authors also thank Mr. C. Gaspar for his contribution in the experimental part of this manuscript. 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PD OCT 30 PY 2008 VL 158 IS 2-3 BP 375 EP 383 DI 10.1016/j.jhazmat.2008.01.083 PG 9 SC Engineering, Environmental; Engineering, Civil; Environmental Sciences GA 358AB UT ISI:000259887400017 ER PT J AU de Haro, ML Santos, A Yuste, SB AF Lopez de Haro, Mariano Santos, Andres Yuste, Santos B. TI Simple equation of state for hard disks on the hyperbolic plane SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID HIGH DIMENSIONALITY; FLUID; SPHERES C1 [Lopez de Haro, Mariano] Univ Nacl Autonoma Mexico, Ctr Invest Energia, Temixco 62580, Morelos, Mexico. [Santos, Andres; Yuste, Santos B.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP de Haro, ML, Univ Nacl Autonoma Mexico, Ctr Invest Energia, Temixco 62580, Morelos, Mexico. EM malopez@servidor.unam.mx andres@unex.es santos@unex.es FU Ministerio de Educacion y Ciencia (Spain) [FIS2007-60977]; Junta de Extremadura [GRU08069]; DGAPA-UNAM [IN-109408] FX We want to thank C. D. Modes and R. D. Kamien for kindly providing us with their simulation data and their values for the virial coefficients. The work of A.S. and S.B.Y. has been supported by the Ministerio de Educacion y Ciencia (Spain) through Grant No. FIS2007-60977 (partially financed by FEDER funds) and by the Junta de Extremadura through Grant No. GRU08069. M.L.H. acknowledges the partial financial support of DGAPA-UNAM under Project No. IN-109408. 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PD SEP 21 PY 2008 VL 129 IS 11 AR 116101 DI 10.1063/1.2981061 PG 2 SC Physics, Atomic, Molecular & Chemical GA 357YT UT ISI:000259883900047 ER PT J AU Mulero, A Cachadina, I Parra, MI AF Mulero, Angel Cachadina, Isidro Parra, Maria I. TI Comparison of Corresponding-States-Based Correlations for the Prediction of the Vaporization Enthalpy of Fluids SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID NONPOLAR FLUIDS; PURE SUBSTANCES; LATENT-HEAT; BOILING ENTHALPY; VAPOR-PRESSURES; EQUATION; TEMPERATURES; EXTENSION; BEHAVIOR; MODELS AB Four analytical correlations, including one proposed very recently, were used to calculate the enthalpy of vaporization of fluids. These correlations are based on the Pitzer et al. corresponding states principle and require as input the critical temperature and the acentric factor. 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EM mulero@unex.es FU Ministerio de Educacion y Ciencia of Spain [FIS2006-02794]; Fondo Europeo de Desarrollo Regional (FEDER) of the European Union FX This work was supported by Project FIS2006-02794 of the Ministerio de Educacion y Ciencia of Spain and the Fondo Europeo de Desarrollo Regional (FEDER) of the European Union. 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Eng. Chem. Res. PD OCT 15 PY 2008 VL 47 IS 20 BP 7903 EP 7916 DI 10.1021/ie800557q PG 14 SC Engineering, Chemical GA 358GK UT ISI:000259904900048 ER PT J AU Mendez-Vilas, A Jodar-Reyes, AB Diaz, J Gonzalez-Martin, ML AF Mendez-Vilas, A. Jodar-Reyes, A. B. Diaz, J. Gonzalez-Martin, M. L. TI Nanoscale aggregation phenomena at the contact line of air-drying pure water droplets on silicon revealed by atomic force microscopy SO CURRENT APPLIED PHYSICS LA English DT Article DE wetting; organic airborne contamination; silicon; AFM; atomic force microscopy; contact angle; heterogeneity ID CARBON NANOTUBES; ORGANIC CONTAMINANTS; MICA SURFACE; HOLE-GROWTH; FILMS; ADSORPTION; BEHAVIOR; INTERFACE AB In the present work, silicon wafer surfaces were Studied during a pure water dewetting process in ambient conditions by contact atomic force microscopy (AFM). With an acid-free surface cleaning., large network structures of tens of microns in extension but only a few nanometers in height were observed, being stable for days. Fractal-like assemblies have been previously reported in a variety of different scenarios, for example, when an aqueous solution of carbon-based species, especially carbon nanotubes, is left to evaporate on a solid substrate, provided that no complete wetting was produced. Chemical mapping of silicon wafer surfaces, while unable to provide a spatial resolution comparable to that of the AFM, clearly showed the initially formed contact line to be enriched in carbon. Therefore, hydrophobic and/or non-soluable (or slightly soluble) substances which Lire present on every surface exposed to air are expected to be responsible for the observed fractal structures. Reactions of the network structures toward changing environmental conditions were analyzed. When increasing the ambient humidity, the Structures grew only slightly, which is indicative of their highly (but not totally) hydrophobic nature. Heating the sample above 100 degrees C for about 10 h led to an almost complete disappearance of these nanostructures. Due to the lateral extension of these stable network heterogeneities, they are expected to affect contact angle measurements in wetting studies, especially at the micro- and nanoscale. When acid-cleaned wafers are used as substrate, deposited water extends as a film over the silicon surface without droplet formation. No fractal Structures are then observed. (C) 2007 Elsevier B.V. All rights reserved. C1 [Mendez-Vilas, A.; Gonzalez-Martin, M. L.] Univ Extremadura, Dept Appl Phys, E-06071 Badajoz, Spain. [Jodar-Reyes, A. B.] Univ Extremadura, Fac Vet, Dept Appl Phys, Caceres 10071, Spain. [Diaz, J.] Univ Extremadura, Fac Vet, Dept Organ & Inorgan Chem, Caceres 10071, Spain. RP Mendez-Vilas, A, Univ Extremadura, Dept Appl Phys, Campus Univ,Avda Elvas S-N, E-06071 Badajoz, Spain. EM amvilas@formatex.org FU Junta de Extremadura [3PR05AO21]; Ministerio de Educacion y Ciencia [MAT2006-12948-CO4-03]; FEDER ; Fundacion de Investigacion Medica Mutua Madrilena FX The authors are grateful for financial support to: "Junta de Extremadura" (Regional Government) through project 3PR05AO21, "Ministerio de Educacion y Ciencia" (National Government) through the Project MAT2006-12948-CO4-03, FEDER, and "Fundacion de Investigacion Medica Mutua Madrilena". Dr. J.L. Gonzalez-Carrasco is gratefully acknowledged for the SEI/microanalysis experiences at the CENIM (CSIC, Madrid) facilities. M.G. Donoso is acknowledged for the water contact angle measurement. 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Appl. Phys. PD JAN PY 2009 VL 9 IS 1 BP 48 EP 58 DI 10.1016/j.cap.2007.11.009 PG 11 SC Materials Science, Multidisciplinary; Physics, Applied GA 356GB UT ISI:000259765600011 ER PT J AU Gallego, E Moya, M Garcia, AI Ayuga, F AF Gallego, E. Moya, M. Garcia, A. I. Ayuga, F. TI Valuation of low volume roads in Spain. Part 1: Methodology development SO BIOSYSTEMS ENGINEERING LA English DT Article ID FRAGMENTATION; NETWORKS; SYSTEM; PAY AB In rural societies, low volume roads play important social and economic roles. Nevertheless, as yet few developed countries, and practically no developing countries, have programmes for maintaining them. Disrepair is therefore a frequent situation. in Spain, the absence of technical procedures for their inspection and assessment hinders the development of objective criteria that could be included in maintenance and management plans. Therefore, it is the aim of this paper to propose a methodology in order to gather essential information on rural roads in a cheap and systematic manner. In this way both the assessment of their condition and the taking of decisions on repairs can be facilitated. The information that should be gathered with this methodology was included in three different manuals: the first one was for operating procedures, the second one for the descriptive profiles, and the last one for distresses. The proposed method was validated by using it to assess the status of 41 low volume roads in different parts of Spain. (C) 2008 IAgrE. Published by Elsevier Ltd. All rights reserved. C1 [Gallego, E.] Univ Politecn Madrid, EUIT Agr, E-28040 Madrid, Spain. [Moya, M.] Univ Extremadura, Ctr Univ Plasencia, Plasencia 10600, Caceres, Spain. [Garcia, A. I.; Ayuga, F.] Univ Politecn Madrid, ETSI Agron, E-28040 Madrid, Spain. RP Gallego, E, Univ Politecn Madrid, EUIT Agr, Avda Complutense S-N, E-28040 Madrid, Spain. EM eutiquio.gallego@upm.es manuelmi@unex.es ai.garcia@upm.es francisco.ayuga@upm.es FU TRAGSA Company FX The authors thank the TRAGSA Company for funding this work. CR *AM ASS STAT HIGHW, 1962, 7 AASHO *AM SOC TEST MAT, 2004, E86704 ASTM *AUSTR, 1987, GUID VIS ASS PAV CON *BERKSH REG PLANN, 2001, 9806319 BMP BERKSH R *MIN OBR PUBL URB, 1989, CAT DET FIRM *PIARC, 1994, INT ROAD MAINT HDB P *S DAK DEP TRANSP, 2001, VIS DISTR SURV MAN ALQADI IL, 2001, NDT&E INT, V34, P427 ARCHONDOCALLAO R, 1999, 2 WORLD BANK AYUGA F, 2004, CONSERVACION S UNPUB BUSH AJ, 1989, ASTM STP, V1026 CHENG HD, 1998, INFORM SCIENCES, V108, P219 CHOOTE SL, 1998, FHWAOH9904 RES INT I DALRE R, 2001, CAMINOS RURALES PROY FUKUHARA T, 1990, J TRANSPORTATION ENG, V116, P280 GALLEGO E, 2004, P 2004 CIGR INT C CI, P14 GULINCK H, 2002, LANDSCAPE URBAN PLAN, V58, P137 HILL AR, 2001, RESOUR CONSERV RECY, V32, P305 JAARSMA CF, 1997, LANDSCAPE URBAN PLAN, V39, P47 JAARSMA CF, 2002, LANDSCAPE URBAN PLAN, V58, P125 JAARSMA CF, 2002, TRANSPORT RES A-POL, V36, P507 KOKKALIS A, 1998, CHAOS SOLITON FRACT, V11, P1875 KOKKALIS A, 1998, CHAOS SOLITON FRACT, V11, P1891 KSAIBATI K, 1999, EVALUATION PAVEMENT LUGO AE, 2000, FOREST ECOL MANAG, V133, P249 PAUWELS F, 2000, AGR ECOSYST ENVIRON, V77, P95 PRATER M, 1998, FUTURE ADEQUACY RURA ROBINSON R, 2004, ROAD ENG DEV SAARENKETO T, 2000, J APPL GEOPHYS, V43, P119 SAYERS M, 1986, GUIDELINES CONDUCTIN SUN L, 2001, J SOUND VIB, V247, P547 TALVITIE A, 2000, TRANSPORT POLICY, V7, P61 WALTON D, 2004, TRANSPORT RES A-POL, V38, P483, DOI 10.1016/j.tra.2004.03.004 NR 33 TC 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1537-5110 J9 BIOSYST ENG JI Biosyst. Eng. PD SEP PY 2008 VL 101 IS 1 BP 123 EP 134 DI 10.1016/j.biosystemseng.2008.06.009 PG 12 SC Agricultural Engineering GA 356HW UT ISI:000259770300014 ER PT J AU Gallego, E Moya, M Pinies, M Ayuga, F AF Gallego, E. Moya, M. Pinies, M. Ayuga, F. TI Valuation of low volume roads in Spain. Part 2: Methodology validation SO BIOSYSTEMS ENGINEERING LA English DT Article ID NETWORKS AB A methodology for assessing the condition of rural roads using the Road Condition Index (RCI) was developed by the authors in Part 1. However, such a theoretical methodology must be validated in order to corroborate its practical suitability. Therefore, a total of 41 rural roads (total length 109 km) were studied throughout 20 of the 50 Spanish provinces. Climate, the characteristics of the road surface and the use of the adjoining land were considered when selecting the study sample. Principal Components Analysis (PCA) was used to examine the Condition Index (CI) values for the roads analyzed. The information accounted for by the first three factors was then examined by Hierarchical Ascendant Classification (HAC) to place the roads in groups with similar characteristics. Thus, the influence of the different Condition indices (Cls) on overall evaluation status could be established and the possible similarities between roads could be studied as well. The results allowed the current condition of the roads to be described and helped to identify those features with the greatest influence on this status. (C) 2008 IAgrE. Published by Elsevier Ltd. All rights reserved. C1 [Gallego, E.] Univ Politecn Madrid, EUIT Agr, E-28040 Madrid, Spain. [Moya, M.] Univ Extremadura, Ctr Univ Plasencia, Plasencia 10600, Caceres, Spain. [Pinies, M.] CSIC, UPM, Unidad Asociada Metodos Estadist, E-28040 Madrid, Spain. [Ayuga, F.] Univ Politecn Madrid, ETSI Agron, E-28040 Madrid, Spain. RP Gallego, E, Univ Politecn Madrid, EUIT Agr, Avda Complutense S-N, E-28040 Madrid, Spain. EM eutiquio.gallego@upm.es manuelmi@unex.es mpinies@est.etsia.upm.es francisco.ayuga@upm.es FU TRAGSA Co FX The authors thank TRAGSA Co. for funding this research and Lucinio judez for his help in the statistical analysis. 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PD SEP PY 2008 VL 101 IS 1 BP 135 EP 142 DI 10.1016/j.biosystemseng.2008.06.010 PG 8 SC Agricultural Engineering GA 356HW UT ISI:000259770300015 ER PT J AU Alvarez, FJ Urena, J Hernandez, A Mazo, M Garcia, JJ Jimenez, A AF Alvarez, Fernando J. Urena, J. Hernandez, A. Mazo, M. Garcia, J. J. Jimenez, A. TI Influence of atmospheric refraction on the performance of an outdoor ultrasonic pulse compression system SO APPLIED ACOUSTICS LA English DT Article DE atmospheric refraction; ultrasonic sensory systems; pulse compression AB Nowadays, many ultrasonic sensory systems are being developed to operate outdoors, where they are finding a variety of applications, such as local positioning, vehicle navigation or obstacle detection. To assure the reliable operation of these systems under any meteorological condition, it is necessary to achieve a thorough comprehension of the effects that the different atmospheric phenomena can have on the propagation of these acoustic waves. This paper deals with one of these phenomena, atmospheric refraction, and its influence on the performance of an ultrasonic system whose signals are detected by matched filtering. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Alvarez, Fernando J.] Univ Extremadura, Dept Elect Engn Elect & Automat, Caceres 10071, Spain. [Urena, J.; Hernandez, A.; Mazo, M.; Garcia, J. J.; Jimenez, A.] Univ Alcala De Henares, Dept Elect, Madrid 28871, Spain. RP Alvarez, FJ, Univ Extremadura, Dept Elect Engn Elect & Automat, Caceres 10071, Spain. EM fafranco@unex.es CR *ISO TC, 1993, 961311993E ISOTC *POL CORP, 1999, 600 SER INSTR GRAD E ALVAREZ FJ, 2006, IEEE T ULTRASON FERR, V53, P1862 CUERVA A, 2000, J WIND ENG IND AEROD, V88, P25 EMBLETON TFW, 1996, J ACOUST SOC AM, V100, P31 GOLDER D, 1972, BOUND-LAY METEOROL, V3, P47 JORG KW, 1998, ROBOT AUTON SYST, V25, P241 LESPERANCE A, 1994, CAN ACOUST, V22, P125 MONIN AS, 1954, T GEOPHYS I AKAS NAU, V24, P163 PANOFSKY HA, 1984, MODELS METHODS ENG A PEREMANS H, 1993, IEEE T ROBOTIC AUTOM, V9, P36 PEREMANS H, 1994, THESIS U GENT NR 12 TC 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X J9 APPL ACOUST JI Appl. Acoust. PD NOV PY 2008 VL 69 IS 11 BP 994 EP 1002 DI 10.1016/j.apacoust.2007.07.006 PG 9 SC Acoustics GA 357GI UT ISI:000259833900008 ER PT J AU Penas-Lledo, EM Loeb, KL Puerto, R Hildebrandt, TB Llerena, A AF Penas-Lledo, Eva M. Loeb, Katharine L. Puerto, Rosa Hildebrandt, Thomas B. Llerena, Adrian TI Subtyping undergraduate women along dietary restraint and negative affect SO APPETITE LA English DT Article DE Dietary restraint; Negative mood; Binge eating; Fasting; Purging; Exercise ID BINGE-EATING DISORDER; SCALES VALID MEASURES; AFFECT DIMENSIONS; BULIMIA-NERVOSA; ADOLESCENT GIRLS; RISK-FACTORS; DATA SUGGEST; RESTRICTION AB Cluster-analytic studies of clinical populations of eating disordered women who binge eat have yielded two subtypes - pure dietary restraint and mixed dietary restraint-negative affect - consistent with etiologic and maintenance models of binge eating. This study aimed to replicate this subtyping scheme in university women. The scores of 623 undergrad females on the TFEQ-restraint and BDI scales were submitted to a cluster analysis and revealed three subtypes, "healthy" (47.4%), restrained (36.3%) and mixed (116.3%). In addition, comparisons between Subtypes on bulimic behaviors showed that the mixed and restrained subtypes were characterized by greater likelihood than the healthy group to engage in fasting, purging and exercise to control weight, as well as in disinhibition of eating. The mixed subtype revealed higher scores than the restrained subtype on eating disinhibition and purging, and the restrained group was more likely than the mixed subtype to exercise to control weight. These findings provide further support for the reliability and validity of this subtyping scheme, in which the confluence of even mild levels of negative affect and dietary restraint differentiated a more "disturbed" group of undergraduate females. Findings also put into question the dietary restraint theory of eating pathology and suggest the need to control negative affect when studying eating behavior. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Penas-Lledo, Eva M.; Llerena, Adrian] Univ Extremadura, Sch Med, E-06071 Badajoz, Spain. [Loeb, Katharine L.] Fairleigh Dickinson Univ, Teaneck, NJ 07666 USA. [Puerto, Rosa] Univ Extremadura, Sch Educ, E-06071 Badajoz, Spain. [Loeb, Katharine L.; Hildebrandt, Thomas B.] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA. RP Penas-Lledo, EM, Univ Extremadura, Sch Med, Avda Elvas Sn, E-06071 Badajoz, Spain. EM elledo@unex.es FU Spanish Ministry of Health, Instituto Carlos III-FIS [P106/1681]; European Union FEDER ; Network RETICS: Red de Enfermedades Mentales [RD06-0011 REM-TAP] FX This study was supported by a grant from Spanish Ministry of Health, Instituto Carlos III-FIS (P106/1681) and European Union FEDER and the Network RETICS: Red de Enfermedades Mentales (RD06-0011 REM-TAP). 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Ruiz-Lorenzo, J. J. TI Scaling analysis of the site-diluted Ising model in two dimensions SO PHYSICAL REVIEW E LA English DT Article ID PHASE-TRANSITION STRENGTH; PARTITION-FUNCTION ZEROS; TEMPERATURE SERIES ANALYSIS; EXACT CRITICAL-BEHAVIOR; MONTE-CARLO; CRITICAL EXPONENTS; CONCENTRATION EXPANSION; LOGARITHMIC CORRECTIONS; GENERAL DISTRIBUTIONS; ENSEMBLE APPROACH AB A combination of recent numerical and theoretical advances are applied to analyze the scaling behavior of the site-diluted Ising model in two dimensions, paying special attention to the implications for multiplicative logarithmic corrections. The analysis focuses primarily on the odd sector of the model (i.e., that associated with magnetic exponents), and in particular on its Lee-Yang zeros, which are determined to high accuracy. Scaling relations are used to connect to the even (thermal) sector, and a first analysis of the density of zeros yields information on the specific heat and its corrections. The analysis is fully supportive of the strong scaling hypothesis and of the scaling relations for logarithmic corrections. C1 [Kenna, R.] Coventry Univ, Appl Math Res Ctr, Coventry CV1 5FB, W Midlands, England. [Ruiz-Lorenzo, J. J.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Kenna, R, Coventry Univ, Appl Math Res Ctr, Coventry CV1 5FB, W Midlands, England. FU MEC [FIS2006-08533, FIS2007-60977] FX We thank Boris Shalaev for e-mail correspondences. This work has been partially supported by MEC through Contracts No. FIS2006-08533 and No. FIS2007-60977. 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Rev. E PD SEP PY 2008 VL 78 IS 3 PN Part 1 AR 031134 DI 10.1103/PhysRevE.78.031134 PG 7 SC Physics, Fluids & Plasmas; Physics, Mathematical GA 355BD UT ISI:000259682700041 ER PT J AU Chacon, R Bote, D Carretero-Gonzalez, R AF Chacon, R. Bote, D. Carretero-Gonzalez, R. TI Controlling chaos of a Bose-Einstein condensate loaded into a moving optical Fourier-synthesized lattice SO PHYSICAL REVIEW E LA English DT Article ID DYNAMICS; WAVES; GASES; ATOMS AB We study the chaotic properties of steady-state traveling-wave solutions of the particle number density of a Bose-Einstein condensate with an attractive interatomic interaction loaded into a traveling optical lattice of variable shape. We demonstrate theoretically and numerically that chaotic traveling steady states can be reliably suppressed by small changes of the traveling optical lattice shape while keeping the remaining parameters constant. We find that the regularization route as the optical lattice shape is continuously varied is fairly rich, including crisis phenomena and period-doubling bifurcations. The conditions for a possible experimental realization of the control method are discussed. C1 [Chacon, R.] Univ Extremadura, Dept Fis Aplicada, Escuela Ingn Ind, E-06071 Badajoz, Spain. [Bote, D.] Univ Extremadura, Dept Matemat, Escuela Ingn Ind, E-06071 Badajoz, Spain. [Carretero-Gonzalez, R.] San Diego State Univ, Nonlinear Dynam Syst Grp, Computat Sci Res Ctr, San Diego, CA 92182 USA. [Carretero-Gonzalez, R.] San Diego State Univ, Dept Math & Stat, San Diego, CA 92182 USA. RP Chacon, R, Univ Extremadura, Dept Fis Aplicada, Escuela Ingn Ind, Apartado Postal 382, E-06071 Badajoz, Spain. 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Rev. E PD SEP PY 2008 VL 78 IS 3 PN Part 2 AR 036215 DI 10.1103/PhysRevE.78.036215 PG 6 SC Physics, Fluids & Plasmas; Physics, Mathematical GA 355BH UT ISI:000259683100038 ER PT J AU Torrecilla, JS Rodriguez, F Bravo, JL Rothenberg, G Seddon, KR Lopez-Martin, I AF Torrecilla, Jose S. Rodriguez, Francisco Bravo, Jose L. Rothenberg, Gadi Seddon, Kenneth R. Lopez-Martin, Ignacio TI Optimising an artificial neural network for predicting the melting point of ionic liquids SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID HOMOGENEOUS CATALYSIS; DESULFURIZATION; EXTRACTION; CYCLOADDITIONS; BROMIDES; DESIGN; SCOPE; OIL; COP AB We present an optimised artificial neural network ( ANN) model for predicting the melting point of a group of 97 imidazolium salts with varied anions. Each cation and anion in the model is described using molecular descriptors. Our model has a mean prediction error of 1.30%, a regression coefficient of 0.99 and a mean P-value of 0.92. The ANN's prediction performance depends mainly on the anion size. In particular, the prediction error decreases as the anion size increases. The high statistical relevance makes this model a useful tool for predicting the melting points of imidazolium-based ionic liquids. C1 [Torrecilla, Jose S.; Rodriguez, Francisco] Univ Complutense Madrid, Fac Chem, Dept Chem Engn, E-28040 Madrid, Spain. [Bravo, Jose L.] Univ Extremadura, Dept Quim Organ & Inorgan, E-06071 Badajoz, Spain. [Rothenberg, Gadi] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1018 WV Amsterdam, Netherlands. [Seddon, Kenneth R.; Lopez-Martin, Ignacio] Queens Univ Belfast, Sch Chem & Chem Engn, QUILL Res Ctr, Belfast BT9 5AG, Antrim, North Ireland. RP Lopez-Martin, I, Univ Extremadura, Dept Quim Organ & Inorgan, Ave Univ S-N, E-10071 Caceres, Spain. EM iglomar@unex.es FU Spain's Ministerio de Educacion y Ciencia [CTQ2006-04644, CTQ2005-07676]; Ramon y Cajal research contract (JST) ; EPSRC [EP/D029538/1] FX JST and FR wish to thank Spain's Ministerio de Educacion y Ciencia for financial support (Project CTQ2006-04644) and for a Ramon y Cajal research contract (JST). JLB is grateful to Spain's Ministerio de Educacion y Ciencia for grant CTQ2005-07676. KRS and ILM gratefully acknowledge BP, QUILL, as well as the EPSRC (Grant EP/D029538/1) for funding. 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TI Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID NITRIC-OXIDE SYNTHASE; CEREBELLAR GRANULE CELLS; PARKINSONS-DISEASE; HUMAN NEUROBLASTOMA; PESTICIDE EXPOSURE; OXIDATIVE STRESS; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; ENVIRONMENTAL-FACTORS; DOPAMINERGIC-NEURONS; DNA FRAGMENTATION AB Paraquat (PQ) (1,1-dimethyl-4,4'-bipyridinium dichloride), a widely used herbicide, has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD). In this sense, understanding of the molecular mechanism underlying PQ-induced toxicity to neural cells is important for optimal use as well as for the development of new drugs. To gain insights into PQ-induced neurotoxicity, polymerase chain reaction (PCR) array analysis focused on a panel of apoptosis-related genes was performed using neuroblastoma SH-SY5Y cells. Up to 65 apoptosis-related genes were monitored. Our analysis of apoptotic process through microarray technology showed that in PQ-induced neuroblastoma SH-SY5Y cells, there is a different expression of BIK, CASP3, CASP7, CRADD, DAPK, FAS, and other related genes, in comparison to unstimulated cells. Evaluation of genes regulated differentially is essential for the development of therapeutic approaches in multifactorial diseases as PD. Our data provide a useful basis for screening candidate targets for early diagnosis and further intervention in PQ-mediated toxicity of neural cells. Paraquat (PQ) (1,1-dimethyl-4,4'-bipyridinium dichloride), a widely used herbicide, has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD). In this sense, understanding of the molecular mechanism underlying PQ-induced toxicity to neural cells is important for optimal use as well as for the development of new drugs. To gain insights into PQ-induced neurotoxicity, polymerase chain reaction (PCR) array analysis focused on a panel of apoptosis-related genes was performed using neuroblastoma SH-SY5Y cells. Up to 65 apoptosis-related genes were monitored. Our analysis of apoptotic process through microarray technology showed that in PQ-induced neuroblastoma SH-SY5Y cells, there is a different expression of BIK, CASP3, CASP7, CRADD, DAPK, FAS, and other related genes, in comparison to unstimulated cells. Evaluation of genes regulated differentially is essential for the development of therapeutic approaches in multifactorial diseases as PD. Our data provide a useful basis for screening candidate targets for early diagnosis and further intervention in PQ-mediated toxicity of neural cells. C1 [Moran, Jose M.; Gonzalez-Polo, Rosa A.; Ortiz-Ortiz, Miguel A.; Niso-Santano, Mireia; Soler, German; Fuentes, Jose M.] Univ Extremadura, Dept Bioquim Biol Mol & Genet, EU Enfermeria & TO, EU Enfermeria & TO, Caceres 10071, Spain. RP Moran, JM, Univ Extremadura, Dept Bioquim Biol Mol & Genet, EU Enfermeria & TO, EU Enfermeria & TO, Avda Univ S-N, Caceres 10071, Spain. EM jmmorang@unex.es jfuentes@unex.es FU Second Vice-presidency and Regional Ministry of Economy, Commerce and Innovation ; Spanish Ministry of Education and Science ; Junta de Extremadura [PRI06B124]; FIS-ISCIII, Spanish Ministry of Health and Consumer Affairs [PI040828, PI070400] FX The authors would like to thank to Maria Pura Delgado for helpful assistance in the laboratory work. Miguel Angel Ortiz Ortiz is a predoctoral recipient of a fellowship from Second Vice-presidency and Regional Ministry of Economy, Commerce and Innovation, from the Junta of Extremadura. Rosa Ana Gonzalez Polo is currently recipient of a "Juan de la Cierva" grant from Spanish Ministry of Education and Science. This work was supported by grants PRI06B124 from Junta de Extremadura and PI040828 and PI070400 from FIS-ISCIII, Spanish Ministry of Health and Consumer Affairs. 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Toxicol. Env. Health Part A PY 2008 VL 71 IS 22 BP 1457 EP 1467 DI 10.1080/15287390802329364 PG 11 SC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology GA 356ET UT ISI:000259762200001 ER PT J AU Reyes, FV Garzo, V Santos, A AF Reyes, Francisco Vega Garzo, Vicente Santos, Andres TI Impurity in a granular gas under nonlinear Couette flow SO JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT LA English DT Article DE granular matter; kinetic theory of gases and liquids; rheology and transport properties ID HOMOGENEOUS COOLING STATE; MONTE-CARLO-SIMULATION; BINARY-MIXTURES; LOW-DENSITY; KINETIC-THEORY; THERMAL-DIFFUSION; ELASTIC SPHERES; CIRCULAR DISKS; SHEAR FLOWS; HYDRODYNAMICS AB We study in this work the transport properties of an impurity immersed in a granular gas under stationary nonlinear Couette flow. The starting point is a kinetic model for low-density granular mixtures recently proposed by the authors (Vega Reyes et al 2007 Phys. Rev. E 75 061306). Two routes have been considered. First, a hydrodynamic or normal solution is found by exploiting a formal mapping between the kinetic equations for the gas particles and for the impurity. We show that the transport properties of the impurity are characterized by the ratio between the temperatures of the impurity and gas particles and by five generalized transport coefficients: three related to the momentum flux (a nonlinear shear viscosity and two normal stress differences) and two related to the heat flux (a nonlinear thermal conductivity and a cross-coefficient measuring a component of the heat flux orthogonal to the thermal gradient). Second, by means of a Monte Carlo simulation method we numerically solve the kinetic equations and show that our hydrodynamic solution is valid in the bulk of the fluid when realistic boundary conditions are used. Furthermore, the hydrodynamic solution applies to arbitrarily (inside the continuum regime) large values of the shear rate, of the inelasticity, and of the rest of the parameters of the system. Preliminary simulation results of the true Boltzmann description show the reliability of the nonlinear hydrodynamic solution of the kinetic model. This shows again the validity of a hydrodynamic description for granular flows, even under extreme conditions, beyond the Navier-Stokes domain. C1 [Reyes, Francisco Vega; Garzo, Vicente; Santos, Andres] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Reyes, FV, Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. EM fvega@unex.es vicenteg@unex.es andres@unex.es FU Ministerio de Educacion y Ciencia (Spain) [FIS2007-60977]; FEDER FX This research has been supported by the Ministerio de Educacion y Ciencia (Spain) through Programa Juan de la Cierva (FVR) and grant no. FIS2007-60977, partially financed by FEDER funds. 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Stat. Mech.-Theory Exp. PD SEP PY 2008 AR P09003 DI 10.1088/1742-5468/2008/09/P09003 PG 30 SC Mechanics; Physics, Mathematical GA 355HQ UT ISI:000259700400009 ER PT J AU Lopez, MG Sanchez, AM AF Lopez, M. Gaian Sanchez, A. Martin TI Present status of Rn-222 in groundwater in Extremadura SO JOURNAL OF ENVIRONMENTAL RADIOACTIVITY LA English DT Article DE radon; uranium series radionuclides; groundwater radioactivity; radon risk zones; dose AB Radon-222 was measured in groundwater sources of Extremadura (Spain), analyzing 350 samples from private and public springs, wells, and spas by liquid scintillation counting (LSC) and gamma spectrometry. The Rn-222 activity concentrations ranged from 0.24 to 1168 Bq L-1. The statistical analysis showed a log-normal distribution with a mean of (111 +/- 7) Bq L-1 and a median of (36 +/- 3) Bq L-1. A hydrogeological study revealed correlations between the activity concentration and the aquifer material's characteristics. A map of Rn-222 in groundwater was elaborated and compared with the natural gamma radiation map for this region. About 35% of the samples showed Rn-222 activity concentrations above the Euratom recommended limit of 100 Bq L-1. Three uranium series radionuclides (U-238, U-234, and Ra-226) were also assayed by alpha-particle spectrometry, estimating the annual effective dose due to the presence of these natural radionuclides in drinking water. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Lopez, M. Gaian] CIEMAT, Lab Metrol Radiaciones Ionizantes, E-28040 Madrid, Spain. [Sanchez, A. Martin] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Lopez, MG, CIEMAT, Lab Metrol Radiaciones Ionizantes, Ave Complutense 22, E-28040 Madrid, Spain. EM monica.galan@ciemat.es CR *UNSCEAR, 1993, SOURC EFF RISKS ION *UNSCEAR, 2000, SOURC EFF ION RAD LOPEZ MG, 2004, J RADIOANAL NUCL CH, V261, P631 LOPEZ MG, 2004, RADIAT PROT DOSIM, V111, P3, DOI 10.1093/rpd/nch350 LOPEZ MG, 2006, P LSC 2005 C RAD SPE, P165 MAHOU ES, 2000, COLECCION INFORM TEC, V5 MATARRANZ JLM, 2004, COLECCION INFORM TEC, V13 ROSINO J, 2003, RECURSOS MINEROS EXT SANCHEZ AM, 1995, J ENVIRON RADIOACTIV, V28, P209 NR 9 TC 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0265-931X J9 J ENVIRON RADIOACT JI J. Environ. Radioact. PD OCT PY 2008 VL 99 IS 10 BP 1539 EP 1543 DI 10.1016/j.jenvrad.2007.12.013 PG 5 SC Environmental Sciences GA 355QS UT ISI:000259724000006 ER PT J AU Garcia, N Gutierrez, G Lorenzo, M Garcia, JE Piriz, S Quesada, A AF Garcia, Nuria Gutierrez, Gloria Lorenzo, Maria Garcia, Jose E. Piriz, Segundo Quesada, Alberto TI Genetic determinants for cfxA expression in Bacteroides strains isolated from human infections SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article DE beta-lactamases; enzyme expression; antibiotic resistance; mobile elements; up-regulation ID A BETA-LACTAMASES; ANTIBIOTIC-RESISTANCE; CEPHALOSPORINASE GENE; FRAGILIS; IDENTIFICATION; TRANSPOSON; PREVOTELLA; SEQUENCE; CEPA; CFIA AB Objectives: To identify genetic determinants that determine beta-lactamase expression in Bacteroides strains isolated from human infections. Methods: beta-Lactam susceptibility and beta-lactamase enzyme expression were characterized in selected strains. beta-Lactamase genes and surrounding regions were analysed by PCR, inverse PCR and Southern hybridization. Results: High resistance to penicillins and cephalosporins was found among most isolated strains, in which all known beta-lactamase genes from Bacteroides are represented, but differences were found in their expression of enzyme activity. In contrast to the cepA gene, ubiquitously found but frequently inactive, or cfiA, which only confers carbapenem resistance in two strains, the detection of high beta-lactamase expression correlates closely with the presence of cfxA genes. This genetic determinant shares variability of upstream regulatory elements, including sequence tags from Tn4555, Tn4351 and IS614B, and polymorphisms of encoded amino acid sequences at positions G(57) C and (YC)-C-259, which might determine enzyme expression characteristics. Conclusions: The main determinant for beta-lactamase expression in Bacteroides strains is the cfxA gene, in which IS614B integration upstream of the coding sequence represents a molecular marker for higher levels of enzyme activity. C1 [Garcia, Nuria; Lorenzo, Maria; Piriz, Segundo] Univ Extremadura, Fac Vet, Dept Med & Sanidad Anim, Caceres 10071, Spain. [Gutierrez, Gloria; Quesada, Alberto] Univ Extremadura, Fac Vet, Dept Bioquim, Caceres 10071, Spain. [Garcia, Jose E.] Univ Salamanca, Univ Hosp, Dept Microbiol, Salamanca 37007, Spain. RP Quesada, A, Univ Extremadura, Fac Vet, Dept Bioquim, Avda Univ S-N, Caceres 10071, Spain. EM aquesada@unex.es FU Consejeria de Salud y Consumo, Junta de Extremadura, Espana [SCSS0459, SCSS0506, SCSS0629]; Ministerio de Educacion y Ciencia, Espana [AGL2005-02416] FX This work was supported by grants SCSS0459, SCSS0506 and SCSS0629 (Consejeria de Salud y Consumo, Junta de Extremadura, Espana) and AGL2005-02416 (Ministerio de Educacion y Ciencia, Espana). 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Antimicrob. Chemother. PD NOV PY 2008 VL 62 IS 5 BP 942 EP 947 DI 10.1093/jac/dkn347 PG 6 SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 359GP UT ISI:000259974700016 ER PT J AU Garcia-Martin, E Martinez, C Serrador, M Alonso-Navarro, H Navacerrada, F Agundez, JAG Jimenez-Jimenez, FJ AF Garcia-Martin, Elena Martinez, Carmen Serrador, Mercedes Alonso-Navarro, Hortensia Navacerrada, Francisco Agundez, Jose A. G. Jimenez-Jimenez, Felix Javier TI Histamine-N-methyl transferase polymorphism and risk for migraine SO HEADACHE LA English DT Article DE migraine; genetics; genetic polymorphisms; histamine-n-methyl-transferase; risk factors ID FAMILIAL HEMIPLEGIC MIGRAINE; PLASMA HISTAMINE; COMMON MIGRAINE; RELEASE; METHYLTRANSFERASE; LEUKOCYTES; SYSTEM; TYPE-2; BRAIN AB Background/Objectives.-Histamine has been implicated in the pathogenesis of migraine. In the CNS, histamine is almost exclusively metabolized by the polymorphic enzyme histamine N-methyltransferase (HNMT). The HNMT gene (chromosome 2q22.1), shows diverse single nucleotide polymorphisms. One of these, located in exon 4 C314T, causes the amino acid substitution Thr105IIe, related to decreased enzyme activity. The aim of this study was to investigate the possible association between HNMT polymorphism and the risk for migraine. Methods.-We studied the frequency of the HNMT genotypes and allelic variantes in 197 patients with migraine and 245 healthy controls using a PCR-RLFP method. Results.-The frequencies of the HNMT genotypes and allelic variants did not differ significantly between migraine patients and controls, and were unrelated with the age of onset of migraine attacks, gender, personal history of allergic diseases, family history of migraine, or presence of aura. Conclusion.-The results of the present study suggest that HNMT polymorphism in not related with the risk for migraine. C1 [Garcia-Martin, Elena] Univ Extremadura, Sch Biol Sci, Dept Biochem & Mol Biol, Madrid, Spain. [Martinez, Carmen; Agundez, Jose A. G.] Univ Extremadura, Sch Med, Dept Pharmacol & Psychiat, Madrid, Spain. [Serrador, Mercedes] Univ Alcala De Henares, Hosp Principe Asturias, Serv Family Med, Madrid, Spain. [Alonso-Navarro, Hortensia] Hosp Virgen Concha, Serv Neurol, Zamora, Spain. [Navacerrada, Francisco] Univ Alcala De Henares, Hosp Ramon y Cajal, Dept Med Neurol, Madrid, Spain. [Jimenez-Jimenez, Felix Javier] Univ Alcala De Henares, Hosp Principe Asturias, Dept Med Neurol, Madrid, Spain. RP Garcia-Martin, E, Univ Extremadura, Sch Biol Sci, Dept Biochem & Mol Biol, Madrid, Spain. FU Ministerio de Ciencia y Tecnologia [SAF 2003-00967]; Fondo de Investigacion Sanitaria, Instituto de Salad Carlos III [FIS 0511056, 06/1252]; Consejeria de Sanidad y Consumo, Junta de Extremadura [SCSS 0610, 0611, 0626] FX This work was supported in part by Grants SAF 2003-00967 from Ministerio de Ciencia y Tecnologia, FIS 0511056 and 06/1252 from Fondo de Investigacion Sanitaria, Instituto de Salad Carlos III, and SCSS 0610, 0611 and 0626 from Consejeria de Sanidad y Consumo, Junta de Extremadura. CR AAMODT AH, 2007, HEADACHE, V47, P204, DOI 10.1111/j.1526-4610.2006.00597.x BULPITT CJ, 1987, LANCET, V1, P494 CASTILLO J, 1995, REV NEUROL, V23, P749 DEFUSCO M, 2003, NAT GENET, V33, P192, DOI 10.1038/ng1081 DICHGANS M, 2005, LANCET, V366, P371 GAZERANI P, 2003, SCAND J IMMUNOL, V57, P286 HAIMART M, 1987, CEPHALALGIA, V7, P39 HEATLEY RV, 1982, CLIN ALLERGY, V12, P145 KEMPER RHA, 2001, CEPHALALGIA, V21, P549 KIM SH, 2002, NEUROSCI LETT, V321, P169 KRABBE AA, 1980, PAIN, V8, P253 KU M, 2006, ANN ALLERG ASTHMA IM, V97, P226 LASSEN LH, 1995, NEUROREPORT, V6, P1475 LAUNAY JM, 1987, REV MED INTERNE, V8, P273 MILLANGUERRERO RO, 2006, CAN J NEUROL SCI, V33, P195 OBATA T, 2002, NEUROCHEM RES, V27, P263 OPHOFF RA, 1996, CELL, V87, P543 PANULA P, 1984, P NATL ACAD SCI-BIOL, V81, P2572 PREUSS CV, 1998, MOL PHARMACOL, V53, P708 RASMUSSEN BK, 2006, HEADACHES, P235 REUTER U, 2001, BRAIN 12, V124, P2490 RUSSELL MB, 1995, BRIT MED J, V311, P541 SANDERS WM, 1980, HEADACHE, V20, P307 SELMAJ K, 1983, CEPHALALGIA, V3, P37 SELMAJ K, 1984, CEPHALALGIA, V4, P97 WATANABE T, 1984, BRAIN RES, V295, P13 WEABER C, 2006, HEADACHES, P143 NR 27 TC 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0017-8748 J9 HEADACHE JI Headache PD OCT PY 2008 VL 48 IS 9 BP 1343 EP 1348 DI 10.1111/j.1526-4610.2007.01056.x PG 6 SC Clinical Neurology GA 359PH UT ISI:000260000100006 ER PT J AU Bejarano, I Lozano, GM Ortiz, A Garcia, JF Paredes, SD Rodriguez, AB Pariente, JA AF Bejarano, Ignacio Lozano, Graciela M. Ortiz, Agueda Garcia, Juan F. Paredes, Sergio D. Rodriguez, Ana B. Pariente, Jose A. TI Caspase 3 activation in human spermatozoa in response to hydrogen peroxide and progesterone SO FERTILITY AND STERILITY LA English DT Article DE apoptosis; caspases; calcium; H2O2; progesterone; spermatozoa ID PANCREATIC ACINAR-CELLS; NF-KAPPA-B; INDUCED APOPTOSIS; HUMAN PLATELETS; INTRACELLULAR STORES; CALCIUM MOBILIZATION; SPERM CAPACITATION; ACROSOME REACTION; GENERATION; RELEASE AB Objective: To determine the role of calcium signaling on apoptosis evoked by the reactive oxygen species H2O2 and by the physiological agonist P in human ejaculated spermatozoa. Design: Laboratory study. Setting: Center for assisted human reproduction in a hospital in Spain. Patient(s): Forty-five healthy volunteers. Intervention(s): Spermatozoa were treated with increasing concentrations of hydrogen peroxide (H2O2; 10 mu M, 100 mu M, and 1 mM) or with 20 mu M of P for 5-120 minutes. Main Outcome Measure(s): Activation of caspase-3 and -9 as well as phosphatidylserine externalization were examined in human ejaculated spermatozoa by fluorescence methods. Result(s): Hydrogen peroxide and P induced activation of caspase-3 and -9. In addition, the effect of H2O2 and P was time dependent. Dimethyl-1,2-bis (aminophenoxy) ethane-N,N,N ',N '-tetraacetic acid loading was able to inhibit H2O2- and P-induced caspase-3 activation and phosphatidylserine externalization. Pretreatment of spermatozoa with Ru360, to block the calcium uptake into mitochondria, also was able to decrease the activation of caspase-3 and phosphatidylserine exposure that was stimulated by either H2O2 or P. Conclusion(s): These findings suggest that H2O2- and P-induced mitochondrial apoptosis is dependent on calcium signaling. C1 [Bejarano, Ignacio; Paredes, Sergio D.; Rodriguez, Ana B.; Pariente, Jose A.] Univ Extremadura, Fac Sci, Dept Physiol, Badajoz, Spain. [Lozano, Graciela M.; Ortiz, Agueda; Garcia, Juan F.] Infantile Hosp, Extremadura Ctr Human Assisted Reprod, Badajoz, Spain. RP Pariente, JA, Univ Extremadura, Fac Sci, Dept Physiol, Elvas Ave S-N, Badajoz, Spain. EM pariente@unex.es FU Ministerio de Educacion y Ciencia Direccion General de Investigacion [BFU2004-00165, BFU2007-60091]; Laboratories SERONO, S.A. (Madrid, Spain) FX Supported by Ministerio de Educacion y Ciencia Direccion General de Investigacion grants BFU2004-00165 and BFU2007-60091 (Madrid, Spain) and Laboratories SERONO, S.A. (Madrid, Spain). 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Steril. PD OCT PY 2008 VL 90 SU Suppl. 2 BP 1340 EP 1347 DI 10.1016/j.fertnstert.2007.08.069 PG 8 SC Obstetrics & Gynecology; Reproductive Biology GA 358US UT ISI:000259943600002 ER PT J AU Benitez, FJ Acero, JL Leal, AI AF Benitez, F. Javier Acero, Juan L. Leal, Ana I. TI Treatment of wastewaters from the cork process industry by using ultrafiltration membranes SO DESALINATION LA English DT Article DE ultrafiltration; rejection coefficients; volume reduction factor; fouling mechanisms; cork wastewater ID WASTE-WATER TREATMENT; NANOFILTRATION MEMBRANES; REMOVAL; PURIFICATION; REJECTION; RECOVERY; FLUX; OIL AB Wastewaters produced in the cork process Industry were treated by means of two commercial ultrafiltration membranes with MWCO of 10 kDa and 5 kDa, respectively. Previous experiments were conducted for the evalualion of the water hydraulic permeability of the membranes. Experiments with total recycling of the retentate and permeate streams, as well as experiments in batch concentration with partial recycling of the retentate stream were conducted. In both procedures, the influence of the main operating variables (transmembrane pressure, feed flow rate, temperature and nature of the membranes) oil the permeate flux was established. The purification levels reached by the membranes were also evaluated by determining the rejection coefficients referred to several parameters which measure the global pollutant content of the effluent: COD, absorbance at 254 nm, tannic Content, colour, and ellagic acid, one of the organic pollutant compounds which is present in this wastewater. Finally, experiments in Continuous mode. without recycling of both streams, were also carried Out. After the determination of the rejection coefficients, the fouling mechanism of the membranes was established by considering some filtration fouling models which are proposed in the literature. C1 [Benitez, F. Javier; Acero, Juan L.; Leal, Ana I.] Univ Extremadura, Dept Ingn Quim & Energet, E-06071 Badajoz, Spain. RP Benitez, FJ, Univ Extremadura, Dept Ingn Quim & Energet, E-06071 Badajoz, Spain. EM javben@unex.es FU Ministero de Educacion y Ciencia of Spain [CTQ2004-00961/PPQ] FX This research was Supported by the Ministero de Educacion y Ciencia of Spain through the Project CTQ2004-00961/PPQ. 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Math. 140:253-270, 2004) to study the automorphic and partially automorphic character of Banach spaces. We then introduce and study the automorphy index a(center dot) for a Banach space, showing that a(l(infinity)) = H-0 while a(C[0,1]) = H-1. C1 Univ Extremadura, Escuela Politecn Caceres, Dept Matemat, Caceres 10071, Spain. RP Moreno, Y, Univ Extremadura, Escuela Politecn Caceres, Dept Matemat, Avda Univ S-N, Caceres 10071, Spain. EM ymoreno@unex.es FU [MTM2004-02635] FX This research has been supported in part by project MTM2004-02635. 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PD OCT PY 2008 VL 16 IS 5 BP 617 EP 627 DI 10.1007/s10485-007-9074-7 PG 11 SC Mathematics GA 355NT UT ISI:000259716300002 ER PT J AU Luque-Almagro, VM Huertas, MJ Saez, LP Luque-Romero, MM Moreno-Vivian, C Castillo, F Roldan, MD Blasco, R AF Luque-Almagro, Victor M. Huertas, Maria-J. Saez, Lara P. Luque-Romero, Manuel Martinez Moreno-Vivian, Conrado Castillo, Francisco Roldan, M. Dolores Blasco, Rafael TI Characterization of the Pseudomonas pseudoalcaligenes CECT5344 cyanase, an enzyme that is not essential for cyanide assimilation SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID K-12 CYN OPERON; ESCHERICHIA-COLI; FLUORESCENS NCIMB-11764; CARBONIC-ANHYDRASE; INDUCIBLE CYANASE; NITROGEN; PROTEINS; CARBAMOYLATION; METABOLISM; STRAIN AB Cyanase catalyzes the decomposition of cyanate into CO2 and ammonium, with carbamate as an unstable intermediate. The cyanase of Pseudomonas pseudoalcaligenes CECT5344 was negatively regulated by ammonium and positively regulated by cyanate, cyanide, and some cyanometallic complexes. Cyanase activity was not detected in cell extracts from cells grown with ammonium, even in the presence of cyanate. Nevertheless, a low level of cyanase activity was detected in nitrogen-starved cells. The cyn gene cluster of P. pseudoalcaligenes CECT5344 was cloned and analyzed. The cynA, cynB, and cynD genes encode an ABC-type transporter, the cynS gene codes for the cyanase, and the cynF gene encodes a novel sigma(54)-dependent transcriptional regulator which is not present in other bacterial cyn gene clusters. The CynS protein was expressed in Escherichia coli and purified by following a simple and rapid protocol. The P. pseudoalcaligenes cyanase showed an optimal pH of 8.5 degrees C and a temperature of 65 degrees C. An insertion mutation was generated in the cynS gene. The resulting mutant was unable to use cyanate as the sole nitrogen source but showed the same resistance to cyanate as the wild-type strain. These results, in conjunction with the induction pattern of the enzymatic activity, suggest that the enzyme has an assimilatory function. Although the induction of cyanase activity in cyanide-degrading cells suggests that some cyanate may be generated from cyanide, the cynS mutant was not affected in its ability to degrade cyanide, which unambiguously indicates that cyanate is not a central metabolite in cyanide assimilation. C1 [Blasco, Rafael] Univ Extremadura, Fac Vet, Dept Bioquim & Biol Mol & Genet, E-10071 Caceres, Spain. [Luque-Almagro, Victor M.; Huertas, Maria-J.; Saez, Lara P.; Luque-Romero, Manuel Martinez; Moreno-Vivian, Conrado; Castillo, Francisco; Roldan, M. Dolores] Univ Cordoba, Dept Bioquim & Biol Mol, E-14071 Cordoba, Spain. RP Blasco, R, Univ Extremadura, Fac Vet, Dept Bioquim & Biol Mol & Genet, Avenida Univ SN, E-10071 Caceres, Spain. EM rblasco@unex.es FU Ministerio de Ciencia y Tecnologia [BMC2002-04126-C03-01, BMC2002-04126-C03-03, BIO2005-077741]; Junta de Andalucia [CVI-1728]; Junta de Extremadura [2PR04A022, PRI07A097] FX This work was funded by the Ministerio de Ciencia y Tecnologia (grants BMC2002-04126-C03-01, BMC2002-04126-C03-03, and BIO2005-077741), Junta de Andalucia (grant CVI-1728), and Junta de Extremadura (grants 2PR04A022 and PRI07A097). V.M.L.-A. was the recipient of a fellowship from the Ministerio de Educacion y Ciencia, and M. D. R. holds a postdoctoral fellowship from the Junta de Andaluc a (Spain). We gratefully acknowledge the help of Maria Dolores Luque de Castro and B. Vallejo-Pecharroman for some of the analytical determinations. We also thank GEMASUR S. L. and Kinbauri Espana S. L. for their fruitful collaboration. 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Chen, Yangquan TI A fractional adaptation scheme for lateral control of an AGV SO JOURNAL OF VIBRATION AND CONTROL LA English DT Proceedings Paper DE fractional control; adaptive control; autonomous vehicles ID ADAPTIVE-CONTROL; VEHICLE AB Lateral control of an autonomous guided vehicle is influenced strongly by both the longitudinal speed and the position input command ( magnitude of the reference signal) of the vehicle. For that reason some suitable strategies for governing the vehicle are adaptive and robust controllers. In this article, an adaptive scheme which combines a model reference approach with a fractional order adjustment rule for a feedforward gain adjustment is proposed. Two parameters can be tuned to obtain robustness with respect to variations in speed and magnitude of the reference signal: Adaptation gain, and derivative order of the adjustment rule. 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Vargas-Quesada, Benjamin Moya-Anegon, Felix TI A quick MST-based algorithm to obtain Pathfinder networks (infinity, n-1) SO JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY LA English DT Article ID SCIENCE; COCITATION; MAPS AB Network scaling algorithms such as the Pathfinder algorithm are used to prune many different kinds of networks, including citation networks, random networks, and social networks. However, this algorithm suffers from run time problems for large networks and online processing due to its O(n(4)) time complexity. In this article, we introduce a new alternative, the MST-Pathfinder algorithm, which will allow us to prune the original network to get its PFNET(infinity, n - 1) in just O(n(2).log n) time. The underlying idea comes from the fact that the union (superposition) of all the Minimum Spanning Trees extracted from a given network is equivalent to the PFNET resulting from the Pathfinder algorithm parameterized by a specific set of values (r = infinity and q = n - 1), those usually considered in many different applications. Although this property is well-known in the literature, it seems that no algorithm based on it has been proposed, up to now, to decrease the high computational cost of the original Pathfinder algorithm. We also present a mathematical proof of the correctness of this new alternative and test its good efficiency in two different case studies: one dedicated to the post-processing of large random graphs, and the other one to a real world case in which medium networks obtained by a cocitation analysis of the scientific domains in different countries are pruned. C1 [Quirin, Arnaud; Cordon, Oscar] European Ctr Soft Comp, Mieres, Spain. [Guerrero-Bote, Vicente P.] Univ Extremadura, Dept Informat & Commun, Badajoz, Spain. [Vargas-Quesada, Benjamin; Moya-Anegon, Felix] Univ Granada, SClmago Grp, Commun & Informat Sci Fac, Granada, Spain. RP Quirin, A, European Ctr Soft Comp, Edf Cientif Tecnol, Mieres, Spain. EM arnaud.quirin@softcomputing.es oscar.cordon@softcomputing.es guerrero@unex.es benjamin@ugr.es felix@ugr.es FU Plan Nacional de Investigacion Cientifica ; Desarrollo a Innovacion Tecnologica ; Fondo Europeo de Desarrollo Regional (FEDER) [SEJ-2004-08358-C02-01, SEJ2004-08358-C02-02] FX This work was funded by the Plan Nacional de Investigacion Cientifica, Desarrollo a Innovacion Tecnologica 2004-2007 and the Fondo Europeo de Desarrollo Regional (FEDER) as part of research projects SEJ-2004-08358-C02-01 and SEJ2004-08358-C02-02. We would like to thank the anonymous reviewers for their interesting comments and suggestions, which has allowed us to improve the quality of the contribution. 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Am. Soc. Inf. Sci. Technol. PD OCT PY 2008 VL 59 IS 12 BP 1912 EP 1924 DI 10.1002/asi.20904 PG 13 SC Computer Science, Information Systems; Information Science & Library Science GA 351WB UT ISI:000259455500004 ER PT J AU Sampaio, J Ibanez, SJ Gomez, MA Lorenzo, A Ortega, E AF Sampaio, Jaime Jose Ibanez, Sergio Angel Gomez, Miguel Lorenzo, Alberto Ortega, Enrique TI Game location influences basketball players' performance across playing positions SO INTERNATIONAL JOURNAL OF SPORT PSYCHOLOGY LA English DT Article DE basketball; home advantage; playing position ID SOCIAL FACILITATION; HOME ADVANTAGE; SPORT COMPETITIONS; STATISTICS; TASKS AB Home advantage in sport has been the subject of much empirical work, although the causes underlying this effect are still unclear. In team sports such as Basketball, available literature has analyzed home versus away performances at a team level. The present study investigated the presence of home advantage at the level of the individual player's position. It also attempted to identify a subset of game-related statistics that could discriminate home and away performances according to each players position. To achieve these aims, archival data were obtained from 225 games for the 2004-2005 Euroleague. Players were subdivided so that the "point guards" and "offguards" were pooled as guards (n=493), the "small forwards" and "power forwards" were grouped as forwards (n=485) and the centres (n=233). A 2x3 (game location: home and away; playing position: guards, forwards and centres) factorial MANOVA followed by a discriminant analysis was performed. For the guards, the discriminant function was significant and the game-related statistics that differentiated most home and away performances were the successful two point field-goals, defensive rebounds, assists, steals, blocks and committed fouls. The forwards' home and away performances were discriminated by successful free-throws, assists, steals, blocks and committed fouls. The function for centres was non significant. Results suggested a differential effect of home advantage in basketball players by role in the team, with guards from home teams playing more assertively, whereas in away teams forwards played more assertively. These results provide initial evidence to support a position specific approach when preparing for home and away games in team sports. C1 [Sampaio, Jaime] Univ Tras os Montes & Alto Douro, Sport Sci Dept, P-5001911 Vila Real, Portugal. [Jose Ibanez, Sergio] Univ Extremadura, Fac Sport Sci, E-06071 Badajoz, Spain. [Angel Gomez, Miguel; Lorenzo, Alberto] Univ Politecn Madrid, Fac Phys Act & Sport Sci, Madrid, Spain. [Ortega, Enrique] Catholic Univ St Anthony, Dept Phys Act & Sport Sci, Murcia, Spain. RP Sampaio, J, Univ Tras os Montes & Alto Douro, Dept Desporto, Apartado 202, P-5001911 Vila Real, Portugal. 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J. Sport Psychol. PD JUL-SEP PY 2008 VL 39 IS 3 BP 205 EP 216 PG 12 SC Hospitality, Leisure, Sport & Tourism; Psychology; Psychology, Multidisciplinary; Sport Sciences GA 352SW UT ISI:000259518700003 ER PT J AU Marme, A Zimmermann, HP Moldenhauer, G Schorpp-Kistner, M Muller, C Keberlein, O Giersch, A Kretschmer, J Seib, B Spiess, E Hunziker, A Merchan, F Moller, P Hahn, U Kurek, R Marme, F Bastert, G Wallwiener, D Ponstingl, H AF Marme, Alexander Zimmermann, Hans-Peter Moldenhauer, Gerhard Schorpp-Kistner, Marina Mueller, Claudia Keberlein, Olga Giersch, Antje Kretschmer, Juergen Seib, Brigitte Spiess, Eberhard Hunziker, Andreas Merchan, Faustino Moeller, Peter Hahn, Uwe Kurek, Raffael Marme, Frederik Bastert, Gunther Wallwiener, Diethelm Ponstingl, Herwig TI Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE biomarker; epigenetic regulation; hMOF ID RECESSIVE CEREBELLAR-ATAXIA; NUCLEAR-MEMBRANE; BREAST-CANCER; HISTONE ACETYLTRANSFERASE; GENE-EXPRESSION; PROTEIN; METHYLATION; SYNE-1; HETEROZYGOSITY; TISSUES AB In a study on gene deregulation in ovarian carcinoma we found a mRNA ceding for a 350 kDa protein, Drop1, to be downregulated 20- to 180-fold in the majority of ovarian and mammary carcinomas. The mRNA is encoded by a set of exons in the 5' region of the SYNE1 gene. Immunohistochemical staining for Drop1 protein by a specific monoclonal antibody corresponds to the pattern seen for the mRNA. cDNA arrays of matched pairs of tumor and normal tissue and in situ hybridizations confirmed the drastic loss of Drop1 mRNA as a common feature in uterus, cervix, kidney, lung, thyroid and pancreas carcinomas, already at early tumor stages and in all metastases. Two-hybrid studies suggest a role of this deficiency in the malignant progression of epithelial tumors. (c) 2008 Wiley-Liss, Inc. C1 [Zimmermann, Hans-Peter; Mueller, Claudia; Keberlein, Olga; Giersch, Antje; Kretschmer, Juergen; Seib, Brigitte; Ponstingl, Herwig] German Canc Res Ctr, Div Mol Biol Mitosis, D-69120 Heidelberg, Germany. [Marme, Alexander; Hahn, Uwe; Marme, Frederik; Bastert, Gunther] Univ Heidelberg, Dept Obstet & Gynecol, Heidelberg, Germany. [Marme, Alexander; Kurek, Raffael; Wallwiener, Diethelm] Univ Tubingen, Dept Obstet & Gynecol, D-7400 Tubingen, Germany. [Moldenhauer, Gerhard] Deutsch Krebsforschungszentrum, Div Mol Immunol, D-6900 Heidelberg, Germany. [Schorpp-Kistner, Marina] Deutsch Krebsforschungszentrum, Div Signal Transduct & Growth Control, D-6900 Heidelberg, Germany. [Spiess, Eberhard] Deutsch Krebsforschungszentrum, Biomed Struct Anal Grp, D-6900 Heidelberg, Germany. [Hunziker, Andreas] Deutsch Krebsforschungszentrum, DNA Sequencing Unit, D-6900 Heidelberg, Germany. [Merchan, Faustino] Univ Extremadura, Fac Vet Med, Dept Biochem & Mol Biol, Caceres, Spain. [Moeller, Peter] Univ Ulm, Dept Pathol, Ulm, Germany. RP Ponstingl, H, German Canc Res Ctr, Div Mol Biol Mitosis, Neuenheimer Feld 280, D-69120 Heidelberg, Germany. EM ponstingl@dkfz.de FU Strategiefords ; Helmholtz-Gemeinschaft Deutscher Forschungszentren FX Strategiefords Grant, Helmholtz-Gemeinschaft Deutscher Forschungszentren. 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J. Cancer PD NOV 1 PY 2008 VL 123 IS 9 BP 2048 EP 2056 DI 10.1002/ijc.23763 PG 9 SC Oncology GA 357HE UT ISI:000259836100009 ER PT J AU Balbontin, J Negro, JJ Sarasola, JH Ferrero, JJ Rivera, D AF Balbontin, Javier Negro, Juan Jose Sarasola, Jose Hernan Ferrero, Juan Jose Rivera, Domingo TI Land-use changes may explain the recent range expansion of the Black-shouldered Kite Elanus caeruleus in southern Europe SO IBIS LA English DT Article DE colonization; dehesa; habitat selection; land-use change; occurrence models; raptors ID HABITAT SELECTION; CLIMATE-CHANGE; MODELS; BEHAVIOR; SPAIN; BIRDS; CONSERVATION; MANAGEMENT; DISPERSAL; EVOLUTION AB Occasional observations of Black-shouldered Kites Elanus caeruleus in Europe date back to the mid-19th century, but it was only recorded as a breeding species in the early 1960s in Portugal and a few years later in neighbouring Spain. This recent colonization, possibly from Africa where the species is abundant, may be due to climate change, land-use changes in southern Europe, or both. As a first step to understanding this range expansion process we have developed a habitat selection model using data from the current strongholds of its European distribution. Comparing the proportion of different habitat types around 46 breeding sites and 45 randomly chosen plots, we have found that the area of cultivated parklands known as dehesas in Spain is a strong predictor of the current distribution range of breeding pairs of Black-shouldered Kites. Specifically, the percentage of dehesas with planted cereal and a low density of trees (i.e. < 7 trees/ha and thus a savannah-like habitat) within the study plots explained 44.6% of the residual deviance in our model. The minimal adequate model classified 81.3% of breeding sites and random plots correctly. Our results suggest that Black-shouldered Kites may have taken advantage of the gradual increase of cultivated dehesas in the second half of the 20th century to expand its range in Europe. This particular type of dehesa is structurally similar to the African savannahs where the species thrives and may offer a higher density of rodents than traditional dehesas, which primarily contain pastureland for livestock ranching. C1 [Balbontin, Javier] Univ Extremadura, Dept Anat Biol Celular & Zool, E-06071 Badajoz, Spain. [Negro, Juan Jose] CSIC Pabellon Peru, Dept Evolutionary Ecol, Estac Biol Donana, Seville 41013, Spain. [Sarasola, Jose Hernan] UNLPam, Fac Cs Exactas & Nat, CECARA, RA-6300 Santa Rosa, La Pampa, Argentina. [Ferrero, Juan Jose; Rivera, Domingo] Junta Extremadura, Direcc Gen Meido Nat, Merida 06800, Spain. RP Balbontin, J, Univ Extremadura, Dept Anat Biol Celular & Zool, Elvas S-N, E-06071 Badajoz, Spain. EM jbalare@unex.es FU Consejeria de Medio Ambiente of Extremadura FX We are grateful to J.M. Casas for searching and finding many nest-sites. We also thank J.M. Lopez Caballero who supervised the Elanus research project in the Consejeria de Medio Ambiente of Extremadura. J. M. Sayago, M. Vazquez, M. De la Riva, O. Gonzalez, C. Corbacho, J. C. Nunez, F. Sanchez, J. Zalba and J. Hernandez are thanked for their help with fieldwork. We would like to thank J. Davalos and A. Anega, and the staff of the Extremadura Government (Junta de Extremadura, Consejeria de Medio Ambiente) who gave access to the raster cartography used in this study. We also thank three anonymous reviewers, Simon Butler and Rauri Bowie for their constructive comments. 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Prieto, M. H. Daza, C. Monino, M. J. Garcia, M. I. TI Using digital images to characterize canopy coverage and light interception in a processing tomato crop SO HORTSCIENCE LA English DT Article DE photosynthetically active radiation; low-lying crops; percent of ground cover; crop canopy ID LEAF-AREA INDEX; PHOTOSYNTHETICALLY ACTIVE RADIATION; CORN CANOPIES; GROUND COVER; GROWTH; YIELD; PRODUCTIVITY; RED AB Canopy light interception (LI) is a determining factor for crop growth and yield. Crop yield depends on a canopy's capacity to intercept incident solar radiation, which in turn depends on the available leaf area, its structure, and its efficiency in converting the energy captured by the plant into biomass. Digital images offer a series of advantages over other methods of LI estimation, including the possibility to directly process images by computer for which free software is available. The objectives of this work were to develop a simple, economical method for determining LI in low-lying crops such as processing tomato using digital images obtained with a standard, commercial camera and free software and to evaluate the influence of different types of soil coverage (bare soil and plastic mulch) on LI. Photographs of the selected areas were taken using a digital camera at a distance of 160 cm above the center of each area. The resulting digital images were then analyzed with the free software GIMP 2.2 and IMAGE J. Three methods [area (SA), contour (SC). and reclassification (SR)] were used to quantify the percentage of groundcover (PGC). They were applied to the same images and compared with LI as measured with a line quantum sensor at solar noon. There was a close relationship between LI and estimated PGC with all three methods and for different soil cover regimes. In all cases, there was a linear adjustment with a significant correlation coefficient (P < 0.01) and an r(2) of greater than 0.88. The adjustment with RI was narrowest when the SR method was used to estimate PGC (r(2)=0.93) followed by SC (r(2) = 0.92) and SA (r(2) = 0.88). Measurements of LI based on digital images offered practical advantages with respect to the use of photosynthetically active radiation bars because the latter must be used at solar noon. In contrast, measurements obtained with a digital camera can be taken at any time of day and bright sunshine is not necessary. Different correlations were obtained for bare soil and plastic mulch conditions, so it was necessary to use a different equation to estimate LI under each condition. C1 [Campillo, C.; Prieto, M. H.; Daza, C.; Monino, M. J.; Garcia, M. I.] Junta Extremadura, Consejeria Infraestructuras & Desarrollo Tecnol, Ctr Invest Finca La Orden Valdesequera, Badajoz 06187, Spain. RP Campillo, C, Junta Extremadura, Consejeria Infraestructuras & Desarrollo Tecnol, Ctr Invest Finca La Orden Valdesequera, Badajoz 06187, Spain. EM carlos.campillo@juntaextremadura.net FU INIA [RTA04-060-C6-03]; FEDER FX This work was carried out as part of the INIA project RTA04-060-C6-03 and was cofinanced by FEDER funds. 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N. Navarro, C. de Lope, F. Moller, A. P. TI Effects of an immune challenge on multiple components of song display in barn swallows Hirundo rustica: Implications for sexual selection SO ETHOLOGY LA English DT Article ID IMMUNOCOMPETENCE-HANDICAP HYPOTHESIS; TRADE-OFFS; BIRD SONG; FEMALE CANARIES; SERINUS-CANARIA; PASSERINE BIRD; PARASITE LOAD; MATE CHOICE; TESTOSTERONE; ORNAMENTS AB Bird song is believed to honestly reveal male quality including the ability of singers to face parasitism. In a natural population of barn swallows Hirundo rustica, we experimentally imposed a cost on song production by an immune challenge. We therefore vaccinated a group of reproducing males with an antigen (Newcastle disease virus), and injected phosphate-buffered saline to a control group. Immune challenge significantly reduced one song feature, rattle duration. This decrease was related to male quality, as measured by tail length, because males with short tails reduced the duration of their rattle significantly more than males with long tails. In addition, another song feature, strophe duration, decreased in the control group, while it remained constant in the challenged group. Duration of the rattle has previously been found to be positively related to testosterone level, and it may hence reflect male competitive ability. Thus, male barn swallows may not have the potential to produce long rattles when their immune system is challenged. By maintaining their strophe duration after an immune challenge, males may compensate for the decrease in rattle duration. Our results suggest that different song features may convey different types of information, and that barn swallow song, in particular their rattle, may reliably reveal information about activation of the immune system. C1 [Dreiss, A. N.] Univ Paris 06, Lab Fonctionnement & Evolut Syst Ecol, Paris, France. [Navarro, C.] CSIC, Dept Ecol Func & Evolut, Almeria, Spain. [de Lope, F.] Univ Extremadura, Dept Biol Anim, Badajoz, Spain. [Moller, A. P.] Univ Paris 06, Lab Parasitol Evolut, Paris, France. RP Dreiss, AN, Univ Lausanne, Dept Ecol & Evolut, Biol Bldg, CH-1015 Lausanne, Switzerland. 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Lorda-Diez, Carlos I. Ganan, Yolanda Macias, Domingo Hurle, Juan M. TI Activin/TGF beta and BMP crosstalk determines digit chondrogenesis SO DEVELOPMENTAL BIOLOGY LA English DT Article DE limb development; digit morphogenesis; chondrogenesis; interdigital cell death; BMP; activin; TGF beta; BMP antagonist ID BONE MORPHOGENETIC PROTEIN; PROGRAMMED CELL-DEATH; BRACHYDACTYLY TYPE A2; CHICK LEG BUD; LIMB DEVELOPMENT; MOUSE LIMB; RECEPTOR; PATTERN; DIFFERENTIATION; FOLLISTATIN AB The progress zone (PZ) is a specialized area at the distal margin of the developing limb where mesodermal cells are kept in proliferation and undifferentiated, allowing limb outgrowth. At stages of digit morphogenesis the PZ cells can undergo two possible fates, either aggregate initiating chondrogenic differentiation to configure the digit blastemas, or to die by apoptosis if they are incorporated in the interdigital mesenchyme. While both processes are controlled by bone morphogenetic proteins (BMPs) the molecular basis for such contrasting differential behavior of the autopodial mesoderm remains unknown. Here we show that a well-defined Crescent domain of high BMP activity located at the tip of the forming digits, which we termed the digit crescent (DC), directs incorporation and differentiation of the PZ mesenchymal cells into the digit aggregates. The presence of this domain does not correlate with an exclusive expression domain of BMP receptors and its abrogation by surgical approaches or by local application of BMP antagonists is followed by digit truncation and cell death. We further show that establishment of the DC is directed by Activin/TGF beta signaling, which inhibits Smad 6 and Bambi, two specific BMP antagonists expressed in the interdigits and Progress zone mesoderm. The interaction between Activin/TGF beta and BMP pathways at the level of DC promotes the expression of the chondrogenic factor SOX9 accompanied by a local decrease in cell proliferation. Characteristically, the DC domain is asymmetric, it being extended towards the posterior interdigit. The presence of the DC is transitorily dependent of the adjacent posterior interdigit and its maintenance requires also the integrity of the AER. (C) 2008 Elsevier Inc. All rights reserved. C1 [Montero, Juan A.; Lorda-Diez, Carlos I.; Hurle, Juan M.] Univ Cantabria, Fac Med, Dept Anat & Biol Celular, Santander 39011, Spain. [Ganan, Yolanda; Macias, Domingo] Univ Extremadura, Dept Ciencias Morfol & Biol Celular & Anim, E-06071 Badajoz, Spain. RP Hurle, JM, Univ Cantabria, Fac Med, Dept Anat & Biol Celular, Santander 39011, Spain. 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Biol. PD SEP 15 PY 2008 VL 321 IS 2 BP 343 EP 356 DI 10.1016/j.ydbio.2008.06.022 PG 14 SC Developmental Biology GA 352TP UT ISI:000259520600006 ER PT J AU Garcia-Relriz, A Damiani, PC Olivieri, AC Canada-Canada, F de la Pena, AM AF Garcia-Relriz, Alejandro Damiani, Patricia C. Olivieri, Alejandro C. Canada-Canada, Florentina de la Pena, Arsenio Munoz TI Nonlinear four-way kinetic-excitation-emission fluorescence data processed by a variant of parallel factor analysis and by a neural network model achieving the second-order advantage: Malonaldehyde determination in olive oil samples SO ANALYTICAL CHEMISTRY LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; TRILINEAR LEAST-SQUARES; RESIDUAL TRILINEARIZATION; MULTIVARIATE CALIBRATION; FOLIC-ACID; MATRIX FLUORESCENCE; MALONDIALDEHYDE; METHOTREXATE; SERUM; BILINEARIZATION AB Four-way data were obtained by recording the kinetic evolution of excitation-emission fluorescence matrices for the product of the Hantzsch reaction between the analyte malonaldehyde and methylamine. The reaction product, 1,4-disubstituted-1,4-dihydropyridine-3,5-dicarbaldehyde, is a highly fluorescent compound. The nonlinear nature of the kinetic fluorescence data has been demonstrated, and therefore the four-way data were processed with parallel factor analysis combined with a nonlinear pseudounivariate regression, based on a quadratic polynomial fit, and also with a recently introduced neural network methodology, based on the combination of unfolded principal component analysis, residual trilinearization, and radial basis functions. The applied chemometric strategies are not only able to adequately model the nonlinear data but also to successfully determine malonaldehyde in olive oil samples. This is possible since the experimentally recorded four-way data, modeled with the above-mentioned advanced chemometric approaches, permit the achievement of the second-order advantage. This allows us to predict the analyte concentration in a complex background, in spite of the nonlinear behavior and in the presence of uncalibrated interferences. The present work is a new example of the use of higher-order data for the resolution of a complex nonlinear system, successfully employed in the context of food chemical analysis. C1 [Garcia-Relriz, Alejandro; Damiani, Patricia C.; Olivieri, Alejandro C.] Univ Nacl Rosario, Inst Quim, CONICET, Fac Ciencias Bioquim & Farmaceut,Dept Quim Analit, RA-2000 Rosario, Santa Fe, Argentina. [Canada-Canada, Florentina; de la Pena, Arsenio Munoz] Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. RP Olivieri, AC, Univ Nacl Rosario, Inst Quim, CONICET, Fac Ciencias Bioquim & Farmaceut,Dept Quim Analit, Suipacha 531,S2002LRK, RA-2000 Rosario, Santa Fe, Argentina. EM aolivier@fbioyf.unr.edu.ar arsenio@unex.es FU Ministerio de Educacion y Ciencia of Spain [CTQ2005-02389]; AECI [A/6576/06]; Universidad Nacional de Rosario ; CONICET (Consejo Nacional de Investigaciones Cientificas y Tecnicas) [PIP 5303]; ANPCyT (Agencia Nacional de Promocion Cientifica y Tecnologica) [PICT-25825] FX The following institutions are gratefully acknowledged for financial support: Ministerio de Educacion y Ciencia of Spain (Project CTQ2005-02389), AECI (Programa Intercampus Iberoamerica/PCI Project A/6576/06), Universidad Nacional de Rosario, CONICET (Consejo Nacional de Investigaciones Cientificas y Tecnicas, Project No. PIP 5303), and ANPCyT (Agencia Nacional de Promocion Cientifica y Tecnologica, Project No. PICT-25825). 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Chem. PD OCT 1 PY 2008 VL 80 IS 19 BP 7248 EP 7256 DI 10.1021/ac8007829 PG 9 SC Chemistry, Analytical GA 353XS UT ISI:000259603100013 ER PT J AU Cardoso, BM Sant'Anna, MK Dias, VV Andreazza, AC Cereser, KM Kapczinski, F AF Cardoso, Betina Mariante Sant'Anna, Marcia Kauer Dias, Vasco Videira Andreazza, Ana Christina Cereser, Keila Maria Kapczinski, Flavio TI The impact of co-morbid alcohol use disorder in bipolar patients SO ALCOHOL LA English DT Article DE bipolar disorder; substance use disorder; suicide; functioning; alcohol ID SUBSTANCE USE DISORDERS; QUALITY-OF-LIFE; DRUG-ABUSE; ANXIETY DISORDERS; DUAL DIAGNOSIS; RISK-FACTORS; I DISORDER; COMORBIDITY; DEPENDENCE; SUICIDE AB Alcohol use is highly prevalent in patients with bipolar disorder (131)) and is associated with significant mortality and morbidity. The detrimental effects of each condition are compounded by the presence of the other. The objective of this study was to examine the impact of alcohol abuse and of alcohol dependence in BD in a Brazilian sample, as indicated by clinical severity, functional impairment, and quality of life (QOL). A cross-sectional survey of 186 bipolar outpatients were interviewed using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-4th Edition. The primary outcome measures were functioning, as indicated by the Global Assessment of Functioning Scale scores and QOL, as indicated by the World Health Organization Quality of Life Instrument. Secondary outcomes were clinical severity features. Alcohol abuse and dependence were associated with male gender, lower education, earlier age of onset, psychosis within first episode, depressive symptoms, and worse functioning. In addition, the presence of alcohol abuse or dependence was associated with remarkably high rates of suicide attempt. Our findings suggest that the co-occurrence of alcohol abuse/ dependence with BD increases the risk for suicide attempt, which may reflect in part the greater severity of symptoms and impaired functioning. This subgroup of bipolar patients requires a treatment tailored to address both conditions. (C) 2008 Elsevier Inc. All rights reserved. C1 [Cardoso, Betina Mariante; Sant'Anna, Marcia Kauer; Dias, Vasco Videira; Andreazza, Ana Christina; Cereser, Keila Maria; Kapczinski, Flavio] Hosp Clin Porto Alegre, Ctr Pesquisas, Lab Mol Psychiat, BR-90035000 Porto Alegre, RS, Brazil. [Cardoso, Betina Mariante; Sant'Anna, Marcia Kauer; Dias, Vasco Videira; Andreazza, Ana Christina; Cereser, Keila Maria; Kapczinski, Flavio] Hosp Clin Porto Alegre, Bipolar Disorders Program, BR-90035000 Porto Alegre, RS, Brazil. [Sant'Anna, Marcia Kauer; Andreazza, Ana Christina] Univ Fed Rio Grande do Sul, Dept Biochem, BR-90046900 Porto Alegre, RS, Brazil. [Dias, Vasco Videira] Univ Extremadura, Badajoz, Spain. RP Kapczinski, F, Hosp Clin Porto Alegre, Ctr Pesquisas, Lab Mol Psychiat, Ramiro Barcelos 2350, BR-90035000 Porto Alegre, RS, Brazil. EM kapcz@terra.com.br FU Canadian Institutes of Health Research ; Stanley Medical Research Institute ; NARSAD Young Investigator ; CNPq FX Dr. Kauer-Sant' Anna has been an investigator in clinical trials sponsored by Servier, Canadian Institutes of Health Research, and Stanley Medical Research Institute and is a NARSAD Young Investigator. Dr. Andreazza has been supported by CNPq (Brazil). Dr. Kapczinski has been an investigator in clinical trials sponsored by CNPq, Canadian Institutes of Health Research, Stanley Medical Research Institute and Servier. He has worked as consultant/speaker for Servier, Astra-Zeneca, Eli-Lilly, and Abbott. Dr. Dias is a consultant for Angelini Pharmaceuticals. Dr. Cardoso reports no conflicting interest. 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Cubero, Javier Rodriguez, Ana B. Barriga, Carmen TI Circadian variations of serotonin in plasma and different brain regions of rats SO MOLECULAR AND CELLULAR BIOCHEMISTRY LA English DT Article DE serotonin; circadian variations; plasma; brain ID SUPRACHIASMATIC NUCLEUS; PINEAL-GLAND; RAPHE NUCLEI; ACID OUTPUT; IN-VIVO; MELATONIN; RHYTHM; RELEASE; PHAGOCYTOSIS; STIMULATION AB Most of the physiological processes that take place in the organism follow a circadian rhythm. Serotonin is one of the most important neurotransmitters in our nervous system, and has been strongly implicated in the regulation on the mammalian circadian clock, located in the suprachiasmatic nuclei (SCN). The present study analysed the levels of serotonin over a period of 24 h in the plasma and in different brain regions. The model used was of male Wistar rats, 14 +/- 2 weeks of age (n = 120), maintained under conditions of 12 h light and 12 h dark, and food and water ad libitum. The serotonin levels were measured by ELISA every hour at night (20:00-08:00 h) and every 4 h during the daytime (08:00-20:00 h). Ours results show that the maximum levels of serotonin in plasma were obtained at 09:00 and 22:00 and a minor peak at 01:00 h. In hypothalamus there was a significant peak at 22:00 and two minor peaks at 17:00 and 02:00 h; the same occurred in hippocampus with a significant peak at 21:00, and two secondary peaks at 24:00 and 05:00 h; in cerebellum there were two peaks at 21:00 and 02:00 h, while in striatum and pineal there were peaks at 21:00 h and 23:00, respectively. In conclusion, the higher levels of serotonin were during the phase of darkness, which varies depending on the region in which it is measured. C1 [Sanchez, Soledad; Sanchez, Cristina; Paredes, Sergio D.; Cubero, Javier; Rodriguez, Ana B.; Barriga, Carmen] Univ Extremadura, Dept Physiol, Fac Sci, Neuroimmunophysiol Res Grp, E-06071 Badajoz, Spain. RP Sanchez, S, Univ Extremadura, Dept Physiol, Fac Sci, Neuroimmunophysiol Res Grp, Avda Elvas S-N, E-06071 Badajoz, Spain. EM solsan@unex.es FU Fundacion Fernando Valhondo Calaff ; Consejeria de Economia ; Comercio e Innovacion-Fondo Social Europeo [POS07012] FX The authors would like to express their thanks to Ms Elena Circujano Vadillo for her technical assistance, and to Professors Juan Antonio Madrid (University of Murcia) and Ruben V. Rial (University of the Balearic Islands) for their advice and collaboration in the chronobiological and statistical study. Soledad Sanchez Mateos held a grant awarded by the Fundacion Fernando Valhondo Calaff. Sergio D. Paredes was the beneficiary of a grant from Consejeria de Economia, Comercio e Innovacion-Fondo Social Europeo (Junta de Extremadura POS07012). 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Cell. Biochem. PD OCT PY 2008 VL 317 IS 1-2 BP 105 EP 111 DI 10.1007/s11010-008-9836-z PG 7 SC Cell Biology GA 351QX UT ISI:000259440500012 ER PT J AU Lopez, JJ Salido, GM Pariente, JA Rosado, JA AF Lopez, J. J. Salido, G. M. Pariente, J. A. Rosado, J. A. TI Thrombin induces activation and translocation of Bid, Bax and Bak to the mitochondria in human platelets SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS LA English DT Article DE apoptosis; Bax; Bid; hydrogen peroxide; mitochondria; platelets; thrombin ID MEDIATED CALCIUM-ENTRY; CYTOCHROME-C RELEASE; APOPTOSIS-LIKE EVENTS; HYDROGEN-PEROXIDE; ACTIN CYTOSKELETON; CELL-DEATH; CA2+ MOBILIZATION; INVOLVEMENT; GENERATION; DYSFUNCTION AB Background: Thrombin is a physiological platelet agonist that activates apoptotic events, including cytochrome c release and phosphatidylserine exposure; however, the mechanisms underlying these events remain unclear. Objectives: The present study is aimed to investigate whether thrombin induces activation and mitochondrial translocation of Bid, Bax and Bak. Methods: Changes in the mitochondrial membrane potential were registered using the dye JC-1; Bid, Bax and Bak translocation to the mitochondria was detected by immunoprecipitation and Western blotting in samples from mitochondrial and cytosolic fractions. Results: Treatment of platelets with thrombin or ADP induces activation and mitochondrial association of active Bid, Bax and Bak. Translocation of Bid and Bax to the mitochondria was reduced by cytochalasin D, latrunculin A or jasplakinolide. Platelet exposure to exogenous H2O2 (10 mu M) results in activation of Bid and Bax, which was found to be similar to the effect of thrombin. Thrombin evokes mitochondrial membrane depolarization, which is attenuated by catalase. Conclusion: Our results indicate that thrombin induces activation and mitochondrial translocation of Bid, Bax and Bak, which is likely to be one of the apoptotic events in human platelets. C1 [Lopez, J. J.; Salido, G. M.; Pariente, J. A.; Rosado, J. A.] Univ Extremadura, Dept Physiol, Cellular Physiol Res Grp, Caceres 10071, Spain. RP Rosado, JA, Univ Extremadura, Dept Physiol, Cellular Physiol Res Grp, Caceres 10071, Spain. EM jarosado@unex.es FU MEC-DGI [BFU2007-60104, BFU2007-60091] FX This work and JJL were supported by MEC-DGI BFU2007-60104 and BFU2007-60091. We thank M. Gomez for assistance. 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Thromb. Haemost. PD OCT PY 2008 VL 6 IS 10 BP 1780 EP 1788 DI 10.1111/j.1538-7836.2008.03111.x PG 9 SC Hematology; Peripheral Vascular Disease GA 350OK UT ISI:000259361900026 ER PT J AU Martin, JA Solla, A Domingues, MR Coimbra, MA Gila, L AF Martin, Juan A. Solla, Alejandro Domingues, M. Rosario Coimbra, Manuel A. Gila, Luis TI Exogenous phenol increase resistance of Ulmus minor to Dutch elm disease through formation of suberin-like compounds on xylem tissues SO ENVIRONMENTAL AND EXPERIMENTAL BOTANY LA English DT Article DE Ulmus minor Mill.; Ophiostoma novo-ulmi Brasier; Dutch elm disease; phenol; suberin ID TRANSFORM-INFRARED-SPECTROSCOPY; TANDEM MASS-SPECTROMETRY; BARRIER ZONE FORMATION; OPHIOSTOMA-NOVO-ULMI; SOLID-STATE C-13-NMR; SCOLYTUS-MULTISTRIATUS; FATTY-ACIDS; MECHANISM; CORK; PLANTS AB The survival of some elms to Dutch elm disease (DED) epidemics could be related with the application of disinfectant products based on simple phenols. To test this hypothesis, the protective effect of different phenolic treatments in Ulmus minor trees was evaluated through inoculations with Ophiostoma novo-ulmi, the current DED pathogen. During spring 2004 and spring 2005, 4-year-old elms were: (i) watered with a 0.02% solution of the phenolic fraction of phenolic oil, (ii) watered with a 0.02 and 0.2% solution of a phenol-cresol mixture, and (iii) trunk injected with a 0.2% solution of phenol-cresol mixture. In May, trees were artificially inoculated with O. novo-ulmi. At the end of the 2004 and 2005 vegetative periods, phenol-treated trees showed significantly lower wilting values than control trees. One week of bud break delay was observed in trees watered with the 0.2% solution of phenol-cresol mixture. Fourier transform-infrared spectroscopy and electrospray ionisation mass spectrometry evidenced enhanced levels of suberin-like compounds in phenol-treated trees with respect to non-treated trees. The deposition of suberin in xylem tissues, as a response to phenol treatments, might be considered as one of the mechanisms of resistance of elms to O. novo-ulmi. (c) 2008 Elsevier B.V. All rights reserved. C1 [Solla, Alejandro] Univ Extremadura, Plasencia 10600, Spain. [Martin, Juan A.; Gila, Luis] Univ Politecn Madrid, ETSI Montes, E-28040 Madrid, Spain. [Domingues, M. Rosario; Coimbra, Manuel A.] Univ Aveiro, Dept Quim, P-3810193 Aveiro, Portugal. RP Solla, A, Univ Extremadura, Avenida Virgen Puerto 2, Plasencia 10600, Spain. EM asolla@unex.es FU DGB (Ministerio de Medio Ambiente) ; ETSI Montes (Universidad Politecnica de Madrid) ; INIA [RTA2005-00151-00-00] FX We thank M. Buron, D. Gonzalez (Universidad Politecnica de Madrid, Spain), and A. Ferreira (Universidade de Aveiro, Portugal) for their technical support, and M. Venturas (Universidad Politecnica de Madrid) for the English revision. The collaboration of Dr. I. Delgadillo, Dr. S. Rocha, and Dr. A. Barros (Universidade de Aveiro) is gratefully acknowledged. This work was supported by an agreement established between DGB (Ministerio de Medio Ambiente) and ETSI Montes (Universidad Politecnica de Madrid), and by the INIA Project RTA2005-00151-00-00 (Ministerio de Educacion y Ciencia). 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Exp. Bot. PD SEP PY 2008 VL 64 IS 1 BP 97 EP 104 DI 10.1016/j.envexpbot.2008.05.004 PG 8 SC Plant Sciences; Environmental Sciences GA 351QJ UT ISI:000259438800013 ER PT C AU Barrio, R Blanco, E Parrondo, J Gonzalez, J Fernandez, J AF Barrio, Raul Blanco, Eduardo Parrondo, Jorge Gonzalez, Jose Fernandez, Joaquin TI The effect of impeller cutback on the fluid-dynamic pulsations and load at the blade-passing frequency in a centrifugal pump SO JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Proceedings Paper DE centrifugal pump; volute casing; blade-tongue interaction; unsteady flow simulation; pressure fluctuation measurements; blade-passing frequency load; effect of impeller-tongue radial gap ID ROTOR-STATOR INTERACTION; UNSTEADY-FLOW; PRESSURE-FLUCTUATIONS; VOLUTE; FORCES; TONGUE; DIFFUSER; NUMBER; NOISE AB A study is presented on the fluid-dynamic pulsations and the corresponding dynamic forces generated in a centrifugal pump with single suction and vaneless volute due to blade-volute interaction. Four impellers with different outlet diameters, obtained from progressive cutbacks (trimmings) of the greatest one, were successively considered in the test pump, so that the radial gap between the impeller and the volute ranged from 8.8% to 23.2% of the impeller radius. The study was based on the numerical computation of the unsteady flow through the machine for a number of flow rates by means of the FLUENT code, solving the 3D unsteady Reynolds-averaged Navier-Stokes equations. Additionally, an experimental series of tests was conducted for the pump with one of the impellers, in order to obtain pressure fluctuation data along the volute front wall that allowed contrasting the numerical predictions. The data collected from the numerical computations were used to estimate the dynamic radial forces and torque at the blade-passing frequency, as a function of flow rate and blade-tongue radial gap. As expected, for a given impeller diameter, the dynamic load increases for off-design conditions, especially for the low range of flow rates, whereas the progressive reduction of the impeller-tongue gap brings about corresponding increments in dynamic load. In particular, varying the blade-tongue gap within the limits of this study resulted in multiplying the maximum magnitude of the blade-passing frequency radial force by a factor of about 4 for low flow rates (i.e., below the nominal flow rate) and 3 for high flow rates. C1 [Barrio, Raul; Blanco, Eduardo; Parrondo, Jorge; Gonzalez, Jose] Univ Oviedo, Area Mecan Fluidos, Gijon 33271, Spain. [Fernandez, Joaquin] Univ Extremadura, Escuela Ingn Ind, E-06071 Badajoz, Spain. RP Barrio, R, Univ Oviedo, Area Mecan Fluidos, Campus Viesques, Gijon 33271, Spain. EM parrondo@uniovi.es CR BACHERT R, 2005, P FEDSM 05 HOUST TX BRENNEN CE, 1994, HYDRODYNAMICS PUMPS BYSKOV RK, 2003, ASME, V125, P73 CHU S, 1995, J FLUID ENG-T ASME, V117, P30 DONG R, 1997, ASME, V119, P506 FATSIS A, 1997, ASME, V119, P94 GONZALEZ J, 2002, J FLUID ENG-T ASME, V124, P348 GONZALEZ J, 2006, J FLUID ENG-T ASME, V128, P454 GONZALEZ J, 2006, J FLUID ENG-T ASME, V128, P937 GUELICH JF, 1992, J VIB ACOUST, V114, P272 HASEGAWA Y, 1990, JSME INT J II-FLUID, V33, P736 HASEGAWA Y, 1990, P 15 IAHR S 1990 BEL JAPIKSE D, 1997, CENTRIFUGAL PUMP DIS JEKAT WK, 1985, PUMP HDB KAUPERT KA, 1999, J FLUID ENG-T ASME, V121, P621 KITTREDGE CP, 1985, PUMP HDB MAJIDI K, 2005, J TURBOMACH, V127, P363, DOI 10.1115/1.1776587 MINER SM, 1992, J TURBOMACH, V114, P333 MORGENROTH M, 1998, J TURBOMACH, V120, P736 NEUMANN B, 1991, INTERACTION GEOMETRY PARRONDOGAYO JL, 2002, J FLUID ENG-T ASME, V124, P784, DOI 10.1115/1.1493814 SHI F, 2001, ASME, V123, P466 VANESCH BPM, 2001, J FLUID ENG-T ASME, V123, P256 WANG H, 2001, J FLUID ENG-T ASME, V123, P737 ZHANG M, 2005, J FLUID ENG-T ASME, V127, P743, DOI 10.1115/1.1949640 NR 25 TC 0 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0098-2202 J9 J FLUID ENG JI J. Fluids Eng.-Trans. ASME PD NOV PY 2008 VL 130 IS 11 AR 111102 DI 10.1115/1.2969273 PG 11 SC Engineering, Mechanical GA 351JZ UT ISI:000259421900002 ER PT C AU Jerez, S Motas, M Tortosa, MDM Ortiz, J Valera, F Palacios, MJ Benzal, J de la Cruz, C Cuervo, J Martinez, A Barbosa, A AF Jerez, Silvia Motas, Miguel Tortosa, Maria Del Mar Ortiz, Juana Valera, Francisco Palacios, Maria Jose Benzal, Jesus de la Cruz, Carlos Cuervo, Javier Martinez, Ana Barbosa, Andres TI Trace and toxic elements in three species of Antarctic penguins: A preliminary research SO TOXICOLOGY LETTERS LA English DT Meeting Abstract C1 [Jerez, Silvia; Motas, Miguel; Tortosa, Maria Del Mar; Ortiz, Juana] Univ Murcia, Murcia, Spain. [Valera, Francisco; Palacios, Maria Jose; Benzal, Jesus; Cuervo, Javier; Martinez, Ana; Barbosa, Andres] Estac Expt Zonas Aridas, Almeria, Spain. [de la Cruz, Carlos] Univ Extremadura, Badajoz, Spain. NR 0 TC 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD OCT 5 PY 2008 VL 180 SU Suppl. 1 BP S186 EP S186 DI 10.1016/j.toxlet.2008.06.182 PG 1 SC Toxicology GA 349AV UT ISI:000259252100605 ER PT C AU Risco, A Izquierdo, M Hernandez-Garcia, FI AF Risco, A. Izquierdo, M. Hernandez-Garcia, F. I. TI Development of estrous induction-synchronization protocols based on hormonal treatments and calf management in retinta cattle SO REPRODUCTION IN DOMESTIC ANIMALS LA English DT Meeting Abstract C1 [Risco, A.; Izquierdo, M.; Hernandez-Garcia, F. I.] Agr Res Ctr Extremadura, Badajoz 06071, Spain. NR 0 TC 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0936-6768 J9 REPROD DOMEST ANIM JI Reprod. Domest. Anim. PD OCT PY 2008 VL 43 SU Suppl. 4 BP 61 EP 61 PG 1 SC Agriculture, Dairy & Animal Science; Reproductive Biology; Veterinary Sciences GA 349VG UT ISI:000259310800041 ER PT J AU Galvan, IF Volbeda, A Fontecilla-Camps, JC Field, MJ AF Galvan, Ignacio Fdez. Volbeda, Anne Fontecilla-Camps, Juan C. Field, Martin J. TI A QM/MM study of proton transport pathways in a [NiFe] hydrogenase SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS LA English DT Article DE Desulfovibrio fructosovorans; minimum energy path; nudged elastic band method; molecular dynamics; proton transfer ID NICKEL-IRON HYDROGENASE; ACTIVE-SITE; DESULFOVIBRIO-GIGAS; MOLECULAR-DYNAMICS; CRYSTAL-STRUCTURE; CATALYTIC CYCLE; FE HYDROGENASES; H-2; DENSITY; ATOM AB A theoretical QM/MM study of the [NiFe] hydrogenase from Desulfovibrio fructosovorans has been performed to investigate possible routes of proton transfer between the active site and the protein surface. We obtained the minimum energy paths, with a modified version of the nudged elastic band method, for a set of proposed pathways. The calculations were carried out for the crystallographic structure and for several structures Of the protein obtained from a molecular dynamics simulation. The results show one of the studied pathways to be preferred for transport from the active site to the surface, but the preference is not so strong when transport occurs in the opposite direction. C1 [Galvan, Ignacio Fdez.; Field, Martin J.] Univ Grenoble 1, CNRS, CEA, Lab Dynam Mol,Inst Biol Struct Jean Pierre Ebel, F-38027 Grenoble, France. [Volbeda, Anne; Fontecilla-Camps, Juan C.] Univ Grenoble 1, CNRS, CEA,Inst Biol Struct Jean Pierre Ebel, Lab Cristallog & Cristallogenese Prot, F-38027 Grenoble, France. RP Galvan, IF, Univ Extremadura, Avda Elvas S-N, E-06071 Badajoz, Spain. EM jellby@unex.es FU Secretaria de Estado de Universidades e Investigacion ; Spanish Ministerio de Educacion y Ciencia FX Grant sponsor: Secretaria de Estado de Universidades e Investigacion, Spanish Ministerio de Educacion y Ciencia. 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In contrast to previous theoretical attempts, the approach is not limited to the near-elastic case, takes into account the influence of both thermal gradients and gravity, and applies for moderate densities. The form of the phase diagrams for the BNE-RBNE transition depends sensitively on the value of gravity relative to the thermal gradient, so that it is possible to switch between both states for given values of the mass and size ratios, the coefficients of restitution, and the solid volume fraction. In particular, the influence of collisional dissipation on segregation becomes more important when the thermal gradient dominates over gravity than in the opposite limit. The present analysis extends previous results derived in the dilute limit case and is consistent with the findings of some recent experimental results. C1 Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Garzo, V, Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. EM vicenteg@unex.eg FU Ministerio de Educacion y Ciencia (Spain) [FIS2007-60977]; FEDER ; Junta de Extremadura (Spain) [GRU08069] FX I am grateful to C. M. Hrenya, J. W. Dufty, and A. Santos for useful comments on an early version of this paper. This work has been supported by the Ministerio de Educacion y Ciencia (Spain) through Grant No. FIS2007-60977, partially financed by FEDER funds, and by the Junta de Extremadura (Spain) through Grant No. GRU08069. 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Rev. E PD AUG PY 2008 VL 78 IS 2 PN Part 1 AR 020301 DI 10.1103/PhysRevE.78.020301 PG 4 SC Physics, Fluids & Plasmas; Physics, Mathematical GA 349EH UT ISI:000259263600003 ER PT J AU Yuste, SB Oshanin, G Lindenberg, K Benichou, O Klafter, J AF Yuste, S. B. Oshanin, G. Lindenberg, K. Benichou, O. Klafter, J. TI Survival probability of a particle in a sea of mobile traps: A tale of tails SO PHYSICAL REVIEW E LA English DT Article ID DIFFUSION-CONTROLLED REACTIONS; RANDOM-WALK; ASYMPTOTIC-BEHAVIOR; TRAPPING REACTIONS; ENERGY SPECTRUM; WIENER SAUSAGE; KINETICS; POLYMERS; DENSITIES; SITES AB We study the long-time tails of the survival probability P(t) of an A particle diffusing in d-dimensional media in the presence of a concentration p of traps B that move subdiffusively, such that the mean square displacement of each trap grows as t(gamma) with 0 <= gamma <= 1. Starting from a continuous time random walk description of the motion of the particle and of the traps, we derive lower and upper bounds for P(t) and show that for gamma <= 2/(d+2) these bounds coincide asymptotically, thus determining asymptotically exact results. The asymptotic decay law in this regime is exactly that obtained for immobile traps. This means that for sufficiently subdiffusive traps, the moving A particle sees the traps as essentially immobile, and Lifshitz or trapping tails remain unchanued. For gamma>2/(d+2) and d <= 2 the upper and lower bounds again coincide, leading to a decay law equal to that of a stationary particle. Thus, in this regime the moving traps see the particle as essentially immobile. For d>2, however, the upper and lower bounds in this gamma regime no longer coincide, and the decay law for the survival probability of the A particle remains ambiguous. C1 [Yuste, S. B.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. [Oshanin, G.; Benichou, O.] Univ Paris 06, Lab Phys Theor Mat Condensee, F-75252 Paris, France. [Lindenberg, K.] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. [Klafter, J.] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel. RP Yuste, SB, Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. FU Ministerio de Educacion y Ciencia (Spain) [FIS2007-60977]; FEDER ; National Science Foundation [PHY-0354937]; Agence Nationale de la Recherche (ANR) ; DYOPTRI-Dynamique et Optimisation des Processus de Transport Intermittents FX The research of S.B.Y. has been supported by the Ministerio de Educacion y Ciencia (Spain) through Grant No. FIS2007-60977 (partially financed by FEDER funds). K.L. gratefully acknowledges the support of the National Science Foundation under Grant No. PHY-0354937. The research of O.B. and G.O. is partially supported by Agence Nationale de la Recherche (ANR) under grant "DYOPTRI-Dynamique et Optimisation des Processus de Transport Intermittents." 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Rev. E PD AUG PY 2008 VL 78 IS 2 PN Part 1 AR 021105 DI 10.1103/PhysRevE.78.021105 PG 7 SC Physics, Fluids & Plasmas; Physics, Mathematical GA 349EH UT ISI:000259263600014 ER PT J AU Acero, JL Rodriguez, E Majado, ME Sordo, A Meriluoto, J AF Acero, Juan L. Rodriguez, Eva Majado, Maria E. Sordo, Ana Meriluoto, Jussi TI Oxidation of microcystin-LR with chlorine and permanganate during drinking water treatment SO JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA LA English DT Article DE chlorine; drinking water; microcystin-LR; oxidation kinetics; permanganate ID CYANOBACTERIAL TOXINS; HEPATOTOXINS; CYANOTOXINS; KINETICS; CHROMATOGRAPHY; DESTRUCTION; REMOVAL; OZONE; MODEL AB The oxidation of microcystin-LR (MC-LR) present in natural waters with chlorine and potassium permanganate under real drinking water treatment conditions has been investigated in the present work. The natural waters were spiked with MC-LR, using the typical concentration of 5 mu gL(-1) found in natural waters. The influence of some operational parameters such as the initial oxidant concentration, pH and temperature and of some drinking water quality parameters such as the NOM and ammonia content has been studied. The initial chlorine concentration and the temperature have a positive effect on MC-LR elimination. However, the pH exerts a negative influence on the MC-LR elimination by chlorine, which indicates that HOCl is the main active oxidant species. High concentrations of NOM and ammonia, which consume chlorine, impede the elimination of MC-LR. During the oxidation with permanganate, the initial permanganate concentration and the temperature have a positive effect on MC-LR removal, while the pH and the ammonia content do not exert any influence on its oxidation. However, high concentrations of NOM reduce the extent of oxidation of MC-LR with permanganate. C1 [Acero, Juan L.; Rodriguez, Eva; Majado, Maria E.; Sordo, Ana] Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. [Meriluoto, Jussi] Abo Akad Univ, Dept Biochem & Pharm, Turku 20520, Finland. RP Acero, JL, Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. EM jlacero@unex.es FU European Commission [EVK1-CT-2002-00107] FX This work was supported by the European Commission under the Fifth Framework Programme, research project TOXIC (EVK1-CT-2002-00107). 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Water Supply Res Technol.-Aqua PD SEP PY 2008 VL 57 IS 6 BP 371 EP 380 DI 10.2166/aqua.2008.188 PG 10 SC Engineering, Civil; Water Resources GA 348AI UT ISI:000259182800002 ER PT J AU Navarro, J Sancho, JB AF Navarro, Jose Sancho, Juan B. TI On the naturalness of Einstein's equation SO JOURNAL OF GEOMETRY AND PHYSICS LA English DT Article DE Einstein's equation; natural bundles; natural tensors ID TENSOR AB We compute all 2-covariant tensors naturally constructed from a semi-Riemannian metric which are divergence-free and have weight greater than -2. As a consequence, it follows a characterization of the Einstein tensor as the only, up to a constant factor, 2-covariant tensor naturally constructed from a semi-Riemannian metric which is divergence-free and has weight 0 (i.e., is independent of the unit of scale). Since these two conditions are also satisfied by the energy-momentum tensor of a relativistic space-time, we discuss in detail how these theorems lead to the field equation of General Relativity. (C) 2008 Elsevier B.V. All rights reserved. C1 [Navarro, Jose; Sancho, Juan B.] Univ Extremadura, Dept Math, E-06071 Badajoz, Spain. RP Navarro, J, Univ Extremadura, Dept Math, Avenida Elvas S-N, E-06071 Badajoz, Spain. EM navarrogarmendia@unex.es jsancho@unex.es FU Spanish FPU [AP2006-02414] FX We would like to thank R. Faro and C. Tejero for their helpful comments and the invaluable collaboration of Prof. J. A. Navarro. The first author has been partially supported by a Spanish FPU grant, AP2006-02414. 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PD AUG PY 2008 VL 58 IS 8 BP 1007 EP 1014 DI 10.1016/j.geomphys.2008.03.007 PG 8 SC Mathematics, Applied; Physics, Mathematical GA 349FZ UT ISI:000259268000007 ER PT J AU van Schaik, NLMB Schnabel, S Jetten, VG AF van Schaik, N. L. M. B. Schnabel, S. Jetten, V. G. TI The influence of preferential flow on hillslope hydrology in a semi-arid watershed (in the Spanish Dehesas) SO HYDROLOGICAL PROCESSES LA English DT Article DE hillslope hydrology; preferential flow; macropores; subsurface stormflow; semi-arid; soil moisture ID SYSTEM EXTREMADURA; SW SPAIN; MACROPORES; RUNOFF; INFILTRATION; TRANSPORT; SCALE; SOILS; MODEL AB Preferential flow is known to influence hillslope hydrology in many areas around the world. Most research on preferential flow has been performed in temperate regions. Preferential infiltration has also been found in semi-arid regions, but its impact oil the hydrology of these regions is poorly known. The aim of this study is to describe and quantify the influence of preferential flow on the hillslope hydrology from small scale (infiltration) to large scale (subsurface stormflow) in a semi-arid Dehesa landscape. Precipitation, soil moisture content, piezometric water level and discharge data were used to analyse the hydrological functioning of a catchment in Spain. Variability of soil moisture content during the transition from dry to wet season (September to November) within horizontal soil layers leads to the conclusion that there is preferential infiltration into the soils. When the rainfall intensity is high. a water level rapidly builds up in the piezometer pipes in the area, sometimes even reaching soil surface. This water level also drops back to bedrock within a few hours (under dry catchment conditions) to clays (under wet catchment conditions). As the soil matrix is not necessarily wet while this water layer is built up, it is thought to be a transient water table in large connected pores which drain partly to the matrix, partly fill up bedrock irregularities and partly drain through subsurface flow to the channels. When the soil matrix becomes wetter the loss of water from macropores to the matrix and bedrock decreases and Subsurface stormflow increases. It may be concluded that the hillslope hydrological system consists of a fine matrix domain and a macropore domain. which have their own flow characteristics but which also interact, depending on the soil matrix and macropore Moisture contents. The macropore flow can result in subsurface flow, ranging from 13% contribution to total discharge for a large event of high intensity rainfall or high discharge to 80% of total discharge for a small event with low intensity rainfall or low discharge. During lame events the fraction of subsurface stromflow in the discharge is suppressed by the large amount of surface runoff. Copyright (C) 2008 John Wiley & Sons, Ltd. C1 [van Schaik, N. L. M. B.] Univ Utrecht, Dept Phys Geog, NL-3584 CS Utrecht, Netherlands. [Schnabel, S.] Univ Extremadura, Area Geog Fis, Caceres 10071, Spain. [Jetten, V. G.] Int Inst Geoinformat Sci & Earth Observat, Dept Earth Syst Anal, NL-7500 AA Enschede, Netherlands. RP van Schaik, NLMB, Univ Utrecht, Dept Phys Geog, Heidelberglaan 2, NL-3584 CS Utrecht, Netherlands. EM l.vanSchaik@geo.uu.nl FU Spanish Ministry of Education and Science [REN2001-2268-C02, CGL2004-04919-C02-02] FX The staff of the University of Extremadura, Koen Rutten and Joachim Hunnink are acknowledged for their great help in gathering all the field data which was used for this research. Part of the research is financed by the Spanish Ministry of Education and Science through projects REN2001-2268-C02 and CGL2004-04919-C02-02. 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Process. PD AUG 30 PY 2008 VL 22 IS 18 BP 3844 EP 3855 DI 10.1002/hyp.6998 PG 12 SC Water Resources GA 349LC UT ISI:000259281300023 ER PT J AU Gonzalez, LM Oria, J Sanchez, R Margalida, A Aranda, A Prada, L Caldera, J Molina, JI AF Gonzalez, Luis Mariano Oria, Javier Sanchez, Roberto Margalida, Antoni Aranda, Antonio Prada, Luis Caldera, Javier Molina, Jose Ignacio TI Status and habitat changes in the endangered Spanish Imperial Eagle Aquila adalberti population during 1974-2004: implications for its recovery SO BIRD CONSERVATION INTERNATIONAL LA English DT Article ID BREEDING SUCCESS; WILD RABBIT; SELECTION; SPAIN; FRAGMENTATION; CONSERVATION; DIET AB The distribution and abundance of Spanish Imperial Eagle Aquila adalberti populations between 1974 and 2004 were determined using information from national censuses. Its breeding area occupies the south-western quadrant of the Iberian Peninsula (Spain and Portugal) and is composed of 13 nuclei and 5 subpopulations. Since 1974, population levels in all nuclei, except the one in Donana, have expanded. The non-breeding dispersion area, according to sightings of juvenile and immature individuals in quadrants of 10 x 10 km, coincided with that of the breeding area. Bibliographical information showed that halfway through the 19(th) century the Spanish Imperial Eagle was considered abundant, at least locally; and most cited breeding areas were in relatively human-occupied plains. Towards the end of the 19th century the population became scarce; remaining so for most of the 20th century, with remote mountain ranges being the most cited breeding habitats. The comparison between the data from the first census, in 1974, that located 38 territorial pairs, and the 2004 census that located 198 Pairs, shows that: 1) percentages of pairs in plains have increased, while those in mountains have decreased; 2) the trophic quality of the habitat, based on rabbit abundance, has decreased, and 3) numbers of nests in both protected areas and on private ground have increased significantly. The type of land ownership did not seem to affect breeding performance. Populations have increased more outside protected areas than within, despite the availability of potential habitat. In the past century, legal protection and attitude changes towards this eagle seem to have been influential in preventing its extinction. At present, habitat management seems also to be an important factor in its continuing recovery. C1 [Margalida, Antoni] Bearded Vulture Study & Protect Grp, E-25520 El Pont De Suert, Lleida, Spain. [Gonzalez, Luis Mariano] Minist Med Ambiente, Direcc Gen Biodiversidad, E-28005 Madrid, Spain. [Oria, Javier] Boscaje SL, E-40001 Segovia, Spain. [Sanchez, Roberto] TRAGSA, Madrid, Spain. [Aranda, Antonio] Junta Castilla La Mancha, Toledo 45071, Spain. [Prada, Luis] Consejeria Med Ambiente, Madrid 28008, Spain. [Caldera, Javier] Junta Extremadura, Sierra De Fuentes 10181, Caceres, Spain. [Molina, Jose Ignacio] Junta Castilla & Leon, Valladolid 47071, Spain. RP Margalida, A, Bearded Vulture Study & Protect Grp, Apdo 43, E-25520 El Pont De Suert, Lleida, Spain. EM margalida@inf.entorno.es FU Ministerio de Medio Ambiente ; Consejerias de Medio Ambiente ; European Commission [03/NAT/E/000050] FX We are indebted to R. Moreno-Opo, J. Sanchez, A. Calvo, R. Jimenez, J P. Castano, J. Caballero, M. Fernandez, F. Robles, J.M. Garcia, F. Silvestre, L. Garcia, C. Urdiales, C. Soria, C. Silver, A. Mogena, M. Martin, A. Arredondo, J. Guzman, E. Morales, J. Panadero, J. Duque, J. Miron, L. Bolonio, M. Panadero, R. Jimenez, S. Pla, C. Davila, J. L. Moreno, F. Guil and J. L. Freije for their help with the fieldwork. We would particularly like to thank V. Garcia Matarranz. Thanks also to J.M. Blanco, N. El Khadir, P. Garzon, J. Garzon, D. Martin, I. Mosqueda, F. Sanchez, J. L.Gonzalez, J.Jimenez, A. Gomez, A. Rodriguez, A. Sanchez, M. J. Palacios, N. Gonzalez, S. Centenera, B. Heredia, C. Rodriguez-Vigal, F. Jimenez, C. Pacheco, H. Blanco and the official wardens and personnel of the National Parks and the Wildlife Services of the Autonomous Communities of Madrid, Castilla y Leon, Castilla-La Mancha and Extremadura for the information on sightings they kindly provided. The comments of J.L. Tella and D.P. Whitfield improved the Manuscript. We also want to thank to Fundacion CBD-Habitat and TRAGSA. This study was jointly funded by the Direccion General para la Biodiversidad del Ministerio de Medio Ambiente and the Consejerias de Medio Ambiente of the above mentioned Autonomous Communities and by the European Commission throughout LIFE-project 03/NAT/E/000050. 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Int. PD SEP PY 2008 VL 18 IS 3 BP 242 EP 259 DI 10.1017/S0959270908000245 PG 18 SC Ornithology GA 348JY UT ISI:000259208000004 ER PT C AU Alexandre-Franco, M Fernandez-Gonzalez, C Macias-Garcia, A Gomez-Serrano, V AF Alexandre-Franco, M. Fernandez-Gonzalez, C. Macias-Garcia, A. Gomez-Serrano, V. TI Uptake of lead by carbonaceous adsorbents developed from tire rubber SO ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY LA English DT Proceedings Paper DE tire rubber; carbonaceous adsorbents; lead adsorption ID WASTE TYRE RUBBER; ADSORPTION; REMOVAL AB The adsorption of lead in aqueous solution by discarded tire rubber (TR) and by carbonaceous adsorbents (CAs) prepared from it by thermal and chemical treatments is studied. TR was heated at 400 or 900 degrees C for 2 h in N-2 atmosphere or treated chemically with H2SO4, HNO3, H2SO4/HNO3, HCl, NaOH, HCl-NaOH or NaOH-HCl for 24 h. TR and CAs were characterized physico-chemically with regard to their texture, elemental composition and surface chemistry. The adsorption of lead was studied, mainly from the kinetic standpoint, using 4x10(-3) stop molL(-1) stop Pb2+ stop solutions at initial pH 2.0, 5.7 and 12.6. TR is practically a non-porous material. The heat treatment of TR mainly develops meso- and macroporosity. The effect on macroporosity is stronger when HNO3 and H2SO4/HNO3 are used. For all adsorbents, the adsorption of lead is not measurable when adsorptive solution at pH 2 is used. With an increase of pH from 5.7 to 12.6, the kinetics of adsorption becomes faster and the amount of lead adsorbed significantly increases. For the solution at pH 12.6 and an adsorption time of 8 h, the adsorption percentage is 36 wt% for TR. For the CAs prepared by heat treatment of TR, it is higher than 50 wt%. For longer adsorption times, the kinetics is much slower for the product of TR treatment with HNO3. However, the corresponding adsorption percentage is as high as 93 wt% for an adsorption time of 264 h. TR and the CAs, in particular the product heated at 400 degrees C, are good adsorbents to be used in the rapid removal of a significant amount of lead from aqueous solution. C1 [Alexandre-Franco, M.; Fernandez-Gonzalez, C.; Gomez-Serrano, V.] Univ Extremadura, Dept Quim Organ & Inorgan, E-06071 Badajoz, Spain. [Macias-Garcia, A.] Univ Extremadura, Area Ciencias Mat, Escuela Ingn Ind, E-06071 Badajoz, Spain. RP Gomez-Serrano, V, Univ Extremadura, Dept Quim Organ & Inorgan, Avda Elvas S-N, E-06071 Badajoz, Spain. EM vgomez@unex.es CR BAES CF, 1976, HYDROLYSIS CATIONS CASTELLS XE, 2000, RECICLAJE RESIDUOS I COOKSON JT, 1978, CARBON ADSORPTION HD, P241 GREENWOOD NN, 1984, CHEM ELEMENTS HO YS, 1999, PROCESS BIOCHEM, V34, P451 JAIN AK, 2003, J HAZARD MATER, V101, P31, DOI 10.1016/S0304-3894(03)00146-8 LAGERGREN S, 1898, VETENSKAPSAKAD HANDL, V24, P1 MANCHONVIZUETE E, 2004, MICROPOR MESOPOR MAT, V67, P35, DOI 10.1016/j.micromeso.2003.10.002 MANCHONVIZUETE E, 2005, J HAZARD MATER, V119, P231, DOI 10.1016/j.jhazmat.2004.12.028 MOHAN D, 2002, WATER RES, V36, P2304 NETZER A, 1974, WATER RES, V8, P813 ONEILL P, 1993, ENV CHEM PRETSCH E, 1980, TABLAS ELUCIDACION E RODRIGUEZ ID, 2001, FUEL PROCESS TECHNOL, V72, P9 ROWLEY AG, 1984, WATER RES, V18, P981 SANMIGUEL G, 2003, CARBON, V41, P1009, DOI 10.1016/S0008-6223(02)00449-9 YAN D, 2006, RANLIAO HUAXUE XUEBA, V34, P353 ZHANG Z, 2004, RANLIAO HUAXUE XUEBA, V32, P312 NR 18 TC 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0929-5607 J9 ADSORPTION JI Adsorpt.-J. Int. Adsorpt. Soc. PD OCT PY 2008 VL 14 IS 4-5 BP 591 EP 600 DI 10.1007/s10450-008-9115-z PG 10 SC Chemistry, Physical; Engineering, Chemical GA 348CO UT ISI:000259188800017 ER PT C AU Olivares-Marin, M Fernandez-Gonzalez, C Macias-Garcia, A Gomez-Serrano, V AF Olivares-Marin, M. Fernandez-Gonzalez, C. Macias-Garcia, A. Gomez-Serrano, V. TI Adsorption of mercury from single and multicomponent metal systems on activated carbon developed from cherry stones SO ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY LA English DT Proceedings Paper DE cherry stones; activated carbon; mercury adsorption ID BASIC SURFACE OXIDES; AQUEOUS-SOLUTION; CHEMICAL ACTIVATION; REMOVAL; SPECTROSCOPY; ADSORBENTS; SORPTION; MODELS; SITES; WOOD AB The adsorption of mercury from a single/multi-solute aqueous solution by activated carbon (AC) prepared from cherry stones (CS) by chemical activation with H3PO4, ZnCl2 or KOH is studied. Three series of AC (i.e., P, H3PO4; Z, ZnCl2; K, KOH) were prepared by controlling the impregnation ratio and carbonization temperature. The textural characterization of AC was carried out by gas adsorption, mercury porosimetry and density measurements. The surface chemistry was analyzed by the pH of the point of zero charge (pH(zpc)), FT-IR spectroscopy and Boehm's method. Experiments of mercury adsorption were conducted by the batch method, using aqueous solutions of mercury and of mercury, cadmium and zinc without pH adjustment. The ACs possess a wide range of pore volumes and sizes. Their microporosity is usually well developed. The meso- and macropore volumes are higher for the P carbons and K carbons, respectively. BET surface areas as a rule range between 1000 and 2000 m(2) g(-1) stop. The pH(zpc) is much lower for the P carbons. The content of acidic oxygen surface groups is lower for the K carbons, whereas the content of basic groups is higher for these carbons. The kinetics of the adsorption process of mercury is faster for ACs with high volumes of large size pores. However, the surface groups have a marked unfavorable influence on the kinetics. The pseudo-second order rate constant (k(2) x 10(-3) stop, g/mol h) is higher by the order Z-4-800 (67.69)> K-3-800 (43.45)> P-3.44-400 (36.98). The incorporation of zinc and cadmium to the mercury solution usually decelerates the adsorption process for the P carbons and Z carbons and accelerates it for the K carbons. The amount adsorbed of mercury is much larger for the K carbons than for the other ACs. For the Z carbons, competition effects of zinc and cadmium on the adsorption of mercury are negligible, which indicates that mercury adsorbs specifically on surface active sites of these adsorbents. C1 [Olivares-Marin, M.; Fernandez-Gonzalez, C.; Gomez-Serrano, V.] Univ Extremadura, Dept Quim Organ & Inorgan, Fac Ciencias, E-06071 Badajoz, Spain. [Macias-Garcia, A.] Univ Extremadura, Area Ciencia Mat, Escuela Ingn Ind, E-06071 Badajoz, Spain. RP Gomez-Serrano, V, Univ Extremadura, Dept Quim Organ & Inorgan, Fac Ciencias, Avda Elvas S-N, E-06071 Badajoz, Spain. 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Int. Adsorpt. Soc. PD OCT PY 2008 VL 14 IS 4-5 BP 601 EP 610 DI 10.1007/s10450-008-9111-3 PG 10 SC Chemistry, Physical; Engineering, Chemical GA 348CO UT ISI:000259188800018 ER PT J AU Leuzzi, L Parisi, G Ricci-Tersenghi, F Ruiz-Lorenzo, JJ AF Leuzzi, L. Parisi, G. Ricci-Tersenghi, F. Ruiz-Lorenzo, J. J. TI Dilute one-dimensional spin glasses with power law decaying interactions SO PHYSICAL REVIEW LETTERS LA English DT Article ID OFF-EQUILIBRIUM DYNAMICS; LONG-RANGE INTERACTIONS; FIELD-THEORY; PHASE-TRANSITIONS; CRITICAL-BEHAVIOR; RANDOM-SYSTEMS; MONTE-CARLO; MODEL; ULTRAMETRICITY; ABSENCE AB We introduce a diluted version of the one-dimensional spin-glass model with interactions decaying in probability as an inverse power of the distance. In this model, varying the power corresponds to changing the dimension in short-range models. The spin-glass phase is studied in and out of the range of validity of the mean-field approximation in order to discriminate between different theories. Since each variable interacts only with a finite number of others the cost for simulating, the model is drastically reduced with respect to the fully connected version, and larger sizes can be studied. We find both static and dynamic indications in favor of the so-called replica symmetry breaking theory. C1 [Leuzzi, L.; Parisi, G.; Ricci-Tersenghi, F.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy. [Leuzzi, L.; Parisi, G.] Stat Mech & Complex Ctr SMC INFM CNR, Rome, Italy. [Ruiz-Lorenzo, J. J.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Leuzzi, L, Univ Roma La Sapienza, Dipartimento Fis, P Le Aldo Moro 2, I-00185 Rome, Italy. FU MEC [FIS2006-08533-C03, FIS2007-60977] FX We thank Silvio Franz for useful discussions and suggestions. This work has been partially supported by MEC, Contracts Nos. FIS2006-08533-C03 and FIS2007-60977. Part of simulations were performed in the BIFI cluster. 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Rev. Lett. PD SEP 5 PY 2008 VL 101 IS 10 AR 107203 DI 10.1103/PhysRevLett.101.107203 PG 4 SC Physics, Multidisciplinary GA 345DB UT ISI:000258975100059 ER PT J AU Martin, D Muriel, E Gonzalez, E Viguera, J Ruiz, J AF Martin, Diana Muriel, Elena Gonzalez, Elena Viguera, Javier Ruiz, Jorge TI Effect of dietary conjugated linoleic acid and monounsaturated fatty acids on productive, carcass and meat quality traits of pigs SO LIVESTOCK SCIENCE LA English DT Article DE conjugated linoleic acid; MUFA; pig; fatty acid profile; meat quality ID SUBSEQUENT PORK QUALITY; ADIPOSE-TISSUE; SENSORY CHARACTERISTICS; CLA SUPPLEMENTATION; LIPID-COMPOSITION; MUSCLE; PERFORMANCE; PROFILE; SWINE; OXIDATION AB Three levels (0, 1 and 2%) of conjugated linoleic acid (CLA) were combined with two levels (low and high) of mono-unsaturated fatty acids (MUFA) for pig feeding. Productive, carcass and meat quality traits were studied. Large White male x Landrace x Large White female gilts (n=288) weighting 70 kg were randomly allotted to 6 different feeding treatments and fed to a final aver-age weight of 107 kg. Loins were taken from 48 animals (8 animals randomly selected from each treatment). No differences due to dietary CLA, MUFA or CLA x MUFA interaction were found on average daily gain, average daily consumption, feed conversion ratio, carcass yield, back fat thickness, loin weight, loin pH and loin colour. A significant increase in intramuscular fat content (p=0.010) and in saturated fatty acids (SFA) (p<0.001), and a decrease in MUFA (p=0.001) and desaturase indices were found as consequence of dietary CLA, regardless the MUFA level. Therefore, dietary CLA, MUFA and their interaction did not influence productive and carcass traits of pigs. However, the use of CLA for swine feeding increased the intramuscular fat content and modified the fatty acid profile, regardless the MUFA level of the diets. (C) 2007 Elsevier B.V. All rights reserved. C1 [Martin, Diana; Muriel, Elena; Ruiz, Jorge] Univ Extremadura, Fac Vet, Caceres 10071, Spain. [Gonzalez, Elena] Univ Extremadura, Escuela Ingn Agr, Badajoz 06071, Spain. [Viguera, Javier] Imasde Agropecuaria, Pozuelo De Alarcon 28224, Spain. RP Ruiz, J, Univ Extremadura, Fac Vet, Avda Univ S-N, Caceres 10071, Spain. EM jruiz@unex.es FU Ministerio de Educacion y Ciencia, Spain [AGL 2003-03538] FX This research was supported by the Ministerio de Educacion y Ciencia, Spain (AGL 2003-03538). CLA was generously provided by BASF. The valuable cooperation of Dr. Clemente Upez-Bote, the valuable suggestions of Dra. Teresa Antequera and the colaboration of I+D Agropecuaria in designing the experimental diets, sampling and pig management are also acknowledged. Diana Martin thanks the Ministerio de Educacion y Ciencia for funding her research. 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Sci. PD SEP PY 2008 VL 117 IS 2-3 BP 155 EP 164 DI 10.1016/j.livsci.2007.12.005 PG 10 SC Agriculture, Dairy & Animal Science GA 347IM UT ISI:000259133800005 ER PT J AU Montanero, JM Ganan-Calvo, AM AF Montanero, J. M. Ganan-Calvo, A. M. TI Viscoelastic effects on the jetting-dripping transition in co-flowing capillary jets SO JOURNAL OF FLUID MECHANICS LA English DT Article ID NEWTONIAN LIQUID JETS; LINEAR-ANALYSIS; FREE-SURFACE; INSTABILITY; GENERATION; DEVICES AB Linear hydrodynamics stability analysis is used to determine the influence of elasticity on the jetting dripping transition and on the temporal stability of non-axisymmetric modes in co-flowing capillary jets. The critical Weber number for which axisymmetric perturbations undergo a transition from convective to absolute instability is calculated from the spatio-temporal analysis of the dispersion relation for Oldroyd-B liquids, as a function of the density and viscosity ratios, and the Reynolds and Deborah numbers. Elasticity increases the critical Weber number for all cases analysed and, consequently, fosters the transition from jetting to dripping. The temporal analysis of the dispersion relation for the m = 1 lateral mode shows that elasticity does not affect its stability. C1 [Montanero, J. M.] Univ Extremadura, Dept Ingn Mecan Energet & Mat, E-06071 Badajoz, Spain. [Ganan-Calvo, A. M.] Univ Seville, Dept Ingn Aeroespacial & Mecan Fluidos, E-41092 Seville, Spain. RP Montanero, JM, Univ Extremadura, Dept Ingn Mecan Energet & Mat, E-06071 Badajoz, Spain. CR ANNA SL, 2006, PHYS FLUIDS, V18, ARTN 121512 BASARAN OA, 2002, AICHE J, V48, P1842 BAUER HF, 1986, ACTA ASTRONAUT, V13, P9 BRENN G, 2000, INT J MULTIPHAS FLOW, V26, P1621 BRIGGS RJ, 1964, ELECT STREAM INTERAC COHEN I, 2002, PHYS REV LETT, V88, ARTN 074501 COULLET P, 2005, J FLUID MECH, V526, P1, DOI 10.1017/S0022112004002307 DELAMORA JF, 2007, ANNU REV FLUID MECH, V39, P217, DOI 10.1146/annurev.fluid.39.050905.110159 EGGERS J, 2008, REP PROG PHYS, V71, ARTN 036601 EGGLETON CD, 2001, PHYS REV LETT, V87, ARTN 048302 FUNADA T, 2003, J NON-NEWTON FLUID, V111, P87, DOI 10.1016/S0377-0257(03)00013-2 GANANCALVO AM, 1998, PHYS REV LETT, V80, P285 GANANCALVO AM, 2007, NAT PHYS, V3, P737, DOI 10.1038/nphys710 GUILLOT P, 2007, PHYS REV LETT, V99, ARTN 104502 HUERRE P, 1990, ANNU REV FLUID MECH, V22, P473 JOSEPH DD, 1990, FLUID DYNAMICS VISCO LEIB SJ, 1986, J FLUID MECH, V168, P479 LIN SP, 2003, BREAKUP LIQUID SHEET LIU ZH, 2006, J FLUID MECH, V559, P451, DOI 10.1017/S0022112006000413 MONTANERO JM, 2008, PHYS REV E 2, V77, ARTN 046301 SCHROLL RD, 2007, PHYS REV LETT, V98, ARTN 133601 STONE HA, 2004, ANNU REV FLUID MECH, V36, P381, DOI 10.1146/annurev.fluid.36.050802.122124 SURYO R, 2006, PHYS FLUIDS, V18, ARTN 082102 TAYLOR GI, 1934, PROC R SOC LON SER-A, V146, P501 VANSAARLOOS W, 1987, PHYS REV LETT, V58, P2571 VANSAARLOOS W, 2003, PHYS REP, V386, P29, DOI 10.1016/j.physrep.2003.08.001 ZHOU CF, 2006, PHYS FLUIDS, V18, ARTN 092105 NR 27 TC 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD SEP 10 PY 2008 VL 610 BP 249 EP 260 DI 10.1017/S0022112008002681 PG 12 SC Mechanics; Physics, Fluids & Plasmas GA 346CM UT ISI:000259046000010 ER PT J AU Pinna, MAC Vargas, RM Moralo, MJR Correas, MAS AF Cuervo Pinna, Miguel Angel Mota Vargas, Rafael Redondo Moralo, Maria Jose Sanchez Correas, Miguel Angel TI Pharmacologic intervention for cancer-related dyspnea SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Letter ID CHLORPROMAZINE C1 [Cuervo Pinna, Miguel Angel; Mota Vargas, Rafael; Redondo Moralo, Maria Jose; Sanchez Correas, Miguel Angel] Palliat Care Team Badajoz, Reg Palliat Care Program Extremadura, Badajoz, Spain. RP Pinna, MAC, Palliat Care Team Badajoz, Reg Palliat Care Program Extremadura, Badajoz, Spain. CR ALLARD P, 1999, J PAIN SYMPTOM MANAG, V17, P256 BENAHARON I, 2008, J CLIN ONCOL, V26, P2396, DOI 10.1200/JCO.2007.15.5796 MAN GCW, 1986, CHEST, V90, P832 MCIVER B, 1994, J PAIN SYMPTOM MANAG, V9, P341 NAVIGANTE AH, 2006, J PAIN SYMPTOM MANAG, V31, P38, DOI 10.1016/j.jpainsymmnan.2005.06.009 ONEILL PA, 1985, BRIT J CLIN PHARMACO, V19, P793 PINNA MAC, 2008, MED PALIATIVA, V15, P143 NR 7 TC 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD SEP 1 PY 2008 VL 26 IS 25 BP 4225 EP 4225 DI 10.1200/JCO.2008.18.3566 PG 1 SC Oncology GA 350KB UT ISI:000259350200032 ER PT J AU Garcia-Herreros, M Baron, FJ Aparicio, IM Santos, AJ Garcia-Marin, LJ Gil, MC AF Garcia-Herreros, M. Baron, F. J. Aparicio, I. M. Santos, A. J. Garcia-Marin, L. J. Gil, M. C. TI Morphometric changes in boar spermatozoa induced by cryopreservation SO INTERNATIONAL JOURNAL OF ANDROLOGY LA English DT Article DE sperm; changes; computer-assisted sperm morphometry analysis; cryopreservation; morphometry ID SPERM HEAD MORPHOMETRY; RAM SPERM; ARTIFICIAL-INSEMINATION; SUPEROXIDE-DISMUTASE; MORPHOLOGY ANALYSIS; PHASE-TRANSITIONS; MAMMALIAN SPERM; FROZEN STORAGE; COLD SHOCK; SEMEN AB Computer-assisted sperm morphometry analysis was used to determine the effects of cryopreservation on boar sperm head and midpiece morphometry. Sperm-rich fractions were collected from five mature boars. Three microscope slides were prepared from single extended sperm samples prior freezing and post-thawing. All slides were stained with Hemacolor, and 250 sperm images were obtained from each slide. The sperm head dimensions for length, width, area, perimeter and four shape factors and sperm-midpiece dimensions for area, width, angle and distance were determined in each spermatozoa. The effects of sperm freezing on sperm dimensions within and among boars were determined. A previous discriminant analysis of the results was able to correctly classify a 78.3 and 82% of fresh and frozen-thawed spermatozoa respectively. Sperm heads were significantly smaller in cryopreserved spermatozoa than in the companion extended samples for length, width, area and perimeter. Sperm midpieces were also significantly smaller in cryopreserved spermatozoa for width and area. The highest changes in morphometric dimensions after the freeze-thawing process were found in the midpiece of spermatozoa. The variability of morphometric measurements only was significantly different between fresh and thawed samples for head rugosity and midpiece area. The effects of cryopreservation on morphometric parameters were similar in the boars, which allow us to conclude that cryopreservation process does not have a different effect in each individual boar. In summary, morphometric changes associated with the cryopreservation process on boar spermatozoa do not apparently depends on an effect at individual level. C1 [Garcia-Herreros, M.; Aparicio, I. M.; Garcia-Marin, L. J.; Gil, M. C.] Univ Extremadura, Fac Vet, Unity Reprod & Obstet, Intracellular Signaling & Technol Reprod Res Grp, Caceres 10071, Spain. [Baron, F. J.] Univ Malaga, Dept Biostat, E-29071 Malaga, Spain. [Santos, A. J.] ACOREX, Dept Vet, Badajoz, Spain. RP Gil, MC, Univ Extremadura, Fac Vet, Unity Reprod & Obstet, Intracellular Signaling & Technol Reprod Res Grp, Avda Univ S-N, Caceres 10071, Spain. EM crgil@unex.es FU Basque Government-Eusko Jaurlaritza, Spain ; Ministerio de Educacio n y Ciencia, Spain [AGL 2005-01205, RZ 2004-00012] FX M. Garcia-Herreros was supported by a Doctoral grant from the Department of Education, Universities and Investigation of the Basque Government-Eusko Jaurlaritza, Spain. This work received financial support from Ministerio de Educacio n y Ciencia, Spain, AGL 2005-01205 and RZ 2004-00012. 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J. Androl. PD OCT PY 2008 VL 31 IS 5 BP 490 EP 498 DI 10.1111/j.1365-2605.2007.00794.x PG 9 SC Andrology GA 345VL UT ISI:000259025400007 ER PT J AU Canada-Canada, F de la Pena, AM Diez, NM Giron, AJ Heisel, F Miehe, JA Potes, J AF Canada-Canada, F. Munoz de la Pena, A. Mora Diez, N. Jimenez Giron, A. Heisel, F. Miehe, J. A. Potes, J. TI Laser-induced fluorescence imaging system for weather stress analysis in plant leaves of different wheat varieties SO CHEMIA ANALITYCZNA LA English DT Article DE wheat; LIF imaging system; chlorophyll fluorescence ID EMISSION-SPECTRA; GREEN; BLUE; SIGNATURES AB Field plants can be exposed to several stresses. Early detection of any change in plant health is important in order to undertake an action to restore its vitality. In this paper, a new approach towards characterization of nutritional lacks in wheat leaves of different varieties has been proposed. The developed procedure is based on a laser-induced fluorescence (LIF) imaging system, which allows scanning of emission intensity distribution over the sample surface. Importantly, the new technique is non-invasive and allows for in-situ field analysis of leaves, as the LIF system is housed in a laboratory vehicle. Detection is based oil chlorophyll fluorescence-emission band ratios. It allows for the analysis of leaf surface and for the establishment of the relation between emission and the type of wheat variety. The measurements were made in test areas grown with different varieties of a particular wheat type, called long cycle wheat. The proposed technique provides an appropriate method of analysis of different wheat varieties with regard to irregular weather conditions in the investigated region. C1 [Canada-Canada, F.; Munoz de la Pena, A.; Mora Diez, N.; Jimenez Giron, A.] Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. [Heisel, F.; Miehe, J. A.] Ctr Rech Nucl, Appl Opt Grp, F-67037 Strasbourg 2, France. RP Canada-Canada, F, Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. EM floricanada@gmail.com FU the Commission of the European Communities ; FUNCECYT ; FISAC [IN310401] FX The financial support from the Commission of the European Communities in the frames of the project,. Fluorescence imaging system of plant leaves for stress analysis of agriculturalcultures" (FISAC, IN310401), coordinated by FUNCECYT, Consejeria de Infraestructura, Desarrollo Tecnologico e Innovacion de la Junta de Extremadura " is acknowledged. 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Anal. PY 2008 VL 53 IS 4 BP 545 EP 556 PG 12 SC Chemistry, Analytical GA 347TK UT ISI:000259163800005 ER PT J AU De Mendoza, MF Exposito, JM Gordillo, CD Casas, JS AF Fuentes De Mendoza, M. Marin Exposito, J. De Miguel Gordillo, C. Sanchez Casas, J. TI Extraction systems and quality parameters of extra virgin olive oils from the olive-oil producing zone "Tierra de Barros" (Extremadura, Spain) SO RIVISTA ITALIANA DELLE SOSTANZE GRASSE LA English DT Article DE extra-virgin olive oil; quality; extraction system ID OXIDATIVE STABILITY AB The influence was studied of the extraction system on the standard quality parameters (acidity, peroxide index, polyphenol content, oxidative stability, readings in the ultraviolet K-232 and K-270) and organoleptic assessment of extra-virgin olive oils obtained from the varieties carrasquena and morisca - the main varieties cultivated in the olive-oil producing zone of tierra de barros. The elementary physico-chemical quality parameters of 60 samples, 30 from 10 industrial oil mills and the other 30 oils obtained in the laboratory, were analyzed using the abencor system. Although for the industrial oils there were statistically significant differences (a=0.05) in acidity, peroxide index, polyphenol content, and stability, no differences were found between the oils extracted in the laboratory. C1 [Fuentes De Mendoza, M.; De Miguel Gordillo, C.] Inst Tecnol Agroalimentario Extremadura, Badajoz 06071, Spain. [Marin Exposito, J.] Uex, Dept Biol Vegetal Ecol & Ciencias Tierra, Badajoz, Spain. [Sanchez Casas, J.] Uex, Dept Quim Analit, Badajoz, Spain. RP Casas, JS, Inst Tecnol Agroalimentario Extremadura, Ctra San Vicente S-N,Apartado 20107, Badajoz 06071, Spain. 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Ital. Sostanze Grasse PD APR-JUN PY 2008 VL 85 IS 2 BP 120 EP 127 PG 8 SC Food Science & Technology GA 344NV UT ISI:000258935500006 ER PT J AU Gonzalez-Novo, A Correa-Bordes, J Labrador, L Sanchez, M de Aldana, CRV Jimenez, J AF Gonzalez-Novo, Alberto Correa-Bordes, Jaime Labrador, Leticia Sanchez, Miguel Vazquez de Aldana, Carlos R. Jimenez, Javier TI Sep7 is essential to modify septin ring dynamics and inhibit cell separation during Candida albicans hyphal growth SO MOLECULAR BIOLOGY OF THE CELL LA English DT Article ID SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTOR; POLARIZED GROWTH; YEAST; MORPHOGENESIS; ORGANIZATION; CYCLE; LOCALIZATION; PROTEINS; MOTHER AB When Candida albicans yeast cells receive the appropriate stimulus, they switch to hyphal growth, characterized by continuous apical elongation and the inhibition of cell separation. The molecular basis of this inhibition is poorly known, despite its crucial importance for hyphal development. In C. albicans, septins are important for hypha formation and virulence. Here, we used fluorescence recovery after photobleaching analysis to characterize the dynamics of septin rings during yeast and hyphal growth. On hyphal induction, septin rings are converted to a hyphal-specific state, characterized by the presence of a frozen core formed by Sep7/Shs1, Cdc3 and Cdc12, whereas Cdc10 is highly dynamic and oscillates between the ring and the cytoplasm. Conversion of septin rings to the hyphal-specific state inhibits the translocation of Cdc14 phosphatase, which controls cell separation, to the hyphal septum. Modification of septin ring dynamics during hyphal growth is dependent on Sep7 and the hyphal-specific cyclin Hgc1, which partially controls Sep7 phosphorylation status and protein levels. Our results reveal a link between the cell cycle machinery and septin cytoskeleton dynamics, which inhibits cell separation in the filaments and is essential for hyphal morphogenesis. C1 [Gonzalez-Novo, Alberto; Labrador, Leticia; Sanchez, Miguel; Vazquez de Aldana, Carlos R.; Jimenez, Javier] Univ Salamanca, Consejo Super Invest Cient, Inst Microbiol Bioquim, Dept Genet & Microbiol, Salamanca 37007, Spain. [Correa-Bordes, Jaime] Univ Extremadura, Fac Ciencias, Dept Ciencias Biomed, E-06071 Badajoz, Spain. RP de Aldana, CRV, Univ Salamanca, Consejo Super Invest Cient, Inst Microbiol Bioquim, Dept Genet & Microbiol, Salamanca 37007, Spain. EM cvazquez@usal.es javier.jimenezj@upf.edu FU Fundacion Ramon Areces ; Junta de Castilla y Leon [SA013B05]; Ministerio de Ciencia y Tecnologia [BFU2006-10318, BFU-2004-00778] FX We dedicate this work to Miguel Sanchez-Perez. We thank J. Konopka (State University of New York, Stony Brook, NY), P. Sudbery, and Y. Wang (Institute of Molecular and Cell Biology, Singapore) for strains and plasmids; D. Kellogg for Western protocol and anti-Shs1 antibody; Y. Barral, B. Stern, P. Perez, E. Pablo, and VJ. Cid for critical reading and suggestions; E. Duenas, E. Pablo, and AB. Martin-Cuadrado for literally thousands of hours of help and saintly patience; F. Gonzalez-Camacho from the Centro de Investigacion del Cancer for FRAP analysis, and N.Skinner for language revision.This work was supported by grants from the Fundacion Ramon Areces (to M.S.), Junta de Castilla y Leon (SA013B05) (to J.J.), and from the Ministerio de Ciencia y Tecnologia (BFU2006-10318 to J.C.-B.and BFU-2004-00778 to C.R.V.).A.G.-N. held a fellowship from the Ministerio de Ciencia y Tecnologia. 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Biol. Cell PD APR PY 2008 VL 19 IS 4 BP 1509 EP 1518 DI 10.1091/mbc.E07-09-0876 PG 10 SC Cell Biology GA 344TZ UT ISI:000258951500021 ER PT J AU Jardin, I Lopez, JJ Salido, GM Rosado, JA AF Jardin, Isaac Lopez, Jose J. Salido, Gines M. Rosado, Juan A. TI Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channels SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID CAPACITATIVE CALCIUM-ENTRY; STORE-OPERATED CHANNEL; HUMAN PLATELETS; ACTIN CYTOSKELETON; PHOSPHOLIPASE-C; PLASMA-MEMBRANE; CRAC CHANNEL; CELLS; RECEPTOR; INFLUX AB Orai1 and hTRPC1 have been presented as essential components of store-operated channels mediating highly Ca2+ selective I-CRAC and relatively Ca2+ selective I-SOC, respectively. STIM1 has been proposed to communicate the Ca2+ content of the intracellular Ca2+ stores to the plasma membrane storeoperated Ca2+ channels. Here we present evidence for the dynamic interaction between endogenously expressed Orai1 and both STIM1 and hTRPC1 regulated by depletion of the intracellular Ca2+ stores, using the pharmacological tools thapsigargin plus ionomycin, or by the physiological agonist thrombin, independently of extracellular Ca2+. In addition we report that Orai1 mediates the communication between STIM1 and hTRPC1, which is essential for the mode of activation of hTRPC1-forming Ca2+ permeable channels. Electrotransjection of cells with anti-Orai1 antibody, directed toward the C-terminal region that mediates the interaction with STIM1, and stabilization of an actin cortical barrier with jasplakinolide prevented the interaction between STIM1 and hTRPC1. Under these conditions hTRPC1 was no longer involved in store-operated calcium entry but in diacylglycerol-activated non-capacitative Ca2+ entry. These findings support the functional role of the STIM1-Orai1-hTRPC1 complex in the activation of store-operated Ca2+ entry. C1 [Jardin, Isaac; Lopez, Jose J.; Salido, Gines M.; Rosado, Juan A.] Univ Extremadura, Cellular Physiol Res Grp, Dept Physiol, Caceres 10071, Spain. RP Rosado, JA, Univ Extremadura, Cellular Physiol Res Grp, Dept Physiol, Caceres 10071, Spain. EM jarosado@unex.es FU Spanish Ministry of Education and Science [BFU2007-60104] FX This work was supported in part by Spanish Ministry of Education and Science Grant BFU2007-60104. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. Section 1734 solely to indicate this fact. 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Biol. Chem. PD SEP 12 PY 2008 VL 283 IS 37 BP 25296 EP 25304 DI 10.1074/jbc.M802904200 PG 9 SC Biochemistry & Molecular Biology GA 345QZ UT ISI:000259012700023 ER PT J AU Garcia, J Beltran-Heredia, J AF Garcia, Juan Beltran-Heredia, Jesus TI Chemical treatment by Fenton's reagent oxidation and ozonation of wastewaters from olive oil mill SO JOURNAL OF ADVANCED OXIDATION TECHNOLOGIES LA English DT Article DE olive oil mill wastewater; Fenton's reagent; ozonation kinetic study ID WASTE-WATER; ANAEROBIC-DIGESTION; IMPERATIVE TECHNOLOGIES; DEGRADATION; EFFLUENT; REMOVAL AB In this work olive oil mill wastewater has been treated as first step by means of a Fenton's reagent process and later by an ozonation treatment, in batch reactors in both cases. In the Fenton's reagent oxidation step, a reduction of 33% and 90% is obtained for chemical oxygen demand and total polyphenolic compounds, respectively. In the ozonation step, ozone partial pressure and temperature were varied leading to chemical oxygen demand removal in the range 5-17% and total polyphenolic compounds removal in the range 26-62%. A kinetic study, which consideres mixed flow reactor model for both phases, allows to determine the rate constant for the ozone reaction in the reduction of chemical oxygen demand and total polyphenolic compounds. Kinetic rate constants were correlated with temperature to Arrhenius equations. C1 [Garcia, Juan; Beltran-Heredia, Jesus] Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. RP Beltran-Heredia, J, Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. EM jbelther@unex.es FU "Comision Interministerial de Ciencia y Tecnologia" (CICYT) of Spain [CTQ2007-60255/PPQ] FX This research was supported by the "Comision Interministerial de Ciencia y Tecnologia" (CICYT) of Spain, under Project CTQ2007-60255/PPQ. 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Adv. Oxid. Technol. PD AUG 31 PY 2008 VL 11 IS 3 BP 568 EP 572 PG 5 SC Chemistry, Physical GA 345DC UT ISI:000258975200017 ER PT J AU Serrano, JC AF Caldera Serrano, Jorge TI Agency dispatches (teletypes) as a documentary type SO INVESTIGACION BIBLIOTECOLOGIA LA Spanish DT Article DE teletypes; news agencies : journalistic documentation; documentary management; data bases ID NEWS AGENCIES AB An agency's dispatch is analyzed as a documentary type (print, audiovisual and sound material) which must be preserved and analyzed by the documentation departments of the mass media. In order to carry Out Such analysis, a study of the semantic structure of their discourse is made to serve as a basis for the identification of access points that the data base requires if it is to store such material: subject, chronological, geographic and author information. C1 Univ Extremadura, E-06071 Badajoz, Spain. RP Serrano, JC, Univ Extremadura, E-06071 Badajoz, Spain. 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Bibliotecol. PD JAN-JUN PY 2007 VL 21 IS 42 BP 177 EP 193 PG 17 SC Information Science & Library Science GA 342LZ UT ISI:000258786900008 ER PT J AU Pinna, MA AF Cuervo Pinna, Miguel Angel TI Is there a higher risk of respiratory depression in opioid-naive palliative care patients during symptomatic therapy of dyspnea with strong opioids? SO JOURNAL OF PALLIATIVE MEDICINE LA English DT Letter ID CANCER-PATIENTS C1 ESCP Badajoz, Programa Reg Cuidados Paliat Extremadura, Badajoz 06010, Extremadura, Spain. RP Pinna, MA, ESCP Badajoz, Programa Reg Cuidados Paliat Extremadura, Avda Damian Tellez Lafuente 30-1 B, Badajoz 06010, Extremadura, Spain. EM 924252539@telefonica.net CR ALLARD P, 1999, J PAIN SYMPTOM MANAG, V17, P256 CLEMENS K, 2008, J PALLIAT MED, V2, P204 VIOLA R, 2008, SUPPORT CARE CANCER, V16, P329, DOI 10.1007/s00520-007-0389-6 NR 3 TC 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-6218 J9 J PALLIAT MED JI J. Palliat. Med. PD JUL-AUG PY 2008 VL 11 IS 6 BP 822 EP 822 DI 10.1089/jpm.2008.0065 PG 1 SC Health Care Sciences & Services GA 343ZX UT ISI:000258896100006 ER PT J AU Vaquero, JM Valente, MA Trigo, RM Ribeiro, P Gallego, MC AF Vaquero, J. M. Valente, M. A. Trigo, R. M. Ribeiro, P. Gallego, M. C. TI The 1870 space weather event: Geomagnetic and auroral records SO JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS LA English DT Article ID LOW-LATITUDE AURORAS; SOLAR-ACTIVITY; HISTORICAL RECORDS; MAGNETIC STORM; 4 CENTURIES; RECONSTRUCTION; ENVIRONMENT; AUGUST AB The great solar storm that took place on 24-25 October 1870 is not well known and has been almost absent from previous studies. In this work, a large amount of information that was registered at the time is compiled and analyzed, including early geomagnetic data and several comprehensive descriptions of the auroras observed during these two nights. These descriptions reveal unusual characteristics for a typical low-latitude aurora. For example, unlike most low-latitude auroras (generally red and diffuse), this event was mostly characterized by a variable palette of colors, including greenish and white. The geomagnetic records analyzed from Lisbon and Coimbra (Portugal), Greenwich (United Kingdom), Munich (Germany), and Helsinki (Finland) clearly show an intense geomagnetic disturbance on 24-25 October. The Coimbra magnetograms reveal that this disturbance consisted of two distinct geomagnetic storms, the first on 24 October (with amplitudes of 37' in D and 182 nT and 48 nT in H and Z, respectively), and the second on 25 October (with amplitudes of 33' in D and 281 nT and 192 nT in H and Z, respectively). Finally, from early photographic solar observations made during 1870, we have identified a long-lived group of sunspots that are most likely related to the solar source of this great event of space weather. C1 [Vaquero, J. M.] Univ Extremadura, Escuela Politecn, Dept Fis Aplicada, E-10071 Caceres, Spain. [Ribeiro, P.] Univ Coimbra, Inst Geofis, P-300134 Coimbra, Portugal. [Valente, M. A.] Univ Lisbon, Inst Geofis Infante D Luis, P-1250102 Lisbon, Portugal. [Valente, M. A.; Trigo, R. M.] Univ Lisbon, Ctr Geofis, Fac Ciencias, P-1749016 Lisbon, Portugal. [Trigo, R. M.] Univ Lusofona, Dept Engn & Ciencias Nat, Lisbon, Portugal. [Ribeiro, P.] Univ Coimbra, Ctr Geofis, Coimbra, Portugal. [Gallego, M. C.] Univ Extremadura, Fac Ciencias, Dept Fis, E-06071 Badajoz, Spain. RP Vaquero, JM, Univ Extremadura, Escuela Politecn, Dept Fis Aplicada, Ave Univ S-N, E-10071 Caceres, Spain. EM jvaquero@unex.es FU Spanish Science Ministry ; Portuguese project Signatures of Environmental Change in the Observations of the Geophysical Institutes [POCTI/CTA/47803/2002] FX The authors are in debt to Heikki Nevanlinna and Heather McCreadie, who provided the Helsinki and Munich geomagnetic data, respectively. The assistance provided by Alexandra Pais and David Vaz with the Coimbra geomagnetic data is also gratefully acknowledged. The authors are in debt to Andrew Jackson for providing access to the geomagnetic database as well as to the gufm1 model. We are also particularly thankful to Sam Silverman for providing his historical aurora data set from the National Space Science Data Center. J. M. V. acknowledges the Programme `` Jose ' Castillejo'' of the Spanish Science Ministry. The authors acknowledge the geomagnetic data and auroral descriptions provided through the Portuguese project Signatures of Environmental Change in the Observations of the Geophysical Institutes (SIGN) under POCTI/CTA/47803/2002. [50] Zuyin Pu thanks Walter D. Gonzalez and another reviewer for their assistance in evaluating this manuscript. 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Geophys. Res-Space Phys. PD AUG 28 PY 2008 VL 113 IS A8 AR A08230 DI 10.1029/2007JA012943 PG 16 SC Astronomy & Astrophysics GA 343AN UT ISI:000258824800002 ER PT J AU Roman, S Gonzalez, JF Gonzalez-Garcia, CM Zamora, F AF Roman, S. Gonzalez, J. F. Gonzalez-Garcia, C. M. Zamora, F. TI Control of pore development during CO2 and steam activation of olive stones SO FUEL PROCESSING TECHNOLOGY LA English DT Article DE olive stones; activated carbon; gasification; steam; carbon dioxide ID CARBON-DIOXIDE; GASIFICATION; ADSORPTION; AGENTS; H2O AB Several series of activated carbons were prepared from olive stones by means of carbonization followed by activation with carbon dioxide, water steam and a mixture of them, under different experimental conditions. The changes in porosity of the original char during activation were studied by adsorption of N-2 at 77 K, CO2 at 273 K and Hg porosimetry. The study was carried out covering a wide range of burn-off (19-83%) using activation times of 20-120 min, and temperatures between 650 and 950 degrees C. It is shown quantitatively how the individual factors influence the development of microporosity. It was found that in general terms, increasing activation produces a continuous increase in the volume of micropores and mesopores. However, this development occurs in a different proportion whether CO2 or steam are used: while CO2 produces narrow micropores on the carbons and widens them as time is increased, steam yields pores of all the sizes from the early stages of the process. The simultaneous use of these two activating agents resulted positive at times higher than 1 h, since it yielded carbons with higher volumes of pores. (C) 2008 Elsevier B.V. All rights reserved. C1 [Roman, S.; Gonzalez, J. F.; Gonzalez-Garcia, C. M.; Zamora, F.] Univ Extremadura, Dept Appl Phys, E-06071 Badajoz, Spain. RP Roman, S, Univ Extremadura, Dept Appl Phys, Avda Elvas S-N, E-06071 Badajoz, Spain. EM sroman@unex.es FU "Junta de Extremadura-Consejeria de Educacion, Ciencia y Tecnologia" ; "Almaraz Nuclear Plant" [2PRO4B016, 169/06] FX The authors would like to express their gratitude to the "Junta de Extremadura-Consejeria de Educacion, Ciencia y Tecnologia" and the "Almaraz Nuclear Plant" for the financial support through projects 2PRO4B016 and 169/06, respectively. S. Roman and F. Zamora would like to thank the "Junta de Extremadura" for the research grant received. CR ARRIAGADA R, 1989, CARBON, V27, P23 BESSANT GAR, 1994, CARBON, V32, P1171 BRUNAUER S, 1938, J AM CHEM SOC, V60, P309 CARROTT PJM, 1991, CARBON, V29, P499 DUBININ MM, 1975, PROGR SURFACE MEMBRA, V9 GONZALEZ JF, 2006, APPL SURF SCI, V252, P5999, DOI 10.1016/j.apsusc.2005.11.029 GONZALEZ MT, 1997, CARBON, V35, P159 GONZALEZMARTIN ML, 1994, LANGMUIR, V10, P844 HARKINS WD, 1944, J AM CHEM SOC, V66, P919 HU ZH, 1995, MICROPOROUS MATER, V3, P603 KUHL H, 1992, FUEL, V71, P879 LINARESSOLANO A, 2000, ENERG FUEL, V14, P142 OYA A, 1995, CARBON, V33, P1085 RODRIGUEZREINOSO F, 1995, CARBON, V33, P15 ROMAN S, 2006, APPL SURF SCI, V252, P6036, DOI 10.1016/j.apsusc.2005.11.023 ROUQUEROL F, 1999, ADSORPTION POWDERS P RYU SK, 1993, CARBON, V31, P841 SANCHEZ AR, 2001, CARBON, V39, P1367 TOLES CA, 2000, BIORESOURCE TECHNOL, V75, P197 TOMKOW K, 1977, FUEL, V56, P121 WALKER PL, 1959, ADV CATAL, V11, P133 WALKER PL, 1996, CARBON, V34, P1297 NR 22 TC 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3820 J9 FUEL PROCESS TECHNOL JI Fuel Process. Technol. PD AUG PY 2008 VL 89 IS 8 BP 715 EP 720 DI 10.1016/j.fuproc.2007.12.015 PG 6 SC Chemistry, Applied; Energy & Fuels; Engineering, Chemical GA 342WG UT ISI:000258813700001 ER PT J AU Gonzalez, JF Roman, S Bragado, D Calderon, M AF Gonzalez, J. F. Roman, S. Bragado, D. Calderon, M. TI Investigation on the reactions influencing biomass air and air/steam gasification for hydrogen production SO FUEL PROCESSING TECHNOLOGY LA English DT Article DE olive waste; hydrogen; gasification; catalyst ID FLUIDIZED-BED REACTOR; STEAM-GASIFICATION; RICH GAS; PYROLYSIS; OLIVINE AB Hydrogen could be the energy carrier of the next world scene provided that its production, transportation and storage are solved. In this work the production of an hydrogen-rich gas by air/steam and air gasification of olive oil waste was investigated. The study was carried out in a laboratory reactor at atmospheric pressure over a temperature range of 700-900 degrees C using a steam/biomass ratio of 1.2 w/w. The influence of the catalysts ZnCl2 and dolomite was also studied at 800 and 900 degrees C. The solid, energy and carbon yield (%), gas molar composition and high heating value of the gas (kJ NL-1), were determined for all cases and the differences between the gasification process with and without steam were established. Also, this work studies the different equilibria taking place, their predominance in each process and how the variables considered affect the final gas hydrogen concentration. The results obtained suggest that the operating conditions were optimized at 900 degrees C in steam gasification (a hydrogen molar fraction of 0.70 was obtained at a residence time of 7 min). The use of both catalysts resulted positive at 800 degrees C, especially in the case of ZnCl2 (attaining a H-2 molar fraction of 0.69 at a residence time of 5 min). (C) 2008 Elsevier B.V. All rights reserved. C1 [Gonzalez, J. F.; Roman, S.; Bragado, D.] Univ Extremadura, Dept Fis Aplicada, E-06071 Badajoz, Spain. [Calderon, M.] Univ Extremadura, Dept Elect & Ingn Electromecan, E-06071 Badajoz, Spain. RP Gonzalez, JF, Univ Extremadura, Dept Appl Phys, E-06071 Badajoz, Spain. EM jfelixgg@unex.es FU "Junta de Extremadura" [2PR04B016] FX The authors express their gratitude to "Junta de Extremadura" for the financial support through the project 2PR04B016. S. Roman would like to thank the "Junta de Extremadura" for the research grant received. CR *UNE, 1981, 3200181 UNE *UNE, 1984, 32004844 UNE *UNE, 1984, 3201984 UNE CAGLAR A, 2002, ENERG CONVERS MANAGE, V43, P109 DEMIRBAS A, 2001, FUEL, V80, P1885 ENCINAR JM, 2002, FUEL PROCESS TECHNOL, V75, P27 FRANCO C, 2003, FUEL, V82, P835 GARCIAIBANEZ P, 2004, BIOMASS BIOENERG, V27, P183, DOI 10.1016/j.biombioe.2003.11.007 GONZALEZ JF, 2006, APPL SURF SCI, V252, P5999, DOI 10.1016/j.apsusc.2005.11.029 HAN J, 2006, RENEWABLE S IN PRESS HANAOKA T, 2005, BIOMASS BIOENERG, V28, P63, DOI 10.1016/j.biombioe.2004.03.009 HARYANTO A, 2005, ENERG FUEL, V19, P2098, DOI 10.1021/ef0500538 HOFBAUER H, 2001, PROGR THERMOCHEMICAL, P199 HU G, 2006, FUEL PROCESS TECHNOL, V87, P375, DOI 10.1016/j.fuproc.2005.07.008 JOHNSON JL, 1976, KINETICS COAL GASIFI KOTHARI R, 2006, RENEWABLE S IN PRESS LV P, 2007, RENEW ENERG, V32, P2173, DOI 10.1016/j.renene.2006.11.010 MARBAN G, 2007, INT J HYDROGEN ENERG, V32, P1625, DOI 10.1016/j.ijhydene.2006.12.017 PACALA S, 2004, SCIENCE, V305, P968 RAPAGNA S, 1997, BIOMASS BIOENERG, V12, P281 RAPAGNA S, 1998, INT J HYDROGEN ENERG, V23, P551 RAPAGNA S, 2000, BIOMASS BIOENERG, V19, P187 SCHILLING HD, 1981, COAL GASIFICATION EX SHIYING L, 2002, FUEL, V81, P2079 TURN S, 1998, INT J HYDROGEN ENERG, V23, P641 NR 25 TC 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3820 J9 FUEL PROCESS TECHNOL JI Fuel Process. Technol. PD AUG PY 2008 VL 89 IS 8 BP 764 EP 772 DI 10.1016/j.fuproc.2008.01.011 PG 9 SC Chemistry, Applied; Energy & Fuels; Engineering, Chemical GA 342WG UT ISI:000258813700008 ER PT J AU Wiper, MP Giron, FJ Pewsey, A AF Wiper, M. P. Giron, F. J. Pewsey, Arthur TI Objective Bayesian inference for the half-normal and half-t distributions SO COMMUNICATIONS IN STATISTICS-THEORY AND METHODS LA English DT Article DE bias-correction; Gaussian-modulated gamma distribution; Gibbs sampling; likelihood based inference; model selection; right-truncated normal-gamma distribution ID MARGINAL LIKELIHOOD; DENSITIES; PARAMETER; OUTPUT AB In this article, Bayesian inference for the half-normal and half-t distributions using uninformative priors is considered. It is shown that exact Bayesian inference can be undertaken for the half-normal distribution without the need for Gibbs sampling. Simulation is then used to compare the sampling properties of Bayesian point and interval estimators with those of their maximum likelihood based counterparts. Inference for the half-t distribution based on the use of Gibbs sampling is outlined, and an approach to model comparison based on the use of Bayes factors is discussed. The fitting of the half-normal and half-t models is illustrated using real data on the body fat measurements of elite athletes. C1 [Pewsey, Arthur] Univ Extremadura, Dept Matemat, Escuela Politecn, Caceres 10071, Spain. [Wiper, M. P.] Univ Carlos III Madrid, Dept Estadist, Madrid, Spain. [Giron, F. J.] Univ Malaga, Dept Estadist & Invest Operat, Malaga, Spain. RP Pewsey, A, Univ Extremadura, Dept Matemat, Escuela Politecn, Caceres 10071, Spain. EM apewsey@unex.es FU [SEJ2007-04438]; [SEJ2004-02447]; [MTM2007-61470] FX Michael Wiper was partially supported in this research by the project SEJ2007-04438, Javier Giron by projects SEJ2004-02447, and Arthur Pewsey by project MTM2007-61470. 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Stat.-Theory Methods PY 2008 VL 37 IS 20 BP 3165 EP 3185 DI 10.1080/03610920802105184 PG 21 SC Statistics & Probability GA 344DB UT ISI:000258904900001 ER PT J AU Brissos, S Dias, VV Kapczinski, F AF Brissos, Sofia Dias, Vasco Videira Kapczinski, Flavio TI Cognitive performance and quality of life in bipolar disorder SO CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE LA English DT Article DE bipolar disorder; euthymia; cognitive impairment; quality of life; remission ID MANIC SYMPTOMS; RATING-SCALE; IMPACT; SCHIZOPHRENIA; METAANALYSIS; IMPAIRMENT; DEPRESSION; RELIABILITY; REMISSION; VALIDITY AB Objective: In patients with bipolar disorder (BD), quality of life (QOL) scores have been largely attributed to mood symptoms. However, impairments in QOL may occur even in euthymia, and differential factors have been put forward as important determinants of QOL. Our study was designed to assess the role of cognitive performance in self-reported QOL in patients with BD. Method: In this cross-sectional study, we examined the relation between cognitive variables and self-reported QOL in 55 bipolar I euthymic patients and 50 healthy subjects. Participants were administered the World Health Organization Quality of Life Assessment-Abbreviated version and a battery of neuropsychological tests. Results: BD patients showed lower scores in all QOL domains as compared with control subjects. Poorer self-reported QOL correlated significantly with worse cognitive performance, especially on tests of executive functioning and verbal abstraction. A linear regression model revealed that all QOL domains were significantly predicted by cognitive variables, with variances ranging from 12% to 37%, and from 24% to 54% when clinical variables were added to the model. Conclusions: Deficits in executive functioning and verbal abstraction were strong predictors of poor self-reported QOL. Our findings suggest that, along with mood stabilization, adequate cognitive functioning is desirable for achieving better QOL. These findings suggest that cognitive rehabilitation may be an important factor for restoring QOL to baseline levels among BD patients. C1 [Brissos, Sofia] Ctr Hosp Psiquiatr Lisboa, Lisbon, Portugal. [Dias, Vasco Videira] Univ Extremadura, Badajoz, Spain. [Dias, Vasco Videira; Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Fed Univ, Hosp Clin, Bipolar Disorders Program & Mol Psychiat Unit, Porto Alegre, RS, Brazil. RP Brissos, S, Rua Conde Redondo 8 3 Dt, P-1150105 Lisbon, Portugal. 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J. Psychiat.-Rev. Can. Psychiat. PD AUG PY 2008 VL 53 IS 8 BP 517 EP 524 PG 8 SC Psychiatry GA 343IS UT ISI:000258847400005 ER PT J AU Molina, M Jacob, C Ramos, A AF Molina, Manuel Jacob, Christine Ramos, Alfonso TI Bisexual branching processes with offspring and mating depending on the number of couples in the population SO TEST LA English DT Article DE branching processes; bisexual processes; population-size dependent processes ID GALTON-WATSON PROCESSES; LIMIT BEHAVIOR; VARYING ENVIRONMENTS; EXTINCTION; IMMIGRATION AB In this work, we introduce a discrete-time bisexual branching process which considers both offspring and mating depending on the number of couples in the population at the previous generation. For such a model, we determine several probabilistic properties and provide some theoretical results concerning its limiting evolution. As an illustration, some simulated examples are given. C1 [Molina, Manuel; Ramos, Alfonso] Univ Extremadura, Dept Math, E-06071 Badajoz, Spain. [Jacob, Christine] INRA, Appl Math & Informat Unity, F-78352 Jouy En Josas, France. RP Molina, M, Univ Extremadura, Dept Math, E-06071 Badajoz, Spain. EM mmolina@unex.es cjacob@jouy.inra.fr FU Ministerio de Ciencia y Tecnologia ; FEDER ; Desarrollo e Innovacion Tecnologica [BFM2003-06074] FX Research supported by the Ministerio de Ciencia y Tecnologia and the FEDER through the Plan Nacional de Investigacion Cient fica, Desarrollo e Innovacion Tecnologica, grant BFM2003-06074 CR ALSMEYER G, 1996, ANN APPL PROBAB, V6, P922 ALSMEYER G, 2002, ANN APPL PROBAB, V12, P125 BAGLEY JH, 1986, J APPL PROBAB, V23, P820 BRUSS FT, 1984, J APPL PROBAB, V21, P915 DALEY DJ, 1968, Z WAHRSCHEINLICHKEIT, V9, P315 DALEY DJ, 1986, J APPL PROBAB, V23, P585 FLEMING IA, 1996, REV FISH BIOL FISHER, V6, P379 GONZALEZ M, 1996, J APPL PROBAB, V33, P960 GONZALEZ M, 1997, J APPL PROBAB, V34, P575 GONZALEZ M, 2000, STAT PROBABIL LETT, V49, P19 GONZALEZ M, 2001, STOCH ANAL APPL, V19, P933 HILLE E, 1957, FUNCTIONAL ANAL SEMI HULL DM, 1982, J APPL PROBAB, V19, P847 HULL DM, 2003, EXTRACTA MATH, V18, P321 JAGERS P, 1975, BRANCHING PROCESSES KLEBANER FC, 1984, J APPL PROBAB, V21, P40 KLEBANER FC, 1985, J APPL PROBAB, V22, P48 MOLINA M, 2002, J APPL PROBAB, V39, P479 MOLINA M, 2003, STOCH ANAL APPL, V21, P1353, DOI 10.1081/SAP-120026110 MOLINA M, 2004, STOCH PROC APPL, V112, P309, DOI 10.1016/j.spa.2004.02.003 MOLINA M, 2004, TEST, V13, P481 WILLIAMS D, 1991, PROBABILITY MARTINGA XING YS, 2005, J APPL PROBAB, V42, P175 NR 23 TC 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1133-0686 J9 TEST JI Test PD AUG PY 2008 VL 17 IS 2 BP 265 EP 281 DI 10.1007/s11749-006-0031-9 PG 17 SC Statistics & Probability GA 341DQ UT ISI:000258694800010 ER PT J AU Alves-Pereira, I Canales, J Cabezas, A Cordero, PM Costas, MJ Cameselle, JC AF Alves-Pereira, Isabel Canales, Jose Cabezas, Alicia Martin Cordero, Paloma Jesus Costas, Maria Carlos Cameselle, Jose TI CDP-alcohol hydrolase, a very efficient activity of the 5 '-nucleotidase/UDP-sugar hydrolase encoded by the ushA gene of yersinia intermedia and Escherichia coli SO JOURNAL OF BACTERIOLOGY LA English DT Article ID CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; PREDICTING SUBCELLULAR-LOCALIZATION; LIPOPOLYSACCHARIDE O-ANTIGEN; DIPHOSPHATE-SUGAR HYDROLASE; BENDING DOMAIN ROTATION; CORYNEBACTERIUM-GLUTAMICUM; STREPTOCOCCUS-PNEUMONIAE; NUDIX HYDROLASES; ADP-RIBOSE; LICC GENE AB Nucleoside 5'-diphosphate-X hydrolases are interesting enzymes to study due to their varied activities and structure-function relationships and the roles they play in the disposal, assimilation, and modulation of the effects of their substrates. Few of these enzymes with a preference for CDP-alcohols are known. In Yersinia intermedia suspensions prepared from cultures on Columbia agar with 5% sheep blood, we found a CDP-alcohol hydrolase liberated to Triton X-100-containing medium. Growth at 25 C was deemed optimum in terms of the enzyme-activity yield. The purified enzyme also displayed 5'-nucleotidase, UDP-sugar hydrolase, and dinucleoside-polyphosphate hydrolase activities. It was identified as the protein product (UshA(Yi)) of the Y. intermedia ushA gene (ushA(Yi)) by its peptide mass fingerprint and by PCR cloning and expression to yield active enzyme. All those activities, except CDP-alcohol hydrolase, have been shown to be the properties of UshA of Escherichia coli (UshA(Ec)). Therefore, UshA(Ec) was expressed from an appropriate plasmid and tested for CDP-alcohol hydrolase activity. UshA(Ec) and UshA(Yi) behaved similarly. Besides being the first study of a UshA enzyme in the genus Yersinia, this work adds CDP-alcohol hydrolase to the spectrum of UshA activities and offers a novel perspective on these proteins, which are viewed here for the first time as highly efficient enzymes with k(cat)/K-m ratios near the theoretical maximum level of catalytic activities. The results are discussed in the light of the known structures of UshA(Ec) conformers and the respective homology models constructed for UshA(Yi), and also in relation to possible biological functions. Interestingly, every Yersinia species with a sequenced genome contains an intact ushA gene, except Y. pestis, which in all its sequenced biovars contains a ushA gene inactivated by frameshift mutations. C1 [Alves-Pereira, Isabel; Canales, Jose; Cabezas, Alicia; Jesus Costas, Maria; Carlos Cameselle, Jose] Univ Extremadura, Fac Med, Dept Bioquim & Biol Mol & Genet, Grp Enzimol, E-06080 Badajoz, Spain. [Alves-Pereira, Isabel] Univ Evora, Dept Quim, Evora, Portugal. [Martin Cordero, Paloma] Complejo Hosp Univ Badajoz, Microbiol Serv, Serv Extremeno Salud, Badajoz, Spain. RP Cameselle, JC, Univ Extremadura, Fac Med, Dept Bioquim & Biol Mol & Genet, Grp Enzimol, Apartado 108, E-06080 Badajoz, Spain. EM camselle@unex.es FU Ministerio de Educacion y Ciencia, Spain [BFU2006-00510]; FEDER ; Consejeria de Infraestructuras y Desarrollo Tecnologico, Junta de Extremadura Spain [GRU06031, GRU07066]; FSE ; Vicerrectorado de Investigacion, Desarrollo e Innovacion, UEx [A7-09] FX We are grateful to Ifor Beacham and Dennis Burns, Griffith University, Australia, for their kind gift of plasmid pLM-2. This research was supported by grant BFU2006-00510 from the Ministerio de Educacion y Ciencia, Spain, cofinanced by FEDER; grants GRU06031 and GRU07066 from the Consejeria de Infraestructuras y Desarrollo Tecnologico, Junta de Extremadura Spain, cofinanced by FSE and FEDER; and grant A7-09 from the Vicerrectorado de Investigacion, Desarrollo e Innovacion, UEx. 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Bacteriol. PD SEP 15 PY 2008 VL 190 IS 18 BP 6153 EP 6161 DI 10.1128/JB.00658-08 PG 9 SC Microbiology GA 343CC UT ISI:000258829200013 ER PT J AU Plaza, AJ AF Plaza, Antonio J. TI Parallel processing of remotely sensed hyperspectral imagery: full-pixel versus mixed-pixel classification SO CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE LA English DT Article DE parallel image processing; hyperspectral imaging; cluster computing; parallel processing; load balance; morphological processing; spatial/spectral integration; hyperspectral applications ID ENDMEMBER EXTRACTION ALGORITHMS; MORPHOLOGICAL TRANSFORMATIONS; ENVIRONMENT; DESIGN; IMPACT AB The rapid development of space and computer technologies allows for the possibility to store huge amounts of remotely sensed image data, collected using airborne and satellite instruments. In particular, NASA is continuously gathering high-dimensional image data with Earth observing hyperspectral sensors such as the jet Propulsion Laboratory's airborne visible-infrared imaging spectrometer (AVIRIS), which measures reflected radiation in hundreds of narrow spectral bands at different wavelength channels for the same area on the surface of the Earth. The development of fast techniques for transforming massive amounts of hyperspectral data into scientific understanding is critical for space-based Earth science and planetary exploration. Despite the growing interest in hyperspectral imaging research, only it few efforts have been devoted to the design of parallel implementations in the literature, and detailed comparisons of standardized parallel hyperspectral algorithms are currently unavailable. This paper compares several existing and new parallel processing techniques for pure and mixed-pixel classification in hyperspectral imagery. The distinction of pure versus mixed-pixel analysis is linked to the considered application domain, and results from the very rich spectral information available from hyperspectral instruments. In some cases, such information allows image analysts to overcome the constraints imposed by limited spatial resolution. In most cases, however, the spectral bands collected by hyperspectral instruments have high statistical correlation, and efficient parallel techniques are required to reduce the dimensionality of the data while retaining, the spectral information that allows for the separation of the classes. In order to address this issue, this paper also develops a new parallel feature extraction algorithm that integrates the spatial and spectral information. The proposed technique is evaluated (from the viewpoint of both classification accuracy and parallel performance) and compared with other parallel techniques for dimensionality reduction and classification in the context of three representative application case studies: urban characterization, land-cover classification in agriculture, and mapping of geological features, using AVIRIS data sets with detailed ground-truth. Parallel performance is assessed using T, a massively parallel Beowulf cluster at NASA's Goddard Space Flight Center. The detailed cross-validation of parallel algorithms conducted in this work may specifically help image analysts in selection of parallel algorithms for specific applications. Copyright (C) 2008 John Wiley & Sons, Ltd. C1 Univ Extremadura, Dept Technol Comp & Commun, E-10071 Caceres, Spain. RP Plaza, AJ, Univ Extremadura, Dept Technol Comp & Commun, Avda Univ S-N, E-10071 Caceres, Spain. EM aplaza@unex.es FU European Commission ; Hyperspectral Imaging Network [MRTN-CT-2006-035927]; Spanish Ministry of Education and Science [PR2003-0360] FX This research was supported by the European Commission through the project 'Hyperspectral Imaging Network' (Contract no. MRTN-CT-2006-035927). Funding from the Spanish Ministry of Education and Science (Fellowship PR2003-0360), which allowed the author to conduct research as postdoctoral research associate at NASA's Goddard Space Flight Center and University of Maryland, is also gratefully acknowledged. The author would like to thank Drs John E. Dorband, James C. Tilton, and J. Anthony Gualtieri at NASA's Goddard Space Flight Center for their collaboration in the development of experiments on the Thunderhead cluster. Last but not least, the author gratefully thanks Dr Alejandro Curado from the Department of English at the University of Extremadura for his linguistic revision of the manuscript. 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Comput.-Pract. Exp. PD SEP 10 PY 2008 VL 20 IS 13 BP 1539 EP 1572 DI 10.1002/cpe.1291 PG 34 SC Computer Science, Software Engineering; Computer Science, Theory & Methods GA 341UM UT ISI:000258740600003 ER PT J AU Lopez-Pineiro, A Albarran, A Nunes, JMR Barreto, C AF Lopez-Pineiro, A. Albarran, A. Nunes, J. M. Rato Barreto, C. TI Short and medium-term effects of two-phase olive mill waste application on olive grove production and soil properties under semiarid mediterranean conditions SO BIORESOURCE TECHNOLOGY LA English DT Article DE de-oiled TPOMW; two-phase olive mill waste; olive grove; organic amendment; soil quality ID AGRICULTURAL USE; CORN PRODUCTION; SOLID-WASTE; BY-PRODUCT; WATER; COMPOST; PHOSPHORUS; YIELD; SUBSTANCES; AMENDMENTS AB A five-year field study was conducted to evaluate the potential use of oiled and de-oiled two-phase olive mill waste (TPOMW and DTPOMW, respectively) as soil amendment on a representative olive grove soil: a Cutanic Luvisol. Treatments included a non-amended control, TPOMW1, TPOMW2, DTPOMW1 and DTPOMW2 (30, 60, 27 and 54 Mg ha(-1) dry weight equivalent). Significant increases (P < 0.05) in organic carbon, total N, available P and K, and aggregate stability were observed in the amended soils. Leaf analysis showed significant increases in N, P, and K concentrations in treated plots after the two first years of TPOMW or DTPOMW amendments. Also, a general increase in olive production was observed in the treated plots, this increase being higher in the TPOMW1 and DTPOMW1 treated soils. After five years of repeated TPOMW and DTPOMW application, the increase in yield was 29%, 9.8%, 30%, and 19% for TPOMW1, TPOMW2, DTPOMW1, and DTPOMW2, respectively. Raw TPOMW and DTPOMW have the potential to be valuable soil amendments and source of organic matter, with a positive effect on olive yield, and closing the cycle of residues-resources. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Lopez-Pineiro, A.] Univ Extremadura, Fac Ciencias, Area Edafol & Quim Agr, E-06071 Badajoz, Spain. [Albarran, A.] Univ Extremadura, Escuela Ingn Agr, Area Prod Vegetal, E-06071 Badajoz, Spain. [Nunes, J. M. Rato; Barreto, C.] Escola Super Agr Elvas, P-7350 Elvas, Portugal. RP Lopez-Pineiro, A, Univ Extremadura, Fac Ciencias, Area Edafol & Quim Agr, Avda Elvas S-N, E-06071 Badajoz, Spain. EM pineiro@unex.es FU Consejeria de Educacion Ciencia y Tecnologia de la junta de Extremadura [2PR02B030]; Spanish Ministries of Science and Technology [AGL2004-0518-C02-02]; Education and Science [AGL2007-655771-C02-02] FX This research was supported by the Consejeria de Educacion Ciencia y Tecnologia de la junta de Extremadura (Project 2PR02B030) and the Spanish Ministries of Science and Technology (Project AGL2004-0518-C02-02) and Education and Science (Project AGL2007-655771-C02-02). 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Technol. PD NOV PY 2008 VL 99 IS 17 BP 7982 EP 7987 DI 10.1016/j.biortech.2008.03.051 PG 6 SC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy & Fuels GA 341TT UT ISI:000258738700010 ER PT J AU Diaz, TG Cabanillas, AG Soto, MDL Ortiz, JM AF Galeano Diaz, T. Guiberteau Cabanillas, A. Lopez Soto, M. D. Ortiz, J. M. TI Determination of fenthion and fenthion-sulfoxide, in olive oil and in river water, by square-wave adsorptive-stripping voltammetry SO TALANTA LA English DT Article DE fenthion; fenthion-sulfoxide; square-wave; adsorptive-stripping voltammetry (AdSV); olive oil; water ID ORGANOPHOSPHORUS PESTICIDE-RESIDUES; GAS-CHROMATOGRAPHY; METABOLITES; SAMPLES AB Square-wave adsorptive-stripping voltammetry technique has been used to develop a method for the determination of fenthion in olive oil. Due to the fact that fenthion does not give any electrochemical signal at mercury electrode, the method has been based on a previous oxidation of fenthion to its metabolite, fenthion-sulfoxide, by using KMnO4. The metabolite gives rise to a peak due to an adsorptive-reductive process at -0.786V. Fenthion is isolated from olive oil by carrying out a solid-liquid extraction procedure using silica cartridge, followed by a liquid-liquid partitioning with acetonitrile. The detection limit in olive oil is 78.8 ng g(-1) and recoveries for four levels of fortification are ranged from 85% to 109%. On the other hand, it has been developed a method for the simultaneous determination of fenthion and its metabolite fenthion-sulfoxide, in river water. Pesticides are isolated from water by carrying out a liquid-liquid partitioning with trichloromethane. The detection limits are 0.41 ng g(-1) and 0.44 ng g(-1), for fenthion and fenthion-sulfoxide, respectively. Recoveries for three levels of fortification are ranged from 96% to 103% for fenthion and 94% to 104% for fenthion-sulfoxide. (C) 2008 Elsevier B.V. All rights reserved. C1 [Galeano Diaz, T.; Guiberteau Cabanillas, A.; Lopez Soto, M. D.; Ortiz, J. M.] Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. RP Diaz, TG, Univ Extremadura, Dept Analyt Chem, Avd Elvas S-N, E-06071 Badajoz, Spain. 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Immaculada Rioja, Luis A. Blas, Miguel Arocena, Juan Duran, Esther Uson, Jesus TI Endourologic techniques for ureteropelvic junction obstruction therapy. Comparative animal study SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE ureteropelvic junction; laparoscopic pyeloplasty; endoluminal ultrasound; endopyelotomy; experimental ID ANDERSON-HYNES PYELOPLASTY; LAPAROSCOPIC PYELOPLASTY; RETROGRADE ENDOPYELOTOMY; ACUCISE ENDOPYELOTOMY; URETERAL STRICTURE; EXPERIENCE; MANAGEMENT; ULTRASOUND; CHILDREN; UROLOGY AB Purpose: The aim of this work is to compare 3 endourologic techniques for treating a ureteropelvic junction (UPJ) obstruction. To accomplish this, we performed a study in a porcine animal specimen, in which we compared laparoscopic pyeloplasty that emerges as the future gold standard technique, with 2 endopyelotomy techniques. Material and methods: Twenty-four healthy large white female pigs were randomly divided in 3 groups-group I (laparoscopic pyeloplasty), group II (endopyelotomy-Acucise, Applied Medical, Rancho Margarita, CA), and group III (endoballoon rupture endopyelotomy). Percutaneous and endoluminal ultrasonographic and fluoroscopic studies were analyzed during the different phases of the study. The study was divided in 3 phases. First one included premodel documentation of normal urinary tract and laparoscopic UPJ obstruction induction. During second phase at 6 weeks later, diagnosis and endourologic treatment were carried out. Fifteen weeks after obstruction treatment, follow-up imaging Studies and postmortem evaluation of all animals were performed. Results: After the sonographic and fluoroscopic assessment, we determined the percentage of success rate for each technique-with an 87.5% for groups I and II and 75% for group III. Significant statistical differences were found between the 2 pyelotomy groups and the pyeloplasty group regarding the duration of the intervention. Significant statistical differences are evident in the evolution of the UPJ's diameter between groups I and III. Conclusions: Laparoscopic pyeloplasty is the technique that produces fewer side effects in the reconstructed area, as well as a wider dilation of the UPJ. Nevertheless, as we show in this Study, we found similar results between endopyelotomy in selected patients than pyeloplasty, and it is simpler and less invasive than the latter. (C) 2008 Elsevier Inc. All rights reserved. C1 [Soria, Federico; Delgado, M. Immaculada; Uson, Jesus] Minimally Invas Surg Ctr Jesus Uson, Endoscopy Dept, Caceres, Spain. [Rioja, Luis A.; Blas, Miguel] Miguel Servel Univ Hosp, Dept Urol, Zaragoza, Spain. [Arocena, Juan] Costa Sol Hosp, Dept Urol, Marbella, Spain. [Duran, Esther] Univ Extremadura, Dept Pathol, Badajoz, Spain. RP Soria, F, Minimally Invas Surg Ctr Jesus Uson, Endoscopy Dept, Caceres, Spain. EM fsoria@ccmi.es CR ARAKI H, 2005, J ENDOUROL, V19, P143 BAARD J, 2007, CURR UROL REP, V8, P134 BALDWIN DD, 2003, J ENDOUROL, V17, P155 BEAVER BV, 2001, J AM VET MED ASSOC, V218, P669 BOGAERT GA, 1996, J UROLOGY 2, V156, P734 BRAGA LH, 2007, J ENDOUROL, V21, P738, DOI 10.1089/end.2006.0420 BRAGA LH, 2007, J UROLOGY, V178, P2571, DOI 10.1016/j.juro.2007.08.050 DAVIS DM, 1943, SURG GYNECOL OBSTET, V76, P513 ELNAHAS AR, 2006, J UROLOGY, V175, P614, DOI 10.1016/S0022-5347(05)00142-4 FERNBACH SK, 1993, PEDIATR RADIOL, V23, P478 FIGENSHAU RS, 1996, J UROLOGY, V156, P2025 FIGENSHAU RS, 1998, UROL CLIN N AM, V25, P199 GALLUCCI M, 1996, J ENDOUROL, V10, P127 GOGUS C, 2004, UROL INT, V73, P11, DOI 10.1159/000078796 HERNANDEZ AP, 2006, ACTAS UROL ESP, V30, P933 MANIKANDAN R, 2005, UROLOGY, V65, P422, DOI 10.1016/j.urology.2004.08.036 MOON DA, 2006, UROLOGY, V67, P932, DOI 10.1016/j.urology.2005.11.024 NAKADA SY, 1996, J ENDOUROL, V10, P311 NGUYEN HT, 1998, BRIT J UROL S2, V81, P13 NICHOLLS G, 2001, BJU INT, V87, P525 OREILLY PH, 2001, BJU INT, V87, P287 OST MC, 2005, UROLOGY S, V66, P47, DOI 10.1016/j.urology.2005.06.115 OTERO JR, 2007, ACTAS UROL ESP, V31, P146 PARDALIDIS NP, 2002, J UROLOGY, V168, P1937, DOI 10.1097/01.ju.0000034996.46510.45 SCHENKMAN EM, 1998, J UROLOGY, V159, P1013 SCHWALB D, 1989, J ENDOUROL, V3, P85 SIM HG, 2005, ANN ACAD MED SINGAP, V34, P179 SORIA F, 2005, J VASC INTERV RADIOL, V16, P521, DOI 10.1097/01.RVI.0000147074.74604.35 STEIN RJ, 2007, CURR UROL REP, V8, P140 STOLZENBURG JU, 2006, CURR OPIN UROL, V16, P413 TALLAI B, 2004, J ENDOUROL, V18, P952 TAM JC, 1994, MED J AUSTRALIA, V160, P633 UMEKAWA T, 1996, ACTA UROL JPN, V42, P895 VANCANGH PJ, 1994, J UROLOGY, V151, P934 WICKHAM JEA, 1983, EUR UROL, V9, P122 NR 35 TC 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 J9 J PEDIAT SURG JI J. Pediatr. Surg. PD AUG PY 2008 VL 43 IS 8 BP 1528 EP 1532 DI 10.1016/j.jpedsurg.2007.12.074 PG 5 SC Pediatrics; Surgery GA 339QQ UT ISI:000258592500019 ER PT J AU Nunez, P Vazquez-Martin, R Bandera, A Sandoval, F AF Nunez, P. Vazquez-Martin, R. Bandera, A. Sandoval, F. TI An algorithm for fitting 2-D data on the circle: Applications to mobile robotics SO IEEE SIGNAL PROCESSING LETTERS LA English DT Article DE circle fitting; laser landmark acquisition; mobile robotics AB In this paper, an approach for fitting a circle to 2-D data which represent only a small part of the curve is described. This approach deals with the particular case where data is specified in terms of its Cartesian coordinates and the errors in both coordinates are not independent. Besides, an associated uncertainty ellipse which describes the measurement error and the variance matrix associated to the estimated parameters are obtained. This method is particularly well designed to fit a circle to a set of measured range readings provided by a 2-D laser range finder when these range readings are specified in terms of its Cartesian coordinates. Therefore, it has been successfully applied to acquire circle-shaped landmarks in a mobile robotics navigation task. C1 [Nunez, P.] Univ Extremadura, Dept Tecnol Computadores & Comunicac, E-06071 Badajoz, Spain. [Vazquez-Martin, R.; Bandera, A.; Sandoval, F.] Univ Malaga, Dept Tecnol Elect, Grp Ingn Sistemas Integrados, E-29071 Malaga, Spain. RP Nunez, P, Univ Extremadura, Dept Tecnol Computadores & Comunicac, E-06071 Badajoz, Spain. EM pmnt@uma.es rvmartin@uma.es ajbandera@uma.es sandoval@dte.uma.es FU Spanish Ministerio de Educacion y Ciencia (MEC) [TIN2005-01359] FX This work was supported in part by a grant from the Spanish Ministerio de Educacion y Ciencia (MEC) under Project TIN2005-01359. The associate editor coordinating the review of this manuscript and approving it for publication was Dr. Dominic Ho. CR BAILEY T, 2002, THESIS U SYDNEY SYDN CHERNOV N, 2005, J MATH IMAGING VIS, V23, P239, DOI 10.1007/s10851-005-0482-8 COX MG, 1989, IMA J NUMER ANAL, V9, P285 DIOSI A, 2003, MECSE262003 MON U DE NUNEZ P, 2006, P IEEE INT C ROB AUT, P1167 SHAKARJI CM, 1998, J RES NATL INST STAN, V103, P633 UMBACH D, 2003, IEEE T INSTRUM MEAS, V52, P1881, DOI 10.1109/TIM.2003.820472 ZHANG S, 2006, ROBOT AUTON SYST, V54, P277, DOI 10.1016/j.robot.2005.11.008 NR 8 TC 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1070-9908 J9 IEEE SIGNAL PROCESS LETT JI IEEE Signal Process. Lett. PY 2008 VL 15 BP 127 EP 130 DI 10.1109/LSP.2007.912964 PG 4 SC Engineering, Electrical & Electronic GA 339NZ UT ISI:000258585600034 ER PT C AU Samhan-Arias, AK Gutierrez-Merino, C AF Samhan-Arias, A. K. Gutierrez-Merino, C. TI Plasma membrane-bound cytochrome b5 reductase is associated with lipid rafts in cerebellar granule neurons in culture SO FREE RADICAL RESEARCH LA English DT Meeting Abstract C1 [Samhan-Arias, A. K.; Gutierrez-Merino, C.] Univ Extremadura, Depto Bioquim & Biol Mol, Fac Ciencias, E-06071 Badajoz, Spain. NR 0 TC 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1071-5762 J9 FREE RADICAL RES JI Free Radic. Res. PD JUL PY 2008 VL 42 SU Suppl. 1 BP S51 EP S51 PG 1 SC Biochemistry & Molecular Biology GA 340BW UT ISI:000258622100057 ER PT C AU Hortigon-Vinagre, MP Gutierrez-Martin, Y Roman, AC Henao, F AF Hortigon-Vinagre, M. P. Gutierrez-Martin, Y. Roman, A. C. Henao, F. TI 4-hydroxy-2-nonenal inhibits Serca1a function by its interaction with the ATP binding site SO FREE RADICAL RESEARCH LA English DT Meeting Abstract C1 [Hortigon-Vinagre, M. P.; Gutierrez-Martin, Y.; Roman, A. C.; Henao, F.] Univ Extremadura, Fac Ciencias, Dept Bioquim & Biol Mol & Genet, E-06071 Badajoz, Spain. NR 0 TC 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1071-5762 J9 FREE RADICAL RES JI Free Radic. Res. PD JUL PY 2008 VL 42 SU Suppl. 1 BP S60 EP S60 PG 1 SC Biochemistry & Molecular Biology GA 340BW UT ISI:000258622100075 ER PT J AU Martin, JA Solla, A Coimbra, MA Gil, L AF Martin, J. A. Solla, A. Coimbra, M. A. Gil, L. TI Metabolic fingerprinting allows discrimination between Ulmus pumila and U-minor, and between U-minor clones of different susceptibility to Dutch elm disease SO FOREST PATHOLOGY LA English DT Article ID OPHIOSTOMA-NOVO-ULMI; TRANSFORM-INFRARED-SPECTROSCOPY; CERATOCYSTIS-ULMI; XYLEM TISSUES; RESISTANCE; INOCULATION; STARCH; CULTURES; FTIR AB Experiments were conducted to test whether Fourier transform-infrared (FT-IR) spcctroscopy, coupled with chemometric methods, call distinguish healthy xylem tissues collected from elms known to differ significantly in their susceptiblility to Ophiostoma novo-ulmi Brasier. Twig samples from resistant Ulms pumila L., susceptible U. minor Mill. and resistant U. minor clones were harvested oil 1 May, 15May, 1 June, 1 July and 1 September 2004, and subjected to FT-IR analysis. The application of principal component analysis to the spectral data, followed by discriminant function analysis, discriminated between the three groups of samples in all harvesting dates. The examination of the DF-loading pints allowed the identification of key regions within the Spectra for the separation between clusters. The chemical assignments of these key regions allowed the following interpretations to be made: (i) U. pumila tissues contained enhanced levels of starch, cellulose and lignin with respect to U. minor tissues and (ii) resistant U. minor tissues contained enhanced levels of starch, cellulose and Pectic polysaccharides With respect to susceptible U. minor tissues. The possible roles of the compositional differences in disease resistance, as well as the potential use of FT-IR spectroscopy and chemometrics as a tool for screening resistant elms are discussed. C1 [Solla, A.] Univ Extremadura, Plasencia 10600, Spain. [Martin, J. A.; Gil, L.] Univ Politecn Madrid, Unidad Anat Fisiol & Genet Forestal, ETSI Montes, E-28040 Madrid, Spain. [Coimbra, M. A.] Univ Aveiro, Dept Quim, P-3810193 Aveiro, Portugal. RP Solla, A, Univ Extremadura, Ave Virgen Puerto 2, Plasencia 10600, Spain. EM asolla@unex.es FU Direccion General para la Biodiversidad (Ministerio de Medio Ambiente) ; ETSI de Montes in Madrid FX We thank M. Buron, D. Lopez, D. Gonzalez (polytechnic University of Madrid, Spain) and A. Ferreira (University, of Aveiro, Portugal) for their technical support. The collaboration of Dr I. Delgadillo, Dr S. Rocha and Dr A. Barros (University of Aveiro) is gratefully acknowledged. This work was supported by an agreement established between Direccion General para la Biodiversidad (Ministerio de Medio Ambiente) and ETSI de Montes in Madrid. 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PD AUG PY 2008 VL 38 IS 4 BP 244 EP 256 DI 10.1111/j.1439-0329.2007.00542.x PG 13 SC Forestry GA 338JR UT ISI:000258504500002 ER PT J AU Saavedra, JM Torres, S Caro, B Escalante, Y De la Cruz, E Duran, MJ Rodriguez, FA AF Saavedra, Jose M. Torres, Silvia Caro, Berta Escalante, Yolanda De la Cruz, Ernesto Duran, Maria J. Rodriguez, Ferran A. TI Relationship between health-related fitness and educational and income levels in Spanish women SO PUBLIC HEALTH LA English DT Article DE evaluation; health; female ID LIFE-STYLE FACTORS; 2-KM WALKING TEST; PHYSICAL-ACTIVITY; RISK-FACTORS; LEISURE-TIME; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS; POPULATION; ADULTS; PREVALENCE AB Objectives: The aim of this study was to determine whether a relationship exists between heatth-retated fitness, taken as an indicator of regular physical activity, and educational and income levels in adult Spanish women. Study design: Descriptive, correlation, cross-sectional study. Methods: A stepwise stratification procedure according to population size, age and level of physical activity according to a previous epidemiological survey was used for sampling. Two thousand and thirty-eight women gave their written consent to participate (62.8% of those invited). The final sample consisted of 1709 healthy women (aged 18-88 years). Subjects were categorized into high, medium and tow level groups for education and income. All participants were assessed for morphological and physical heatth-related fitness. Three-way MANCOVA (age as covariate) and Bonferroni's post hoc test were used to determine the differences between groups. Results: No significant relationships were found between age-adjusted educational and income levels. The lowest values for heatth-retated fitness were found in the lowest educational and income groups (P<0.001). The higher the level of education and income, the better the values for all fitness variables (P<0.001), except anterior trunk flexibility. Conclusions: A positive relationship was found between health-related fitness and educational and income levels, which appeared to be most evident in the lowest educational and income groups. This implies that health-related promotion policies in Spain should stress the importance of regular physical activity in social classes with tow levels of education and income. (C) 2007 The Royal Institute of Public Health. Published by Elsevier Ltd. AR rights reserved. C1 [Saavedra, Jose M.; De la Cruz, Ernesto] Univ Extremadura, Fac Ciencias Deporte, AFIDES Res Grp, E-06071 Badajoz, Spain. [Torres, Silvia; Caro, Berta] Univ Extremadura, Fac Med, AFIDES Res Grp, Caceres, Spain. [Escalante, Yolanda] Univ Extremadura, Fac Formac Profesorado, AFIDES Res Grp, Caceres, Spain. 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Rosario Marcos, Daniel Berrocal, Maria Raeymaekers, Luc Mata, Ana M. Wuytack, Frank TI Activity and localization of the Secretory Pathway Ca2+-ATPase isoform 1 (SPCA1) in different areas of the mouse brain during postnatal development SO MOLECULAR AND CELLULAR NEUROSCIENCE LA English DT Article DE SPCA 1; development; cortex; hippocampus; cerebellum; Golgi complex ID HAILEY-HAILEY-DISEASE; SECRETORY PATHWAY CA2+; TRANS-GOLGI NETWORK; PARKINSONS-DISEASE; CA2+-ATPASE SPCA1; CHICK CEREBELLUM; CALCIUM PUMPS; EXPRESSION; MUTATIONS; APPARATUS AB Ca2+ and Mn2+ play an important role in many events in the nervous system, ranging from neural morphogenesis to neurodegeneration. As part of the homeostatic control of these ions, the Secretory Pathway Ca2+-ATPase isoform 1 (SPCA 1) mediates the accumulation of Ca2+ or Mn2+ with high affinity into Golgi reservoirs. This SPCA 1 represents a relatively recently characterized P-type pump that is highly expressed in nervous tissue, but information on its involvement in neural maturation is currently lacking. In this study, we have analyzed the expression and distribution of the SPCA 1 pump in mouse brain during postnatal development. RT-PCR and Western blot assays showed that SPCA 1 is particularly highly expressed at nearly constant levels during this entire period of development in cortex, hippocampus, and cerebellum. In spite of the apparently unchanged expression levels, functional assays showed that SPCA-associated Ca2+-ATPase activity increased with the stage of development in these areas. Immunohistochemical studies pointed to SPCA 1 localization in Golgi stacks of the soma and the initial part of primary dendritic trunk in main cortical, hippocampal and cerebellar neurons from the earliest postnatal stages. This suggests a potential role in intracellular signaling and in Golgi secretory processes involved in dendritic growth and in functional maturation of the mouse nervous system. (C) 2008 Elsevier Inc. All rights reserved. C1 [Sepulveda, M. Rosario; Raeymaekers, Luc; Wuytack, Frank] Katholieke Univ Leuven, Lab Ca2 Transport ATPases, Dept Mol Cell Biol, BE-3000 Louvain, Belgium. [Marcos, Daniel; Berrocal, Maria; Mata, Ana M.] Univ Extremadura, Dept Bioquim & Biol Mol & Genet, Fac Ciencias, E-06071 Badajoz, Spain. RP Wuytack, F, Katholieke Univ Leuven, Lab Ca2 Transport ATPases, Dept Mol Cell Biol, Campus Gasthuisberg O&N1,Herestr 49, BE-3000 Louvain, Belgium. 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Cell. Neurosci. PD AUG PY 2008 VL 38 IS 4 BP 461 EP 473 DI 10.1016/j.mcn.2008.02.012 PG 13 SC Neurosciences GA 336EO UT ISI:000258347300001 ER PT J AU Camello-Almaraz, C Gomez-Pinilla, PJ Pozo, MJ Camello, PJ AF Camello-Almaraz, Cristina Gomez-Pinilla, Pedro J. Pozo, Maria J. Camello, Pedro J. TI Age-related alterations in Ca2+ signals and mitochondrial membrane potential in exocrine cells are prevented by melatonin SO JOURNAL OF PINEAL RESEARCH LA English DT Article DE Ca2+ entry; Ca2+ oscillations; Ca2+ stores; melatonin; mitochondria ID PANCREATIC ACINAR-CELLS; OXIDATIVE STRESS; CALCIUM HOMEOSTASIS; OLD MICE; SECRETION; RELEASE; THAPSIGARGIN; OSCILLATIONS; LYMPHOCYTES; ACTIVATION AB Information regarding age-induced Ca2+ signal alterations in nonexcitable cells is limited. In addition, little evidence exists on the ability of melatonin to palliate the effects of aging on Ca2+ signals and mitochondrial potential, a parameter involved in both Ca2+ signaling and aging. We studied the ability of melatonin to prevent the effects of aging on intracellular Ca2+ homeostasis and mitochondrial potential in exocrine cells. Pancreatic acinar cells were obtained from adult (3 months old) and aged (22-24 months old) mice by collagenase dispersion. Ca2+ signals, in situ mitochondrial potential and in vitro amylase secretion were determined. Secretion in response to increasing levels of the secretagogues, acetylcholine and cholecystokinin (CCK), were impaired in aged pancreatic acini. This decrease was accompanied by an inhibition in the amplitude of the peak response to maximal concentrations of the agonists, and by a decrease in the pattern of Ca2+ oscillations induced by postprandial levels of CCK. Both the size of the calcium pools, assessed by low levels of ionomycin, and capacitative calcium entry, induced by depletion of the stores with thapsigargin, were diminished in aged cells. These changes in Ca2+ homeostasis were associated with depolarization of intracellular mitochondria. Oral administration of melatonin for 3 months to aged mice restored the secretory response, the amplitude and frequency of Ca2+ responses, the size of intracellular calcium pools, the capacitative calcium entry, and the mitochondrial potential. In conclusion, melatonin restores secretory function, Ca2+ signals and mitochondrial potential of aged exocrine cells. C1 [Camello, Pedro J.] Univ Extremadura, Fac Vet Sci, Dept Physiol, Sch Nursing, Caceres 10071, Spain. Univ Extremadura, RETICEF, Caceres 10071, Spain. RP Camello, PJ, Univ Extremadura, Fac Vet Sci, Dept Physiol, Sch Nursing, Caceres 10071, Spain. 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Pineal Res. PD SEP PY 2008 VL 45 IS 2 BP 191 EP 198 DI 10.1111/j.1600-079X.2008.00576.x PG 8 SC Endocrinology & Metabolism; Neurosciences; Physiology GA 336QT UT ISI:000258380400010 ER PT J AU Gusi, N Herrera, E Quesada, F Cebrian, C Juan, CC AF Gusi, Narcis Herrera, Emilo Quesada, Fabian Cebrian, Clarencio Juan, Campon C. TI Exercise looks after you: From research to practice in elderly SO JOURNAL OF AGING AND PHYSICAL ACTIVITY LA English DT Meeting Abstract C1 [Gusi, Narcis] Univ Extremadura, Fac Sports Sci, E-06071 Badajoz, Spain. [Herrera, Emilo; Quesada, Fabian; Cebrian, Clarencio; Juan, Campon C.] Govt Extremadura, Badajoz, Spain. NR 0 TC 0 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1063-8652 J9 J AGING PHYS ACTIV JI J. Aging Phys. Act. PD JUL PY 2008 VL 16 SU Suppl. S BP S73 EP S74 PG 2 SC Geriatrics & Gerontology; Gerontology; Sport Sciences GA 333EL UT ISI:000258135400096 ER PT J AU Parraca, JA Gusi, N Adsuar, JC Olivares, PR Herrera, E Alejandre, P AF Parraca, Jose Alberto Gusi, Narcis Adsuar, Jose C. Olivares, Pedro R. Herrera, Emilio Alejandre, P. TI Test-retest reliability of the Biodex Balance SD in physically active old people SO JOURNAL OF AGING AND PHYSICAL ACTIVITY LA English DT Meeting Abstract C1 [Parraca, Jose Alberto; Gusi, Narcis; Adsuar, Jose C.; Olivares, Pedro R.] Univ Extremadura, Fac Sports Sci, Caceres, Spain. [Herrera, Emilio; Alejandre, P.] Board Extremadura, Merida, Spain. NR 0 TC 0 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1063-8652 J9 J AGING PHYS ACTIV JI J. Aging Phys. Act. PD JUL PY 2008 VL 16 SU Suppl. S BP S88 EP S88 PG 1 SC Geriatrics & Gerontology; Gerontology; Sport Sciences GA 333EL UT ISI:000258135400114 ER PT S AU Woodard, GE Rosado, JA AF Woodard, Geoffrey E. Rosado, Juan A. TI Natriuretic peptides in vascular physiology and pathology SO INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 268 SE INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY LA English DT Review DE ANP(1-28); ATP; renal glomeruli; ATP gamma S; hypertensive rats; Wistar Kyoto (WKY) rat ID SMOOTH-MUSCLE-CELLS; MEDIATED CALCIUM-ENTRY; SPONTANEOUSLY HYPERTENSIVE-RATS; ACUTE MYOCARDIAL-INFARCTION; CHRONIC HEART-FAILURE; INTRACELLULAR CA2+ STORES; DEPENDENT PROTEIN-KINASE; CORONARY BLOOD-FLOW; OXIDATIVE STRESS; HUMAN PLATELETS AB Four major natriuretic peptides have been isolated: atria[ natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and Dendroaspis-type natriuretic peptide (DNP). Natriuretic peptides play an important role in the regulation of cardiovascular homeostasis maintaining blood pressure and extracellular fluid volume. The classical endocrine effects of natriuretic peptides to modulate fluid and electrolyte balance and vascular smooth muscle tone are complemented by autocrine and paracrine actions that include regulation of coronary blood flow and, therefore, myocardial perfusion; modulation of proliferative responses during myocardial and vascular remodeling; and cytoprotective anti-ischemic effects. The actions of natriuretic peptides are mediated by the specific binding of these peptides to three cell surface receptors: type A natriuretic peptide receptor (NPR-A), type B natriuretic peptide receptor (NPR-B), and type C natriuretic peptide receptor (NPR-C). NPR-A and NPR-B are guanylyl cyclase receptors that increase intracellular cGMP concentration and activate cGMP-dependent protein kinases. NPR-C has been presented as a clearance receptor and its activation also results in inhibition of adenylyl cyclase activity. The wide range of effects of natriuretic peptides might be the base for the development of new therapeutic strategies of great benefit in patients with cardiovascular problems including coronary artery disease or heart failure. This review summarizes current literature concerning natriuretic peptides, their receptors and their effects on fluid/electrolyte balance, and vascular and cardiac physiology and pathology, including primary hypertension and myocardial infarction. In addition, we will attempt to provide an update on important issues regarding natriuretic peptides in congestive heart failure. C1 [Woodard, Geoffrey E.] NIAID, Bethesda, MD 20892 USA. [Rosado, Juan A.] Univ Extremadura, Dept Physiol, Caceres, Spain. RP Woodard, GE, NIAID, MSC 1876, Bethesda, MD 20892 USA. 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Rev. Cell Mol. Biol. PY 2008 VL 268 BP 59 EP 93 DI 10.1016/S1937-6448(08)00803-4 PG 35 SC Biochemistry & Molecular Biology; Cell Biology GA BIC03 UT ISI:000258322100003 ER PT J AU Rodriguez, JL Taboada, JM Araujo, MG Basteiro, FO Landesa, L Garcia-Tunon, I AF Luis Rodriguez, Jose Manuel Taboada, Jose Araujo, Marta G. Obelleiro Basteiro, Fernando Landesa, Luis Garcia-Tunon, Ines TI On the use of the singular value decomposition in the fast multipole method SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE electromagnetic scattering; fast solvers; method of momoents (MoM); radar cross section (RCS); singular value decomposition (SVD) ID ELECTROMAGNETIC SCATTERING; EFFICIENT SOLUTION; ALGORITHM; MOMENTS; FORMULATION; COMPRESSION; RADIATION; FREEDOM; EFIE; 3-D AB The authors present a new matrix compression algorithm to improve the efficiency of the fast multipole method (FMM). 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PD AUG PY 2008 VL 8 IS 8 BP 2626 EP 2627 DI 10.1021/cg800491f PG 2 SC Chemistry, Multidisciplinary; Crystallography; Materials Science, Multidisciplinary GA 335DL UT ISI:000258270900011 ER PT C AU Morrell, JM Pena, FJ Johannisson, A Dalin, AM Samper, JC Rodriguez-Martinez, H AF Morrell, J. M. Pena, F. J. Johannisson, A. Dalin, A. -M. Samper, J. C. Rodriguez-Martinez, H. TI Techniques for sperm clean-up and selection of stallion spermatozoa SO ANIMAL REPRODUCTION SCIENCE LA English DT Meeting Abstract C1 [Morrell, J. M.; Johannisson, A.; Dalin, A. -M.; Rodriguez-Martinez, H.] Swedish Univ Agr Sci SLU, Fac Vet Med & Anim Sci, S-75007 Uppsala, Sweden. [Pena, F. J.] Univ Extremadura, Lab Spermatol, Caceres, Spain. [Samper, J. C.] Vet Reprod Serv, Vancouver, BC V2Z 2E6, Canada. EM Jane.Morrell@kv.slu.se NR 0 TC 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4320 J9 ANIM REPROD SCI JI Anim. Reprod. Sci. PD SEP PY 2008 VL 107 IS 3-4 BP 31 DI 10.1016/j.anireprosci.2008.05.110 PG 2 SC Agriculture, Dairy & Animal Science; Reproductive Biology GA 337LO UT ISI:000258437800044 ER PT J AU MacKenzie, DA Defernez, M Dunn, WB Brown, M Fuller, LJ de Herrera, SRMS Guenther, A James, SA Eagles, J Philo, M Goodacre, R Roberts, IN AF MacKenzie, Donald A. Defernez, Marianne Dunn, Warwick B. Brown, Marie Fuller, Linda J. Seco de Herrera, Santago R. M. Guenther, Andreas James, Steve A. Eagles, John Philo, Mark Goodacre, Royston Roberts, Ian N. TI Relatedness of medically important strains of Saccharomyces cerevisiae as revealed by phylogenetics and metabolomics SO YEAST LA English DT Article DE direct injection mass spectrometry; GC-ToF-MS; yeast metabolomics; AFLP fingerprinting; Saccharomyces cerevisiae; Saccharomyces boulardii ID SENSU-STRICTO COMPLEX; YEAST MUTANTS; BOULARDII; GENE; RECONSTRUCTION; SENSITIVITY; TREHALASE; SEQUENCES; EMERGENCE; INSIGHTS AB Ten medically important Saccharomyces strains, comprising six clinical isolates of Saccharomyces cerevisiae and four probiotic strains of Saccharomyces boulardii, were characterized at the genetic and metabolic level and compared with non-medical, commercial yeast strains used in baking and wine-making. Strains were compared by genetic fingerprinting using amplified fragment length polymorphism (AFLP) analysis, by ribosomal DNA ITS1 sequencing and by metabolic footprinting using both direct injection mass spectrometry (DIMS) and gas chromatography-time of flight-mass spectrometry (GC-ToF-MS). Overall, the clinical isolates fell into different groupings when compared with the non-medical strains, with good but not perfect correlation amongst strains at both the genetic and metabolic levels. Probiotic strains of S. boulardii that are used therapeutically to treat human gastrointestinal tract disorders showed tight clustering both genetically and metabolically. Metabolomics was found to be of value both as a taxonomic tool and as a means to investigate anomalous links between genotype and phenotype. Key discriminatory metabolites were identified when comparing the three main groups of clinical, probiotic and non-medical strains and included molecules such as trehalose, myoinositol, lactic acid, fumaric acid and glycerol 3-phosphate. This study confirmed the link between a subset of clinical isolates and baking or probiotic strains but also highlighted that in general the clinical strains were more diverse at both the genomic and metabolic levels. Copyright (c) 2008 John Wiley & Sons, Ltd. C1 [MacKenzie, Donald A.; Fuller, Linda J.; James, Steve A.; Roberts, Ian N.] Inst Food Res, Inst Food Res, Natl Collect Yeast Cultures, Norwich NR4 7UA, Norfolk, England. [Dunn, Warwick B.] Univ Manchester, Manchester Interdisciplinary Bioctr, Manchester Ctr Integrat Syst Biol, Manchester M1 7DN, England. [Brown, Marie] Univ Manchester, Manchester Interdisciplinary Bioctr, Bioanalyt Sci Grp, Manchester M1 7DN, England. [Seco de Herrera, Santago R. 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We establish the geometric growth of the chain, suitably normed, by investigating its almost sure and L2-convergence. Both sufficient and necessary conditions for these convergences are provided depending on certain constraints on the transition mean vectors and the transition covariance matrices of the chain. Finally, we apply the obtained results to a general class of controlled multitype branching processes. C1 [Gonzalez, Miguel; Martinez, Rodrigo; Mota, Manuel] Univ Extremadura, Dept Math, E-06071 Badajoz, Spain. RP Gonzalez, M, Univ Extremadura, Dept Math, E-06071 Badajoz, Spain. EM mvelasco@unex.es CR COHN H, 1986, STOCH ANAL APPL, V4, P283 GONZALEZ M, 2002, J APPL PROBAB, V39, P804 GONZALEZ M, 2003, J APPL PROBAB, V40, P995 GONZALEZ M, 2004, STAT PROBABIL LETT, V67, P277, DOI 10.1016/j.spl.2003.12.009 GONZALEZ M, 2004, STAT PROBABIL LETT, V70, P145, DOI 10.1016/j.spl.2004.08.012 GONZALEZ M, 2005, BERNOULLI, V11, P37 GONZALEZ M, 2005, BERNOULLI, V11, P559 GONZALEZ M, 2005, J APPL PROBAB, V42, P1015 GONZALEZ M, 2006, J APPL PROBAB, V43, P159 KLEBANER FC, 1984, ADV APPL PROBAB, V16, P30 KLEBANER FC, 1984, J APPL PROBAB, V21, P40 KLEBANER FC, 1985, J APPL PROBAB, V22, P48 KLEBANER FC, 1989, ANN PROBAB, V17, P1466 LALAM N, 2004, ADV APPL PROBAB, V36, P582 MAYSTER P, 2005, J APPL PROBAB, V42, P1095 RAHIMOV I, 2007, STOCH ANAL APPL, V25, P337, DOI 10.1080/07362990601139545 SENETA E, 1981, NONNEGATIVE MATRICES YANEV GP, 1995, LECT NOTES STAT, V99, P36 YANEV GP, 2004, STOCH ANAL APPL, V22, P721, DOI 10.1081/SAP-120030453 YANEV NM, 1975, THEOR PROBAB APPL, V20, P421 NR 20 TC 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-6349 J9 STOCH MODELS JI Stoch. Models PY 2008 VL 24 IS 3 BP 401 EP 424 DI 10.1080/15326340802232269 PG 24 SC Statistics & Probability GA 335CC UT ISI:000258267400004 ER PT J AU Lozano, J Arroyo, T Santos, JP Cabellos, JM Horrillo, MC AF Lozano, J. Arroyo, T. Santos, J. P. Cabellos, J. M. Horrillo, M. C. TI Electronic nose for wine ageing detection SO SENSORS AND ACTUATORS B-CHEMICAL LA English DT Article DE wine ageing; odor recognition; artificial olfactory system ID OAK-MATURED WINES; SAW SENSOR ARRAY; RED WINES; VOLATILE COMPOUNDS; PHENOLIC-COMPOUNDS; FILM SENSORS; BARRELS; WOOD; DISCRIMINATION; CLASSIFICATION AB This paper reports a novel application of an electronic nose (e-nose) for recognition and detection of wine ageing. Two different measurements are performed with the following samples: first, in an experimental cellar the same wine is aged in different type of oak barrel (French and American oak) and during different time (0, 3, 6 and 12 months) and second, several wines made with the same grape variety and from different wine cellars aged in French and American oak. This identification has a great importance for origin denominations for control of frauds. The e-nose is home-developed and home-fabricated for this purpose: a tin oxide multisensor prepared with RF sputtering onto an alumina substrate and doped with chromium and indium is used. The sampling method employed is static headspace followed by a dynamic injection. Linear techniques like principal component analysis (PCA) and nonlinear ones like probabilistic neural networks (PNN) are used for pattern recognition. A classification success rate (correct predicted number over total number of measurements) of 97% and 84% is achieved in detection of the different ageing process experimented by the wines tested. (C) 2008 Elsevier B.V. All rights reserved. C1 [Lozano, J.] Univ Extremadura, Grp Clasificac Patrones & Anal Imagenes, Badajoz 06006, Spain. [Santos, J. P.; Horrillo, M. C.] CSIC, Lab Sensores, E-28006 Madrid, Spain. [Arroyo, T.; Cabellos, J. M.] Inst Madrileno Invest & Desarrollo Rural Agrario, Dept Agroalimentac, Alcala De Henares 28800, Spain. RP Lozano, J, Univ Extremadura, Grp Clasificac Patrones & Anal Imagenes, Av Elvas S-N, Badajoz 06006, Spain. EM jesuslozano@unex.es CR AMPUERO S, 2003, SENSOR ACTUAT B-CHEM, V94, P1, DOI 10.1016/S0925-4005(03)00321-6 APETREI C, 2007, ELECTROCHIM ACTA, V52, P2588, DOI 10.1016/j.electacta.2006.09.014 BALDACCI S, 1998, SENSOR MATER, V10, P185 BARTLETT PN, 1997, FOOD TECHNOL-CHICAGO, V51, P44 BISHOP CM, 1999, NEURAL NETWORKS PATT BOIDRON JN, 1988, CONNAISS VIGNE VIN, V22, P275 CADAHIA E, 2001, J AGR FOOD CHEM, V49, P1790 CHATONNET P, 1990, SCI ALIMENT, V10, P565 CHATONNET P, 1999, J AGR FOOD CHEM, V47, P4319 DERKS EPP, 1995, COMPUT CHEM, V20, P439 DESIMON BF, 2003, EUR FOOD RES TECHNOL, V216, P150, DOI 10.1007/s00217-002-0637-4 DINATALE C, 1995, SENSOR ACTUAT B-CHEM, V24, P801 DINATALE C, 1996, SENSOR ACTUAT B-CHEM, V33, P83 DINATALE C, 1997, SENSOR ACTUAT B-CHEM, V44, P521 DUDA RO, 2001, PATTERN CLASSIFICATI GARDE T, 2002, FOOD RES INT, V35, P603 GARDNER J, 2002, HDB MACHINE OLFACTIO GARDNER JW, 1991, NANOTECHNOLOGY, V2, P19 GARDNER JW, 1999, ELECT NOSES GETINO J, 1997, SENSOR ACTUAT B-CHEM, V43, P200 GUADARRAMA A, 2000, ANAL CHIM ACTA, V411, P193 GUILLEN DA, 2005, J AGR FOOD CHEM, V53, P2412, DOI 10.1021/jf048522b GUTIERREZOSUNA R, 2002, IEEE SENS J, V2, P189 HAHN SH, 2003, THIN SOLID FILMS, V436, P17, DOI 10.1016/S0040-6090(03)00520-0 HALE MD, 1999, AM J ENOL VITICULT, V50, P495 HORRILLO MC, 1996, MAT CHALLENGE, V9, P12 HORRILLO MC, 1997, SENSOR ACTUAT B-CHEM, V43, P193 JACKSON RS, 1994, WINE SCI PRINCIPLES LOZANO J, 2005, EUROSENSORS, V19, MP17 LOZANO J, 2005, TALANTA, V67, P610, DOI 10.1016/j.talanta.2005.03.015 LOZANO J, 2006, IEEE SENS J, V6, P173, DOI 10.1109/JSEN.2005.854598 LOZANO J, 2006, SENSOR ACTUAT B-CHEM, V120, P166, DOI 10.1016/j.snb.2006.02.014 MATEJICEK D, 2005, FOOD CHEM, V90, P791, DOI 10.1016/j.foodchem.2004.05.057 ORTEGAHERAS M, 2004, ANAL CHIM ACTA, V513, P341, DOI 10.1016/j.aca.2003.10.051 PARRA V, 2006, ANAL CHIM ACTA, V563, P229, DOI 10.1016/j.aca.2005.09.044 PEARCE TC, 1997, SENSORS UPDATE, V3, P62 PENZA M, 2001, SENSOR ACTUAT B-CHEM, V73, P76 PEREZPRIETO LJ, 2003, J FOOD COMPOS ANAL, V16, P697, DOI 10.1016/S0889-1575(03)00080-2 PEREZPRIETO LJ, 2003, J SCI FOOD AGR, V83, P1445, DOI 10.1002/jsfa.1551 PERSAUD KC, 1997, ELECT NOSES HDB BIOS, P563 PUECH JL, 1996, VITIS, V35, P211 RICKERBY D, 1997, J NANOSTRUCT MAT, V9, P43 RODRIGUEZMENDEZ ML, 2004, IEEE SENS J, V4, P348, DOI 10.1109/JSEN.2004.824236 SANTOS JP, 2004, SENSOR ACTUAT B-CHEM, V103, P98, DOI 10.1016/j.snb.2004.04.042 SANTOS JP, 2005, SENSOR ACTUAT B-CHEM, V107, P291, DOI 10.1016/j.snb.2004.10.013 SPILLMAN PJ, 2004, AUST J GRAPE WINE R, V10, P216 ZAMUZ S, 2004, J I BREWING, V110, P220 NR 47 TC 0 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-4005 J9 SENSOR ACTUATOR B-CHEM JI Sens. Actuator B-Chem. PD JUL 28 PY 2008 VL 133 IS 1 BP 180 EP 186 DI 10.1016/j.snb.2008.02.011 PG 7 SC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation GA 331KL UT ISI:000258011000025 ER PT J AU Sanudo, J Lopez-Ruiz, R AF Sanudo, Jaime Lopez-Ruiz, Ricardo TI Statistical complexity and Fisher-Shannon information in the H-atom SO PHYSICS LETTERS A LA English DT Article DE statistical complexity; Fisher-Shannon information; hydrogen atom; Bohr orbits ID MATHEMATICAL-THEORY; ENTROPIES; COMMUNICATION; POSITION AB The Fisher-Shannon information and a statistical measure of complexity are calculated in the position and momentum spaces for the wave functions of the H-atom. For each level of energy, it is found that these two indicators take their minimum values on the orbitals that correspond to the highest orbital angular momentum. (C) 2008 Elsevier B.V. All rights reserved. C1 [Lopez-Ruiz, Ricardo] Univ Zaragoza, Fac Ciencias, DIIS, E-50009 Zaragoza, Spain. [Lopez-Ruiz, Ricardo] Univ Zaragoza, Fac Ciencias, BIFI, E-50009 Zaragoza, Spain. [Sanudo, Jaime] Univ Extremadura, Fac Ciencias, Dept Fis, E-06071 Badajoz, Spain. RP Lopez-Ruiz, R, Univ Zaragoza, Fac Ciencias, DIIS, E-50009 Zaragoza, Spain. EM jsr@unex.es rilopez@unizar.es CR BETHE HA, 1977, QUANTUM MECH ONE 2 E CALBET X, 2001, PHYS REV E 2, V63, ARTN 066116 CATALAN RG, 2002, PHYS REV E 1, V66, ARTN 011102 CHATZISAVVAS KC, 2005, J CHEM PHYS, V123, P74111, ARTN 174111 COFFEY MW, 2003, J PHYS A-MATH GEN, V36, P7441 DEMBO A, 1991, IEEE T INFORM THEORY, V37, P1501 EISBERG JL, 1961, FUNDAMENTALS MODERN FISHER RA, 1925, P CAMB PHILOS SOC, V22, P700 GADRE SR, 1985, PHYS REV A, V32, P2602 GADRE SR, 1987, PHYS REV A, V36, P1932 GALINDO A, 1991, QUANTUM MECH, V1 LANDAU LD, 1981, QUANTUM MECH NONRELA, V3 LEBEDEV VS, 1998, PHYS HIGHLY EXCITED LOPEZRUIZ R, 1995, PHYS LETT A, V209, P321 LOPEZRUIZ R, 2005, BIOPHYS CHEM, V115, P215, DOI 10.1016/j.bpc.2004.12.035 MONTGOMERY HE, 2008, PHYS LETT A, V372, P2271, DOI 10.1016/j.physleta.2007.11.041 PANOS CP, 2007, PHYS LETT A, V363, P78, DOI 10.1016/j.physleta.2006.10.075 PATIL SH, 2007, J PHYS B-AT MOL OPT, V40, P2147, DOI 10.1088/0953-4075/40/11/016 ROMERA E, 2004, J CHEM PHYS, V120, P8906, DOI 10.1063/1.1697374 ROMERA E, 2005, CHEM PHYS LETT, V414, P468, DOI 10.1016/j.cplett.2005.08.032 SHANNON CE, 1948, BELL SYST TECH J, V27, P379 SHANNON CE, 1948, BELL SYST TECH J, V27, P623 YANEZ RJ, 1994, PHYS REV A, V50, P3065 NR 23 TC 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 J9 PHYS LETT A JI Phys. Lett. A PD AUG 4 PY 2008 VL 372 IS 32 BP 5283 EP 5286 DI 10.1016/j.physleta.2008.06.012 PG 4 SC Physics, Multidisciplinary GA 334XG UT ISI:000258254400006 ER PT J AU Martinez-Nova, A Huerta, JP Sanchez-Rodriguez, R AF Martinez-Nova, Alfonso Huerta, Javier Pascual Sanchez-Rodriguez, Raquel TI Cadence, age, and weight as determinants of forefoot plantar pressures using the Biofoot in-shoe system SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION LA English DT Article ID HEALTHY-SUBJECTS; NONOBESE ADULTS; MUSCLE-ACTIVITY; FOOT STRUCTURE; WALKING SPEED; FORCES; RELIABILITY; PREDICTORS; NEUROPATHY; PATTERNS AB Background: We evaluated normal plantar pressures and studied the effect of weight, cadence, and age on forefoot plantar pressures in healthy subjects by using the Biofoot (Instituto de Biomecanica de Valencia, Valencia, Spain) in-shoe measurement system. Methods: The feet of 45 healthy subjects with no evident foot or lower-limb diseases were measured with the Biofoot in-shoe system. The forefoot was divided into seven areas: the first through fifth metatarsal heads, the hallux, and the second through fifth lesser toes. Three trials of 8 sec each were recorded twice in each subject, and the mean was used to analyze peak and mean plantar pressures. A multiple regression model including weight, age, and cadence was run for each metatarsal head, the hallux, and the lesser toes. Intraclass correlation coefficients and coefficients of variation were also calculated to assess reliability. Results: The second metatarsal head had the greatest peak (960 kPa) and mean (585.1 kPa) pressures, followed by the third metatarsal head. Weight and cadence combined explained 18% and 23% of peak plantar pressure at the second and third metatarsal heads, respectively (P < .001). The intraclass correlation coefficient varied from 0.76 to 0.96 for all variables. The coefficient of variation between sessions ranged from 5.8% to 9.0%. Conclusion: The highest peak and mean plantar pressures were found at the second and third metatarsal heads in healthy subjects. Weight, cadence, and age explained a low variability of this pressure pattern. The Biofoot in-shoe system has good reliability to measure plantar pressures. These data will have implications for the understanding of normal foot biomechanics and its determinants. C1 [Martinez-Nova, Alfonso; Sanchez-Rodriguez, Raquel] Univ Extremadura, Ctr Univ Plasencia, Caceres 10600, Spain. [Huerta, Javier Pascual] Univ Europea Madrid, Madrid, Spain. RP Martinez-Nova, A, Univ Extremadura, Ctr Univ Plasencia, Avda Virgen Puerto 2, Caceres 10600, Spain. 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Am. Podiatr. Med. Assoc. PD JUL-AUG PY 2008 VL 98 IS 4 BP 302 EP 310 PG 9 SC Orthopedics GA 335DH UT ISI:000258270500008 ER PT J AU Alvarez, FJ Kuc, R AF Alvarez, Fernando J. Kuc, Roman TI Dispersion relation for air via Kramers-Kronig analysis SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ATTENUATION AB A general expression for the dispersion of acoustic waves in air is obtained by combining the attenuation coefficient given by the ISO:9613-1 standard and the twice-subtracted Kramers-Kronig relation. Good agreement is found with published data of sound velocity at different frequencies and relative humidities. The resulting expression is used to investigate changes in local dispersion with temperature and humidity. (C) 2008 Acoustical Society of America. C1 [Alvarez, Fernando J.] Univ Extremadura, Dept Elect Engn Elect & Automat, E-06071 Badajoz, Spain. [Kuc, Roman] Yale Univ, Dept Elect Engn, New Haven, CT 06520 USA. RP Alvarez, FJ, Univ Extremadura, Dept Elect Engn Elect & Automat, E-06071 Badajoz, Spain. EM fafranco@unex.es roman.kuc@yale.edu CR *ISO TC 43 TECHN C, 961311993E ISOTC 43 EVANS LB, AD0738576 US DEP COM MOBLEY J, 2000, J ACOUST SOC AM 1, V108, P2091 MOBLEY J, 2002, J ACOUST SOC AM, V112, P760, DOI 10.1121/1.1494808 ODONNELL M, 1981, J ACOUST SOC AM, V69, P696 TICHMARSH EC, 1986, INTRO THEORY FOURIER WATERS KR, 2004, IEEE ULTR S, V1, P561 WATERS KR, 2005, IEEE T ULTRASON FERR, V52, P822 WEAVER RL, 1981, J MATH PHYS, V22, P1909 WINTLE HJ, 1999, J APPL PHYS, V85, P44 NR 10 TC 1 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AMER JI J. Acoust. Soc. Am. PD AUG PY 2008 VL 124 IS 2 BP EL57 EP EL61 DI 10.1121/1.2947631 PG 5 SC Acoustics GA 334OG UT ISI:000258230500008 ER PT J AU Pulido, F Valladares, F Calleja, JA Moreno, G Gonzalez-Bornay, G AF Pulido, Fernando Valladares, Fernando Antonio Calleja, Juan Moreno, Gerardo Gonzalez-Bornay, Guillermo TI Tertiary relict trees in a Mediterranean climate: abiotic constraints on the persistence of Prunus lusitanica at the eroding edge of its range SO JOURNAL OF BIOGEOGRAPHY LA English DT Article DE abiotic constraints; climatic oscillations; drought tolerance; habitat shift; peripheral populations; rear edge; shade tolerance; Tertiary relicts ID SHADE TOLERANCE; LAUREL FOREST; DROUGHT; REGENERATION; IRRADIANCE; ORIGIN; SHRUBS; LIGHT; PHOTOINHIBITION; PHOTOSYNTHESIS AB Aim To investigate the ecophysiological traits allowing persistence of a subtropical relict tree (Prunus lusitanica L.) under a dry Mediterranean climate at the eroding edge of its range. Location A glasshouse for the study under controlled conditions and two marginal populations located in riparian forests of central Spain and exposed to summer drought, in contrast to subtropical populations that grow in mountain cloud forests. Methods Two experiments were conducted to assess tolerance to the abiotic conditions found in riparian habitats. In a glasshouse experiment, gas-exchange and light-use parameters were measured to evaluate seedling responses to a factorial combination of irradiance (60%, 10%, 2% and 0.5% full sun) and moisture (well watered control and drought stress). In a parallel field experiment, irradiance and soil moisture were measured as predictors of seedling survival at two sites in which half the seedlings were subjected to a threefold increase in summer precipitation by adding water every 10 days. Results Soil moisture strongly determined survival both in the glasshouse and in the two field sites. In the field, periodic addition of water failed to increase survival. Water-use efficiency (WUE) increased with drought. Seedlings did not tolerate deep shade (2-0.5%) and their performance and survival were better when exposed to moderate (10%) or high (60%) irradiance. The effect of water stress on seedling performance was stronger at moderate irradiance, moderate at high irradiance and negligible at very low light. Seedling size (height and number of leaves) attained after I month of experimental treatments had a positive effect on survival at the end of the summer, hence greater survival was not achieved at the expense of vertical growth. Main conclusions While studies in Macaronesia have shown that P. lusitanica occupies a wide range of moisture conditions along mountain slopes, it behaves as an obligate riparian species in dry peripheral populations. Intolerance to deep shade and tolerance to moderate and high irradiance allow the species to grow in small and moist gaps, or in treeless river sections. Despite the species' low range filling in marginal, drought-prone regions, long-term persistence might have been achieved through shifts to riparian habitats serving as local refuges. C1 [Pulido, Fernando; Moreno, Gerardo; Gonzalez-Bornay, Guillermo] Univ Extremadura, Grp Invest Forestal, EUIT Forestal, E-10600 Plasencia, Spain. [Valladares, Fernando] CSIC, Inst Recursos Nat, Ctr Ciencias Medioambientales, Madrid, Spain. [Antonio Calleja, Juan] Univ Autonoma Madrid, Dept Biol Bot, Madrid, Spain. RP Pulido, F, Univ Extremadura, Grp Invest Forestal, EUIT Forestal, Ave Virgen Puerto 2, E-10600 Plasencia, Spain. EM nando@unex.es CR *IPCC, 2001, CLIM CHANG 2001 SCI *STATSOFT INC, 2003, STAT REL 6 0 ABRAMS MD, 1995, TREE PHYSIOL, V15, P361 AREVALO JR, 1998, J VEG SCI, V9, P297 AUBREVILLE A, 1976, ADANSONIA 2, V16, P297 BARRON E, 2006, PALEOAMBIENTES CAMBI, P54 BLANCO E, 1997, BOSQUES IBERICOS INT BORTIRI E, 2006, PLANT SYST EVOL, V259, P53, DOI 10.1007/s00606-006-0427-8 CALLEJA JA, 2006, THESIS U AUTONOMA MA CLARK JS, 2001, AM NAT, V157, P537 EHLERINGER JR, 1993, STABLE ISOTOPES PLAN, P155 FERNANDEZPALACIOS JM, 1998, PLANT ECOL, V137, P21 GOMEZAPARICIO L, 2006, TREE PHYSIOL, V26, P947 HAMPE A, 2002, BIOL CONSERV, V107, P263 HAMPE A, 2005, ECOL LETT, V8, P461, DOI 10.1111/j.1461-0248.2005.00739.x HANBA YT, 2002, PLANT CELL ENVIRON, V25, P1021 HERRERA CM, 1992, AM NAT, V140, P421 KALKMAN C, 1965, BLUMEA, V13, P1 KUBISKE ME, 1996, TREES-STRUCT FUNCT, V11, P76 LIPSCOMB MV, 1990, AM J BOT, V77, P108 MEJIAS JA, 2002, BOT J LINN SOC, V140, P297 MILNE RI, 2002, ADV BOT RES, V38, P281 MILNE RI, 2004, MOL PHYLOGENET EVOL, V33, P389, DOI 10.1016/j.ympev.2004.06.009 NIINEMETS U, 2006, ECOL MONOGR, V76, P521 PALAMAREV E, 1989, PLANT SYST EVOL, V162, P93 PETIT RJ, 2006, ANNU REV ECOL EVOL S, V37, P187, DOI 10.1146/annurev.ecolsys.37.091305.110215 PIGNATTI S, 1978, VEGETATIO, V37, P175 PRIDER JN, 2004, FUNCT ECOL, V18, P67 QUERO JL, 2006, NEW PHYTOL, V170, P819, DOI 10.1111/j.1469-8137.2006.01713.x SACK L, 2004, OIKOS, V107, P107 SANCHEZGOMEZ D, 2006, NEW PHYTOL, V170, P795, DOI 10.1111/j.1469-8137.2006.01711.x SANTAMARIA L, 2003, ECOLOGY, V84, P1454 SMITH T, 1989, VEGETATIO, V83, P49 SUC JP, 1984, NATURE, V307, P429 SVENNING JC, 2003, ECOL LETT, V6, P646 TZEDAKIS PC, 2002, SCIENCE, V297, P2044 VALLADARES F, 2005, J EXP BOT, V56, P483, DOI 10.1093/jxb/eri037 VALLADARES F, 2005, TREE PHYSIOL, V25, P1041 VALLADARES F, 2006, ANN FOREST SCI, V63, P749 NR 39 TC 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0305-0270 J9 J BIOGEOGR JI J. Biogeogr. PD AUG PY 2008 VL 35 IS 8 BP 1425 EP 1435 DI 10.1111/j.1365-2699.2008.01898.x PG 11 SC Ecology; Geography, Physical GA 334ZI UT ISI:000258260200009 ER PT J AU Andrade, C Trigo, RM Freitas, MC Gallego, MC Borges, P Ramos, AM AF Andrade, C. Trigo, R. M. Freitas, M. C. Gallego, M. C. Borges, P. Ramos, A. M. TI Comparing historic records of storm frequency and the North Atlantic Oscillation (NAO) chronology for the Azores region SO HOLOCENE LA English DT Article DE storminess; documentary record; historical evidence; North Atlantic Oscillation; NAO; Azores; storm-tracking ID SOUTHERN OSCILLATION; MEDITERRANEAN REGION; IBERIAN PENINSULA; RAINFALL; CYCLONES; PRECIPITATION; PORTUGAL; EUROPE; SERIES AB The storminess of the Azores region was investigated using newspaper records from AD 1836 onwards. The information obtained was rank-ordered for intensity and the time series of storm frequency analysed for interannual- to century-scale variability. The documentary data set was validated by comparison with objective cyclones intensity for the period AD 1958-2000. Results indicate that four periods of contrasting storm frequency are present ( AD 1836-1870, 1870-1920, 1920-1940 and 1940-1998). The average storm lasts for 2.3 days and the average secular storm frequency is 3.1 storms/yr. Low intensity events occur four times every five years whereas an extreme storm occurs on average once every seven years. The documentary index of storminess is highly variable at different timescales, which is consistent with other studies of storminess in the North Atlantic. Nevertheless, an objective comparison between late nineteenth- and late twentieth-century storm frequency does not reveal a significant difference. Between AD 1865 and the late twentieth century the winter NAO and storminess indices show a statistically significant anti-correlation pattern at the monthly and seasonal scales. In the late nineteenth century and between AD 1950 and 1970 the NAO index was low and the storminess index high, whilst the opposite occurred from the early twentieth century until the middle 1950s; since AD 1970 both indexes reveal positive trends and are predominantly positive. The NAO mode of circulation is partially responsible for the storminess spatial pattern and temporal distribution over the Azores region since AD 1865 and for about a century, however this relation appears to have weakened since the 1960s. C1 [Andrade, C.; Freitas, M. C.] Univ Lisbon, Fac Ciencias, Dept Geol, Ctr Geol, P-1749016 Lisbon, Portugal. [Trigo, R. M.; Ramos, A. M.] Univ Lisbon, CGUL, IDL, P-1749016 Lisbon, Portugal. [Trigo, R. M.] Univ Lusofona, Dept Engn, Lisbon, Portugal. [Gallego, M. C.] Univ Extremadura, Fac Ciencias, Dept Fis, E-06071 Badajoz, Spain. [Borges, P.] Univ Acores, Dept Geociencias, P-9501801 Ponta Delgada, Portugal. RP Andrade, C, Univ Lisbon, Fac Ciencias, Dept Geol, Ctr Geol, Bloco C6,3 Piso, P-1749016 Lisbon, Portugal. EM candrade@fc.ul.pt CR *INT PAN CLIM CHAN, 2001, CLIM CHANG 2001 SCI *WASA GROUP, 1998, B AM METEOROLOGICAL, V79, P741, DOI 10.1175/1520-0477(1998)079<0741:CWASIT>2.0.CO;2 *WORLD MET ORG, 1995, GLOB CLIM SYST REV C AGOSTINHO J, 1938, ACOREANA, V2, P35 AGOSTINHO J, 1939, ACOREANA, V2, P107 AGOSTINHO J, 1940, ACOREANA, V2, P160 AGOSTINHO J, 1941, ACOREANA, V2, P224 AGOSTINHO J, 1942, ACOREANA, V3, P49 AGOSTINHO J, 1947, ACOREANA, V4, P149 AGOSTINHO J, 1948, ACOREANA, V4, P263 ANDRADE C, 1996, PARTNERSHIP COASTAL, P159 AZEVEDO A, 2006, ANTICICLONE ACORES BABIN S, 2006, ATLANTIC HURRICANE T BARON WR, 1992, CLIMATE AD 1500, P74 BETTENCOURT ML, 1979, CLIMA PORTUGAL, V13 BISTER M, 1998, METEOROL ATMOS PHYS, V65, P233 BLENDER R, 1997, Q J ROY METEOR SOC A, V123, P727 BORGES MF, 2003, SCI MAR S1, V67, P235 BOUWS E, 1996, B AM METEOROL SOC, V77, P2275 BRADLEY R, 1999, PALEOCLIMATOLOGY CARTER DJT, 1988, NATURE, V332, P494 CHENOWETH M, 2006, CLIMATIC CHANGE, V76, P169, DOI 10.1007/s10584-005-9005-2 EMANUEL K, 2005, NATURE, V436, P686, DOI 10.1038/nature03906 FERREIRA DB, 1981, FINISTERRA, V16, P15 FRUTUOSO GC, 1586, SAUDADES TERRA, V1 GALLEGO MC, 2005, CLIMATE RES, V29, P103 GOODESS CM, 2002, INT J CLIMATOL, V22, P1593, DOI 10.1002/joc.810 HANSON CE, 2004, CLIM DYNAM, V22, P757, DOI 10.1007/s00382-004-0415-z HAYDEN BP, 1981, MON WEATHER REV, V109, P159 HURRELL JW, 1995, SCIENCE, V269, P676 JONES PD, 1997, INT J CLIMATOL, V17, P1433 JONES PD, 1999, CLIMATIC CHANGE, V42, P131 JUNG T, 2001, J CLIMATE, V14, P3932 KLEIN WH, 1957, 40 US WEATHER BUREAU, P1 KUSHNIR Y, 1997, J CLIMATE, V10, P2107 LIMA M, 1943, ANAIS MUNICIPIO HORT LU J, 2002, GEOPHYS RES LETT, V29 OSBORN TJ, 1999, CLIM DYNAM, V15, P685 PETTERSSEN S, 1956, WEATHER ANAL FORECAS, V1, P428 RAPOSO AGB, 1998, ACOREANA, V8, P571 REALE O, 2001, GEOPHYS RES LETT, V28, P2085 RODO X, 1997, CLIM DYNAM, V13, P275 ROGERS JC, 1984, MON WEATHER REV, V112, P1999 SOUTHERN RL, 1979, AUST METEOROL MAG, V27, P175 TRIGO IF, 1999, J CLIMATE, V12, P1685 TRIGO IF, 2005, CLIM DYNAM, V26, P127, DOI 10.1007/S00382-005-0065-9 TRIGO R, 2006, MEDITERRANEAN CLIMAT, P179 TRIGO RM, 2002, CLIMATE RES, V20, P9 TRIGO RM, 2004, INT J CLIMATOL, V24, P925, DOI 10.1002/joc.1048 VALADAO P, 2002, NAT HAZARD EARTH SYS, V2, P51 ZEZERE JL, 2005, NAT HAZARD EARTH SYS, V5, P331 NR 51 TC 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0959-6836 J9 HOLOCENE JI Holocene PD AUG PY 2008 VL 18 IS 5 BP 745 EP 754 DI 10.1177/0959683608091794 PG 10 SC Geography, Physical; Geosciences, Multidisciplinary GA 335FW UT ISI:000258277200007 ER PT J AU Lucena, MI Andrade, RJ Martinez, C Ulzurrun, E Garcia-Martin, E Borraz, Y Fernandez, MC Romero-Gomez, M Castiella, A Planas, R Costa, J Anzola, S Agundez, JAG AF Lucena, M. Isabel Andrade, Raul J. Martinez, Carmen Ulzurrun, Eugenia Garcia-Martin, Elena Borraz, Yolanda Fernandez, M. Carmen Romero-Gomez, Manuel Castiella, Agustin Planas, Ramon Costa, Joan Anzola, Sandra Agundez, Jose A. G. CA Spanish Grp Study Drug Induced TI Glutathione S-transferase M1 and T1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury SO HEPATOLOGY LA English DT Article ID GLUTATHIONE S-TRANSFERASES; GENETIC POLYMORPHISMS; HEPATOTOXICITY; RISK; ACETAMINOPHEN; TROGLITAZONE; CANCER; GSTM1; GSTT1; M1 AB Individual vulnerability to drug-induced liver injury (DILI) might result from deficiencies in the detoxification process, which determines the level of exposure to the reactive metabolite. We evaluated whether a genetically determined reduction in the ability to detoxify electrophilic compounds, such as that expected among individuals with glutathione S-transferase (GST) null genotypes, might play a role in determining the risk for DILI and its clinical expression. Genomic DNA from 154 patients (74 men, 80 women; mean age, 53 years) with a diagnosis of DILI as assessed with the Council for International Organizations of Medical Science scale and 250 sex-and age-matched healthy controls were analyzed. A multiplex polymerase chain reaction-based method was used to detect GSTM1 and GSTT1 gene deletions. Carriers of double GSTT1-M1 null genotypes had a 2.70-fold increased risk of developing DILI compared with noncarriers (odds ratio 2.70, 95% confidence interval 1.45-5.03; P = 0.003). The odds ratio for DILI patients receiving antibacterials, and NSAIDs were 3.52 (P = 0.002), and 5.61 (P = 0.001), respectively. Patients with amoxicillin-clavulanate hepatotoxicity (n = 32) had a 2.81-fold increased risk (P = 0.037). Patients classified by the combined GSTT1 and GSTM1 null genotypes did not differ with regard to the type of injury, clinical presentation, or outcome, except for the predominance of women in the combined null genotype (P < 0.001). Conclusion. The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI, as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women. C1 [Lucena, M. Isabel] Hosp Univ Virgen Victoria, Univ Hosp, Sch Med,Dept Farmacol, Liver Unit,Fac Med,Clin Pharmacol Serv, Malaga 29071, Spain. [Andrade, Raul J.] Hosp Univ Virgen Victoria, Univ Hosp, Sch Med, Liver Unit,Fac Med,Unidad Hepatol, Malaga 29071, Spain. [Martinez, Carmen; Agundez, Jose A. G.] Univ Extremadura, Fac Med, Dept Farmacol, Sch Med, E-06071 Badajoz, Spain. [Garcia-Martin, Elena] Univ Extremadura, Fac Ciencias, Dept Bioquim & Biol Mol & Genet, Sch Sci, E-06071 Badajoz, Spain. [Fernandez, M. Carmen] Hosp Torrecardenas, Serv Farmacol Clin & Aparato Digestivo, Almeria, Spain. [Romero-Gomez, Manuel] Univ Hosp Virgen Valme, Gastroenterol Serv, Serv Aparato Digest, Seville, Spain. [Castiella, Agustin] Hosp Mendaro, Gastroenterol Serv, Serv Aparato Digest, Guipuzcoa, Spain. [Planas, Ramon; Costa, Joan; Anzola, Sandra] Hosp Badalona Germans Trias & Pujol, Gastroenterol & Clin Pharmacol Serv, Badalona, Spain. RP Lucena, MI, Hosp Univ Virgen Victoria, Univ Hosp, Sch Med,Dept Farmacol, Liver Unit,Fac Med,Clin Pharmacol Serv, Blvd Louis Pasteur 32,Campus Teatinos S-N, Malaga 29071, Spain. 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Ruiz, Jorge TI Oxidative changes of fresh loin from pig, caused by dietary conjugated linoleic acid and monounsaturated fatty acids, during refrigerated storage SO FOOD CHEMISTRY LA English DT Article DE conjugated linoleic acid; monounsaturated fatty acids; pork; lipid oxidation; volatile compounds; refrigerated storage ID LIPID OXIDATION; VOLATILE COMPOUNDS; SUBCUTANEOUS FAT; MUSCLE FOODS; MEAT; COLOR; BEEF; PORK; STABILITY; ISOMERS AB Three levels (0%, 1% and 2%) of a conjugated linoleic acid enriched oil (CLA) were combined with two levels of monounsaturated fatty acids (MUFA) (19% and 39% average) for pig feeding. Changes in instrumental colour, lipid oxidation (thiobarbituric acid reactive substances, TBARS) and volatile profile of fresh loin chops, as affected by dietary CLA, MUFA and CIA x MUFA, were studied throughout 7 days of refrigerated storage. Lightness (L) evolution was conditioned by dietary CLA, whereas changes in redness (a*) and yellowness (b*) were unaffected by dietary supplements. Dietary CLA at 2% led to higher TBARS values of loin chops at day 7 of refrigerated storage (p < 0.05), while MUFA supplementation and CIA x MUFA interaction did not affect lipid oxidation. Dietary CLA, MUFA or CLA x MUFA did not affect most volatile compounds of loin chops after 7 days of storage. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Martin, Diana; Antequera, Teresa; Muriel, Elena; Ruiz, Jorge] Univ Extremadura, Fac Vet, Caceres 10071, Spain. [Andres, Ana I.] Univ Extremadura, Escuela Ingn Agrarias, E-06071 Badajoz, Spain. RP Ruiz, J, Univ Extremadura, Fac Vet, Avda Univ S-N, Caceres 10071, Spain. 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PD DEC 1 PY 2008 VL 111 IS 3 BP 730 EP 737 DI 10.1016/j.foodchem.2008.04.048 PG 8 SC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics GA 333SE UT ISI:000258171800029 ER PT J AU Antunes, NT Tavio, MM Assuncao, P Rosales, RS Poveda, C de la Fe, C Gil, MC Poveda, JB AF Antunes, N. T. Tavio, M. M. Assuncao, P. Rosales, R. S. Poveda, C. de la Fe, C. Gil, M. C. Poveda, J. B. TI In vitro susceptibilities of field isolates of Mycoplasma agalactiae SO VETERINARY JOURNAL LA English DT Article DE Mycoplasma agalactiae; MIC; antimicrobial; contagious agalactia ID STRAINS; SEQUENCES AB In order to determine how widespread antibiotic resistance has become to standard treatments, the in vitro susceptibilities of 29 Mycoplasma agalactiae Spanish field isolates to 16 antimicrobial agents were determined using a broth microdilution method. The most effective antimicrobials based on minimum inhibitory concentration (MIC)(90) values were fluoroquinolones, tetracyclines and macrolides. Two strains were tetracycline resistant. Streptomycin, erythromycin and nalidixic acid resistance was observed in all strains. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Antunes, N. T.; Assuncao, P.; Rosales, R. S.; Poveda, C.; de la Fe, C.; Poveda, J. B.] Univ Las Palmas Gran Canaria, IUSA, Unidad Epidemiol & Med Prevent, Arucas, Spain. [Tavio, M. M.] Univ Las Palmas Gran Canaria, Fac Med, Dept Ciencias Clin, Las Palmas Gran Canaria, Spain. [Gil, M. C.] Univ Extremadura, Fac Vet, Dept Med & Anim Hlth, Caceres, Spain. RP Antunes, NT, Univ Las Palmas Gran Canaria, IUSA, Unidad Epidemiol & Med Prevent, Arucas, Spain. EM nuno.giao101@doctorandos.ulpgc.es CR ANTUNES NT, 2007, VET MICROBIOL, V119, P72, DOI 10.1016/j.vetmic.2006.08.013 BERGONIER D, 1997, REV SCI TECH OIE, V16, P848 DEGRANGE S, 2004, 15 C INT ORG MYC ATH FURNERI PM, 2001, ANTIMICROB AGENTS CH, V45, P2958 HANNAN PCT, 1997, ANTIMICROB AGENTS CH, V41, P2037 KONIGSSON MH, 2002, VET MICROBIOL, V85, P209 LORIA GR, 2003, RES VET SCI, V75, P3, DOI 10.1016/S0034-5288(03)00030-4 MORENO RC, 2002, ENFERM INFEC MICR CL, V20, P176 POVEDA JB, 1998, METH MOL B, V104, P69 ROBERTS MC, 1985, ANTIMICROB AGENTS CH, V28, P141 TOLA S, 1996, VET MICROBIOL, V51, P77 NR 11 TC 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1090-0233 J9 VET J JI Vet. J. PD SEP PY 2008 VL 177 IS 3 BP 436 EP 438 DI 10.1016/j.tvjl.2007.05.008 PG 3 SC Veterinary Sciences GA 331VS UT ISI:000258041300023 ER PT J AU de Vega, FF Cantu-Paz, E AF Fernandez de Vega, Francisco Cantu-Paz, Erick TI Special issue on distributed bioinspired algorithms SO SOFT COMPUTING LA English DT Editorial Material C1 [Fernandez de Vega, Francisco] Univ Extremadura, Ctr Univ Merida, Merida 06800, Spain. [Cantu-Paz, Erick] Yahoo Inc, Sunnyvale, CA 94089 USA. RP de Vega, FF, Univ Extremadura, Ctr Univ Merida, C Sta Teresa de Jornet 38, Merida 06800, Spain. EM fcofdez@unex.es cantupaz@acm.org CR ANDERSON DP, 2004, P 5 IEEE ACM INT WOR, P4 FOSTER I, 2004, GRID 2 BLUEPRINT NEW MINAR N, 2001, PEER TO PEER HARNESS OLARIU S, 2004, HDB BIOINSPIRED ALGO TOMASSINI M, 2005, SPATIALLY STRUCTURED NR 5 TC 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1432-7643 J9 SOFT COMPUT JI Soft Comput. PD OCT PY 2008 VL 12 IS 12 BP 1143 EP 1144 DI 10.1007/s00500-008-0299-7 PG 2 SC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications GA 332CP UT ISI:000258059700001 ER PT J AU Martinez, PE Molpeceres, E Gonzalez, P Gamez, D Cabo, R AF Encinas Martinez, Paloma Molpeceres, Esther Gonzalez, Petra Gamez, David Cabo, Raquel TI Description of psychological problems in family members and palliative care patients SO PSYCHO-ONCOLOGY LA English DT Meeting Abstract C1 [Encinas Martinez, Paloma; Molpeceres, Esther; Gonzalez, Petra; Gamez, David; Cabo, Raquel] Serv Extremeno Salud, Extremadura, Spain. NR 0 TC 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1057-9249 J9 PSYCHO-ONCOL JI Psycho-Oncol. PD JUN PY 2008 VL 17 SU Suppl. S BP S324 EP S324 PG 1 SC Oncology; Psychology; Psychology, Multidisciplinary; Social Sciences, Biomedical GA 329NL UT ISI:000257874200625 ER PT J AU Martinez, ATG Bote, VPG Quesada, BV Anegon, FM AF Garcia Martinez, Ana Teresa Guerrero Bote, Vicente P. Vargas Quesada, Benjamin Moya Anegon, Felix TI Psychology in the Spanish scientific domain through categories cocitation of Journal Citation Report 1990-2005 SO PSICOTHEMA LA Spanish DT Article ID INFORMATION; SCIENCE; PATHFINDER; ALGORITHM; MAPS AB This work aims to reveal some aspects of the scientific domain of Psychology, in the context of the internationally visible Spanish science in the databases of the Citation Index of The Institute for Scientific Information (ISI), which is represented by a map. We used the methodology of cocitation of thematic categories (JCR-Thompson Scientific), with which we obtained a representation of the scientific activity. The resulting map allowed us to focus on the area of Psychology, whose representation acts as database for the analysis of this discipline in the scientific field with international visibility. This study offers an empirical view of the underlying structure of Spanish Psychology. This is important because most scientists have an intuitive idea of this structure, but this may or may not be real. This way, we present a global vision of the entire discipline that favours its objective analysis as a function of scientists' behaviour as it affects their patterns of communication through the established formal channels. C1 [Garcia Martinez, Ana Teresa] Univ Extremadura, Dept Informac & Comunicac, Badajoz 06001, Spain. [Vargas Quesada, Benjamin; Moya Anegon, Felix] Univ Granada, E-18071 Granada, Spain. RP Martinez, ATG, Univ Extremadura, Dept Informac & Comunicac, Badajoz 06001, Spain. EM atmar@alcazaba.unex.es CR ALCAIN MD, 2005, PSICOTHEMA, V17, P179 BLANCO A, 2002, PAPELES PSICOLOGO, V82, P25 BORNER K, 2003, ANNU REV INFORM SCI, V37, P179 CHEN C, 1999, INFORM VISUALIZATION COSTA J, 1998, ESQUEMATICA VISUALIZ DESOLLAPRICE DJ, 1965, SCIENCE, V149, P510 DETEJADA PH, 2002, PAPELES PSICOLOGO, V82 DING Y, 2000, SCIENTOMETRICS, V47, P55 FABAPEREZ C, 2003, SCIENTOMETRICS, V58, P623 FERNANDEZ J, 2002, PAPELES PSICOLOGO, V81, P3 GARCIA JN, 2005, PSICOTHEMA, V17, P190 GARFIELD E, 1964, USE CITATION DATA WR GARFIELD E, 1985, J INFORMATION SCI, V11, P147 GUERREROBOTE VP, 2002, LIBRI, V52, P99 GUERREROBOTE VP, 2006, INFORM PROCESS MANAG, V42, P1484, DOI 10.1016/j.ipm.2006.03.015 HJORLAND B, 1995, J AM SOC INFORM SCI, V46, P400 IGOA JM, 2002, PAPELES PSICOLOGO, V81, P24 KAMADA T, 1989, INFORM PROCESS LETT, V31, P7 LEYDESDORFF L, 1987, SCIENTOMETRICS, V11, P295 MARSHAKOVA IV, 1973, NTI 2, P3 MARTIN BR, 1983, RES POLICY, V12, P61 MCCAIN KW, 1991, J AM SOC INFORM SCI, V42, P290 MOYAANEGON F, 2004, SCIENTOMETRICS, V61, P129 MOYAANEGON F, 2005, INFORM PROCESSING MA, V41, P1520 MOYAANEGON F, 2006, PROF INFORM, V15, P258 ORTIZRECIO G, 2003, PAPELES PSICOLOGO, V84, P53 PEREZ MAG, 2002, PAPELES PSICOLOGO, V81, P11 SANCHEZ E, 2002, PAPELES PSICOLOGO, V82, P3 SANZ J, 2002, PAPELES PSICOLOGO, V81, P54 SCHVANEVELDT RW, 1990, PATHFINDER ASSOCIATI SMALL H, 1999, J AM SOC INFORM SCI, V50, P799 SMALL H, 2003, J AM SOC INF SCI TEC, V54, P394, DOI 10.1002/asi.10225 SOLANA VH, 1999, THESIS GRANADA U VARGASQUESADA B, 2007, VISUALIZING STRUCTUR WHITE HD, 2003, J AM SOC INF SCI TEC, V54, P423, DOI 10.1002/asi.10228 NR 35 TC 1 PU COLEGIO OFICIAL DE PSICOLOGOS DE ASTURIAS PI OVIEDO PA ILDEFONSO S. DEL RIO, 4-1 B, 33001 OVIEDO, SPAIN SN 0214-9915 J9 PSICOTHEMA JI Psicothema PD AUG PY 2008 VL 20 IS 3 BP 465 EP 473 PG 9 SC Psychology, Multidisciplinary GA 326NG UT ISI:000257665600021 ER PT J AU Agundez, JAG Ladero, JM AF Agundez, Jose A. G. Ladero, Jose M. TI Glutathione S-transferase GSTT1 and GSTM1 allozymes: beyond null alleles SO PHARMACOGENOMICS LA English DT Editorial Material DE gene deletion; genotyping; GSTM1; GSTT1; SNPs ID GENETIC POLYMORPHISMS; CANCER-RISK; GENOTYPES; T1; M1 AB Genetic variations in the glutathione S-transferases GSTT1 and GSTM1 have been studied in many human populations, and association of these variations with environmentally-related cancers, drug-induced hepatotoxicity and even chronification of viral hepatitis has been shown. However, studies carried out to date have been limited to gene deletion, designated as null alleles, and no extensive studies on other types of genetic variations have been carried out. This study is of great importance, as it describes the occurrence and the allele frequencies for 18 SNPs in the GSTT1 gene, including four nonsynonymous SNPs, and 69 SNPs, two of which are nonsynonymous, in the GSTM1 gene. The GSTT1 SNPs leading to the amino acid substitutions Asp43Asn, Thr65Met, Thr104Pro and a single nucleotide deletion in exon 4 cause a decrease in immunoreactive protein. Interestingly, the previously described nonsynonymous GSTT1 SNPs rs2266635 (Ala21Thr), rs11550606 (Leu30Pro), rs17856199 (Phe45Cys), rs11550605 (Thr104Pro), rs2266633 (Asp141Asn) and rs2234953 (Glu173Lys) were not identified in 400 subjects, thus indicating that these variant alleles are expected to occur at extremely low frequencies. This study reinforces the need to combine SNP databases and resequencing. On combining the data reported in this study with SNP databases, the most promising target SNPs for GSTT1 association studies are those causing the amino acid changes Asp43Asn, Thr65Met, Thr104Pro and the single nucleotide deletion in exon 4. These gene variants should be analyzed in African-American and Hispanic subjects to increase the predictive capacity of genetic tests. For Caucasians and Oriental subjects, testing for null alleles seems to be sufficient. C1 [Agundez, Jose A. G.] Univ Extremadura, Dept Pharmacol, Sch Med, E-06071 Badajoz, Spain. [Ladero, Jose M.] Univ Complutense, Hosp Clin San Carlos, Serv Gastroenterol, E-28040 Madrid, Spain. RP Agundez, JAG, Univ Extremadura, Dept Pharmacol, Sch Med, Ave Elvas Sin Numero, E-06071 Badajoz, Spain. EM jagundez@unex.es CR ALEXANDRIE AK, 2002, PHARMACOGENETICS, V12, P613 COTE ML, 2005, CARCINOGENESIS, V26, P811, DOI 10.1093/carcin/bgi023 GARCIAMARTIN E, 2006, MOL DIAGN THER, V10, P29 HAYES JD, 2005, ANNU REV PHARMACOL, V45, P51, DOI 10.1146/annurev.pharmtox.45.120403.095857 HUANG YS, 2007, J HEPATOL, V47, P128, DOI 10.1016/j.jhep.2007.02.009 KEEN JH, 1978, J BIOL CHEM, V253, P5654 LADERO JM, 2005, SCAND J GASTROENTERO, V40, P348, DOI 10.1080/00365520510012109 MARTINEZ C, 2006, PHARMACOGENOMICS, V7, P711, DOI 10.2217/14622416.7.5.711 MARTINEZ C, 2007, J INFECT DIS, V195, P1320, DOI 10.1086/513569 MONTERO R, 2007, HUM BIOL, V79, P299 MOYER AM, 2007, CLIN CANCER RES, V13, P7207, DOI 10.1158/1078-0432.CCR-07-0635 PARL FF, 2005, CANCER LETT, V221, P123, DOI 10.1016/j.canlet.2004.06.016 SEOW A, 2002, CARCINOGENESIS, V23, P2055 SIMON T, 2000, CLIN PHARMACOL THER, V67, P432 XU ZL, 2007, EUR J HUM GENET, V15, P1063, DOI 10.1038/sj.ejhg.5201875 NR 15 TC 3 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1462-2416 J9 PHARMACOGENOMICS JI Pharmacogenomics PD MAR PY 2008 VL 9 IS 3 BP 359 EP 363 DI 10.2217/14622416.9.3.359 PG 5 SC Pharmacology & Pharmacy GA 331DQ UT ISI:000257993300010 ER PT J AU Balbontin, J Ferrer, M AF Balbontin, Javier Ferrer, Miguel TI Density-dependence by habitat heterogeneity: individual quality versus territory quality SO OIKOS LA English DT Article ID POPULATION REGULATION; CLUTCH SIZE; INCREASING POPULATION; BREEDING PERFORMANCE; AGE; REPRODUCTION; SITE; PRODUCTIVITY; FECUNDITY; CONSERVATION AB The aim of this comment is to review the ecological issues concerning the role of individual and habitat heterogeneity as possible mechanisms explaining density-dependent fecundity in animal populations. Our intention is to discuss different approaches to determine whether OF not Studied populations are Subjected to density-dependent processes and which mechanisms are involved. We show that because individual quality (e.g. measured in terms of age of breeding individuals) and territory quality can be correlated, untangling both effects on fecundity is frequently a difficult task. We discuss the misuse of statistical methods and other problems related to the specific characteristics of the studied Populations that call have a strong influence oil the conclusions reached by researchers working in this field. C1 [Balbontin, Javier] Univ Extremadura, Fac Ciencias, Area Zool Biol Anim, Grp Invest Comportamiento Anim, ES-06071 Badajoz, Spain. [Ferrer, Miguel] CSIC, Estac Biol Donana, Dept Biodivers Conservat, ES-41013 Seville, Spain. RP Balbontin, J, Univ Extremadura, Fac Ciencias, Area Zool Biol Anim, Grp Invest Comportamiento Anim, Avda Elvas S-N, ES-06071 Badajoz, Spain. 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Carrier, David James, Nicholas Calvo, Vanessa Ljung, Karin Kramer, Eric Roberts, Rebecca Graham, Neil Marillonnet, Sylvestre Patel, Kanu Jones, Jonathan D. G. Taylor, Christopher G. Schachtman, Daniel P. May, Sean Sandberg, Goran Benfey, Philip Friml, Jiri Kerr, Ian Beeckman, Tom Laplaze, Laurent Bennett, Malcolm J. TI The auxin influx carrier LAX3 promotes lateral root emergence SO NATURE CELL BIOLOGY LA English DT Article ID CULTURED TOBACCO CELLS; ARABIDOPSIS-THALIANA; GENE; TRANSPORT; INITIATION; ORGANIZATION; EXPRESSION; MUTATIONS AB Lateral roots originate deep within the parental root from a small number of founder cells at the periphery of vascular tissues and must emerge through intervening layers of tissues. We describe how the hormone auxin, which originates from the developing lateral root, acts as a local inductive signal which re-programmes adjacent cells. Auxin induces the expression of a previously uncharacterized auxin influx carrier LAX3 in cortical and epidermal cells directly overlaying new primordia. Increased LAX3 activity reinforces the auxin-dependent induction of a selection of cell-wall-remodelling enzymes, which are likely to promote cell separation in advance of developing lateral root primordia. C1 [Swarup, Kamal; Swarup, Ranjan; Parry, Geraint; Carrier, David; James, Nicholas; Roberts, Rebecca; Graham, Neil; May, Sean; Bennett, Malcolm J.] Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, Leics, England. [Benkova, Eva; Friml, Jiri] Univ Tubingen, ZMBP, D-72074 Tubingen, Germany. [Casimiro, Ilda; Calvo, Vanessa] Univ Extremadura, Fac Ciencias, Badajoz, Spain. [Peret, Benjamin; Laplaze, Laurent] INRA, IRD, UMR DiA PC, Agro M,UM2, F-34394 Montpellier, France. [Yang, Yaodong; Nielsen, Erik; Taylor, Christopher G.; Schachtman, Daniel P.] Donald Danforth Plant Sci Ctr, St Louis, MO 63122 USA. [Benkova, Eva; De Smet, Ive; Vanneste, Steffen; Friml, Jiri] Univ Ghent VIB, Dept Plant Syst Biol, B-9052 Ghent, Belgium. [Levesque, Mitch P.; Benfey, Philip] Duke Univ, Dept Biol, Durham, NC USA. [Levesque, Mitch P.; Benfey, Philip] Duke Univ, Inst Genome Sci & Policy, Durham, NC USA. [Carrier, David; Kerr, Ian] Univ Nottingham, Sch Biomed Sci, Nottingham NG7 2UH, England. [Ljung, Karin] SLU, Dept Forest Genet & Plant Physiol, Umea Plant Sci Ctr, SE-90183 Umea, Sweden. [Kramer, Eric] Simons Rock Coll, Dept Phys, Great Barrington, MA 01201 USA. [Marillonnet, Sylvestre; Patel, Kanu; Jones, Jonathan D. G.] John Innes Ctr, Sainsbury Lab, Norwich, Norfolk, England. [Sandberg, Goran] Umea Univ, Dept Plant Physiol, Umea Plant Sci Ctr, SE-90187 Umea, Sweden. [Parry, Geraint] Indiana Univ, Dept Biol, Bloomington, IN USA. [De Smet, Ive] Univ Tubingen, ZMBP Entwicklungsgenet, D-72074 Tubingen, Germany. [Levesque, Mitch P.] Max Planck Inst Dev Biol, Tubingen, Germany. RP Bennett, MJ, Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, Leics, England. EM malcolm.bennett@nottingham.ac.uk CR BEECKMAN T, 1994, PLANT MOL BIOL REP, V12, P37 BENKOVA E, 2003, CELL, V115, P591 BHALERAO RP, 2002, PLANT J, V29, P325 BOERJAN W, 1995, PLANT CELL, V7, P1405 CASIMIRO I, 2001, PLANT CELL, V13, P843 CASIMIRO I, 2003, TRENDS PLANT SCI, V8, P165, DOI 10.1016/S1360-1385(03)00051-7 COSGROVE DJ, 2000, NATURE, V407, P321 DELBARRE A, 1996, PLANTA, V198, P532 DESMET I, 2007, DEVELOPMENT, V134, P681, DOI 10.1242/dev.02753 DHARMASIRI S, 2006, SCIENCE, V312, P1218, DOI 10.1126/science.1122847 DOLAN L, 1993, DEVELOPMENT, V119, P71 DUBROVSKY JG, 2001, PLANTA, V214, P30 DUBROVSKY JG, 2003, ENCY APPL PLANT SCI, P1101 FUKAKI H, 2002, PLANT J, V29, P153 HELARIUTTA Y, 2000, CELL, V101, P555 HENRISSAT B, 1997, CURR OPIN STRUC BIOL, V7, P637 HOCHHOLDINGER F, 2004, TRENDS PLANT SCI, V9, P42, DOI 10.1016/j.tplants.2003.11.003 IMHOFF V, 2000, PLANTA, V210, P580 IVANCHENKO MG, 2006, PLANT J, V46, P436, DOI 10.1111/j.1365-313X.2006.02702.x KARLINNEUMANN GA, 1991, PLANT CELL, V3, P573 KRAMER EM, 2006, TRENDS PLANT SCI, V11, P382, DOI 10.1016/j.tplants.2006.06.002 LASKOWSKI M, 2006, PLANT CELL PHYSIOL, V47, P788, DOI 10.1093/pcp/pcj043 LASKOWSKI MJ, 1995, DEVELOPMENT, V121, P3303 LJUNG K, 2005, PLANT CELL, V17, P1090 LLORET PG, 2002, LATERAL ROOT INITIAT MALAMY JE, 1997, DEVELOPMENT, V124, P33 MARCHANT A, 2002, PLANT CELL, V14, P589 MARINRODRIGUEZ MC, 2002, J EXP BOT, V53, P2115, DOI 10.1093/jxb/erf089 NEUTEBOOM LW, 1999, PLANT MOL BIOL, V39, P273 OKUSHIMA Y, 2005, PLANT CELL, V17, P444, DOI 10.1105/tpc.104.028316 RASHOTTE AM, 2000, PLANT PHYSIOL, V122, P481 ROBERTS JA, 2002, ANNU REV PLANT BIOL, V53, P131, DOI 10.1146/annurev.arplant.53.092701.180236 SWARUP R, 2004, PLANT CELL, V16, P3069 TIAN Q, 1999, DEVELOPMENT, V126, P711 TISSIER AF, 1999, PLANT CELL, V11, P1841 ULMASOV T, 1997, PLANT CELL, V9, P1963 VISSENBERG K, 2005, J EXP BOT, V56, P673, DOI 10.1093/jxb/eri048 WEN F, 2006, ANN PLANT REV, V25, P91 WU G, 2007, PLANT CELL, V19, P1826, DOI 10.1105/tpc.106.048777 YANG YD, 2006, CURR BIOL, V16, P1123, DOI 10.1016/j.cub.2006.04.029 NR 40 TC 15 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1465-7392 J9 NAT CELL BIOL JI Nat. Cell Biol. PD AUG PY 2008 VL 10 IS 8 BP 946 EP 954 DI 10.1038/ncb1754 PG 9 SC Cell Biology GA 333IV UT ISI:000258147100012 ER PT J AU Pinna, MAC Vargas, RM Moralo, MJR Correas, MAS Pera, G AF Pinna, M. A. Cuervo Vargas, R. Mota Moralo, M. J. Redondo Correas, M. A. Sanchez Pera, G. TI Etiologic factors of dyspnea at the end of life SO MEDICINA PALIATIVA LA Spanish DT Article DE dyspnea; terminal disease; etiology factor ID ILL CANCER-PATIENTS; FREQUENCY; OXYGEN AB Objectives: to analyze the etiologic factors of dyspnea in a population treated by a palliative care support team with both in-hospital and home activities. Methodology: a retrospective longitudinal study of patients included in a palliative care program within Badajoz health area who died in 2005. In all, 195 patients were recruited and the following variables were studied: age, sex, % patients with dyspnea, type of terminal disease, cancer site, etiologic factors of dyspnea (I. Local heart and lung (direct/indirect). 2. Associated disease. 3. Systemic causes). Oxigen saturation, hemoglobin level, and Karnofsky index. The analysis was performed using the statistical Stata9 method and logistic regression models. Results: sixty percent of cases showed dyspnea. Mean age was 73 (64% women). Cancer represented 88% of all cases (lung cancer was most frequent). The "odds" of dyspnea in patients with cardiac and lung disease, both direct (1) and indirect (2), were higher than in patients without that etiology (OR1 = 0.1 OR2 = 0.05, p = 0.0001). The odds of systemic causes were > 50% in patients with dyspnea (p = 0.052). The association was not statistically significant between oxygen saturation and dyspnea (p = 0.12). Hemoglobin levels were statistically associated with dyspnea (OR: 0.09/p = 0.005). Conclusions: the presence of cardiac and lung disease was the most prevalent etiology. Systemic causes were also associated with dyspnea. Patients with lower hemoglobin levels were more likely to suffer from dyspnea. C1 [Pinna, M. A. Cuervo; Vargas, R. Mota; Moralo, M. J. Redondo; Correas, M. A. Sanchez] Esquipo Cuidados Paliativos Badajoz, Programa Reg Cuidados Paliativos Extremadura, Barcelona, Spain. [Pera, G.] Unitat Suport Recera Ambit Barcelones Nord & Mare, Barcelona, Spain. RP Pinna, MAC, Avda Damian Tellez Lafuente 30 1B, Badajoz 06010, Spain. EM 924252539@telefonica.net CR ATOYEBI W, 2003, PALLIATIVE CARE CONS, P177 BOOTH S, 1996, AM J RESP CRIT CARE, V153, P1515 BRUERA E, 1993, LANCET, V342, P13 BRUERA E, 2000, J PAIN SYMPTOM MANAG, P373 BRUERA E, 2000, J PAIN SYMPTOM MANAG, V19, P357 CHAN KS, 2005, OXFORD TXB PALLIATIV, P587 CONILL C, 1997, J PAIN SYMPTOM MANAG, V14, P328 DUDGEON D, 1998, J PAIN SYMPTOM MANAG, P212 DUDGEON D, 2001, J PAIN SYMPTOM MANAG, P95 GLEESON C, 1996, PALL MED, P307 JAY RT, 2006, TXB PALLIATIVE MED, P655 MERCADANTE S, 2000, J PAIN SYMPTOM MANAG, V20, P104 MONTI M, 1996, J PAIN SYMPTOM MANAG, V12, P18 MOORE LHH, 1991, PALL MED, P20 MORALO MJR, 2006, ATEN PRIMARIA S1, V38, P38 MUERS MF, 1993, THORAX, V48, P339 PHILIP J, 2006, J PAIN SYMPTOM MANAG, P541 PORCEL JM, 2003, MED PAL, P142 REUBEN DB, 1986, CHEST, V89, P234 SPATHIS A, 2006, DYSPNOEA ADV DIS GUI, P205 NR 20 TC 1 PU ARAN EDICIONES, S A PI MADRID PA CASTELLO, 128, 1O, 28006 MADRID, SPAIN SN 1134-248X J9 MED PALIATIVA JI Med. Paliativa. PD MAY-JUN PY 2008 VL 15 IS 3 BP 143 EP 148 PG 6 SC Health Care Sciences & Services GA 329UI UT ISI:000257895700007 ER PT C AU Martinez, E Huertas, S Menez, H Pena, JL Alcalde, A AF Martinez, Emilio Huertas, Sonia Menez, Hector Pena, Jose Luis Alcalde, Ana TI Comparison of chemometric techniques applied to near infrared spectra for a gasoline blending control SO JOURNAL OF NEAR INFRARED SPECTROSCOPY LA English DT Proceedings Paper DE chemometric; NIR; PLS; topological method; artificial neural networks; gasoline; blending; control AB In order to fulfil specifications, avoid quality give-aways, improve process safety and save on costs, refineries need to have on-Line methods for the control of their processes. On-line anatysers allow product streams characteristic variables to be controlled, providing a great amount of data in almost real time.(1) Currently, the spectroscopic anaLysers [near infrared INIR), mid infrared, nuclear magnetic resonanc and ultraviolet] are the most widely used. These anaLysers allow the value of the property of interest to be inferred from the measurement of a spectrum. Due to the great quantity of variables that constitute a spectrum, mathematical tools are required to extract the information related to the properties of interest. Repsol YPF has developed, and is in process of implantating, several NIR systems in its different Laboratories, pilot plants and industrial complexes, which include from gasoline or diesel blending systems control to some petrochemical product manufacture controls. In the development of these systems, different hardware and software have been compared. In this work, the results obtained with three different chemometric methods for predicting critical. gasoline properties for blending control are analysed and compared- pa rtiaL least squares, a topological method and artificial neural networks. C1 [Martinez, Emilio; Huertas, Sonia; Pena, Jose Luis; Alcalde, Ana] Repsol YPF, Ctr Tecnol Spain, Madrid 28931, Spain. [Menez, Hector] Repsol YPF, Ctr Tecnol Argentina, RA-1925 Ensenada Bs As, Argentina. RP Huertas, S, Repsol YPF, Ctr Tecnol Spain, Carretera Extremadura Km 18, Madrid 28931, Spain. EM shuertasdlt@repsolypf.com CR BUTTNER G, 1997, PROCESS CONTR QUAL, V9, P197 DAVIES AMC, 2006, J NEAR INFRARED SPEC, V14, P403 JIN L, 2003, ANAL CHIM ACTA, V488, P1, DOI 10.1016/S0003-2670(03)00629-9 NR 4 TC 0 PU N I R PUBLICATIONS PI CHICHESTER PA 6 CHARLTON MILL, CHARLTON, CHICHESTER PO18 0HY, WEST SUSSEX, ENGLAND SN 0967-0335 J9 J NEAR INFRARED SPECTROSC JI J. Near Infrared Spectrosc. PY 2008 VL 16 IS 3 BP 297 EP 303 DI 10.1255/jnirs.791 PG 7 SC Chemistry, Applied; Spectroscopy GA 331CD UT ISI:000257989400022 ER PT J AU Anton, M Serrano, A Cancillo, ML Garcia, JA AF Anton, M. Serrano, A. Cancillo, M. L. Garcia, J. A. TI Relationship between erythemal irradiance and total solar irradiance in South-Western Spain SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID ULTRAVIOLET-RADIATION; CLEARNESS INDEX; GLOBAL RADIATION; OPTICAL DEPTH; URBAN AREA; MU-M; UV; VALENCIA; OZONE; COMPONENTS AB In the last years, many studies have focused on the study of the ultraviolet radiation or the total solar radiation in Southwestern Europe. This area presents a particular interest due to the intense solar radiation which reaches the Earth's surface at these latitudes. Despite of this high interest, the influence of the atmospheric factors on the relationship between both variables is not well documented for that region. In this work, the ultraviolet erythemal irradiance (UVER) and the total solar irradiance (310-2800 nm) at three locations in Southwestern Spain were measured between January 2001 and December 2005. The main goal of this paper is to analyze the relationship between ultraviolet and total solar irradiance as described by their ratio. This ratio represents the percentage of UV erythemal irradiance over the total solar irradiance at Earth's surface. The results show that this ratio varies in time. It shows a day-to-day and seasonal variability mainly due to changes in sky conditions (regarding cloudiness and aerosols) and in the slant column of ozone, respectively. Differences in ozone may cause a relative increase in the ratio higher than 100% between winter and summer. This fact stresses the importance of reporting information about the UV radiation at ground level to the people mainly during summer. Clouds play also an important role, since highly different conditions between consecutive days are responsible for up to 60% of the ratio variability. The results show that cloudiness attenuates more the total solar radiation than the UV solar radiation. Additionally, high changes in aerosol load can produce a short-term decrease in the ratio of 13-15%, attenuating differently UVER than total solar irradiance. C1 [Anton, M.; Serrano, A.; Cancillo, M. L.; Garcia, J. A.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Anton, M, Univ Extremadura, Dept Fis, Avd Elvas S-N, E-06071 Badajoz, Spain. 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Geophys. Res.-Atmos. PD JUL 22 PY 2008 VL 113 IS D14 AR D14208 DI 10.1029/2007JD009627 PG 7 SC Meteorology & Atmospheric Sciences GA 331FA UT ISI:000257996900006 ER PT J AU Barriopedro, D Garcia-Herrera, R Huth, R AF Barriopedro, David Garcia-Herrera, Ricardo Huth, Radan TI Solar modulation of Northern Hemisphere winter blocking SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID QUASI-BIENNIAL OSCILLATION; ATMOSPHERIC BLOCKING; MAUNDER MINIMUM; ATLANTIC OSCILLATION; GEOMAGNETIC-ACTIVITY; SPATIAL STRUCTURE; CYCLE MODULATION; CLIMATE; NAO; QBO AB The blocking response to the 11-year solar cycle is investigated for 44 winters (1955-1999) and stratified according to the level of solar activity and the phase of the Quasi-Biennial Oscillation (QBO). Several blocking features are modulated by solar activity, irrespective of the QBO phase, but the responses amplify under the QBO-west phases. Solar activity modulates the preferred locations for blocking occurrence over both Oceans, causing local frequency responses therein. Over the Pacific Ocean high/low solar activity induces an enhanced blocking activity over its eastern/western part. Atlantic blocking occurrence increases for both (high/low) solar phases, with a spatial dependent response confined to western/eastern Atlantic. Although solar effects are negligible in blocking frequency for the entire Atlantic sector, other blocking features exhibit significant responses. Low solar Atlantic blocking episodes last longer, are located further east and become more intense than high solar blocking events. The implications of these solar-related changes are discussed. Our results suggest that the excessively cold conditions recorded in Europe during the Maunder Minimum may have arisen from an eastward shift of long-lasting blockings with near-normal frequencies. 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Geophys. Res.-Atmos. PD JUL 23 PY 2008 VL 113 IS D14 AR D14118 DI 10.1029/2008JD009789 PG 11 SC Meteorology & Atmospheric Sciences GA 331FE UT ISI:000257997300003 ER PT J AU Pacheco, AF Sanudo, J AF Pacheco, A. F. Sanudo, J. TI Lower bounds for the energy of a many-body model SO INTERNATIONAL JOURNAL OF MODERN PHYSICS E-NUCLEAR PHYSICS LA English DT Article DE lowers bounds; quantum many-body model ID GROUND-STATE ENERGY; APPROXIMATION METHODS; SOLVABLE MODEL; VALIDITY; SYSTEMS AB The well known and analytically solvable Lipkin-Meshkov-Glick model was devised to test several many-body approximation approaches used in nuclear physics. Here, we use this model to illustrate a method that sets lower bounds for the ground state energy of a quantum Hamiltonian. The idea of the method consists of dividing the Hamiltonian into identical groups of terms that represent subdivisions in the particle population of the system, and then to make an appropriate use of the ground energy of one of these groups. The bounds clearly improve as the size of these groups increases. C1 [Pacheco, A. F.] Univ Zaragoza, Fac Ciencias, E-50009 Zaragoza, Spain. [Pacheco, A. F.] Univ Zaragoza, BIFI, E-50009 Zaragoza, Spain. [Sanudo, J.] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Pacheco, AF, Univ Zaragoza, Fac Ciencias, E-50009 Zaragoza, Spain. 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PD JUN PY 2008 VL 17 IS 6 BP 1031 EP 1039 PG 9 SC Physics, Nuclear; Physics, Particles & Fields GA 327XL UT ISI:000257761700003 ER PT J AU Serradilla, MJ Martin, A Aranda, E Hernandez, A Benito, MJ Lopez-Corrales, M Cordoba, MD AF Serradilla, Manuel J. Martin, Alberto Aranda, Emilio Hernandez, Alejandro Benito, Maria J. Lopez-Corrales, Margarita Cordoba, Maria de Guia TI Authentication of "Cereza del Jerte" sweet cherry varieties by free zone capillary electrophoresis (FZCE) SO FOOD CHEMISTRY LA English DT Article DE sweet cherry; authentication; protein profile; FZCE ID PROTEINS; ADULTERATION; DIFFERENTIATION; SEPARATION AB The purpose of this work was to develop a procedure based on protein analysis by free zone capillary electrophoresis (FZCE) that can be used as an alternative to other methods in the determination of sweet cherry varieties for the authentication of "Cereza del Jerte". Two autochthonous varieties of sweet cherry type "Picota", 'Ambrunes' and 'Pico Negro', and the foreign variety 'Sweetheart' were used in the study. Two protocols for extracting the methanol-soluble proteins were tested. On the basis of the results, direct evaporation with nitrogen of a methanol extract was included in the extraction protocol for routine analysis. This method was found to give excellent repeatability of the corrected migration time (CMT), and showed greater effectiveness in discriminating sweet cherry varieties than the SDS-PAGE technique. Three peaks found in the FZCE electropherograms were investigated as a basis for discriminating between varieties. In addition, the FZCE analysis of methanol-soluble proteins provides information about the physico-chemical parameters relevant to the sensorial quality of the sweet cherries. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Martin, Alberto; Aranda, Emilio; Hernandez, Alejandro; Benito, Maria J.; Cordoba, Maria de Guia] Univ Extremadura, Escuela Ingn Agr, E-06071 Badajoz, Spain. [Serradilla, Manuel J.; Lopez-Corrales, Margarita] Ctr Invest Finca Orden Valdesequeera, Badajoz 06187, Spain. RP Martin, A, Univ Extremadura, Escuela Ingn Agr, Ctra Caceres S-N, E-06071 Badajoz, Spain. EM amartin@unex.es CR ALIQUE R, 2005, POSTHARVEST BIOL TEC, V35, P153, DOI 10.1016/j.postharvbio.2004.07.003 BARNWELL P, 1994, J CEREAL SCI, V20, P245 BEAN SR, 1998, ELECTROPHORESIS, V19, P3190 BEAN SR, 2000, J AGR FOOD CHEM, V48, P318 BEAN SR, 2001, ELECTROPHORESIS, V22, P1503 BERNALTE MJ, 1999, J FOOD QUALITY, V28, P303 CANCALON PF, 1995, FOOD TECHNOL-CHICAGO, V49, P52 FLURER CL, 2000, FOOD ADDIT CONTAM, V17, P3 HERNANDEZ A, 2006, J AGR FOOD CHEM, V54, P4141, DOI 10.1021/jf060349r HERNANDEZ A, 2007, FOOD CHEM, V105, P1219, DOI 10.1016/j.foodchem.2007.02.044 LAEMMLI UK, 1970, NATURE, V4, P680 LOOKHART G, 1995, CEREAL CHEM, V72, P42 LOOKHART GL, 1995, CEREAL CHEM, V72, P312 MANABE T, 1999, ELECTROPHORESIS, V20, P3116 PIERGIOVANNI AR, 2005, J AGR FOOD CHEM, V53, P6593, DOI 10.1021/jf0505426 PIERGIOVANNI AR, 2005, J CHROMATOGR, V2, P253 SERRANO M, 2005, J AGR FOOD CHEM, V53, P2741, DOI 10.1021/jf0479160 SKARPEID HJ, 2001, MEAT SCI, V57, P227 TOOROP RM, 1997, FOOD RES INT, V30, P629 NR 19 TC 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0308-8146 J9 FOOD CHEM JI Food Chem. PD NOV 15 PY 2008 VL 111 IS 2 BP 457 EP 461 DI 10.1016/j.foodchem.2008.03.084 PG 5 SC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics GA 330YW UT ISI:000257979700028 ER PT C AU Roman, AC Benitez, DA Carvajal-Gonzalez, JM Fernandez-Salguero, PM AF Roman, A. C. Benitez, D. A. Carvajal-Gonzalez, J. M. Fernandez-Salguero, P. M. TI Transcriptional repression of cis genes via a new murine retrotransposon containing Snail- and bHLH-transcription factors binding sites SO EJC SUPPLEMENTS LA English DT Meeting Abstract C1 [Roman, A. C.; Benitez, D. A.; Carvajal-Gonzalez, J. M.; Fernandez-Salguero, P. M.] Univ Extremadura, Badajoz, Spain. NR 0 TC 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6349 J9 EJC SUPPL JI EJC Suppl. PD JUL PY 2008 VL 6 IS 9 BP 116 EP 116 PG 1 SC Oncology GA 330DF UT ISI:000257919000436 ER PT C AU Tourna, D Walker, RA Shaw, JA AF Tourna, D. Walker, R. A. Shaw, J. A. TI Analysis of TGF beta-induced, as a novel gene targets in breast cancers in young women SO EJC SUPPLEMENTS LA English DT Meeting Abstract C1 [Tourna, D.; Walker, R. A.; Shaw, J. A.] Univ Extremadura, Badajoz, Spain. [Tourna, D.; Walker, R. A.; Shaw, J. A.] Univ Leicester, Leicester, Leics, England. NR 0 TC 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6349 J9 EJC SUPPL JI EJC Suppl. PD JUL PY 2008 VL 6 IS 9 BP 130 EP 130 PG 1 SC Oncology GA 330DF UT ISI:000257919000494 ER PT C AU Sanchez-Martin, FJ Valera, E Merino, JM AF Sanchez-Martin, F. J. Valera, E. Merino, J. M. TI Characterization of zinc toxicity in PC12 cells - reactive oxygen species generation and role of voltage calcium channels SO EJC SUPPLEMENTS LA English DT Meeting Abstract C1 [Sanchez-Martin, F. J.; Valera, E.; Merino, J. M.] Univ Extremadura, Badajoz, Spain. NR 0 TC 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6349 J9 EJC SUPPL JI EJC Suppl. PD JUL PY 2008 VL 6 IS 9 BP 130 EP 130 PG 1 SC Oncology GA 330DF UT ISI:000257919000495 ER PT J AU Agundez, JAG Golka, K Martinez, C Selinski, S Blaszkewicz, M Garcia-Martin, E AF Agundez, Jose A. G. Golka, Klaus Martinez, Carmen Selinski, Silvia Blaszkewicz, Meinolf Garcia-Martin, Elena TI Unraveling ambiguous NAT2 genotyping data SO CLINICAL CHEMISTRY LA English DT Article ID HAPLOTYPE RECONSTRUCTION; BLADDER-CANCER; N-ACETYLTRANSFERASE-2; POPULATION; GENE; POLYMORPHISMS; ACETYLATORS; ALLELES; LOCUS AB BACKGROUND: Arylamine N-acetyltransferase 2 (CoASAc; NAT2, EC 2.3.1.5) is a drug-metabolizing enzyme that displays common polymorphisms leading to impaired drug metabolism and adverse drug effects. Determination of the N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2) genotype in clinical practice is hampered by the occurrence of ambiguous haplotype combinations that may lead to patient misclassification. We determined the frequencies for ambiguous NAT2 haplotypes and diplotypes in a white population and investigated the use of PHASE v2.1.1, a statistical program for haplotype reconstruction, to clarify this ambiguity and classify individuals according to their acetylation status. METHODS: By means of allele-specific haplotype mapping and sequencing, we determined the haplotypes for 7 common single-nucleotide polymorphisms in the NAT2 gene (n = 2624 haplotypes). To test the performance of PHASE, actual genotypes were deconstructed and then reconstructed by haplotype prediction. RESULTS: We identified 21 NAT2 allelic variants, including a new variant allele that combines the singlenucleotide polymorphisms rs1801279, rsl799929, and rs1208. In contrast, the previously described variant alleles *5G, *5J, *6E, *17A, *11A, *11B, and *14B were not identified in the study population. Ambiguous haplotypes were observed in 98 alleles (3.7%), and ambiguous diplotypes were observed in 64 individuals (4.9%). Eleven individuals (0.8%) were misclassified by the use of haplotype prediction. CONCLUSIONs: Ambiguous NAT2 genotyping data are common. Actual NAT2 genotypes cannot be fully determined by haplotype prediction techniques. This study provides real haplotype data that can be used as a guide to convert NAT2 haplotypes and diplotypes into actual genotypes in white individuals. C1 [Agundez, Jose A. G.; Martinez, Carmen] Univ Extremadura, Sch Med, Dept Pharmacol, E-06071 Badajoz, Spain. [Golka, Klaus; Blaszkewicz, Meinolf] Univ Dortmund, Inst Occupat Physsiol IfADo, Dortmund, Germany. [Selinski, Silvia] Tech Univ Dortmund, Fak Stat, Dortmund, Germany. [Garcia-Martin, Elena] Univ Extremadura, Sch Biol Sci, Dept Biochem & Mol Biol, E-06071 Badajoz, Spain. RP Agundez, JAG, Univ Extremadura, Sch Med, Dept Pharmacol, Avda Elvas S-N, E-06071 Badajoz, Spain. EM jagundez@unex.es CR HUMAN NAT2 ALLELES H AGUNDEZ JAG, 1994, CLIN PHARMACOL THER, V56, P202 AGUNDEZ JAG, 1996, PHARMACOGENETICS, V6, P423 AGUNDEZ JAG, 1996, PHARMACOGENETICS, V6, P501 BRANS R, 2004, CLIN CHEM, V50, P1264, DOI 10.1373/clinchem.2003.027748 BRODDE OE, 2005, PHARMACOGENET GENOM, V15, P267 COLMENERO JD, 1994, ANTIMICROB AGENTS CH, V38, P2798 CROOK JE, 1979, SOUTH MED J, V72, P1599 FRAZER KA, 2007, NATURE, V449, P851, DOI 10.1038/nature06258 GARCIAMARTIN E, 2002, CLIN PHARMACOL THER, V71, P196 GOLKA K, 2002, TOXICOL LETT, V128, P229 GOLKA K, 2008, ARCH TOXICOL, V82, P265, DOI 10.1007/s00204-007-0247-9 HUANG JX, 2001, CLIN CHEM, V47, P1912 LI N, 2004, GENETICS, V167, P1039 MARTINEZ C, 1995, PHARMACOGENETICS, V5, P207 MEYER UA, 1997, ANNU REV PHARMACOL, V37, P269 SABBAGH A, 2005, BMC GENET, V6, ARTN 30 STEPHENS M, 2001, AM J HUM GENET, V68, P978 STEPHENS M, 2003, AM J HUM GENET, V73, P1162 VINEIS P, 2001, CANCER EPIDEM BIOMAR, V10, P1249 ZHU YS, 2006, CLIN CHEM, V52, P1033 NR 21 TC 1 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD AUG PY 2008 VL 54 IS 8 BP 1390 EP 1394 DI 10.1373/clinchem.2008.105569 PG 5 SC Medical Laboratory Technology GA 332NQ UT ISI:000258090100018 ER PT J AU Valtuena, FJ Ortega-Olivencia, A Rodriguez-Riano, T Lopez, J AF Valtuena, Francisco J. Ortega-Olivencia, Ana Rodriguez-Riano, Tomas Lopez, Josefa TI Reproductive biology in Anagyris foetida L. (Leguminosae), an autumn-winter flowering and ornithophilous Mediterranean shrub SO BOTANICAL JOURNAL OF THE LINNEAN SOCIETY LA English DT Article DE breeding system; cauliflory; fruit set; phenology; pollen tubes; seed set; self-compatibility; spontaneous self-pollination; stigmatic receptivity ID GENISTEAE FABACEAE; POLLINATION ECOLOGY; SELF-FERTILIZATION; BIRD-POLLINATION; FLORAL LONGEVITY; BREEDING SYSTEM; POLLEN; PHENOLOGY; SEEDS; LORANTHACEAE AB As most plants of the Mediterranean region bloom in spring, there have been few studies of the reproductive biology of species with autumn-winter flowering. In this study, we investigate the breeding system of Anagyris foetida, one of the few shrubs that blooms at this time. The floral, phenological, and reproductive aspects of two populations of this Mediterranean legume from south-west Spain were studied via field and laboratory experiments. The variability of fruit and seeds was studied in another 12 Iberian populations with respect to certain meteorological parameters (temperature and rainfall). Anagyris foetida shows cauliflory, marked floral longevity, and adichogamy. The peak of flowering is in January-February. It is self-compatible, with no clear advantage of cross- over self-pollination, and with virtually no autonomous self-pollination. This is because the stigma, like some other legumes, prevents the germination of pollen if its surface is not ruptured by pollinators. The number of seeds per fruit under natural pollination was positively correlated with the total rainfall during the fruiting period (from January to May), and significantly influenced the percentage of fruit weight represented by the pericarp, in the sense that the smaller the number of viable seeds in the fruit, the greater the percentage of pericarp weight. (c) 2008 The Linnean Society of London. C1 [Valtuena, Francisco J.; Ortega-Olivencia, Ana; Rodriguez-Riano, Tomas; Lopez, Josefa] Univ Extremadura, Area Bot, Fac Ciencias, E-06071 Badajoz, Spain. RP Valtuena, FJ, Univ Extremadura, Area Bot, Fac Ciencias, E-06071 Badajoz, Spain. EM aortega@unex.es CR AIZEN MA, 2003, ECOLOGY, V84, P2613 AIZEN MA, 2005, AUST J BOT, V53, P357 ASHMAN TL, 1994, NATURE, V371, P788 ASMUSSEN CB, 1993, FLORA, V188, P227 AUGSPURGER CK, 1981, ECOLOGY, V62, P775 AUGSPURGER CK, 1983, BIOTROPICA, V15, P257 BAWA KS, 1983, HDB EXPT POLLINATION, P394 BERNARDELLO G, 2004, AM J BOT, V91, P198 BERTIN RI, 1993, BOT REV, V59, P112 DAFNI A, 1991, ACTA HORTIC, V288, P340 DAFNI A, 1996, BOCCONEA, V5, P171 DEVESA JA, 1985, AN JARD BOT MADRID, V42, P165 ESCOS J, 1996, ACTA OECOL, V17, P139 FITTER AH, 1995, FUNCT ECOL, V9, P55 GALLARDO R, 1994, AM J BOT, V81, P1611 GALLONI M, 2003, PLANT SYST EVOL, V238, P127, DOI 10.1007/s00606-002-0270-5 GREUTER W, 1989, MED CHECKLIST DYCOTI, V4 HERRERA CM, 2001, AM J BOT, V88, P1025 LEWIS G, 2005, LEGUMES WORLD LLOYD DG, 1992, INT J PLANT SCI, V153, P358 LOPEZ J, 1999, PLANT SYST EVOL, V216, P23 LOPEZ J, 2000, BOT J LINN SOC, V132, P97 MARTIN FW, 1959, STAIN TECHNOL, V34, P125 NAVARRO L, 1997, PLANT SYST EVOL, V207, P111 NAVARRO L, 1999, NORD J BOT, V19, P281 ORTEGAOLIVENCIA A, 1997, EDINBURGH J BOT, V54, P39 ORTEGAOLIVENCIA A, 2005, OIKOS, V110, P578 OWENS SJ, 1992, FRUIT SEED PRODUCTIO, P33 PACINI E, 1984, WEBBIA, V38, P93 PAIVA J, 1999, FLORA IBERICA, V7, P37 PEREZBANON C, 2003, PLANT SYST EVOL, V241, P29, DOI 10.1007/s00606-003-0004-3 PETANIDOU T, 1993, AM J BOT, V80, P892 PETANIDOU T, 2005, PLANT BIOSYST, V139, P279, DOI 10.1080/11263500500333941 POLHILL RM, 1981, ADV LEGUME SYSTEMATI, V1, P1 PRIMACK RB, 1985, ANNU REV ECOL SYST, V16, P15 PRIMACK RB, 1987, ANNU REV ECOL SYST, V18, P409 RAMIREZ N, 1993, BIOTROPICA, V25, P46 RAMOS FN, 2005, CAN J BOT, V83, P1305, DOI 10.1139/b05-106 RATHCKE BJ, 2003, AM J BOT, V90, P1328 RODRIGUEZRIANO T, 1999, CAN J BOT, V77, P809 RODRIGUEZRIANO T, 1999, NORD J BOT, V19, P345 RODRIGUEZRIANO T, 2001, ACTA HORTIC, V561, P95 RODRIGUEZRIANO T, 2004, ANN BOT FENN, V41, P179 SCHOEN DJ, 1995, EVOLUTION, V49, P131 SHIVANNA KR, 1989, MONOGR SYST BOT MISS, V29, P157 SHMIDA A, 1989, HERBERTIA, V45, P111 SOKAL RR, 1979, BIOMETRIA STILES FG, 1978, AM ZOOL, V18, P715 VAKNIN Y, 1996, SEX PLANT REPROD, V9, P279 VALTUENA FJ, 2007, INT J PLANT SCI, V168, P627 VONHASELBERG C, 2004, J APPL BOT FOOD QUAL, V78, P32 WEBERLING F, 1992, MORPHOLOGY FLOWERS I NR 52 TC 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0024-4074 J9 BOT J LINN SOC JI Bot. J. Linnean Soc. PD JUL PY 2008 VL 157 IS 3 BP 519 EP 532 PG 14 SC Plant Sciences GA 327GM UT ISI:000257717600009 ER PT J AU Gusi, N Reyes, MC Gonzalez-Guerrero, JL Herrera, E Garcia, JM AF Gusi, Narcis Reyes, Maria C. Gonzalez-Guerrero, Jose L. Herrera, Emilio Garcia, Jose M. TI Cost-utility of a walking programme for moderately depressed, obese, or overweight elderly women in primary care: a randomised controlled trial SO BMC PUBLIC HEALTH LA English DT Article ID PHYSICAL-ACTIVITY INTERVENTION; RECRUITING PATIENTS; ECONOMIC-EVALUATION; OLDER-ADULTS; LIFE-STYLE; EXERCISE; HEALTH; PREVALENCE; SAMPLE; MANAGEMENT AB Background: There is a considerable public health burden due to physical inactivity, because it is a major independent risk factor for several diseases (e. g., type 2 diabetes, cardiovascular disease, moderate mood disorders neurotic diseases such as depression, etc.). This study assesses the cost utility of the adding a supervised walking programme to the standard "best primary care" for overweight, moderately obese, or moderately depressed elderly women. Methods: One-hundred six participants were randomly assigned to an interventional group (n = 55) or a control group (n = 51). The intervention consisted of an invitation, from a general practitioner, to participate in a 6-month walking-based, supervised exercise program with three 50-minute sessions per week. The main outcome measures were the healthcare costs from the Health System perspective and quality adjusted life years (QALYs) using EuroQol (EQ-5D.) Results: Of the patients invited to participate in the program, 79% were successfully recruited, and 86% of the participants in the exercise group completed the programme. Over 6 months, the mean treatment cost per patient in the exercise group was (sic) 41 more than " best care". The mean incremental QALY of intervention was 0.132 (95% CI: 0.104-0.286). Each extra QALY gained by the exercise programme relative to best care cost (sic) 311 (95% CI, (sic) 143-(sic) 394). The cost effectiveness acceptability curves showed a 90% probability that the addition of the walking programme is the best strategy if the ceiling of inversion is (sic) 350/QALY. Conclusion: The invitation strategy and exercise programme resulted in a high rate of participation and is a feasible and cost-effective addition to best care. The programme is a cost-effective resource for helping patients to increase their physical activity, according to the recommendations of general practitioners. Moreover, the present study could help decision makers enhance the preventive role of primary care and optimize health care resources. Trial Registration: [ISRCTN98931797] C1 [Gusi, Narcis; Reyes, Maria C.] Univ Extremadura, Fac Sports Sci, Caceres, Spain. [Gonzalez-Guerrero, Jose L.] Hosp Caceres, Geriatr Unite, Caceres, Spain. [Herrera, Emilio; Garcia, Jose M.] Hlth Syst Extremadura, Junta De Extremadura, Merida, Spain. RP Gusi, N, Univ Extremadura, Fac Sports Sci, Caceres, Spain. 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To this end, a computable general equilibrium model for this region is presented, with which we analyse the economic effects caused by a simulated removal of these subsidies. Different scenarios involving the labour market rigidities and tax compensation are considered. Model parameters are determined by the procedure known as calibration, using a social accounting matrix constructed for this economy. The results clearly show the negative effects that this elimination would produce on the main micro and macroeconomic variables. C1 [de Miguel, Francisco Javier] Univ Extremadura, Fac Econ, Dept Econ, E-06071 Badajoz, Spain. [Manresa, Antonio] Univ Barcelona, Dept Econ Theory, Fac Econ, Barcelona 08034, Spain. [Manresa, Antonio] CREB, Barcelona 08034, Spain. RP de Miguel, FJ, Univ Extremadura, Fac Econ, Dept Econ, Elvas Ave, E-06071 Badajoz, Spain. 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PY 2008 VL 40 IS 16 BP 2109 EP 2120 DI 10.1080/00036840600949371 PG 12 SC Economics GA 331NY UT ISI:000258020100006 ER PT J AU Giron, AJ Duran-Meras, I Espinosa-Mansilla, A de la Pena, AM Canada, FC Olivieri, AC AF Jimenez Giron, A. Duran-Meras, I. Espinosa-Mansilla, A. Munoz de la Pena, A. Canada Canada, F. Olivieri, A. C. TI On line photochemically induced excitation-emission-kinetic four-way data Analytical application for the determination of folic acid and its two main metabolites in serum by U-PLS and N-PLS/residual trilinearization (RTL) calibration SO ANALYTICA CHIMICA ACTA LA English DT Article DE folic acid; tetrahydrofolic acid; 5-methyltetrahydrofolic acid; photochemically induced fluorescence; four-way data; unfolded partial least-squares/residual trilinearization; N-dimensional partial least-squares/residual trilinearization ID PARTIAL LEAST-SQUARES; RESIDUAL TRILINEARIZATION; MULTIVARIATE CALIBRATION; 2ND-ORDER ADVANTAGE; HUMAN URINE; METHOTREXATE; FLUORESCENCE; PARAFAC; LEUCOVORIN; EXTRACTION AB The determination of folic acid and its two main serum metabolites, 5-methyltetrahydrofolic acid and tetrahydrofolic acid, has been accomplished using four-way data modelled by the third-order multivariate calibration methods unfolded and N-dimensional partial leastsquares (U-PLS and N-PLS), in combination with the separate procedure known as residual trilinearization (RTL). The four-way data were acquired by following the photochemical reaction of these compounds by on line irradiation with a UV lamp. The excitation-emission matrices (EEMs) were recorded as a function of the irradiation time, using a fast scanning spectrofluorimeter. The method achieves selectivity from the different rates at which the corresponding photoproducts of the folic acid derivatives are formed and degraded. Several N-dimensional chemometric algorithms were used and the method was applied to the determination of these compounds in serum samples. The best algorithms to perform the multivariate calibration were U-PLS and N-PLS in combination with the separate residual trilinearization procedure, achieving the second-order advantage. The approach allows minimizing or eliminating traditionally time-consuming sample pre-treatments and can facilitate quantifying an analyte in its native environment. (c) 2008 Elsevier B.V. All rights reserved. C1 [Jimenez Giron, A.; Duran-Meras, I.; Espinosa-Mansilla, A.; Munoz de la Pena, A.; Canada Canada, F.] Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. [Olivieri, A. C.] Univ Nacl Rosario, Inst Quim Rosario, CONICET, Fac Ciencias Bioquim & Farmaceut,Dept Quim Analit, RA-2000 Rosario, Santa Fe, Argentina. RP de la Pena, AM, Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. 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Chim. Acta PD AUG 1 PY 2008 VL 622 IS 1-2 BP 94 EP 103 DI 10.1016/j.aca.2008.05.079 PG 10 SC Chemistry, Analytical GA 330RO UT ISI:000257960700008 ER PT J AU Olivera, FC AF Olivera, Fatima Cotano TI The properties of Hernando Alonso de Amusco, canon of the Coria cathedral, at the end of the middle ages SO ANUARIO DE ESTUDIOS MEDIEVALES LA Spanish DT Article DE ecclesiastic history; late middle ages; extremadura; cathedral; chapter; canon; heritage AB Studies about the cathedral's chapters in the Middle Ages have been essential to know the creation and subsequent evolution of bishoprics and dioceses of Spain. The conquest of the city of Coria by Alfonso VII, in 1142, and the restoration of the diocese were the definitive step for the origin and formation of the chapter. The documentation of chapter archive shows the cathedral as the administrative center and symbol of power of the diocese, especially during the Late Middle Ages. This extensive information has revealed the internal structure of the chapter -categories and functions-, social and economic stratification of each of its members, as well as its relationships with other ecclesiastical and civil institutions. However, there are few occasions when the documentation provides very comprenhensive information about life, work and customs of a Chapter member. C1 Univ Extremadura, Dept Hist Medieval, Fac Filosofia & Letras, Caceres 10071, Spain. RP Olivera, FC, Univ Extremadura, Dept Hist Medieval, Fac Filosofia & Letras, Avda Univ S-N, Caceres 10071, Spain. 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Estud. Mediev. PD JAN-JUN PY 2008 VL 38 IS 1 BP 367 EP 383 PG 17 SC History; Medieval & Renaissance Studies GA 327MW UT ISI:000257734200011 ER PT J AU Lopez-Ruiz, R Sanudo, J Calbet, X AF Lopez-Ruiz, Ricardo Sanudo, Jaime Calbet, Xavier TI A geometrical derivation of the Boltzmann factor SO AMERICAN JOURNAL OF PHYSICS LA English DT Article AB We show that the Boltzmann factor has a geometrical origin, which follows from the microcanonical ensemble. The Maxwell-Boltzmann distribution or the wealth distribution in human society are some direct applications of this interpretation. (c) 2008 American Association of Physics Teachers. C1 [Lopez-Ruiz, Ricardo] Univ Zaragoza, DIIS, E-50009 Zaragoza, Spain. [Lopez-Ruiz, Ricardo] Univ Zaragoza, BIFI, Fac Ciencias, E-50009 Zaragoza, Spain. [Sanudo, Jaime] Univ Extremadura, Fac Ciencias, Dept Fis, E-06071 Badajoz, Spain. [Calbet, Xavier] Inst Astrofis Canarias, E-38200 Tenerife, Spain. RP Lopez-Ruiz, R, Univ Zaragoza, DIIS, E-50009 Zaragoza, Spain. EM rilopez@unizar.es jsr@unex.es xcalbet@googlemail.es CR CALBET X, 2007, PHYSICA A, V382, P523, DOI 10.1016/j.physa.2007.04.005 HUANG K, 1987, STAT MECH LOPEZRUIZ R, 2007, AM J PHYS, V75, P752, DOI 10.1119/1.2737472 SINAI YG, 1963, SOV MATH DOKL, V4, P1818 YAKOVENKO VM, 2009, ENCY COMPLEXITY SYST NR 5 TC 0 PU AMER ASSOC PHYSICS TEACHERS AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0002-9505 J9 AMER J PHYS JI Am. J. Phys. PD AUG PY 2008 VL 76 IS 8 BP 780 EP 781 DI 10.1119/1.2907776 PG 2 SC Education, Scientific Disciplines; Physics, Multidisciplinary GA 327YQ UT ISI:000257764800012 ER PT J AU Vaquero, JM Trigo, RM AF Vaquero, Jose M. Trigo, Ricardo M. TI Can the Solar Cycle Amplitude be predicted using the preceding Solar Cycle Length? SO SOLAR PHYSICS LA English DT Article ID GROUP SUNSPOT NUMBERS; ACTIVITY RECONSTRUCTION; LOST; ENVIRONMENT; CLIMATE AB In this work, the evolution of the relationship between Solar Cycle Length of solar cycle n (SCLn ) and Solar Cycle Amplitude of the solar cycle n+1 (SCA(n+1)) is studied by using the R-Z and R-G sunspot numbers. We conclude that this relationship is only strongly significant in a statistical sense during the first half of the historical record of R-Z sunspot number whereas it is considerably less significant for the R-G sunspot number. In this sense we assert that these simple lagged relationships should be avoided as a valid method to predict the following solar activity amplitude. C1 [Vaquero, Jose M.] Univ Extremadura, Dept Fis Aplicada, Escuela Politecn, Caceres, Spain. [Trigo, Ricardo M.] Univ Lisbon, Ctr Geofis, Inst Geofis Infante D Luiz, Dept Engn & Ciencias Nat, P-1699 Lisbon, Portugal. RP Vaquero, JM, Univ Extremadura, Dept Fis Aplicada, Escuela Politecn, Caceres, Spain. 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Phys. PD JUL PY 2008 VL 250 IS 1 BP 199 EP 206 DI 10.1007/s11207-008-9211-y PG 8 SC Astronomy & Astrophysics GA 328DI UT ISI:000257777400014 ER PT J AU Mayoral, JM Segura, AS AF Monterrey Mayoral, Juan Sanchez Segura, Amparo TI Corporate Governance, agency conflicts and auditor choice SO REVISTA ESPANOLA DE FINANCIACION Y CONTABILIDAD-SPANISH JOURNAL OF FINANCE AND ACCOUNTING LA Spanish DT Article DE auditing; Corporate Governance; agency conflicts ID INITIAL PUBLIC OFFERINGS; EARNINGS MANAGEMENT; BOARD CHARACTERISTICS; LEGAL LIABILITY; FIRM; COMMITTEE; QUALITY; INDEPENDENCE; INFORMATION; REPUTATION AB This paper analyzes the factors driving auditor choice in Spanish listed companies. Besides complexity and size of the audited company, there are other reasons explaining the profile of the auditing firm chosen, such as the need to disclose among market participants accounting information endorsed by a reputed auditor, or the desire to mitigate existing agency conflicts. Our analysis focuses primarily on the latter, as well as on the analysis of the impact of Corporate Governance practices -re-garding the size, composition and activity of the Board and the Audit Committee-, on the decision to hire a quality and highly reputed auditor. We find evidence that the demand for quality auditors is explained not only by the desire to mitigate potential agency conflicts and avoid associated costs, but also in terms of the adoption of Corporate Governance good practices, an issue ignored by previous studies. Leverage, the existence of shareholders with a significant share and accounting discretion appear as the main factors driving the choice of a reputed auditor in order to mitigate agency conflicts. On the other hand, the degree of independence and activity of the members of the Board and Audit Committee, and the size of Audit Committee, appear to be relevant explanatory factors. Our results are robust after controlling for other factors and corporate characteristics that could potentially drive auditor choice and, are not affected by endogendity problems. C1 [Monterrey Mayoral, Juan] Univ Extremadura, Fac Ciencias Econ & Empresariales, E-06071 Badajoz, Spain. RP Mayoral, JM, Univ Extremadura, Fac Ciencias Econ & Empresariales, Ave Elvas,S-N, E-06071 Badajoz, Spain. 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Esp. Financ. Contab. PD JAN-MAR PY 2008 VL 37 IS 137 BP 113 EP 135 PG 23 SC Business, Finance GA 325OX UT ISI:000257599300006 ER PT J AU Gonzalez, I Penas-Lledo, EM Perez, B Dorado, P Alvarez, M LLerena, A AF Gonzalez, Idilio Penas-Lledo, Eva M. Perez, Barbaro Dorado, Pedro Alvarez, Mayra LLerena, Adrian TI Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers SO PHARMACOGENOMICS LA English DT Article DE anxiety; CYP2D6; debrisoquine; KSP; personality; pharmacogenetics; pharmacogenomics ID DEBRISOQUINE HYDROXYLATION POLYMORPHISM; CYTOCHROME-P450 2D6; GENETIC-POLYMORPHISM; TRAITS; ASSOCIATION; SEROTONIN; PHARMACOKINETICS; PERPHENAZINE; METABOLIZERS; SENSITIVITY AB Objectives: Our group has previously show that interindividual variability in CYP2D6 hydroxylation capacity was related to personality differences in cognitive social anxiety. Thus, we aimed to analyze whether this relationship between personality and CYP2D6 phenotype and genotype was found in a similar population of healthy volunteers from a different latitude and culture by using the same methodology. Methods: A total of 253 university students and staff from Havana Psychiatric Hospital and Calixto Garcia Medical School in Cuba completed the Karolinska Scales of Personality (KSP), and were evaluated on debrisoquine hydroxylation capacity and C`YP2D6 genotypes. KSP scores were compared between four groups, divided according to their CYP2D6 metabolic capacity: one of poor and three of extensive metabolizers. Furthermore, KSP scores were compared between another four different groups divided according to their number of CYP2D6 active genes: zero, one, two, and more than two. Results: In Cubans, the differences in cognitive social anxiety-related personality traits across the four CYP2D6 hydroxylation capacity groups were strikingly similar to those found in Spaniards. These differences also came out to be significant for psychic anxiety (p = 0.02) and socialization (p = 0.02). The same pattern of results obtained for the subscales of psychic anxiety, socialization, psychasthenia and inhibition of aggression with regard to phenotype in both the Cuban and Spanish studies were seen with regard to CYP2D6 genotypes. Conclusions: Corroborating these results further strengthens evidence of the relationship between CYP2D6 metabolic capacity and personality. In this population of healthy Cuban volunteers, the CYP2D6 hydroxylation capacity was related to the degree of anxiety and socialization. These results support the postulated reduction of serotonin in CYP2D6 poor metabolizers, which may be associated with a cluster of behavioral traits (e.g., anxiety, impulsivity). Thus, research is warranted to determine CYP2D6 functional implications for interindividual differences in vulnerability to neuropsychiatric diseases and drug response. C1 [Gonzalez, Idilio; Penas-Lledo, Eva M.; Alvarez, Mayra; LLerena, Adrian] Univ Extremadura, Fac Med, E-06080 Badajoz, Spain. [Gonzalez, Idilio; Penas-Lledo, Eva M.; Alvarez, Mayra; LLerena, Adrian] Hosp Infanta Cristina, Clin Res Ctr CICAB, E-06080 Badajoz, Spain. RP LLerena, A, Univ Extremadura, Fac Med, Serv Extremeno Salud Avda Elvas S-N, E-06080 Badajoz, Spain. 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Aguilar, Manuel A. Martin, M. Elena TI Retinal models: Comparison of electronic absorption spectra in the gas phase and in methanol solution SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID SOLVENT ELECTROSTATIC POTENTIALS; MEAN-FIELD APPROXIMATION; ENERGY GRADIENT-METHOD; MOLECULAR-DYNAMICS SIMULATION; TRANSITION-STATE OPTIMIZATION; RHODOPSIN CHROMOPHORE; AQUEOUS-SOLUTION; SELF-CONSISTENT; WATER; ACROLEIN AB An accurate study on several models of the 11-cis-retinal protonated Schiff base (PSB) has been performed both in vacuo and in methanol solution. Condensed phase calculations have been carried out making use of the ASEP/MD method, which permits the employment of the same high-level ab initio calculations usually applied in gas phase studies as well as a detailed description of the solvent structure around the solute through molecular dynamics simulations of the complete system. The solute structure was completely optimized in vacuo and in solution at the CASSCF level and/or MP2 level, and the CASPT2 method was applied for the calculation of the vertical transition energies and solvent shift values. Our results reproduce and explain the main features of the experimental absorption spectra of the 11-cis-retinal PSB. Two well-resolved bands can be identified in vacuo (separated by roughly 1.0 eV), whereas only a single broad band is observed in solution. This fact is explained by the existence of two almost degenerate excited states in methanol. The inclusion of two methyl groups at the iminium end of the system permits the reproduction of the experimental solvent shift value. C1 [Munoz-Losa, Aurora; Galvan, Ignacio Fdez.; Aguilar, Manuel A.; Martin, M. Elena] Univ Extremadura, E-06071 Badajoz, Spain. RP Martin, ME, Univ Extremadura, Ave Elvas S-N, E-06071 Badajoz, Spain. 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Phys. Chem. B PD JUL 24 PY 2008 VL 112 IS 29 BP 8815 EP 8823 DI 10.1021/jp800244h PG 9 SC Chemistry, Physical GA 327IY UT ISI:000257724000054 ER PT J AU Munoz-Losa, A Curutchet, C Galvan, IF Mennucci, B AF Munoz-Losa, A. Curutchet, C. Fdez Galvan, I. Mennucci, B. TI Quantum mechanical methods applied to excitation energy transfer: A comparative analysis on excitation energies and electronic couplings SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID ALPHA-84 PHYCOCYANOBILIN CHROMOPHORE; SOLVATED BICHROMOPHORIC SYSTEMS; MOLECULAR SCALE INTERPRETATION; PHOTOSYNTHETIC REACTION-CENTER; 2ND-ORDER PERTURBATION-THEORY; LIGHT-HARVESTING COMPLEX; DENSITY CUBE METHOD; EXCITED-STATES; THROUGH-BOND; FORSTER THEORY AB We present a comparative study on the influence of the quantum mechanical (QM) method (including basis set) on the evaluation of transition energies, transition densities and dipoles, and excitation energy transfer (EET) electronic couplings for a series of chromophores (and the corresponding pairs) typically found in organic electro-optical devices and photosynthetic systems. On these systems we have applied five different QM levels of description of increasing accuracy (ZINDO, CIS, TD-DFT, CASSCF, and SAC-CI). In addition, we have tested the effects of a surrounding environment (either mimicking a solvent or a protein matrix) on excitation energies, transition dipoles, and electronic couplings through the polarizable continuum model (PCM) description. Overall, the results obtained suggest that the choice of the QM level of theory affects the electronic couplings much less than it affects excitation energies. We conclude that reasonable estimates can be obtained using moderate basis sets and inexpensive methods such as configuration interaction of single excitations or time-dependent density functional theory when appropriately coupled to realistic solvation models such as PCM. (C) 2008 American Institute of Physics. C1 [Munoz-Losa, A.; Mennucci, B.] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy. [Curutchet, C.] Univ Parma, Dipartimento Chim Gen & Inorgan, I-43100 Parma, Italy. [Fdez Galvan, I.] Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. RP Munoz-Losa, A, Univ Pisa, Dipartimento Chim & Chim Ind, Via Risorgimento 35, I-56126 Pisa, Italy. 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Chem. Phys. PD JUL 21 PY 2008 VL 129 IS 3 AR 034104 DI 10.1063/1.2953716 PG 16 SC Physics, Atomic, Molecular & Chemical GA 329BA UT ISI:000257840700004 ER PT J AU Vaquero, JM Moreno-Corral, MA AF Vaquero, J. M. Moreno-Corral, M. A. TI Historical sunspot records from Mexico SO GEOFISICA INTERNACIONAL LA English DT Article DE historical records; sunspot observation; solar activity; Mexico ID SOLAR-ACTIVITY AB The historical reconstruction of solar activity is a task of great interest for geophysicists and solar physicists. Historical sunspot observations are a fundamental tool for this task. In this short contribution, we present some historical sunspot observations in Mexico. C1 [Vaquero, J. M.] Univ Extremadura, Dept Fis Aplicada, Caceres, Spain. [Moreno-Corral, M. A.] Univ Nacl Autonoma Mexico, Inst Astron, Mexico City 04510, DF, Mexico. RP Vaquero, JM, Univ Extremadura, Dept Fis Aplicada, Caceres, Spain. EM jvaquero@unex.es mam@astrosen.unam.mx CR CLETTE F, 2007, ADV SPACE RES, V40, P919, DOI 10.1016/j.asr.2006.12.045 CORRAL MAM, 1999, B SOCIEDAD MEXICANA, V13, P71 GONGORA CSY, 1690, LIBRA ASTRONOMICA FI GONGORA CSY, 1986, ALBOROTO MOTIN INDIO HOYT DV, 1998, SOL PHYS, V181, P491 MCKINNON JA, 1986, UAG95 WDC A MORENOCORRAL MA, 1986, QUIPU, V3, P299 MORENOCORRAL MA, 2003, STERNE WELTRAUM, V42, P44 SALADINO A, 1990, CIENTIFICOS ILUSTRAC TREJO JG, 2005, P IAU C, V196, P124 USOSKIN IG, 2004, SOL PHYS, V224, P37, DOI 10.1007/s11207-005-3997-7 VAQUERO JM, 2004, SOL PHYS, V219, P379 VAQUERO JM, 2007, ADV SPACE RES, V40, P929, DOI 10.1016/j.asr.2007.01.087 VAQUERO JM, 2007, SOL PHYS, V240, P165, DOI 10.1007/s11207-006-0264-5 WALDMEIER M, 1961, SUNSPOT ACTIVITY YEA NR 15 TC 0 PU INST GEOPHYSICS UNAM PI MEXICO PA APDO POSTAL 22-118, DEL TLALPAN, MEXICO, 14000 D F, MEXICO SN 0016-7169 J9 GEOFIS INT JI Geofis. Int. PD JUL-SEP PY 2008 VL 47 IS 3 BP 189 EP 192 PG 4 SC Geochemistry & Geophysics GA 326QE UT ISI:000257673200008 ER PT J AU Ramirez, MR Cava, R AF Ramirez, M. R. Cava, R. TI Changes in fatty acid composition of two muscles from three different Iberian x Duroc genotypes after refrigerated storage SO FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL LA English DT Article DE fatty acids; lipolysis; genotype; storage; pork meat; Iberian pig; Duroc line ID DRY-CURED HAM; MEAT QUALITY; INTRAMUSCULAR LIPIDS; ENZYME-ACTIVITIES; METABOLIC TYPE; PORK MEAT; PIGS; STABILITY; LIPOLYSIS; PRODUCTS AB The changes of the fatty acid ( FA) profile of 2 muscles Longissimus dorsi and Biceps femoris from 3 Iberian x Duroc genotypes were studied: GEN1: male Iberian x female Duroc1, GEN2: male Duroc1 x female Iberian; GEN3: male Duroc2 x female Iberian. GEN1 and GEN2 are reciprocal crosses while the difference between GEN2 and GEN3 is the Duroc sire line. The genotype Duroc1 was selected for the production of dry- cured meat products while the genotype Duroc2 was selected for meat production. Longissimus dorsi and Biceps femoris BF from the reciprocal cross showed similar changes in FAs profile after refrigerated storage. However, the Duroc sire line affected the FA profiles of intramuscular fat (IMF) and lipid fractions since some differences were found between GEN2 and GEN3. Meat from GEN3 had the highest level of polyunsaturated fatty acids (PUFA) in IMF and lipid fractions as well as the lowest rate of plasmalogens in polar lipid fraction. After storage, meat from GEN3 showed an increase of long chain PUFA in free fatty acids fraction and the highest increase in the ratio DMA/FA [(dimethylacetals/FAs) x 100] after the refrigerated storage, which was indicative of a higher deterioration of this genotype. Therefore, the crossbreeding of Iberian pigs with Duroc selected genotypes (Duroc2) could affect the changes in the FAs profile of meat under refrigerated storage. C1 [Ramirez, M. R.; Cava, R.] Univ Extremadura, Fac Vet, Dpto Tecnol Alimentos, Caceres 10071, Spain. RP Cava, R, Univ Extremadura, Fac Vet, Dpto Tecnol Alimentos, Avda Univ S-N, Caceres 10071, Spain. 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Technol. Int. PD APR PY 2008 VL 14 IS 2 BP 127 EP 137 DI 10.1177/1082013208091989 PG 11 SC Chemistry, Applied; Food Science & Technology GA 327SP UT ISI:000257749100002 ER PT J AU Carretero, M Montanero, M AF Carretero, Mario Montanero, Manuel TI Teaching and learning history: Cognitive and cultural aspects SO CULTURA Y EDUCACION LA Spanish DT Article DE history education; teaching to think historically; collective memory AB The introductory paper presents this monographic issue titled: Teaching and learning History: Cognitive and cultural aspects. In the first four sections, the current significance of the subject is justified and the contents of the monographic issue are introduced. They are organised around two important dimensions of History education: cognitive and cultural Regarding the cognitive dimension, the scope of the skills and didactic resources involved in learning to think historically are outlined. With respect to the cultural dimension, we analyse why formal history education continues to be closely linked to the construction of identity and transmission of collective memory. In the last section, the aims of the present monographic issue dealing with these two dimensions of History education are described, as well as bow the different papers are organised. C1 [Montanero, Manuel] Univ Extremadura, Fac Educ, E-06071 Badajoz, Spain. RP Carretero, M, Univ Autonoma Madrid, Fac Psicol, E-28049 Madrid, Spain. 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Educ. PD JUN PY 2008 VL 20 IS 2 BP 133 EP 142 PG 10 SC Education & Educational Research GA 329JN UT ISI:000257864000001 ER PT J AU Montanero, M Lucero, M Mendez, JM AF Montanero, Manuel Lucero, Manuel Mendez, Jose M. TI Historical causality in Secondary School teachers' explanations SO CULTURA Y EDUCACION LA Spanish DT Article DE causality; historical explanation; discourse analysis; Secondary Education AB The paper reports two studies analysing various aspects related to the function of historical causality in the explanations of Secondary School teachers. The first study is based on a survey of 54 History teachers. Around 15% of the survey results fits a teaching profile that assigns great importance to students' understanding of causal relations between historical events. The type of activity most frequently carried out by the teachers in this group is to explain historical facts, while students take notes. The great majority makes little use of textbooks, but they tend to introduce more practical activities in their classes than the rest of the teachers. Some strategies the teachers use to support students' understanding are to ask them to explain the reasons underlying the historical events they are studying, However, only part of the teachers preferentially uses graphic representations of causal relations. In the second study, we recorded and analysed two types of experienced teachers that fitted a "causal" profile. Class explanations presented a preponderance of causal-structural relations with verbal support, centred in the most complicated relations. However, teachers did not manage some aspects of students' participation as they had claimed in the survey. The students collaborated 4 clarifying and even extending the information about some concepts and ideas, but they did not verbalise causal reasoning. C1 [Montanero, Manuel] Univ Extremadura, Fac Educ, E-06071 Badajoz, Spain. RP Montanero, M, Univ Extremadura, Fac Educ, E-06071 Badajoz, Spain. EM mmontane@unex.es CR ACHUGAR M, 2005, LINGUISTICS ED, V16, P298 BRAUDEL F, 1968, HIST CIENCIAS SOCIAL CARRETERO M, 2002, CONSTRUIR ENSENAR CI CARRETERO M, 2004, APRENDER PENSAR HIST DUTHIE J, 1986, HIST SOCIAL SCI TEAC, V21, P232 EVANS RJ, 2000, DEFENSE HIST GRAESSER AC, 1985, UNDERSTANDING EXPOSI, P363 HALLDEN O, 1986, OXFORD REV EDUC, V12, P53 LEINHARDT G, 1993, BRIT J EDUC PSYCHOL, V63, P46 MASTERMAN L, 2002, COMPUT EDUC, V38, P165 PERFETTI CA, 1995, TEXT BASED LEARNING SANCHEZ E, 1999, TEACH TEACH EDUC, V15, P37 TOPOLSKI J, 2004, APRENDER PENSAR HIST, P101 TOPOLSKY J, 1991, HIST THEORY, V30, P324 VOSS JF, 1994, COGNITIVE INSTRUCTIO, P403 VOSS JF, 1997, INT J ED RES, V27, P255 NR 16 TC 0 PU FUNDACION INFANCIA APRENDIZAJE PI MADRID PA NARANJO DE BULNES, 69 CIUDALCAMPO, SAN SEBASTIAN DE LOS REYES, MADRID, 28707, SPAIN SN 1135-6405 J9 CULT EDUC JI Cult. Educ. PD JUN PY 2008 VL 20 IS 2 BP 161 EP 179 PG 19 SC Education & Educational Research GA 329JN UT ISI:000257864000003 ER PT J AU Valverde, J AF Valverde, Jesus TI Learning to think historically with information technology supports SO CULTURA Y EDUCACION LA Spanish DT Article DE educational simulation; new educational and informational technologies; history teaching; history learning ID VIGNETTES AB This paper demonstrates bow different information technology supports (simulations, virtual realities, videogames or interactive webs) might facilitate the development of key historical concepts such as signification, cause-effect change and continuity, evidence or report, The objective is therefore to diversify the material and resources available to History students in order to (a) increase the Possibilities of experimentation with historical events, and (h) to make possible the real and direct manipulation of space/time variables. C1 Univ Extremadura, Fac Formac Prof, Caceres 10071, Spain. RP Valverde, J, Univ Extremadura, Fac Formac Prof, Av Univ S-N, Caceres 10071, Spain. 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Educ. PD JUN PY 2008 VL 20 IS 2 BP 181 EP 199 PG 19 SC Education & Educational Research GA 329JN UT ISI:000257864000004 ER PT C AU Gomez, MA Lorenzo, A Sampaio, J Ibanez, SJ Ortega, E AF Angel Gomez, Miguel Lorenzo, Alberto Sampaio, Jaime Jose Ibanez, Sergio Ortega, Enrique TI Game-related statistics that discriminated winning and losing teams from the Spanish men's professional basketball teams SO COLLEGIUM ANTROPOLOGICUM LA English DT Proceedings Paper DE basketball; discriminant analysis; game-related statistics ID QUALITY EVALUATION; PERFORMANCE; CRITERIA; PLAYERS; POSITIONS; HANDBALL; CENTERS; SYSTEM; LEVEL AB The purpose of the present study was to analyse men's basketball competitions, trying to identify which game-related statistics allow to discriminate winning and losing teams. The sample used corresponded to 306 games from the 20042005 Regular Season of the Spanish Men's Professional League. The game-related statistics gathered were: 2 and 3 points field-goals (both successful and unsuccessful), free-throws (both successful and unsuccessful), offensive and defensive rebounds, blocks, assists, fouls, turnovers and steals. The data were analysed in two groups: balanced games (final score differences equal or below 12 points) and unbalanced games (final score differences above 12 points). Discriminant analysis allowed to conclude the following: (i) in balanced games, the variable that best differentiate both groups were the defensive rebounds; (ii) in unbalanced games, the variables that discriminate between both groups were the successful 2 points field-goals, the defensive rebounds and the assists; and (iii) in all games, the statistical analysis identified two variables that discriminate winning and losing teams (defensive rebounds and assists). The defensive rebounds were the only game-related statistic that discriminates both groups in all performed analysis. Coaches and players should be aware of these different profiles in order to increase knowledge about game cognitive and motor solicitation and, therefore, to enhance specificity at the time of practice and game planning. C1 [Angel Gomez, Miguel; Lorenzo, Alberto] Tech Univ Madrid, Fac Phys Activ & Sport Sci, Madrid 28040, Spain. [Jose Ibanez, Sergio] Univ Extremadura, Fac Sport Sci, Caceres, Spain. [Ortega, Enrique] Catholic Univ St Anthony, Dept Phys Activ & Sport Sci, Murcia, Spain. RP Gomez, MA, Tech Univ Madrid, Fac Phys Activ & Sport Sci, Martin Fierro S-N, Madrid 28040, Spain. 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Anthropol. PD JUN PY 2008 VL 32 IS 2 BP 451 EP 456 PG 6 SC Anthropology GA 329FD UT ISI:000257851400019 ER PT J AU Ahmad, A Kabir, MA Kravets, A Andaluz, E Larriba, G Rustchenko, E AF Ahmad, Ausaf Kabir, M. Anaul Kravets, Anatoliy Andaluz, Encamacion Larriba, German Rustchenko, Elena TI Chromosome instability and unusual features of some widely used strains of Candida albicans SO YEAST LA English DT Article DE C. albicans; chromosome instability; fragmentation; strain SC5314; CAI4; CAF4-2; BWP17 ID SACCHAROMYCES-CEREVISIAE; GENE; MUTANTS; SORBOSE; YEAST; TRANSFORMATION; FRAGMENTATION; CONSTRUCTION; ANEUPLOIDY; GAIN AB Electrophoretic karyotyping of the Candida albicans revealed a different migration pattern of ChR in three different stocks of the sequencing strain SC5314. In one stock, the high instability of CbR size prevented the migration of ChR as a compact band; CbR appeared, instead, as a smear. In some stocks, ChR and/or Ch1 ploidy diminished, suggesting mixed populations of disomic and monosomic cells. Similarly, some stocks of widely used derivatives CAI4 and BWP17 contained smearing of ChR. In addition, the most manipulated strain in the lineage of SC5314, the last derivative, BWP17, acquired an increase in the size of Ch7b and revealed an unusual property. BWP17 did not tolerate a well-established procedure of telomere-mediated fragmentation of a chromosome; the remaining intact homologue always duplicated. We suggest that some stocks of SC5314 are unstable and that BWP17 may not be appropriate for general studies. Instead of BWP17 or CAI4, we recommend using for general research CAF4-2, which is a relatively stable Ura(-) derivative, and which has been successfully used for more than a decade in our laboratory. Copyright (D 2008 John Wiley & Sons, Ltd. C1 [Ahmad, Ausaf; Kravets, Anatoliy; Rustchenko, Elena] Univ Rochester, Dept Biochem & Biophys, Med Ctr, Rochester, NY 14642 USA. [Kabir, M. Anaul] PA Coll Engn, Dept Biotechnol, Mangalore 574153, Karnataka, India. [Andaluz, Encamacion; Larriba, German] Univ Extremadura, Fac Ciencias, Dept Microbiol, E-06071 Badajoz, Spain. RP Rustchenko, E, Univ Rochester, Dept Biochem & Biophys, Med Ctr, Box 712, Rochester, NY 14642 USA. 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Real, Francisco J. Benitez, E. Javier Gonzalez, Antonio TI Oxidation of chlorfenvinphos in ultrapure and natural waters by ozonation and photochemical processes SO WATER RESEARCH LA English DT Article DE chlorfenvinphos; ozone; UV radiation; advanced oxidation processes; hydroxyl radicals; rate constants; quantum yields; natural waters ID AQUEOUS PESTICIDE DEGRADATION; DRINKING-WATER; RATE CONSTANTS; HYDROXYL RADICALS; PART I; OZONE; KINETICS; ORGANOPHOSPHORUS; PHARMACEUTICALS; DECOMPOSITION AB The chemical oxidation of the organophosphorus insecticide chlorfenvinphos, a priority pollutant in aquatic environments, has been conducted in ultrapure water, by means of single degradation agents (ozone and UV radiation), and by the Advanced Oxidation Processes constituted by combinations of these oxidants (O-3/H2O2 and UV/H2O2). The influence of the operating variables was discussed, and the degradation rates were evaluated by determining the rate constants for the reactions with ozone (k(O3) = 3.7 +/- 0.2 L mol(-1) s(-1)) and CH radicals (k(OH) = (3.2 +/- 0.2) x 10(9) L mol(-1) s(-1)), as well as the quantum yield for the photodegradation (around 0.1mol E-1, depending on the pH). Additionally, the ozonation of chlorfenvinphos in a natural water system (a surface water from a reservoir) was studied. The influence of the operating conditions on the insecticide removal efficiency was established, and the R-ct parameter was evaluated. A kinetic model was proposed for the prediction of the elimination rate of chlorfenvinphos in the ozonation process and the results obtained reveal a good agreement between experimental results and predicted values. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Acero, Juan L.; Real, Francisco J.; Benitez, E. Javier; Gonzalez, Antonio] Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. RP Acero, JL, Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. 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PD JUN PY 2008 VL 42 IS 12 BP 3198 EP 3206 DI 10.1016/j.watres.2008.03.016 PG 9 SC Engineering, Environmental; Environmental Sciences; Water Resources GA 326HL UT ISI:000257649100037 ER PT J AU Grau, R Albarracin, W Toldra, F Antequera, T Barat, JM AF Grau, Raul Albarracin, William Toldra, Fidel Antequera, Teresa Barat, Jose M. TI Study of salting and post-salting stages of fresh and thawed Iberian hams SO MEAT SCIENCE LA English DT Article DE Iberian hams; salting; post-salting; thawing; mass transfer ID DRY-CURED HAM; BRINE THAWING/SALTING OPERATION; SODIUM-CHLORIDE; PORK; TEMPERATURE; PROTEOLYSIS; DIFFUSION; MEAT AB Fresh raw material has been traditionally used to obtain dry-cured Iberian ham, although the use of thawed raw material is increasing. This type of raw material has been previously studied for dry-cured production employing White pigs, where the salting time has been reduced to reach similar NaCl concentrations. The aim of this work was the analysis of salting and post-salting stages of Iberian hams, employing fresh or thawed raw materials. The results showed that fresh Iberian hams had higher salt concentrations than thawed Iberian hams for the salting time ratio used, a ratio established to reduce the freezing/thawing effect that was previously observed working with White ham. This fact shows that the Iberian raw material in dry-cured ham manufacturing is less affected, by the freezing/thawing process than the White raw material. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Grau, Raul; Albarracin, William; Barat, Jose M.] Univ Politecn Valencia, Inst Ingn Alimentos Desarrollo, Dept Technol Alimentos, E-46071 Valencia, Spain. [Toldra, Fidel] Inst Agroquim & Tecnol Alimentos, Valencia, Spain. [Antequera, Teresa] Univ Extremadura, Unidad Tcenol Alimentos, Dept Zootecnia, Caceres, Spain. RP Grau, R, Univ Politecn Valencia, Inst Ingn Alimentos Desarrollo, Dept Technol Alimentos, E-46071 Valencia, Spain. 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PD AUG PY 2008 VL 79 IS 4 BP 677 EP 682 DI 10.1016/j.meatsci.2007.10.034 PG 6 SC Food Science & Technology GA 326DR UT ISI:000257638800008 ER PT J AU Santa-Catalina, MO Garcia-Martin, LJ Bragado, MJ AF Olivera Santa-Catalina, Marta Jesus Garcia-Martin, Luis Julia Bragado, Maria TI Lovastatin effect in rat neuroblasts of the CNS: inhibition of cap-dependent translation SO JOURNAL OF NEUROCHEMISTRY LA English DT Article DE eukaryotic translation initiation factor 4E-binding protein 1; eIF4G; lovastatin; neuroblasts; translation ID LOCAL PROTEIN-SYNTHESIS; INITIATION-FACTOR MODIFICATIONS; SMOOTH-MUSCLE-CELLS; SYNAPTIC PLASTICITY; BRAIN NEUROBLASTS; INDUCED APOPTOSIS; PHAS-I; MEVALONATE PATHWAY; KINASE PATHWAY; FACTOR 4G AB Mevalonate biosynthesis pathway is important in cell growth and survival and its blockade by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors, statins, arrest brain neuroblasts growth and induce apoptosis. Translation is among the main biochemical mechanisms that controls gene expression and therefore cell growth or apoptosis. In the CNS, translation regulates synaptic plasticity. Thus, our aim was to investigate the effect of lovastatin in protein translation in rat neuroblasts of the CNS and the biochemical pathways involved. Lovastatin treatment in rat brain neuroblasts causes a significant time- and concentration-inhibition of protein synthesis, which is partially mediated by phosphatydilinositol 3-kinase/mammalian target of rapamycin (mTOR) pathway inhibition. Lovastatin treatment decreases the phosphorylation state of mTOR substrates, p70S6K and eukaryotic translation initiation factor (eIF) 4E-binding protein 1 and simultaneously increases eIF4E-binding protein 1 in a time-dependent manner. Concomitantly, lovastatin causes a decrease in eIF4G cellular amount, which is partially mediated by caspase(s) activity excluding caspase 3. These biochemical pathways affected by lovastatin might explain the protein translation inhibition observed in neuroblasts. Cycloheximide treatment, which blocked protein synthesis, does not induce neuroblasts apoptosis. Therefore, we suggest that lovastatin-induced protein synthesis inhibition might not contribute to the concomitant neuroblasts apoptosis previously observed. C1 [Olivera Santa-Catalina, Marta; Julia Bragado, Maria] Dept Biochem Mol Biol & Genet, Res Grp Intracellular Signalling & Technol Reprod, Caceres 10071, Spain. [Jesus Garcia-Martin, Luis] Univ Extremadura, Res Grp Intracellular Signalling & Technol Reprod, Dept Physiol, Caceres 10071, Spain. RP Bragado, MJ, Dept Biochem Mol Biol & Genet, Res Grp Intracellular Signalling & Technol Reprod, Caceres 10071, Spain. 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Neurochem. PD AUG PY 2008 VL 106 IS 3 BP 1078 EP 1091 DI 10.1111/j.1471-4159.2008.05458.x PG 14 SC Biochemistry & Molecular Biology; Neurosciences GA 327CV UT ISI:000257708100009 ER PT J AU Rodriguez, PB Tome, FV Lozano, JC Perez-Fernandez, MA AF Rodriguez, P. Blanco Tome, F. Vera Lozano, J. C. Perez-Fernandez, M. A. TI Influence of soil texture on the distribution and availability of U-238, Th-230, and Ra-226 in soils SO JOURNAL OF ENVIRONMENTAL RADIOACTIVITY LA English DT Article DE uranium; thorium; radium; soil texture; labile activity ID PLANT TRANSFER-FACTORS; SEQUENTIAL EXTRACTION; NATURAL RADIONUCLIDES; PARTICLE-SIZE; SOUTH-WEST; URANIUM; THORIUM; AREA; BIOAVAILABILITY; FRACTIONATION AB The influence of soil texture on the distribution and availability of U-238, Th-230, and Ra-226 in soils was Studied in soil samples collected at a rehabilitated uranium mine located in the Extremadura region in south-west Spain. The activity concentration (Bq kg(-1)) in the soils ranged from 60 to 750 for U-238, from 60 to 260 for Th-230, and from 70 to 330 for Ra-226. The radionuclide distribution was determined in three soil fractions: coarse sand (0.5-2 mm), medium-fine sand (0.067-0.5 mm), and silt and clay (<0.067 mm). The relative mobility of the natural radionuclides in the different fractions was studied by comparison of the activity ratios between radionuclides belonging to the same radioactive series. The lability of these radionuclides in each fraction was also studied through selective extraction from the soils using a one-step sequential extraction scheme. Significant correlations were found for U-238, Th-230, and Ra-226 between the activity concentration per fraction and the total activity concentration in the bulk soil. Thus, from the determination of the activity concentration in the bulk soil, one could estimate the activity concentration in each fraction. Correlations were also found for U-238 and Ra-226 between the labile activity concentration in each fraction and the total activity concentration in bulk soil. Assuming that there is some particle-size fraction that predominates in the process of soil-to-plant transfer, the parameters obtained in this study should be used as correction factors for the transfer factors determined from the bulk soil in previous Studies. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Tome, F. Vera] Univ Extremadura, Fac Ciencias, Dept Fis Aplicada, E-06071 Badajoz, Spain. [Rodriguez, P. Blanco] Univ Extremadura, Fac Ciencias, Dept Fis, E-06071 Badajoz, Spain. [Lozano, J. C.] Univ Salamanca, Fac Ciencias, Lab Radioactividad Ambeintal, E-37008 Salamanca, Spain. [Perez-Fernandez, M. A.] Univ Pablo Olavide, Area Ecol, Seville 41013, Spain. RP Tome, FV, Univ Extremadura, Fac Ciencias, Dept Fis Aplicada, Avd Elvas S-N, E-06071 Badajoz, Spain. EM fvt@unex.es CR *DGT RES LTD, 2001, US GUID DGT TECHN *ENRESA, 1993, PC151DRGXX01 ENRESA *NRCS, 2007, NAT SOIL SURV HDB TI BAEZA A, 2006, APPL RADIAT ISOTOPES, V64, P1020, DOI 10.1016/j.apradiso.2006.04.003 BLANCO P, 2002, APPL RADIAT ISOTOPES, V57, P785 BLANCO P, 2005, J ENVIRON RADIOACTIV, V79, P315, DOI 10.1016/j.jenvard.2004.08.006 CARRETERO G, 2001, P J SOBR REST ANT EX ECHEVARRIA G, 2001, J ENVIRON RADIOACTIV, V53, P257 FRINDIK O, 1999, J RADIOANAL NUCL CH, V241, P291 HALLSTADIUS L, 1984, NUCL INSTRUM METH A, V223, P266 JIANG FS, 1986, J RADIOAN NUCL CH AR, V100, P65 KINGSTON HM, 1997, MICROWAVE ENHANCED C LIVENS FR, 1988, SCI TOTAL ENVIRON, V70, P1 LOZANO JC, 2001, RADIOCHIM ACTA, V89, P633 PEREZFERNANDEZ MA, EUR J SOIL BIO UNPUB QUEVAUVILLER P, 1993, INT J ENVIRON AN CH, V51, P231 RADHAKRISHNA AP, 1996, J ENVIRON RADIOACTIV, V30, P31 RIDDLE C, 1993, ANAL GEOLOGICAL MAT RODRIGUEZ PB, 2006, SCI TOTAL ENVIRON, V361, P1, DOI 10.1016/j.scitotenv.2005.08.020 SCHULTZ MK, 1998, APPL RADIAT ISOTOPES, V49, P1289 TOME FV, 2002, J ENVIRON RADIOACTIV, V59, P41 TOME FV, 2003, J ENVIRON RADIOACTIV, V65, P161, DOI 10.1016/S0265-931X(02)00094-2 VANDENHOVE H, 2007, CHEMOSPHERE, V69, P664, DOI 10.1016/j.chemosphere.2007.02.054 VANDENHOVE H, 2007, ENVIRON POLLUT, V145, P587, DOI 10.1016/j.envpol.2006.04.011 VANDENHOVE H, 2007, SCI TOTAL ENVIRON, V373, P542, DOI 10.1016/j.scitotenv.2006.12.023 VERATOME F, 1994, NUCL INSTRUM METH A, V348, P183 NR 26 TC 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0265-931X J9 J ENVIRON RADIOACT JI J. Environ. Radioact. PD AUG PY 2008 VL 99 IS 8 BP 1247 EP 1254 DI 10.1016/j.jenvrad.2008.03,004 PG 8 SC Environmental Sciences GA 327IH UT ISI:000257722300006 ER PT J AU Mata, A Marques, D Martinez-Burgos, MA Silveira, J Marques, J Mesquita, MF Pariente, JA Salido, GM Singh, J AF Mata, A. Marques, D. Martinez-Burgos, M. A. Silveira, J. Marques, J. Mesquita, M. F. Pariente, J. A. Salido, G. M. Singh, J. TI Effect of oxidative stress on carbachol-evoked secretory responses and caspase3 activity in the isolated rat parotid gland SO FUNDAMENTAL & CLINICAL PHARMACOLOGY LA English DT Meeting Abstract C1 [Mata, A.; Marques, D.; Silveira, J.; Marques, J.] Univ Lisbon, ITB, Biomed Technol Inst, Fac Med Dentaria, P-1699 Lisbon, Portugal. [Martinez-Burgos, M. A.; Pariente, J. A.; Salido, G. M.] Univ Extremadura, Dept Physiol, Caceres, Spain. [Mesquita, M. F.] Inst Super Ciencias Saude Egas Moniz, Oral Biol Res Grp, Monte De Caparica, Portugal. [Singh, J.] Univ Cent Lancashire, Sch Forens & Invest Sci, Preston, Lancs, France. NR 0 TC 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0767-3981 J9 FUNDAM CLIN PHARMACOL JI Fundam. Clin. Pharmacol. PD AUG PY 2008 VL 22 SU Suppl. 2 BP 94 EP 94 PG 1 SC Pharmacology & Pharmacy GA 324WW UT ISI:000257551100358 ER PT J AU Benito, MJ Serradilla, MJ Martin, A Aranda, E Hernandez, A Cordoba, MG AF Benito, Maria J. Serradilla, Manuel J. Martin, Alberto Aranda, Emilio Hernandez, Alejandro Cordoba, Maria G. TI Differentiation of Staphylococci from Iberian dry fermented sausages by protein fingerprinting SO FOOD MICROBIOLOGY LA English DT Article DE Staphylococcus; identification; SDS-PAGE; Iberian dry fermented sausages ID FLAVOR COMPOUNDS; MEAT-PRODUCTS; RIPENING TIME; IDENTIFICATION; MICROCOCCACEAE; STARTER; AUREUS; CARNOSUS; CULTURES; SAFETY AB The Staphylococci populations in different types of Iberian dry fermented sausages from central-west Spain were identified. A simple electrophoretic method of whole-cell proteins and extracellular protein profiling was evaluated for speed of identification. This study was correlated with a 16S rRNA gene sequence analysis and biochemical identification by API Staph. A total of 81 isolates were identified by SDS-PAGE of the whole-cell proteins. These showed stable profiles in the range 99-14 kDa that were clearly different for the different species, and were grouped into clusters together with the profiles of the eight reference strains. SDS-PAGE of the extracellular protein extracts provided additional characteristic banding patterns for the characterization of the Staphylococcus species present. The whole-cell SDS-PAGE showed that the predominant species was Staphylococcus saprophyticus (61.7%) followed by Staphylococcus aureus (19.7%). The identifications were confirmed by the 16S rRNA gene sequencing and by a BLAST search of the GenBank database. However, the API Staph biochemical identifications were frequently erroneous at the species level. In sum, SDS-PAGE analysis showed itself to be rapid and accurate in identifying the most commonly encountered Staphylococcus isolates in dry fermented sausages. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Benito, Maria J.; Serradilla, Manuel J.; Martin, Alberto; Aranda, Emilio; Hernandez, Alejandro; Cordoba, Maria G.] Univ Extremadura, Escuela Ingn Agrarias, Badajoz 06071, Spain. RP Benito, MJ, Univ Extremadura, Escuela Ingn Agrarias, Ctra Caceres S-N, Badajoz 06071, Spain. 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PD AUG PY 2008 VL 25 IS 5 BP 676 EP 682 DI 10.1016/j.fm.2008.03.007 PG 7 SC Biotechnology & Applied Microbiology; Food Science & Technology; Microbiology GA 325ZW UT ISI:000257628700007 ER PT J AU Rubio, S Corominas, A AF Rubio, Sergio Corominas, Albert TI Optimal manufacturing-remanufacturing policies in a lean production environment SO COMPUTERS & INDUSTRIAL ENGINEERING LA English DT Article DE reverse-logistics; lean production; remanufacturing; supply chain management ID REVERSE LOGISTICS; MODEL; RECOVERY; DESIGN; REPAIR AB This study analyses a production-management model that considers the possibility of implementing a reverse-logistics system for remanufacturing end-of-life products in a lean production environment (as opposed to models that use EOQ approaches). Decision variables are identified (including manufacturing and remanufacturing capacities and return rates and use rates for end-of-life products) and optimal policies are determined. Moreover, the structure of these optimal policies is analysed. The conclusion drawn is that, in many realistic scenarios, mixed policies (that is, with return rates and use rates strictly between 0 and 1) can be optimal. This conclusion is contrary to results published in earlier studies, which are based on more restrictive assumptions. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Rubio, Sergio] Univ Extremadura, Sch Ind Engn, E-06071 Badajoz, Spain. [Corominas, Albert] Tech Univ Catalonia, Inst Ind & Control Engn, Barcelona 08028, Spain. RP Rubio, S, Univ Extremadura, Sch Ind Engn, Ave Elvas S-N, E-06071 Badajoz, Spain. 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Ind. Eng. PD AUG PY 2008 VL 55 IS 1 BP 234 EP 242 DI 10.1016/j.cie.2007.12.009 PG 9 SC Computer Science, Interdisciplinary Applications; Engineering, Industrial GA 324RM UT ISI:000257535700016 ER PT J AU Liu, Y Gallardo-Moreno, AM Pinzon-Arango, PA Reynolds, Y Rodriguez, G Camesano, TA AF Liu, Yatao Gallardo-Moreno, Amparo M. Pinzon-Arango, Paola A. Reynolds, Yorke Rodriguez, Guadalupe Camesano, Terri A. TI Cranberry changes the physicochemical surface properties of E. coli and adhesion with uroepithelial cells SO COLLOIDS AND SURFACES B-BIOINTERFACES LA English DT Article DE atomic force microscopy; bacterial adhesion; cranberry; natural products; thermodynamic model; interfacial free energy; urinary tract infection ID FIMBRIATED ESCHERICHIA-COLI; URINARY-TRACT-INFECTIONS; IN-VITRO; INHIBIT ADHERENCE; PSEUDOMONAS-AERUGINOSA; BLUEBERRY JUICES; FREE-ENERGY; PROANTHOCYANIDINS; CONSTITUENT; REDUCTION AB Cranberries have been suggested to decrease the attachment of bacteria to uroepithelial cells (UC), thus preventing urinary tract infections, although the mechanisms are not well understood. A thermodynamic approach was used to calculate the Gibbs free energy of adhesion changes (Delta G(adh)) for bacteria-UC interactions, based on measuring contact angles with three probe liquids. Interfacial tensions and Delta G(adh) values were calculated for Escherichia coli HB101pDC1 (P-fimbriated) and HB101 (non-fimbriated) exposed to cranberry juice (0-27 wt.%). HB101 pDC1 can form strong bonds with the Gal-Gal disaccharide receptor on uroepithelial cells, while HB101-UC interactions are only non-specific. For HB101 interacting with UC, Delta G(adh) was always negative, suggesting favorable adhesion, and the values were insensitive to cranberry juice concentration. For the HB101 pDC1-UC system, Delta G(adh) became positive at 27 wt.% cranberry juice, suggesting that adhesion was unfavorable. Acid-base (AB) interactions dominated the interfacial tensions, compared to Lifshitz-van der Waals (M) interactions. Exposure to cranberry juice increased the AB component of the interfacial tension of HB101 pDC1. LW interactions were small and insensitive to cranberry-juice concentration. The number of bacteria attached to UC was quantified in batch adhesion assays and quantitatively correlated with Delta G(adh). Since the thermodynamic approach should not agree with the experimental results when specific interactions are present, such as HB101 pDC-UC ligand-receptor bonds, our results may suggest that cranberry juice disrupts bacterial ligand-UC receptor binding. These results help form the mechanistic explanation of how cranberry products can be used to prevent bacterial attachment to host tissue, and may lead to the development of better therapies based on natural products. (C) 2008 Elsevier B.V. All rights reserved. C1 [Liu, Yatao; Reynolds, Yorke; Rodriguez, Guadalupe; Camesano, Terri A.] Worcester Polytech Inst, Dept Chem Engn, Worcester, MA 01609 USA. [Pinzon-Arango, Paola A.] Worcester Polytech Inst, Dept Biomed Engn, Worcester, MA 01609 USA. [Gallardo-Moreno, Amparo M.] Univ Extremadura, Dept Appl Phys, Badajoz 06710, Spain. [Gallardo-Moreno, Amparo M.] CIBER BBN, Badajoz, Spain. RP Camesano, TA, WPI Life Sci & Bioengn Ctr Gateway Pk, Dept Chem Engn, 60 Prescott St, Worcester, MA 01605 USA. 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B-Biointerfaces PD AUG 1 PY 2008 VL 65 IS 1 BP 35 EP 42 DI 10.1016/j.colsurfb.2008.02.012 PG 8 SC Biophysics; Chemistry, Physical; Materials Science, Biomaterials GA 325WC UT ISI:000257618200006 ER PT J AU Celma, AR Rojas, S Lopez-Rodriguez, F AF Celma, A. Ruiz Rojas, S. Lopez-Rodriguez, F. TI Mathematical modelling of thin-layer infrared drying of wet olive husk SO CHEMICAL ENGINEERING AND PROCESSING LA English DT Article DE olive husk; infrared drying; moisture-ratio models; statistical test; activation energy ID KINETICS; SLICES; PISTACHIO; BEHAVIOR; POTATO; BARLEY; CAKE AB The thin-layer infrared drying behaviour of wet olive husk (WOH) was experimentally investigated at the temperature range from 80 degrees C to 140 degrees C. The drying rate was found to increase with temperature, hence reducing the total drying time. In particular, as drying temperature was raised from 80 degrees C up to 140 degrees C, the time necessary to reduce the moisture content of the sample from 91.97 wt% down to 8.69 wt% (dry basis) changed from 105 min to 35 min. Using a non-linear regression (Marquart's method) and multiple regression analysis, a mathematical model for the thin-layer infrared drying process of WOH was proposed. The values of the diffusivity coefficients at each temperature were obtained using Fick's second law of diffusion. They varied from 5.958 x 10(-9) m(2)/s to 1.589 x 10(-8) m(2)/s over the temperature range. The temperature dependence of the effective diffusivity coefficient was described following an Arrhenius-type relationship. Activation energy for the moisture diffusion was determined as 21.30 kJ/mol. (c) 2007 Elsevier B.V. All rights reserved. C1 [Celma, A. Ruiz; Rojas, S.] Univ Extremadura, Dept Energy & Chem Engn, E-06071 Badajoz, Spain. [Lopez-Rodriguez, F.] Univ Extremadura, Dept Engn Projects, E-06071 Badajoz, Spain. RP Celma, AR, Univ Extremadura, Dept Energy & Chem Engn, Avda Elvas S-N, E-06071 Badajoz, Spain. 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Eng. Process. PD SEP PY 2008 VL 47 IS 9-10 BP 1810 EP 1818 DI 10.1016/j.cep.2007.10.003 PG 9 SC Energy & Fuels; Engineering, Chemical GA 325XS UT ISI:000257622700039 ER PT J AU Anderson, RH Sanchez-Quintana, D Niederer, P Lunkenheimer, PP AF Anderson, Robert H. Sanchez-Quintana, Damian Niederer, Peter Lunkenheimer, Paul P. TI Structural-functional correlates of the 3-dimensional arrangement of the myocytes making up the ventricular walls SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY LA English DT Editorial Material ID MYOCARDIAL FIBER ARCHITECTURE; HUMAN-HEART; MYOARCHITECTURE; ORIENTATION; SYSTOLE; HELIX; DOG C1 [Anderson, Robert H.] Univ Coll, Inst Child Hlth, Cardiac Unit, London WC1N 1EH, England. [Sanchez-Quintana, Damian] Univ Extremadura, Dept Anat, Badajoz, Spain. [Niederer, Peter] Univ Zurich, Inst Biomed Engn, Zurich, Switzerland. [Niederer, Peter] Swiss Fed Inst Technol, Zurich, Switzerland. [Lunkenheimer, Paul P.] Univ Hosp, Munster, Germany. RP Anderson, RH, Univ Coll, Inst Child Hlth, Cardiac Unit, 30 Guilford St, London WC1N 1EH, England. 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Thorac. Cardiovasc. Surg. PD JUL PY 2008 VL 136 IS 1 BP 10 EP 18 DI 10.1016/j.jtcvs.2007.09.083 PG 9 SC Cardiac & Cardiovascular Systems; Respiratory System; Surgery GA 322OT UT ISI:000257385900003 ER PT J AU Espinosa-Garcia, J Bravo, JL AF Espinosa-Garcia, Joaquin Bravo, Jose L. TI State-to-state dynamics analysis of the F+CHD3 reaction: A Quasiclassical trajectory study SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID ZERO-POINT-ENERGY; HYDROGEN ABSTRACTION REACTION; PRODUCT PAIR CORRELATION; F+CD4 REACTION; REDUCED DIMENSIONALITY; CROSS-SECTIONS; SCATTERING; SURFACE; KINETICS; SPECTRA AB An exhaustive state-to-state dynamics study was performed to analyze the F + CHD3 -> FD(v ''j')+ CHD2(v) gas-phase abstraction reaction. Quasiclassical trajectory (QCT) calculations, including corrections to avoid zero-point energy leakage along the trajectories, were performed at different collision energies on an analytical potential energy surface (PES-2006) recently developed by our group. Whereas the CHD2 coproduct appears vibrationally and rotationally cold, most of the available energy appears as FD(v') product vibrational energy, peaking at v' = 2 and v' = 3, with the population in the latter level growing as the energy increases. The excitation function rises from the threshold of the reaction and then levels off at higher energies, with the maximum contribution from the FD(v' = 3) level. The state-specific FD(v') scattering distributions correlated with the coproduct CHD2 in the v(4) = 2 and v(3) = 1 states, at different collision energies, show a steady change from backward to forward scattering as the energy increases. This similar behavior for the two coproduct vibrational states, v(4) = 2 and v(3) = 1, agrees qualitatively with the experimental measurements. Comparison with theoretical and experimental results for the isotopic analogues, F + CH4 and F + CD4, shows that the title reaction presents a direct mechanism, similar to the perdeuterated reaction, but contrasts with that of the F + CH4 reaction. These results for the dynamics of different isotopic variants, always in qualitative and sometimes in quantitative agreement with experiment, show the capacity of the PES-2006 surface to correctly describe the title reaction, even though there are differences that could be due to deficiencies of the PES but also to the known limitations of the classical treatment in the QCT method. C1 [Espinosa-Garcia, Joaquin; Bravo, Jose L.] Univ Extremadura, Dept Quim Fis, E-06071 Badajoz, Spain. RP Espinosa-Garcia, J, Univ Extremadura, Dept Quim Fis, E-06071 Badajoz, Spain. 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Phys. Chem. A PD JUL 10 PY 2008 VL 112 IS 27 BP 6059 EP 6065 DI 10.1021/jp711218p PG 7 SC Chemistry, Physical; Physics, Atomic, Molecular & Chemical GA 321VQ UT ISI:000257335000002 ER PT J AU Gomez-Duran, A Ballestar, E Carvajal-Gonzalez, JM Marlowe, JL Puga, A Esteller, M Fernandez-Salguero, PM AF Gomez-Duran, Aurea Ballestar, Esteban Carvajal-Gonzalez, Jose M. Marlowe, Jennifer L. Puga, Alvaro Esteller, Manel Fernandez-Salguero, Pedro M. TI Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner SO JOURNAL OF MOLECULAR BIOLOGY LA English DT Article DE LTBP-1; dioxin receptor; CREB1; HDAC2; transcriptional regulation ID GROWTH-FACTOR-BETA; ARYL-HYDROCARBON RECEPTOR; MARMOSETS CALLITHRIX-JACCHUS; BINDING PROTEIN-1 LTBP-1; CELL-CYCLE CONTROL; LATENT-TGF-BETA; AH RECEPTOR; EXTRACELLULAR-MATRIX; HISTONE DEACETYLASE; TARGET GENES AB Latent TGF beta-binding protein 1 (LTBP-1) is a key regulator of TGF beta targeting and activation in the extracellular matrix. LTBP-1 is recognized as a major docking molecule to localize, and possibly to activate, TGF beta in the extracellular matrix. Despite this relevant function, the molecular mechanisms regulating Ltbp-1 transcription remain largely unknown. Previous results from our laboratory revealed that mouse embryonic fibroblasts (MEF) lacking dioxin receptor (AhR) had increased Ltbp(-1) mRNA expression and elevated TGF beta activity, suggesting that AhR repressed Ltbp(-1) transcription. Here, we have cloned the mouse Ltbp(-1) gene promoter and analysed its mechanism of transcriptional repression by AhR. Reporter gene assays, AhR over-expression and site-directed mutagenesis showed that basal Ltbp-1 transcription is AhR-dependent. Chromatin immunoprecipitation (ChIP) and RNA interference (RNAi) revealed that AhR regulates Ltbp-1 transcription by a mechanism involving recruitment of co-activators such as CREB1 and co-repressors such as HDAC2 to the Ltbp-1 promoter. In AhR-expressing (AhR+/+) MEF cells, the recruitment of HDAC1, 2 and 4 correlated with decreased K8H4 acetylation and impaired binding of pCREB(Ser133) to the Ltbp-1 promoter, likely maintaining a constitutive repressed state. AhR-/- MEF cells had the opposite pattern of HDACs and pCREB1(Ser133) binding to Ltbp-1 promoter, and therefore, over-expressed Ltbp-1 mRNA. In agreement, siRNA for HDAC2 increased Ltbp-1 expression and K8H4 acetylation in AhR+/+ but not in AhR-/- MEF cells. We suggest that HDAC2 binding keeps Ltbp-1 promoter repressed in AhR+/+ MEF cells, whereas in AhR-null MEF cells the absence of HDAC2 and the binding of pCREB(Ser133) allow Ltbp-1 transcription. Thus, epigenetics can contribute to constitutive Ltbp-1 repression by a mechanism requiring AhR activity. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Gomez-Duran, Aurea; Carvajal-Gonzalez, Jose M.; Fernandez-Salguero, Pedro M.] Univ Extremadura, Dept Bioquim & Biol Mol, Fac Ciencias, E-06071 Badajoz, Spain. [Ballestar, Esteban; Esteller, Manel] CNIO, Lab Epigenet Canc, Programa Patol Mol, Madrid 28029, Spain. [Marlowe, Jennifer L.; Puga, Alvaro] Univ Cincinnati, Med Ctr, Dept Environm Hlth, Cincinnati, OH 45267 USA. RP Fernandez-Salguero, PM, Univ Extremadura, Dept Bioquim & Biol Mol, Fac Ciencias, Ave Elvas S-N, E-06071 Badajoz, Spain. 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Mol. Biol. PD JUN 27 PY 2008 VL 380 IS 1 BP 1 EP 16 DI 10.1016/j.jmb.2008.04.056 PG 16 SC Biochemistry & Molecular Biology GA 323SV UT ISI:000257469600001 ER PT J AU Rivas, FJ Carbajo, M Beltran, F Gimeno, O Frades, J AF Rivas, F. J. Carbajo, M. Beltran, F. Gimeno, O. Frades, J. TI Comparison of different advanced oxidation processes (AOPs) in the presence of perovskites SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE perovskite; ozone; pyruvic acid; AOPs; UV radiation ID PYRUVIC-ACID; CATALYTIC OZONATION; WATER; OZONE AB The efficacy of the oxidation systems: O-3, UV radiation, O-3/UV radiation, O-3/perovskite, UV radiation/perovskite, O-3/UV radiation/perovskite, H2O2/UV radiation, H2O2/UV radiation/perovskite, has been investigated by using pyruvic acid as probe compound. Under the operating conditions used, the combination of UV radiation and hydrogen peroxide (with or without perovskites) leads to the fastest pyruvic acid removal while the best results in terms of mineralization degree are obtained when combining O-3/UV radiation/perovskite. The effect of the variables: inlet ozone (15-75 mg L-1) and initial pyruvic acid (10(-3) to 10(-2) M) concentrations, catalyst load (0.01-1.5 g L-1) and pH (2-9) was investigated for the photocatalytic ozonation. The most influencing parameter was the ozone concentration fed to the photoreactor. A zero order was observed for pyruvic acid concentration and close to zero for catalyst load. Some deactivation is observed after reusing the catalyst, likely due to leaching of the active phase. (C) 2007 Elsevier B.V All rights reserved. C1 [Rivas, F. J.; Carbajo, M.; Beltran, F.; Gimeno, O.] Univ Extremadura, Dept Ingn Quim & Quim Fis, E-06071 Badajoz, Spain. [Frades, J.] Univ Castilla La Mancha, Dept Ingn Quim, Ciudad Real, Spain. RP Rivas, FJ, Univ Extremadura, Dept Ingn Quim & Quim Fis, Avenida Elvas S-N, E-06071 Badajoz, Spain. EM fjrivas@unex.es CR ANDREOZZI R, 2001, WATER RES, V35, P109 BADER H, 1981, WATER RES, V15, P449 BELTRAN FJ, 2004, OZONE REACTION KINET BELTRAN FJ, 2005, OZONE-SCI ENG, V27, P159, DOI 10.1080/01919510590925338 CARBAJO A, 2006, APPL CATAL B-ENVIRON, V67, P177, DOI 10.1016/j.apcatb.2006.04.019 GIMENO O, 2005, J HAZARD MATER, V119, P99, DOI 10.1016/j.jhazmat.2004.11.024 GOGATE PR, 2004, ADV ENVIRON RES, V8, P553, DOI 10.1016/S1093-0191(03)00031-5 IKEHATA K, 2005, OZONE-SCI ENG, V27, P83, DOI 10.1080/1919510590925220 RIVAS FJ, 2006, APPL CATAL B-ENVIRON, V62, P93, DOI 10.1016/j.apcatb.2005.07.002 NR 9 TC 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD JUL 15 PY 2008 VL 155 IS 3 BP 407 EP 414 DI 10.1016/j.jhazmat.2007.11.081 PG 8 SC Engineering, Environmental; Engineering, Civil; Environmental Sciences GA 320UX UT ISI:000257261600003 ER PT J AU Gomez, JR Khakimdjanov, Y Navarro, RM AF Gomez, J. R. Khakimdjanov, Yu. Navarro, R. M. TI Infinitesimal deformations of the lie superalgebra L-n,L-m SO JOURNAL OF GEOMETRY AND PHYSICS LA English DT Article DE Lie superalgebras; cohomology; deformation; nilpotent; filiform ID COHOMOLOGY AB In this paper, we continue the study of the infinitesimal deformations of the Lie superalgebra L-n,L-m that we have started in [M. Bordemann, J.R. Gomez, Yu. Khakimdjanov, R.M. Navarro, Some deformations of nilpotent Lie superalgebras, J. Geom. Phys. 57 (2007) 1391-1403]. These deformations allow us to obtain all filiform Lie superalgebras. In [M. Bordemann, J.R. Gomez, Yu. Khakimdjanov, R.M. Navarro, Some deformations of nilpotent Lie superalgebras, J. Geom. Phys. 57 (2007) 1391-1403], we gave a method that allows us to determine the dimension of the space of deformations of type Hom(S-2(L-1(n,m)).L-0(n,m)) and we calculated a basis of the aforementioned space of deformations for n >= 2m - 1. In this paper, we conclude the study by developing a method to calculate a basis of the space of deformations Hom(S-2(L-1(n,m)).L-0(n,m)) for the rest of possibilities n < 2m - 1. We particularize for even n and also give an algorithm for computing a cocycle basis for the given concrete dimensions n and in. (C) 2008 Elsevier B.V. All rights reserved. C1 [Navarro, R. M.] Univ Extremadura, Dept Matemat, Caceres, Spain. [Gomez, J. R.] Univ Seville, Dpto Matemat Aplicada 1, Seville, Spain. [Khakimdjanov, Yu.] Univ Haute Alsace, Lab Math & Applicat, Mulhouse, France. RP Navarro, RM, Univ Extremadura, Dept Matemat, Caceres, Spain. EM jrgomez@us.es Y.Hakimjanov@uha.fr rnavarro@unex.es CR BORDEMANN M, 2007, J GEOM PHYS, V57, P1391, DOI 10.1016/j.geomphys.2006.11.001 FUKS DB, 1986, COHOMOLOGY INFINITE GOMEZ JR, 2004, J GEOM PHYS, V51, P473, DOI 10.1016/j.geomphys.2004.01.003 GOZE M, 1989, J GEOM PHYS, V6, P583 HEGAZI A, 1999, INT J THEOR PHYS, V38, P1735 HEGAZI A, 2000, PANAMER MATH J, V10, P75 KHAKIMDJANOV Y, 2005, INT C OP ALG QUANT P, P207 SCHEUNERT M, 1979, LECT NOTES MATH, V716 SCHEUNERT M, 1998, J MATH PHYS, V39, P5024 VERGNE M, 1970, B SOC MATH FRANCE, V98, P81 NR 10 TC 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0393-0440 J9 J GEOM PHYSICS JI J. Geom. Phys. PD JUL PY 2008 VL 58 IS 7 BP 849 EP 859 DI 10.1016/j.geomphys.2008.02.005 PG 11 SC Mathematics, Applied; Physics, Mathematical GA 322BD UT ISI:000257349300004 ER PT J AU Rohrmann, RD Robles, M de Haro, ML Santos, A AF Rohrmann, Rene D. Robles, Miguel de Haro, Mariano Lopez Santos, Andres TI Virial series for fluids of hard hyperspheres in odd dimensions SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID EQUATION-OF-STATE; VOLUME FUNCTION-APPROACH; PERCUS-YEVICK EQUATION; SPHERE FLUID; BINARY-MIXTURES; ARBITRARY DIMENSIONALITY; INFINITE DIMENSIONS; CLASSICAL FLUIDS; COEFFICIENTS; THERMODYNAMICS AB A recently derived method [R. D. Rohrmann and A. Santos, Phys. Rev. E 76, 051202 (2007)] to obtain the exact solution of the Percus-Yevick equation for a fluid of hard spheres in (odd) d dimensions is used to investigate the convergence properties of the resulting virial series. This is done both for the virial and compressibility routes, in which the virial coefficients B-j are expressed in terms of the solution of a set of (d-1)/2 coupled algebraic equations which become nonlinear for d >= 5. Results have been derived up to d=13. A confirmation of the alternating character of the series for d >= 5, due to the existence of a branch point on the negative real axis, is found and the radius of convergence is explicitly determined for each dimension. The resulting scaled density per dimension 2 eta(1/d), where eta is the packing fraction, is wholly consistent with the limiting value of 1 for d ->infinity. Finally, the values for B-j predicted by the virial and compressibility routes in the Percus-Yevick approximation are compared with the known exact values [N. Clisby and B. M. McCoy, J. Stat. Phys. 122, 15 (2006)]. C1 [Rohrmann, Rene D.] Univ Nacl Cordoba, Astron Observ, RA-5000 Cordoba, Argentina. [Robles, Miguel; de Haro, Mariano Lopez] Univ Nacl Autonoma Mexico, Ctr Invest Energia, Temixco 62580, Morelos, Mexico. [Santos, Andres] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. RP Rohrmann, RD, Univ Nacl Cordoba, Astron Observ, Laprida 854,X5000BGR, RA-5000 Cordoba, Argentina. 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Chem. Phys. PD JUL 7 PY 2008 VL 129 IS 1 AR 014510 DI 10.1063/1.2951456 PG 8 SC Physics, Atomic, Molecular & Chemical GA 323SG UT ISI:000257468100028 ER PT J AU Preciado, JC Linaje, M Sanchez-Figueroa, F AF Carlos Preciado, Juan Linaje, Marino Sanchez-Figueroa, Fernando TI Enriching model-based Web applications presentation SO JOURNAL OF WEB ENGINEERING LA English DT Article DE Web Engineering; user interfaces; Web 2.0; Rich Internet Applications; Web UI evolution ID USER INTERFACES AB The Web Engineering community provides Web Models that allow the design and development of Web 1.0 applications. Nowadays, there are a growing number of Web 1.0 applications that are migrating towards Web 2.0 User Interfaces, in search of multimedia support and higher levels of interaction among other features. These Web 2.0 features can be implemented using RIA technologies. However, most of the current Web Models do not fully exploit all the potential benefits of Rich Internet Applications. Therefore it is difficult for developers to adapt Web 1.0 applications to Web 2.0 using a methodology. Although there are interesting works that extend existing methodologies to deal with RIA features, either they do not fully exploit presentation issues or they only work with a single Web methodology. In this paper we use RUX-Method to facilitate the evolution of existing Web 1.0 applications based on Web Models to multi-device Web 2.0 applications. RUX-Method focuses on the enrichment of the User Interface while takes full advantage of the functionality already provided by the existing Web models. Far from explaining RUX-Method in detail, this paper focuses on the way the information provided by Web Models is retrieved and then used by RUX-Method. C1 [Carlos Preciado, Juan; Linaje, Marino; Sanchez-Figueroa, Fernando] Univ Extremadura, Escuela Politecn, Quercus Software Engn Group Homeria, Caceres 10071, Spain. RP Preciado, JC, Univ Extremadura, Escuela Politecn, Quercus Software Engn Group Homeria, Caceres 10071, Spain. EM jcpreciado@cunex.es mlinaje@cunex.es fernando@cunex.es CR BANDELLONI R, 2007, P 2 INT WORKSH AEWSE, P58 BEBJAK M, 2007, P 2 INT WORKSH AEWSE, P80 BOZZON A, 2006, P 6 INT C WEB ENG PA, V263, P353 CALVARY G, 2003, INTERACT COMPUT, V15, P289, DOI 10.1016/S0953-5438(03)00010-9 CERI S, 2002, DESIGNING DATA INTEN CERI S, 2004, LECT NOTES COMPUT SC, V3140, P201 CERI S, 2007, ACM T INTER TECH, V7 CONALLEN J, 1999, COMMUN ACM, V42, P63 DANIEL F, 2007, IEEE INTERNET COMPUT, V11, P59 DETROYER O, 2007, WEB ENG MODELLING IM, V12, P303 DEVIRGILIO R, 2005, P ACM INT WORKSH DAT, P9 FIALA Z, 2005, 7 IEEE INT S 26 SEPT, P39 GARRIGOS I, 2007, P 2 INT WORKSH AEWSE, P13 GOMEZ J, 2001, IEEE MULTIMEDIA, V8, P26 HOUBEN GJ, WEB ENG MODELLING IM, P263 KOCH N, P IWWOST02, P105 LIMBOURG Q, 2005, LNCS, P207 LINAJE M, 2007, IEEE INTERNET COMPUT, V11, P53 LUCCA GA, 2002, P 6 EUR C SOFTW MAIN, P241 MARTINEZRUIZ F, 2006, WEB C 2006 LA WEB 06, P32 MESBAH A, 2007, SOFTW MAINT REENG 20, P181 MORENO N, 2007, IET SOFTWARE J, V1 PRECIADO JC, 2005, WEB SIT EV 2005 WSE, P7 PRECIADO JC, 2007, P AEWSE 1 INT WORKSH PRECIADO JC, 2007, WEB SIT EV 7 IEEE IN, P23 PRECIADO JC, 2008, P 8 INT C WEB ENG YO SCHWABE D, 1996, P 7 ACM C HYP, P116 STEARN B, 2007, IEEE INTERNET COMPUT, V11, P67 URBIETA M, 2007, WEB C 2007 LA WEB 20, P144 NR 29 TC 0 PU RINTON PRESS, INC PI PARAMUS PA 565 EDMUND TERRACE, PARAMUS, NJ 07652 USA SN 1540-9589 J9 J WEB ENG JI J. Web Eng. PD SEP PY 2008 VL 7 IS 3 BP 239 EP 256 PG 18 SC Computer Science, Software Engineering; Computer Science, Theory & Methods GA 321VH UT ISI:000257334100005 ER PT J AU Aureliano, M Henao, F Tiago, T Duarte, RO Moura, JJG Baruah, B Crans, DC AF Aureliano, Manuel Henao, Fernando Tiago, Teresa Duarte, Rui O. Moura, J. J. G. Baruah, Bharat Crans, Debbie C. TI Sarcoplasmic reticulum calcium ATPase is inhibited by organic vanadium coordination compounds: Pyridine-2,6-dicarboxylatodioxovanadium(V), BMOV, and an amavadine analogue SO INORGANIC CHEMISTRY LA English DT Article ID VANADATE OLIGOMERS; SACCHAROMYCES-CEREVISIAE; REVERSE MICELLES; OXIDATIVE STRESS; METAL-ION; INSULIN; CHEMISTRY; BINDING; NMR; DECAVANADATE AB The general affinity of the sarcoplasmic reticulum (SR) Ca2+-ATPase was examined for three different classes of vanadium coordination complexes including a vanadium(V) compound, pyridine-2,6-dicarboxylatodioxovanadium(V) (PDC-V(V)), and two vanadium(IV) compounds, bis(maltolato)oxovanadium(IV) (BMOV), and an analogue of amavadine, bis(N-hydroxylamidoiminodiacetato)vanadium(IV) (HAIDA-V(IV)). The ability of vanadate to act either as a phosphate analogue or as a transition-state analogue with enzymes' catalysis phosphoryl group transfer suggests that vanadium coordination compounds may reveal mechanistic preferences in these classes of enzymes. Two of these compounds investigated, PDC-V(V) and BMOV, were hydrolytically and oxidatively reactive at neutral pH, and one, HAIDA-V(IV), does not hydrolyze, oxidize, or otherwise decompose to a measurable extent during the enzyme assay. The SR Ca2+-ATPase was inhibited by all three of these complexes. The relative order of inhibition was PDC-V(V) > BMOV > vanadate > HAIDA-V(IV), and the IC50 values were 25, 40, 80, and 325 mu M, respectively. Because the observed inhibition is more potent for PDC-V(V) and BMOV than that of oxovanadates, the inhibition cannot be explained by oxovanadate formation during enzyme assays. Furthermore, the hydrolytically and redox stable amavadine analogue HAIDA-V(IV) inhibited the Ca2+-ATPase less than oxovanadates.. To gauge the importance of the lipid environment, studies of oxidized BMOV in microemulsions were performed and showed that this system remained in the aqueous pool even though PDC-V(V) is able to penetrate lipid interfaces. These findings suggest that the hydrolytic properties of these complexes may be important in the inhibition of the calcium pump. Our results show that two simple coordination complexes with known insulin enhancing effects can invoke a response in calcium homeostasis and the regulation of muscle contraction through the SR Ca2+-ATPase. C1 [Aureliano, Manuel; Tiago, Teresa] Univ Algarve, FCT, Dept Quim Bioquim & Farm, P-8005139 Faro, Portugal. [Aureliano, Manuel; Tiago, Teresa] Univ Algarve, CCMar, P-8005139 Faro, Portugal. [Henao, Fernando] Univ Extremadura, Fac Ciencias, Dept Bioquim & Biol Mol, Badajoz, Spain. [Duarte, Rui O.; Moura, J. J. G.] Univ Nova Lisboa, FCT, Dept Quim, REQUIMTE, Monte De Caparica, Portugal. [Baruah, Bharat; Crans, Debbie C.] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA. RP Aureliano, M, Univ Algarve, FCT, Dept Quim Bioquim & Farm, P-8005139 Faro, Portugal. 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Chem. PD JUL 7 PY 2008 VL 47 IS 13 BP 5677 EP 5684 DI 10.1021/ic702405d PG 8 SC Chemistry, Inorganic & Nuclear GA 321BB UT ISI:000257278000030 ER PT J AU Agundez, JAG AF Agundez, Jose A. G. TI N-acetyltransferases: Lessons learned from eighty years of research SO CURRENT DRUG METABOLISM LA English DT Editorial Material ID ACETYLATION; METABOLISM; MECHANISM C1 Univ Extremadura, Sch Med, Dept Pharmacol, E-06071 Badajoz, Spain. RP Agundez, JAG, Univ Extremadura, Sch Med, Dept Pharmacol, Avda Elvas S-N, E-06071 Badajoz, Spain. CR AGUNDEZ JA, 2008, CLIN CHEM IN PRESS AGUNDEZ JA, 2008, CURR DRUG M IN PRESS BATRA J, 2008, CURR DRUG M IN PRESS BLUM M, 1990, DNA CELL BIOL, V9, P193 BLUM M, 1991, P NATL ACAD SCI USA, V88, P5237 BUTCHER NJ, 2008, CURR DRUG M IN PRESS CLARK DWJ, 1985, DRUGS, V29, P342 COLMENERO JD, 1994, ANTIMICROB AGENTS CH, V38, P2798 CROOK JE, 1979, SOUTH MED J, V72, P1599 EVANS DAP, 1960, AM REV RESPIR DIS, V82, P853 EVANS DAP, 1960, BRIT MED J, V2, P485 GARCIAMARTIN E, 2008, CURR DRUG M IN PRESS GRANT DM, 1989, NUCLEIC ACIDS RES, V17, P3978 GRANT DM, 2008, CURR DRUG M IN PRESS HEIN DW, 1994, HUM MOL GENET, V3, P729 LADERO JM, 2008, CURR DRUG M IN PRESS MAKAROVA SI, 2008, CURR DRUG M IN PRESS MUENZEN JB, 1926, J BIOL CHEM, V67, P469 RODRIGUESLIMA F, 2008, CURR DRUG M IN PRESS SIM E, 2008, CURR DRUG M IN PRESS SINCLAIR JC, 2000, NAT STRUCT BIOL, V7, P560 WALRAVEN JM, 2008, CURR DRUG M IN PRESS WEBER WW, 1968, BIOCHIM BIOPHYS ACTA, V151, P276 WU H, 2007, J BIOL CHEM, V282, P30189, DOI 10.1074/jbc.M704138200 NR 24 TC 1 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1389-2002 J9 CURR DRUG METAB JI Curr. Drug Metab. PD JUL PY 2008 VL 9 IS 6 BP 463 EP 464 PG 2 SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 323OL UT ISI:000257455800001 ER PT J AU Garcia-Martin, E AF Garcia-Martin, Elena TI Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms SO CURRENT DRUG METABOLISM LA English DT Review ID ARYLAMINE N-ACETYLTRANSFERASE; DRUG-METABOLIZING-ENZYMES; ALLELE FREQUENCIES; CANCER SUSCEPTIBILITY; GENETIC POLYMORPHISMS; ACETYLATOR GENOTYPE; CHINESE POPULATION; N-ACETYLTRANSFERASE-2; RISK; PHENOTYPE AB Genetic polymorphisms of human arylamine N-acetyltransferase 2 (NAT2) are responsible for interindividual variation in the acetylation of numerous drugs and in the transformation of aromatic and heterocyclic amines into carcinogenic intermediates. Although large interethnic variability in the frequency for NAT2 variant alleles has been reported, comparison of allele frequencies is hampered by differences in the criteria for the assignment of allelic variants. To avoid such sources of bias, in this review we analyze the occurrence of both interethnic and intraethnic variability for the seven commonest single nucleotide polymorphisms (SNP) in the NAT2 gene by using raw SNP data instead of inferred haplotypes. Besides the large interethnic variability observed for all SNPs except C282T, intraethnic variability for NAT2 SNPs was identified for the SNPs G191A among Caucasians (p<0.0001), T341C among Oriental (p<0.001) or African individuals (p<0.012), C481T among Oriental (p<0.001) or African individuals (p<0.001), and G590A among Oriental individuals (p<0.001). In contrast, no major intraethnic differences were identified for the SNPs C282T, A806G or G857A. Intraethnic variability may have relevant clinical implications. For instance, case-control NAT2 studies should not be extrapolated from one Oriental population to another. Nonsynonymous SNPs occur in 32% of alleles in Japanese individuals and in 47% of alleles in Chinese individuals, therefore the frequency of adverse effects and cancer related to slow acetylation is expected to be higher in individuals with Chinese descent than in those with Japanese descent. Intraethnic variability reinforces the need for proper selection of control subjects and points against the use of surrogate control groups for studies involving association of NAT2 alleles with adverse drug effects or spontaneous diseases. C1 Univ Extremadura, Sch Biol Sci, Dept Biochem & Mol Biol & Genet, E-06071 Badajoz, Spain. RP Garcia-Martin, E, Univ Extremadura, Sch Biol Sci, Dept Biochem & Mol Biol & Genet, Avda Elvas S-N, E-06071 Badajoz, Spain. 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Drug Metab. PD JUL PY 2008 VL 9 IS 6 BP 487 EP 497 PG 11 SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 323OL UT ISI:000257455800004 ER PT J AU Agundez, JAG AF Agundez, Jose A. G. TI Polymorphisms of human N-acetyltransferases and cancer risk SO CURRENT DRUG METABOLISM LA English DT Review DE cytochrome P450; polymorphisms; pharmacogenomics; cancer; susceptibility ID GLUTATHIONE-S-TRANSFERASE; SQUAMOUS-CELL CARCINOMA; NAT2 GENETIC POLYMORPHISMS; DRUG-METABOLIZING-ENZYMES; SLOW ACETYLATOR GENOTYPE; URINARY-BLADDER CANCER; RED MEAT INTAKE; MICROSOMAL EPOXIDE HYDROLASE; TEXTILE-INDUSTRY WORKERS; NON-HODGKINS-LYMPHOMA AB Human arylamine N-acetyltransferases (CoASAc; NAT, EC 2.3.1.5) NAT1 and NAT2 play a key role in the metabolism of drugs and environmental chemicals and in the metabolic activation and detoxification of procarcinogens. Phenotyping analyses have revealed an association between NAT enzyme activities and the risk of developing several forms of cancer. As genotyping procedures have become available for NAT1 and NAT2 gene variations, hundreds of association studies on NAT polymorphisms and cancer risk have been conducted. Here we review the findings obtained from these studies. Evidence for a putative association of NAT1 polymorphism and myeloma, lung and bladder cancer, as well as association of NAT2 polymorphisms with non-Hodgkin lymphoma, liver, colorectal and bladder cancer have been reported. In contrast, no consistent evidence for a relevant association of NAT polymorphisms with brain, head & neck, breast, gastric, pancreatic or prostate cancer have been described. Although preliminary data are available, further well-powered studies are required to fully elucidate the role of NAT1 in most human cancers, and that of NAT2 in astrocytoma, meningioma, esophageal, renal, cervical and testicular cancers, as well as in leukaemia and myeloma. This review discusses controversial findings on cancer risk and putative causes of heterogeneity in the proposed associations, and it identifies topics that require further investigation, particularly mechanisms underlying association of NAT polymorphisms and risk for subsets of cancer patients with specific exposures, putative epistatic contribution of polymorphism for other xenobiotic-metabolising enzymes such as glutathione S-transferases of Cytochrome P450 enzymes, and genetic plus environmental interaction. C1 Univ Extremadura, Sch Med, Dept Pharmacol, E-06071 Badajoz, Spain. RP Agundez, JAG, Univ Extremadura, Sch Med, Dept Pharmacol, Avda Elvas S-N, E-06071 Badajoz, Spain. 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Drug Metab. PD JUL PY 2008 VL 9 IS 6 BP 520 EP 531 PG 12 SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 323OL UT ISI:000257455800008 ER PT J AU Nabais, JV Carrott, P Carrott, MMLR Luz, V Ortiz, AL AF Nabais, Joao Valente Carrott, Peter Carrott, M. M. L. Ribeiro Luz, Vania Ortiz, Angel L. TI Influence of preparation conditions in the textural and chemical properties of activated carbons from a novel biomass precursor: The coffee endocarp SO BIORESOURCE TECHNOLOGY LA English DT Article DE activated carbon; coffee endocarp; surface properties; physical activation; chemical activation ID CHARCOAL CLOTH; ADSORPTION; GROUNDS; REMOVAL; RESIDUE; DECOLORIZATION; IMPREGNANTS; ADSORBENTS; FIBERS; SITES AB In this work a novel biomass precursor for the production of activated carbons (AC) was studied. The lignocellulosic material used as precursor is the coffee bean endocarp, which constitutes an industrial residue from the Portuguese coffee industry. Activation by carbon dioxide and potassium hydroxide produces activated carbons with small external areas and pore volumes up to 0.22 and 0.43 cm(3) g(-1), respectively, for CO2 and KOH activation. All the AC's produced are very basic in nature with point of zero charge higher than 8. SEM/EDX studies indicate the presence of K, O, Ca and Si. By FTIR it was possible to identify the formation on the AC's surface of several functional groups, namely phenol, alcohol, quinone, lactone, pyrone and ether as well as Si-H groups. The tailoring of the porous and chemical structure of the activated carbons produced is possible by selecting the appropriate production conditions. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Nabais, Joao Valente; Carrott, Peter; Carrott, M. M. L. Ribeiro; Luz, Vania] Univ Evora, Dept Quim, P-7000 Evora, Portugal. [Nabais, Joao Valente; Carrott, Peter; Carrott, M. M. L. Ribeiro; Luz, Vania] Ctr Quim Evora, P-7000 Evora, Portugal. 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Technol. PD OCT PY 2008 VL 99 IS 15 BP 7224 EP 7231 DI 10.1016/j.biortech.2007.12.068 PG 8 SC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy & Fuels GA 322IE UT ISI:000257367600060 ER PT J AU Canales, J Fernandez, A Ribeiro, JM Cabezas, A Rodrigues, JR Cameselle, JC Costas, MJ AF Canales, Jose Fernandez, Ascension Meireles Ribeiro, Joao Cabezas, Alicia Rui Rodrigues, Joaquim Carlos Cameselle, Jose Jesus Costas, Maria TI Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells SO BIOCHEMICAL JOURNAL LA English DT Article DE ADP-ribose; CDP-choline; immune system; metallophosphoesterase; Nudix; signalling ID OXIDATIVE STRESS; RAT-LIVER; HYDROLASE SUPERFAMILY; PHOSPHODIESTERASE-I; NUDIX HYDROLASES; CALCIUM INFLUX; HUMAN PLACENTA; K-M; TRPM2; ACTIVATION AB ADPRibase-Mn (Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase) was earlier isolated from rat liver supernatants after separation from ADPRibase-I and ADPRibase-II (Mg2+-activated ADP-ribose pyrophosphatases devoid of CDP-alcohol pyrophosphatase activity). The last mentioned are putative Nudix hydrolases, whereas the molecular identity of ADPRibase-Mn is unknown. MALDI (matrix-assisted laser-desorption ionization) MS data from rat ADPRibase-Mn pointed to a hypothetical protein that was cloned and expressed and showed the expected specificity. It is encoded by the RGD1309906 rat gene, which so far has been annotated simply as 'hydrolase'. ADPRibase-Mn is not a Nudix hydrolase, but it shows the sequence and structural features typical of the metallophosphoesterase superfamily. It may constitute a protein family of its own, the members of which appear to be specific to vertebrates, plants and algae. ADPribose was successfully docked to a model of rat ADPRibase-Mn, revealing its putative active centre. Microarray data from the GEO (Gene Expression Omnibus) database indicated that the mouse gene 2310004I24Rik, an orthologue of RGD1309906, is preferentially expressed in immune cells. This was confirmed by Northern-blot and activity assay of ADPRibase-Mn in rat tissues. A possible role of ADPRibase-Mn in immune cell signalling is suggested by the second-messenger role of ADP-ribose, which activates TRPM2 (transient receptor potential melastatin channel-2) ion channels as a mediator of oxidative/nitrosative stress, and by the signalling function assigned to many of the microarray profile neighbours of 2310004I24Rik. Furthermore, the influence of ADPRibase-Mn on the CDP-choline or CDP-ethanolamine pathways of phospholipid biosynthesis cannot be discounted. C1 [Canales, Jose; Fernandez, Ascension; Meireles Ribeiro, Joao; Cabezas, Alicia; Rui Rodrigues, Joaquim; Carlos Cameselle, Jose; Jesus Costas, Maria] Univ Extremadura, Grp Enzimol, Dept Bioquim & Biol Mol & Genet, Fac Med, E-06080 Badajoz, Spain. RP Cameselle, JC, Univ Extremadura, Grp Enzimol, Dept Bioquim & Biol Mol & Genet, Fac Med, E-06080 Badajoz, Spain. 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J. PD JUL 1 PY 2008 VL 413 PN Part 1 BP 103 EP 113 DI 10.1042/BJ20071471 PG 11 SC Biochemistry & Molecular Biology GA 323YF UT ISI:000257483700010 ER PT J AU Ramos, MI Cardoso, MJ Vaz, F Torres, MD Garcia, F Blanco, G Gonzalez, EM AF Ramos, M. I. Cardoso, M. J. Vaz, F. Torres, M. D. Garcia, F. Blanco, G. Gonzalez, E. M. TI Influence of the grade of anxiety and level of cortisol on post-surgical recovery SO ACTAS ESPANOLAS DE PSIQUIATRIA LA English DT Article DE anxiety; cortisol; stress; psychobiology; surgical recovery ID SURGICAL PATIENTS; TRAIT ANXIETY; STRESS; SURGERY; REACTIVITY; RESPONSES; VALIDITY; STYLE; MEN AB Introduction. The objective is to analyze the influence of several biological and/or psychological factors on post-surgery recovery. Method. Our sample was made up of 42 inpatients waiting for surgery. The day before the intervention, they filled out Spielbergers' State/Trait Anxiety Inventory (STAI) and a sample of saliva was collected at 8:00 in order to determine cortisol concentration. Recovery was codified as "good" or "poor" using the Moix criteria (1995). Results. Patients with higher scores on the STAI had higher levels of salivary cortisol and their recovery was worse compared with patients with low anxiety. Conclusions. Our results confirm the relationship between specific psychological variables, cortisol levels and the characteristics of the surgery recovery process of the patients. C1 [Cardoso, M. J.] Univ Extremadura, Fac Med Badajoz, Dept Farmacol & Psiquiatria, E-06071 Badajoz, Spain. [Torres, M. D.] UEx, Fac Med, Dept Fisiol, Badajoz, Spain. [Garcia, F.; Blanco, G.] SES, Hosp Univ Infanta Cristina, Serv Cirugia, Badajoz, Spain. [Gonzalez, E. M.] SES, Ctr Salud Ciudad Jardin, Badajoz, Spain. RP Cardoso, MJ, Univ Extremadura, Fac Med Badajoz, Dept Farmacol & Psiquiatria, Ave Elvas S-N, E-06071 Badajoz, Spain. 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Psiquiatri. PD MAY-JUN PY 2008 VL 36 IS 3 BP 133 EP 137 PG 5 SC Neurosciences; Psychiatry GA 320KV UT ISI:000257233800002 ER PT C AU Respaldiza, MA Ager, FJ Carmona, A Ferrer, J Garcia-Leon, M Garcia-Lopez, J Garcia-Orellana, I Gomez-Tubio, B Morilla, Y Ontalba, MA Ortega-Feliu, I AF Respaldiza, M. A. Ager, F. J. Carmona, A. Ferrer, J. Garcia-Leon, M. Garcia-Lopez, J. Garcia-Orellana, I. Gomez-Tubio, B. Morilla, Y. Ontalba, M. A. Ortega-Feliu, I. TI Accelerator-based research activities at "Centro Nacional de Aceleradores", Seville (Spain) SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Proceedings Paper DE ion accelerators; laboratory portrait; IBA techniques; PET; AMS ID PIXE AB In February 1998, almost 10 years ago, the set-up of the first IBA (ion beam analysis) facility in Spain took place with the arrival of a 3 MV tandem accelerator [J. Garcia-Lopez, F.J. Ager, M. Barbadillo-Rank, F.J. Madrigal, M.A. Ontalba, M.A. Respaldiza, M.D. Ynsa, Nucl. Instr. and Meth. B 161-163 (2000) 1137]. Since then, an intensive research program using IBA techniques has been carried out. Subsequently, a cyclotron for 18 MeV protons has been also installed at the "Centro Nacional de Aceleradores" (CNA), devoted mainly to isotope production for PET (positron emission tomography) techniques, but possibly applied to material analysis and damage studies on a dedicated beam line. Moreover, a 1 MV tandem has been recently installed for AMS (accelerator mass spectrometry) C-14 dating and environmental research with other isotopes. In the present paper we describe the new facilities and the developments of the 3 MV tandem beam lines occurred during the past years, as well as some examples of the most recent research activities in our Center in the fields of Material Science, Archaeometry, Biomedicine and Environment. (C) 2008 Elsevier B.V. All rights reserved. C1 [Respaldiza, M. A.; Ager, F. J.; Carmona, A.; Ferrer, J.; Garcia-Leon, M.; Garcia-Lopez, J.; Garcia-Orellana, I.; Gomez-Tubio, B.; Morilla, Y.; Ontalba, M. A.; Ortega-Feliu, I.] Ctr Nacl Aceleradores, E-41092 Seville, Spain. [Respaldiza, M. A.; Garcia-Leon, M.; Garcia-Lopez, J.; Ortega-Feliu, I.] Univ Seville, Dept Fis Atom Mol & Nucl, Seville, Spain. [Ager, F. J.] Univ Seville, Dept Fis Aplicada 1, Seville, Spain. [Gomez-Tubio, B.] Univ Seville, Dept Fis Aplicada 3, Seville, Spain. [Ontalba, M. A.] Univ Extremadura, Dept Fis, Caceres, Spain. [Carmona, A.] Univ Bordeaux, Lab Chim Nucl Analyt & Environm, Bordeaux, France. RP Respaldiza, MA, Ctr Nacl Aceleradores, Avd Thomas A Edison 7, E-41092 Seville, Spain. EM respaldiza@us.es CR AGER FJ, 2002, NUCL INSTRUM METH B, V189, P494 AGER FJ, 2003, NUCL INSTRUM METH B, V210, P401, DOI 10.1016/S0168-583X(03)01046-2 BATTISTIG G, 2003, MATER SCI FORUM, V433, P625 CHAMIZO E, 2008, NUCL INSTRUM METH B, V266, P2217 FENG ZC, 2004, SIC POWER MAT DEVICE FERRERO A, 2004, P WORKSH RAD EFF COM, P343 GARCIALOPEZ J, 2000, NUCL INSTRUM METH B, V161, P1137 GARCIAORELLANA I, 2004, P 10 INT C PART IND GURBICH AF, 2000, NUCL INSTRUM METH B, V161, P125 MARTIN JE, 2002, NUCL INSTRUM METH B, V188, P102 ONTALBA MA, 2001, NUCL INSTRUM METH B, V181, P664 ONTALBA MA, 2006, NUCL INSTRUM METH B, V249, P622 ORTEGA R, 2005, NUCL INSTRUM METH B, V231, P321, DOI 10.1016/j.nimb.2005.01.077 ORTEGAFELIU I, 2007, NUCL INSTRUM METH B, V260, P329 SALAMANCA MAO, ANAL TESORO CARAMBOL, P176 YNSA MD, 2002, NUCL INSTRUM METH B, V189, P431 NR 16 TC 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH PHYS RES B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAY PY 2008 VL 266 IS 10 BP 2105 EP 2109 DI 10.1016/j.nimb.2008.02.080 PG 5 SC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear GA 319SZ UT ISI:000257185600004 ER PT J AU Jodar-Reyes, AB Lyklema, J Leermakers, FAM AF Jodar-Reyes, A. B. Lyklema, J. Leermakers, F. A. M. TI Comparison between inhomogeneous adsorption of charged surfactants on air-water and on solid-water interfaces by self-consistent field theory SO LANGMUIR LA English DT Article ID INTERACTING CHAIN MOLECULES; NONIONIC SURFACTANTS; SEMIFLUORINATED ALKANES; HYDROPHOBIC SURFACE; COMPUTER-SIMULATION; STATISTICAL-THEORY; FORCE MICROSCOPY; MICELLES; LAYER; SILICA AB We use a realistic molecular model to study the interfacial behavior of hydrocarbon sulfate surfactants within a self-consistent field model and consider the adsorption both at the air-water interface and at ahydrophobic solid-water interface. We focus on the structural properties of the hemimicelles at the critical interface aggregation concentration (CIAC) for the air-water system and the critical surface aggregation concentration (CSAC) for the solid-water system. The major difference between the two systems is that the liquid interface is penetrable but the solid surface is intrinsically impenetrable for the molecular species. At the LG interface the hemimicelles have a lens shape with their centers of mass positioned slightly toward the aqueous side and feature an aspect ratio of approximately 2, with the long dimension parallel to the interface. Hemimicelle formation occurs below a critical (interfacial) area per molecule and above a critical surface pressure depending on tail length and ionic strength. Hemimicelles are not expected at air-water interfaces for a surfactant with a tail length (t) lower than 15 CH2 units. In contrast, at a hydrophobic solid the formation of laterally inhomogeneous micelles even takes place for surfactants with the tail length as short as t = 12. This difference is attributed to the screening of the lateral interactions in the vapor phase. The shape of surface hemimicelles is caplike (or half-lens) with an aspect ratio lower than 2 and the long dimension parallel to the solid surface. The tail length, the ionic strength, the adsorption energies, and the surfactant concentration have an effect on the surface micelle properties such as the aggregation number and size and shape. C1 [Jodar-Reyes, A. B.] Univ Extremadura, Dept Fis Aplicada, Fac Vet, E-10071 Caceres, Spain. [Lyklema, J.; Leermakers, F. A. M.] Wageningen Univ, Lab Phys Chem & Colloid Sci, NL-6703 HB Wageningen, Netherlands. RP Jodar-Reyes, AB, Univ Extremadura, Dept Fis Aplicada, Fac Vet, Avda Univ S-N, E-10071 Caceres, Spain. 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The discontinuity of the processes both in space and in time produces a highly complicated rainfall-runoff relationship. Runoff production and reinfiltration areas produce a discontinuous spatial pattern of runoff; channel flow is ephemeral and restricted to the wet season of the year or to heavy rainfalls, and many local saturated layers of soil separated by unsaturated areas can occur. The hydrological connection of the different parts of the basin produces a nonlinear and complex hydrologic behaviour because different response mechanisms of the basin are triggered as the hydrological connectivity increases. Similarly, as connectivity decreases, so does the information arriving at the monitored state variables used to calibrate the model and to understand the system. This paper describes the application of a distributed hydrologic model to describe the hydrologic behaviour of a small semiarid basin including surface and subsurface processes. The model is parameterized and calibrated to simulate a period of 71 days covering the transition of the basin from a dry to a wet state, during which most of the hydrologic processes of the basin are activated. The calibration strategy used different sources and types of information on the state of the basin and an efficient gradient based search algorithm to find the optimal values of the most sensitive parameters. The modelled hydrograph and the modelled internal description of the basin were analysed in the light of its known behaviour and the existing knowledge of semiarid hydrology reported in the literature. The results indicate that while the integrated behaviour of the basin represented by the output hydrograph can be well reproduced, the subsurface processes and the internal dynamics of the basin are less accurately simulated, mainly due to the lack of information on the geometry of the subsurface domain (soil depths and bedrock topography) and on the spatial distribution of the parameters. Copyright (C) 2007 John Wiley & Sons, Ltd. C1 [Maneta, Marco; Schnabel, Susanne] Univ Extremadura, Dept Geograf & Ordenac Territorio, Caceres, Spain. [Jetten, Victor] ITC, Dept Earth Syst Anal, Enschede, Netherlands. RP Maneta, M, Univ Extremadura, Dept Geograf & Ordenac Territorio, Caceres, Spain. 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Process. PD JUN 30 PY 2008 VL 22 IS 13 BP 2196 EP 2214 DI 10.1002/hyp.6817 PG 19 SC Water Resources GA 318KK UT ISI:000257090200012 ER PT J AU Lopez-Rodriguez, MJ Roncero-Martin, R Canal-Macias, ML Lavado-Garcia, JM Calderon-Garcia, JF Pedrera-Zamorano, JD AF Lopez-Rodriguez, M. J. Roncero-Martin, R. Canal-Macias, M. L. Lavado-Garcia, J. M. Calderon-Garcia, J. F. Pedrera-Zamorano, J. D. TI Body composition and bone mass in healthy children of extremadura (Spain): Correlation with anthropometrics and nutritional factors SO CALCIFIED TISSUE INTERNATIONAL LA English DT Meeting Abstract C1 [Lavado-Garcia, J. M.] Univ Extremadura, Dept Med 1, Caceres, Spain. [Roncero-Martin, R.; Canal-Macias, M. L.; Calderon-Garcia, J. F.; Pedrera-Zamorano, J. D.] Univ Extremadura, Dept Nursing, Caceres, Spain. [Lopez-Rodriguez, M. J.] Univ Extremadura, Complejo Hosp Caceres SES, Serv Pediat, Caceres, Spain. NR 0 TC 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0171-967X J9 CALCIFIED TISSUE INT JI Calcif. Tissue Int. PY 2008 VL 82 SU Suppl. 1 BP S173 EP S173 PG 1 SC Endocrinology & Metabolism GA 306OS UT ISI:000256258300420 ER PT J AU Lavado-Garcia, JM Canal-Macias, ML Roncero-Martin, R Calderon-Garcia, JF Rodriguez-Dominguez, T Pedrera-Zamorano, JD AF Lavado-Garcia, J. M. Canal-Macias, M. L. Roncero-Martin, R. Calderon-Garcia, J. F. Rodriguez-Dominguez, T. Pedrera-Zamorano, J. D. TI Body composition and bone mass in healthy Spanish women: Relationship with gonadal status SO CALCIFIED TISSUE INTERNATIONAL LA English DT Meeting Abstract C1 [Canal-Macias, M. L.; Roncero-Martin, R.; Calderon-Garcia, J. F.; Pedrera-Zamorano, J. D.] Univ Extremadura, Dept Nursing, Caceres, Spain. [Lavado-Garcia, J. M.; Rodriguez-Dominguez, T.] Univ Extremadura, Dept Med 1, Caceres, Spain. NR 0 TC 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0171-967X J9 CALCIFIED TISSUE INT JI Calcif. Tissue Int. PY 2008 VL 82 SU Suppl. 1 BP S173 EP S174 PG 2 SC Endocrinology & Metabolism GA 306OS UT ISI:000256258300421 ER PT J AU Castro, M Masero, JA Megina, C Amat, JA Perez-Hurtado, A AF Castro, Macarena Masero, Jose A. Megina, Cesar Amat, Juan A. Perez-Hurtado, Alejandro TI Energy and macronutrient assimilation efficiencies of Snowy Plover (Charadrius alexandrinus) feeding on the polychaete ragworm Nereis diversicolor SO AUK LA English DT Article DE assimilation efficiency; Charadrius alexandrinus; macronutrients; metabolizable energy; Nereis diversicolor; shorebirds; Snowy Plover ID SEX-RELATED VARIATION; SHOREBIRDS; WADERS; BIRDS; DIET; OYSTERCATCHER; FRUIT; EXPENDITURE; ENERGETICS; DIGESTION AB Macronutrient (protein, lipids, and carbohydrates) assimilation efficiencies of wild birds have rarely been studied, but they may be particularly important for estimating the optimal diet. We assessed experimentally the energy and macronutrient assimilation efficiencies of captive Snowy Plover (Charadrius alexandrinus) feeding on the polychaete ragworm Nereis diversicolor, a major natural prey for migratory shorebirds (Charadrii) along intertidal habitats worldwide. Overall, Snowy Plover consumed 8.64 +/- 1.54 (SD) g of dry ragworms per day, and the apparent metabolizable energy was 136.59 +/- 27.69 kJ.day(-1) (3.5-4.0 times the basal metabolic rate). Assimilation efficiencies were 80.04 +/- 2.04%, 93.48 +/- 1.08%, 84.75 +/- 2.01%, and 89.23 +/- 2.61% for energy, proteins, lipids, and carbohydrates, respectively. Macronutrient assimilation efficiencies were similar during early winter and premigration and between male and female Snowy Plover. Relatively high protein assimilation by Snowy Plover may be associated with their specialized high-protein diet. C1 [Castro, Macarena; Megina, Cesar; Perez-Hurtado, Alejandro] Univ Cadiz, Dept Anim Biol, Fac Ciencias Mar & Ambientales, E-11510 Puerto Real, Spain. [Masero, Jose A.] Univ Extremadura, Fac Ciencias, Grp Invest Conservac, Area Zool, E-06071 Badajoz, Spain. [Amat, Juan A.] CSIC, Estac Biol Donana, E-41080 Seville, Spain. RP Castro, M, Ctr Invest Ecosistemas Patagonia, Bilbao 449, Coyhaique, Chile. 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RP Fitz, FG, Univ Extremadura, Dept Hist, Area Hist Medieval, Fac Filosofia & Letras, Avda Univ S-N, Caceres 10071, Spain. EM fgfitz@unex.es CR JIMENEZ MG, 2002, DISTRIBUTION CITY EL NR 1 TC 0 PU CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS PI MADRID PA VITRUVIO 8, 28006 MADRID, SPAIN SN 0066-5061 J9 ANU ESTUD MEDIEV JI Anu. Estud. Mediev. PD JUL-DEC PY 2007 VL 37 IS 2 BP 1010 EP 1013 PG 4 SC History; Medieval & Renaissance Studies GA 307VF UT ISI:000256346000028 ER PT J AU Martinez, RF Avalos, M Babiano, R Cintas, P Jimenez, JL Light, ME Palacios, JC Perez, EMS AF Martinez, R. Fernando Avalos, Martin Babiano, Reyes Cintas, Pedro Jimenez, Jos L. Light, Mark E. Palacios, Juan C. Perez, Esther M. S. TI An efficient and highly diastereoselective synthesis of C-glycosylated 1,3-oxazolidines from N-methyl-D-glucamine SO TETRAHEDRON LA English DT Article ID RING-CHAIN TAUTOMERISM; CHIRAL AUXILIARIES; AMINO-ACIDS; OXAZOLIDINES; DERIVATIVES; SUGARS AB A one-pot procedure for preparing chiral 1,3-oxazolidines derived from N-methyl-D-glucamine and aryl aldehydes is described. It has been carried out by using readily available reagents and operationally simple conditions allowing the preparation of the acyclic C-nucleoside analogs in high yields. The structure of these derivatives has been fully characterized by NMR correlations and single-crystal X-ray diffraction. Some reactions also provide access to the corresponding tetrahydro-1,3-oxazines by an alternative ring closure. Mechanistic considerations account for the observed steric course. Crown Copyright (c) 2008 Published by Elsevier Ltd. All rights reserved. C1 [Martinez, R. Fernando; Avalos, Martin; Babiano, Reyes; Cintas, Pedro; Jimenez, Jos L.; Palacios, Juan C.; Perez, Esther M. S.] Univ Extremadura, QUOREX Res Grp, Dept Quim Organ & Inorgan, E-06071 Badajoz, Spain. [Light, Mark E.] Univ Southampton, Dept Chem, Southampton S017 1BJ, Hants, England. RP Martinez, RF, Univ Extremadura, QUOREX Res Grp, Dept Quim Organ & Inorgan, E-06071 Badajoz, Spain. EM rmarvaz@unex.es CR ALONSOCRUZ CR, 2007, SYNLETT 1016, P2723, DOI 10.1055/s-2007-991061 ALVA ME, 1985, TETRAHEDRON, V41, P5919 AVALOS M, 2006, EUR J ORG CHEM 0130, P657 AVALOS M, 2008, J ORG CHEM, V73, P661, DOI 10.1021/jo702149m BALDWIN JE, 1976, J CHEM SOC CHEM COMM, P734 BECKE AD, 1993, J CHEM PHYS, V98, P5648 BOCK K, 1983, ADV CARBOHYD CHEM BI, V41, P27 BRUSCHI M, 2006, J PHYS ORG CHEM, V19, P592, DOI 10.1002/poc.1089 CANCES MT, 1997, J CHEM PHYS, V107, P3032 CHAVDA S, 2007, CHIRALITY, V19, P313, DOI 10.1002/chir.20364 COSSI M, 1998, CHEM PHYS LETT, V286, P253 ELZNER S, 2004, SYNTHESIS-STUTT 0906, P2153, DOI 10.1055/s-2004-831173 FRISCH MJ, 2004, GAUSSIAN 03 REVISION FULOP F, 1993, J ORG CHEM, V58, P1967 FULOP F, 1993, TETRAHEDRON, V49, P6701 GESSIER F, 2005, HELV CHIM ACTA, V88, P2235 GNAS Y, 2006, SYNTHESIS-STUTT 0614, P1899, DOI 10.1055/s-2006-942399 HEIN JE, 2005, J ORG CHEM, V70, P9940, DOI 10.1021/jo051696n HENRY AA, 2003, CURR OPIN CHEM BIOL, V7, P727, DOI 10.1016/j.cbpa.2003.10.011 HORTON D, 1974, J ORG CHEM, V39, P1859 IDE WS, 1948, ORG REACTIONS, V4, P269 JUST G, 1983, J ORG CHEM, V48, P2923 KHRUSCHEVA NS, 1997, J CHEM SOC PERK 0821, P2425 KOOL ET, 2002, ACCOUNTS CHEM RES, V35, P936 LEE C, 1988, PHYS REV B, V37, P75 MAIREANU C, 2002, TETRAHEDRON, V58, P2681 MENNUCCI B, 1997, J CHEM PHYS, V106, P5151 NAST AZ, 2004, NUCLEOS NUCLEOT, V23, P1825 NEUVONEN K, 2001, J ORG CHEM, V66, P4132 RAMESH NG, 2003, EUR J ORG CHEM 1128, P4477, DOI 10.1002/ejoc.200300383 ROYER J, 2004, CHEM REV, V104, P2311 SHEN MH, 2004, J ORG CHEM, V69, P7906 SMITH MB, 2001, ADV ORGANIC CHEM REA, P282 SPINO C, 2004, ORG LETT, V6, P2801, DOI 10.1021/ol048936q STEIF F, 2000, SYNTHESIS-STUTTG MAY, P743 STODDART JF, 1971, STEREOCHEMISTRY CARB, P55 VEGAPEREZ JM, 2001, TETRAHEDRON-ASYMMETR, V12, P3189 WELLINGTON KW, 2006, NUCLEOS NUCLEOT NUCL, V25, P1309, DOI 10.1080/15257770600917013 NR 38 TC 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0040-4020 J9 TETRAHEDRON JI Tetrahedron PD JUN 30 PY 2008 VL 64 IS 27 BP 6377 EP 6386 DI 10.1016/j.tet.2008.04.082 PG 10 SC Chemistry, Organic GA 315QS UT ISI:000256895100028 ER PT J AU Santos, A Fantoni, R Giacometti, A AF Santos, Andres Fantoni, Riccardo Giacometti, Achille TI Penetrable square-well fluids: Exact results in one dimension SO PHYSICAL REVIEW E LA English DT Article ID INTERPENETRABLE-SPHERE MODELS; HARD-SPHERES; PHASE-TRANSITIONS; EQUATION; SYSTEMS; MEDIA; MIXTURES; SURFACE; LIQUID; MATTER AB We introduce a model of attractive penetrable spheres by adding a short-range attractive square well outside a penetrable core, and we provide a detailed analysis of structural and thermodynamical properties in one dimension using the exact impenetrable counterpart as a starting point. The model is expected to describe star polymers in regimes of good and moderate solvent under dilute conditions. We derive the exact coefficients of a low-density expansion up to second order for the radial distribution function and up to fourth order in the virial expansion. These exact results are used as a benchmark to test the reliability of approximate theories (Percus-Yevick and hypernetted chain). Notwithstanding the lack of an exact solution for arbitrary densities, our results are expected to be rather precise within a wide range of temperatures and densities. A detailed analysis of some limiting cases is carried out. In particular, we provide a complete solution of the sticky penetrable-sphere model in one dimension up to the same order in density. The issue of Ruelle's thermodynamics stability is analyzed and the region of a well-defined thermodynamic limit is identified. C1 [Santos, Andres] Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. [Fantoni, Riccardo; Giacometti, Achille] Univ Venice, Dipartimento Chim Fis, I-30123 Venice, Italy. RP Santos, A, Univ Extremadura, Dept Fis, E-06071 Badajoz, Spain. 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Rev. E PD MAY PY 2008 VL 77 IS 5 PN Part 1 AR 051206 DI 10.1103/PhysRevE.77.051206 PG 14 SC Physics, Fluids & Plasmas; Physics, Mathematical GA 315MZ UT ISI:000256885400051 ER PT J AU Mandelli, C Porras, L Lopez-Sanchez, C Sicuri, GM Lomonaco, I Garcia-Martinez, V AF Mandelli, C. Porras, L. Lopez-Sanchez, C. Sicuri, G. M. Lomonaco, I. Garcia-Martinez, V. TI The partial labyrinthectomy petrous apicectomy approach to petroclival meningiomas. A quantitative anatomic comparison with other approaches to the same region SO NEUROCIRUGIA LA English DT Article DE meningioma; partial labyrinthectomy; petroclival; petrosal approach; rretrosigmoid approach ID CLIVUS AB The partial labyrinthectomy petrous apicectomy (PLPA) approach is a transpetrous route that provides the advantages of the labyrinthine removal but with hearing preservation. Using seven temporal bone tissue blocks and three formaldehyde-fixed cadaveric heads we have made a morphometric and comparative study on this approach that summarizes the invasiveness, the optimal surgical exposure, the anatomic complexity of the skull base approaches and, on the other hand, the spirit of preservation that is the constant aim of modern neurosurgery. The morphometric analysis is designed to make the bony phase of the PLPA approach safer and to define the relationship between petrous landmarks. The comparative study is made between the PLPA and other neurosurgical routes enhancing the potentiality of the PLPA approach that permits a wider angle of incidence towards the brainstem than with the retrosigmoid routes. C1 [Mandelli, C.; Sicuri, G. M.; Lomonaco, I.] Univ Vita Salute, IRCCS San Raffaele, Dept Neurosurg, Milan, Italy. [Porras, L.] Infanta Cristina Hosp, Dept Neurosurg, Badajoz, Spain. [Lopez-Sanchez, C.; Garcia-Martinez, V.] Univ Extremadura, Dept & Anat, Badajoz, Spain. RP Mandelli, C, Univ Vita Salute, IRCCS San Raffaele, Dept Neurosurg, Milan, Italy. CR AICHHOLZER M, 2000, ACTA NEUROCHIR, V142, P647 ASIAN A, 1997, J LARYNGOL OTOL, V111, P333 AZIZ KMA, 2000, NEUROSURGERY, V47, P139 CHANDA A, 2002, NEUROSURGERY, V51, P147 HAKUBA A, 1988, SURG NEUROL, V30, P108 HORGAN MA, 2000, J NEUROSURG, V93, P108 MCELVEEN JT, 1993, OTOLARYNG HEAD NECK, V108, P671 MILLER CG, 1993, NEUROSURGERY, V33, P461 MORTINI P, 2001, J NEUROSURG SCI, V45, P127 RHOTON AL, 2000, NEUROSURGERY, V47, P211 ROSENWASSER RH, 1993, BRAIN SURG COMPLICAT, V2, P1743 SAMII M, 1999, J CLIN NEUROSCI, V6, P27 SANAN A, 1999, NEUROSURGERY, V45, P1267 SANNA M, 1995, ATLAS TEMPORAL BONE, P51 SEKHAR LN, 1990, NEUROSURGERY, V27, P764 SEKHAR LN, 1999, CRANIAL MICROSURGERY, P352 SEKHAR LN, 1999, CRANIAL MICROSURGERY, P432 SEKHAR LN, 1999, NEUROSURGERY, V44, P537 SEOANE E, 1999, NEUROSURGERY, V44, P553 NR 19 TC 0 PU SOC ESPANOLA NEUROCIRUGIA PI MURCIA PA C/O DR POZA, GRAN VIA SALZILLO 42, 30005 MURCIA, SPAIN SN 1130-1473 J9 NEUROCIRUGIA JI Neurocirugia PD APR PY 2008 VL 19 IS 2 BP 133 EP 142 PG 10 SC Neurosciences; Surgery GA 315IL UT ISI:000256871900005 ER PT J AU Gusi, N Prieto, J Forte, D Gomez, I Gonzalez-Guerrero, JL AF Gusi, Narcis Prieto, Josue Forte, David Gomez, Ignacio Gonzalez-Guerrero, Jose-Luis TI Needs, interests, and limitations for the promotion of health and exercise by a web site for sighted and blind elderly people: A qualitative exploratory study SO EDUCATIONAL GERONTOLOGY LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; PHYSICAL-ACTIVITY; OLDER ADULTS; CARE; WOMEN AB The purpose of this study was to identify needs, interests, and obstacles related to obtaining health education by means of a Web site for elderly people who do not use the Internet. A total of 34 participants were divided into five discussion groups, one of which was made up of blind people. An analysis of the semantic content of the transcriptions of the focal groups' discussions was conducted. Most participants showed a willingness to receive health education (about nutrition, physical exercise, and quality of life) and learn to use the Internet. The main obstacles to the use of the Internet were the lack of free access and the fear of being swindled or becoming addicted to its use. The results suggest that a Web site can be a useful tool for promoting healthy habits such as physical exercise and to increase the circle of friends for normal and blind elderly people. C1 [Gusi, Narcis; Prieto, Josue; Forte, David] Univ Extremadura, Fac Sports Sci, Caceres 10071, Spain. [Gomez, Ignacio] Spanish Natl Org ONCE, Badajoz, Spain. [Gonzalez-Guerrero, Jose-Luis] Caceres Hosp, Geriatr Unit, Caceres, Spain. RP Gusi, N, Univ Extremadura, Fac Sports Sci, Avenida Univ S-N, Caceres 10071, Spain. 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Gerontol. PD JUN PY 2008 VL 34 IS 6 BP 449 EP 461 DI 10.1080/03601270801984432 PG 13 SC Education & Educational Research; Gerontology GA 313VE UT ISI:000256767300001 ER PT J AU El Haouari, M Rosado, JA AF El Haouari, Mohammed Rosado, Juan A. TI Platelet signalling abnormalities in patients with type 2 diabetes mellitus: A review SO BLOOD CELLS MOLECULES AND DISEASES LA English DT Review DE platelets; diabetes mellitus; calcium signalling; reactive oxygen species; protein phosphorylation ID MEDIATED CALCIUM-ENTRY; OXIDATIVE STRESS; NITRIC-OXIDE; HYDROGEN-PEROXIDE; TYROSINE KINASE; NIDDM PATIENTS; CA2+ ENTRY; PROTEIN-PHOSPHORYLATION; VASCULAR COMPLICATIONS; ACTIVATION AB The hyperactivation of platelets is involved in the cardiovascular complications associated with type 2 diabetes mellitus. Altered platelet behavior contributes to the angiopathies associated with diabetes. A number of mechanisms involved in platelet activation are altered in diabetes. Platelets from type 2 diabetic patients show an enhanced endogenous reactive oxygen species production and a reduced antioxidant capability, which increase the activity of several tyrosine kinases, such as the Bruton's tyrosine kinase, MAP kinases or proteins of the SRC family. Oxidative stress is also involved in the abnormal intracellular calcium homeostasis observed in platelets from type 2 diabetics, including an enhanced resting cytosolic calcium concentration and calcium release and entry in response to agonists. Moreover, diabetes alters the bioavailability of nitric oxide in platelets. Basal nitric oxide synthase activity is reduced in homogenates of platelets obtained from patients with type 2 diabetes mellitus. The study of these abnormalities might be helpful in the development of new pharmacological strategies to reduce platelet activation in type 2 diabetes mellitus. (C) 2008 Elsevier Inc. All rights reserved. C1 [Rosado, Juan A.] Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Ciceres 10071, Spain. [El Haouari, Mohammed] Univ Mohammed 1, Fac Sci, Lab Physiol & Ethnopharmacol, Dept Biol, Oujda 60000, Morocco. RP Rosado, JA, Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Av Univ S-N, Ciceres 10071, Spain. 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Dis. PD JUL-AUG PY 2008 VL 41 IS 1 BP 119 EP 123 DI 10.1016/j.bcmd.2008.02.010 PG 5 SC Hematology GA 314CF UT ISI:000256785600019 ER PT J AU Galeano-Diaz, T Guiberteau-Cabanillas, A Espinosa-Mansilla, A Lopez-Soto, MD AF Galeano-Diaz, T. Guiberteau-Cabanillas, A. Espinosa-Mansilla, A. Lopez-Soto, M. D. TI Adsorptive stripping square wave voltammetry (Ad-SSWV) accomplished with second-order multivariate calibration - Determination of fenitrothion and its metabolites in river water samples SO ANALYTICA CHIMICA ACTA LA English DT Article DE fenitrothion; metabolites; adsorptive stripping square wave voltammetry; second-order multivariate calibration; unfolded partial least squares/residual bilinearization ID PARTIAL LEAST-SQUARES; CHROMATOGRAPHY-MASS SPECTROMETRY; GAS CHROMATOGRAPHY; ELECTROCHEMICAL DETECTION; LIQUID-CHROMATOGRAPHY; SPECTRAL ANALYSES; MAIN METABOLITES; PLS CALIBRATION; PESTICIDES; SOIL AB A method, using stripping square wave voltammetry (Ad-SSWV), for the simultaneous determination of fenitrothion (FEN) and its metabolites: fenitrooxon (OXON) and 3-methyl-4-nitrophenol (3-MET) in environmental samples is reported. All three compounds produce, at mercury electrode (HMDE), an electrochemical signal due to an adsorptive-reductive process. The electrochemical approach shows a very high overlap degree for FEN and OXON voltammograms, however the adsorption kinetic profile could be used as an additional differential variable between both analytes. Second-order multivariate calibration has been tested to solve the mixture of the three compounds. The second-order assayed methods were parallel factor analysis (PARAFAC), unfolded partial least squares (U-PLS), multidimensional partial least squares (N-PLS) and the latest ones were used in combination with the residual bilinearization procedure RBL. U-PLS/RBL model was stated as the best second-order algorithm for the simultaneous determination of these three compounds up to 50 ng mL(-1) for each analyte. The detection limits and recovery values were 1.6 ng mL(-1) and 92 +/- 7% for FEN; 3.7 ng mL(-1) and 101 +/- 9% for OXON and 0.6 ng mL(-1) and 97 +/- 8% for 3-MET. (c) 2008 Elsevier B.V. All rights reserved. C1 [Galeano-Diaz, T.; Guiberteau-Cabanillas, A.; Espinosa-Mansilla, A.; Lopez-Soto, M. D.] Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. RP Galeano-Diaz, T, Univ Extremadura, Dept Analyt Chem, E-06071 Badajoz, Spain. 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Chim. Acta PD JUN 23 PY 2008 VL 618 IS 2 BP 131 EP 139 DI 10.1016/j.aca.2008.04.058 PG 9 SC Chemistry, Analytical GA 317FD UT ISI:000257004400002 ER PT J AU Perez, CJ Giron, FJ Martin, J Ruiz, M Rojano, C AF Perez, C. J. Giron, F. J. Martin, J. Ruiz, M. Rojano, C. TI Misclassified multinomial data: a Bayesian approach SO REVISTA DE LA REAL ACADEMIA DE CIENCIAS EXACTAS FISICAS Y NATURALES SERIE A-MATEMATICAS LA English DT Article ID DOUBLE SAMPLING SCHEME; CATEGORICAL-DATA; BERNOULLI PROCESS; INFERENCE; ERRORS AB In this paper, the problem of inference with misclassified multinomial data is addressed. Over the last years there has been a significant upsurge of interest in the development of Bayesian methods to make inferences with misclassified data. The wide range of applications for several sampling schemes and the importance of including initial information make Bayesian analysis an essential tool to be used in this context. 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[Navarro, J. M.] H Costa Del Sol, Serv Ap Digest, Malaga, Spain. [Salmeron, J.] HU S Ceciclio, Serv Ap Digest, Granada, Spain. NR 0 TC 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-8278 J9 J HEPATOL JI J. Hepatol. PY 2008 VL 48 SU Suppl. 2 BP 894 PG 2 SC Gastroenterology & Hepatology GA 312PL UT ISI:000256683201385 ER PT J AU Marzal, A Bensch, S Reviriego, M Balbontin, J de Lope, F AF Marzal, A. Bensch, S. Reviriego, M. Balbontin, J. de Lope, F. TI Effects of malaria double infection in birds: one plus one is not two SO JOURNAL OF EVOLUTIONARY BIOLOGY LA English DT Article DE avian malaria parasites; body condition; Delichon urbica; double infections; reproductive effort; survival ID AVIAN BLOOD PARASITES; TITS PARUS-CAERULEUS; TERMINAL INVESTMENT; GREAT TITS; REPRODUCTIVE EFFORT; IMMUNE-RESPONSE; BODY-MASS; PLASMODIUM-CHABAUDI; FICEDULA-HYPOLEUCA; AMERICAN KESTRELS AB Avian malaria parasites are supposed to exert negative effects on host fitness because these intracellular parasites affect host metabolism. Recent advances in molecular genotyping and microscopy have revealed that coinfections with multiple parasites are frequent in bird-malaria parasite systems. However, studies of the fitness consequences of such double infections are scarce and inconclusive. We tested if the infection with two malaria parasite lineages has more negative effects than single infection using 6 years of data from a natural population of house martins. Survival was negatively affected by both types of infections. We found an additive cost from single to double infection in body condition, but not in reproductive parameters (double-infected had higher reproductive success). These results demonstrate that malaria infections decrease survival, but also have different consequences on the breeding performance of single- and double-infected wild birds. C1 [Marzal, A.; Bensch, S.] Lund Univ, Dept Anim Ecol, S-22362 Lund, Sweden. [Marzal, A.] Univ Extremadura, Dept Ecol, Badajoz, Spain. [Reviriego, M.; Balbontin, J.; de Lope, F.] Univ Extremadura, Dept Biol Anim, Badajoz, Spain. RP Marzal, A, Lund Univ, Dept Anim Ecol, Ecol Bldg, S-22362 Lund, Sweden. 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